{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T02:43:50Z","timestamp":1781923430491,"version":"3.54.5"},"reference-count":51,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"RECOOP HST Association","award":["FUS 016: 2019-2021 extension 2022 Vass-Ertl. Pecs"],"award-info":[{"award-number":["FUS 016: 2019-2021 extension 2022 Vass-Ertl. Pecs"]}]},{"name":"University of Debrecen Program for Scientific Publication","award":["PTP2025"],"award-info":[{"award-number":["PTP2025"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>This study explored IgG N-glycosylation pattern differences in maternal and infant serum in the context of gestational diabetes mellitus (GDM). Serum samples from 15 mother\u2013infant pairs were collected at 12 weeks postpartum and categorized according to maternal body mass index (BMI) and GDM status. The N-glycosylation patterns of the isolated IgG pools were analyzed by capillary electrophoresis with laser-induced fluorescence detection (CE-LIF). Descriptive comparison of the relative area percentage of IgG N-glycan structures revealed differences between the groups. Comparison of the maternal and infant sialo-form\/neutral-form ratio (SF\/NF) of the N-glycans suggested differences between control mothers and their children, as well as between obese mothers and their children. The maternal SF\/NF ratio of IgG varied between the obese and normal-weight GDM mothers. The SF\/NF ratios of IgG from the infants showed variation between infants of control mothers and infants of obese mothers, between infants of obese and infants of obese GDM mothers, and between infants of GDM with normal-weight and GDM with obese mothers. The observed differences in maternal and infant IgG N-glycosylation profiles suggest potentially selective placental transfer mechanisms.<\/jats:p>","DOI":"10.3390\/ijms262110641","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:15:14Z","timestamp":1762175714000},"page":"10641","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["IgG N-Glycan Profiles in Mothers and Infants Postpartum in the Context of Maternal Obesity and Gestational Diabetes"],"prefix":"10.3390","volume":"26","author":[{"given":"Anna","family":"Farkas","sequence":"first","affiliation":[{"name":"Horv\u00e1th Csaba Memorial Laboratory of Bioseparation Sciences, Research Center for Molecular Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2656-259X","authenticated-orcid":false,"given":"Oksana","family":"Matsyura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics No. 2, State Non-Profit Enterprise \u201cDanylo Halytsky Lviv National Medical University\u201d, 79010 Lviv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesya","family":"Besh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics No. 2, State Non-Profit Enterprise \u201cDanylo Halytsky Lviv National Medical University\u201d, 79010 Lviv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7838-082X","authenticated-orcid":false,"given":"Andras","family":"Guttman","sequence":"additional","affiliation":[{"name":"Horv\u00e1th Csaba Memorial Laboratory of Bioseparation Sciences, Research Center for Molecular Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"},{"name":"Translational Glycomics Group, Research Institute of Biomolecular and Chemical Engineering, University of Pannonia, 8200 Veszprem, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2962-2017","authenticated-orcid":false,"given":"Sandor G.","family":"Vari","sequence":"additional","affiliation":[{"name":"Research and Innovation in Medicine Program, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S","article-title":"Definition, diagnosis and classification of diabetes mellitus and its complications. 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