{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T01:37:40Z","timestamp":1761874660305,"version":"build-2065373602"},"reference-count":38,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Obvia Pharmaceuticals, Ltd.","award":["MS-004"],"award-info":[{"award-number":["MS-004"]}]},{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Program","doi-asserted-by":"publisher","award":["RT220041"],"award-info":[{"award-number":["RT220041"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Multiple sclerosis (MS) is a complex disease marked by chronic neuroinflammation and reactive oxygen species (ROS) toxicity in the central nervous system (CNS). Based on this ROS-driven mechanism, we tested whether PrC-210\u2014a new aminothiol ROS scavenger\u2014could lessen MS symptoms in mice with experimental autoimmune encephalomyelitis (EAE)-induced MS. Our goals were to assess the role of ROS in MS and evaluate the potential benefits of PrC-210 for managing MS. Mice with EAE received varying doses of PrC-210 under preventive and therapeutic protocols. Disease progression was measured using clinical scores and spinal cord histology. Safety was assessed by comparing the gastrointestinal and hematological toxicity between PrC-210 and dimethyl fumarate (DMF, Tecfidera\u2019s active agent). PrC-210 reduced MS severity by up to 62% in paralysis scores versus those in the controls (p = 0.0001), whether used preventively or at the onset of paralysis. The group with the greatest decrease also showed the best spinal cord preservation and least demyelination. DMF caused toxicity at a dose that was ineffective, while PrC-210 showed no toxicity at effective levels. These findings suggest that the systemic administration of PrC-210 may offer a safe, effective MS treatment when started at symptom onset.<\/jats:p>","DOI":"10.3390\/ijms262110597","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T01:23:59Z","timestamp":1761873839000},"page":"10597","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Significant Suppression of Multiple Sclerosis in the Mouse EAE Model Using the PrC-210 Aminothiol"],"prefix":"10.3390","volume":"26","author":[{"given":"William E.","family":"Fahl","sequence":"first","affiliation":[{"name":"Obvia Pharmaceuticals Ltd., Mountain View, CA 94043, USA"},{"name":"Wisconsin Institutes for Medical Research, Department of Oncology, University of Wisconsin-Madison, Madison, WI 53705, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan L.","family":"Fahl","sequence":"additional","affiliation":[{"name":"Obvia Pharmaceuticals Ltd., Mountain View, CA 94043, USA"},{"name":"Wisconsin Institutes for Medical Research, Department of Oncology, University of Wisconsin-Madison, Madison, WI 53705, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5220-0370","authenticated-orcid":false,"given":"Sarah R.","family":"Goesch","sequence":"additional","affiliation":[{"name":"Obvia Pharmaceuticals Ltd., Mountain View, CA 94043, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2515-8742","authenticated-orcid":false,"given":"Hannah R.","family":"Goesch","sequence":"additional","affiliation":[{"name":"Obvia Pharmaceuticals Ltd., Mountain View, CA 94043, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torsten R.","family":"Goesch","sequence":"additional","affiliation":[{"name":"Obvia Pharmaceuticals Ltd., Mountain View, CA 94043, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1750-3639.2007.00064.x","article-title":"The Immunopathology of Multiple Sclerosis: An Overview","volume":"17","author":"Lassmann","year":"2007","journal-title":"Brain Pathol."},{"key":"ref_2","first-page":"5793817","article-title":"The Influence of Reactive Oxygen Species in the Immune System and Pathogenesis of Multiple Sclerosis","volume":"2020","author":"Tavassolifar","year":"2020","journal-title":"Autoimmune Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.bbadis.2015.09.018","article-title":"Oxidative Stress and Its Impact on Neurons and Glia in Multiple Sclerosis Lesions","volume":"1862","author":"Lassmann","year":"2016","journal-title":"Biochim. 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