{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:20:20Z","timestamp":1791656420886,"version":"4.3.4"},"reference-count":70,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Karunya University\/Karunya Institute of Technology and Sciences","award":["KU\/AO\/SJF\/SL\/2\/2012"],"award-info":[{"award-number":["KU\/AO\/SJF\/SL\/2\/2012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Chronic wounds present a major clinical challenge, often aggravated by infection and rising antimicrobial resistance. This study investigated the wound-healing efficacy of Lobelia alsinoides Lam., an ethnomedicinal herb, formulated as a topical ointment containing its ethanolic extract (LT). Phytochemical profiling identified high levels of phenolics, terpenoids, and tannins, while in vitro assays demonstrated strong antioxidant, broad-spectrum antimicrobial, and cytocompatible properties. Wound-healing potential was evaluated using excision and incision wound models in rats treated with 5% or 10% LT ointments, with Silverex\u2122 as the reference standard. The 10% LT formulation significantly outperformed Silverex\u2122, accelerating wound contraction (99.33 \u00b1 0.55% by Day 16), shortening epithelialization time (16.1 \u00b1 0.8 days), and enhancing tensile strength (837.36 \u00b1 16.37 g; p &lt; 0.001). Biochemical and histological analyses confirmed improved collagen deposition, extracellular matrix remodeling, and angiogenesis, without hepatic or renal toxicity. Overall, LT exhibited statistically superior wound-healing efficacy compared with Silverex\u2122, supporting its potential as a safe, affordable, and sustainable phytotherapeutic alternative. These findings provide strong scientific validation for L. alsinoides as an evidence-based herbal candidate for integration into modern wound care, with future studies warranted to establish mechanistic and clinical efficacy in chronic and infected wounds.<\/jats:p>","DOI":"10.3390\/ijms262110663","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:15:14Z","timestamp":1762175714000},"page":"10663","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Accelerated Full-Thickness Wound Healing by a Topical Ointment Formulated with Lobelia alsinoides Lam. Ethanolic Extract"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5760-9437","authenticated-orcid":false,"given":"Rex Jeya Rajkumar","family":"Samdavid Thanapaul","sequence":"first","affiliation":[{"name":"Division of Biotechnology, Karunya Institute of Technology and Sciences, Coimbatore 641114, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreeraj K.","family":"Manikandan","sequence":"additional","affiliation":[{"name":"Division of Biotechnology, Karunya Institute of Technology and Sciences, Coimbatore 641114, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8712-1168","authenticated-orcid":false,"given":"Mosae Selvakumar","family":"Paulraj","sequence":"additional","affiliation":[{"name":"Environmental Sciences Program, Green Bangle Movement, Asian University for Women, Chittagong 4000, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. S. A. Muthukumar","family":"Nadar","sequence":"additional","affiliation":[{"name":"Division of Biotechnology, Karunya Institute of Technology and Sciences, Coimbatore 641114, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1152\/physrev.00067.2017","article-title":"Wound Healing: A Cellular Perspective","volume":"99","author":"Rodrigues","year":"2019","journal-title":"Physiol. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/nature07039","article-title":"Wound Repair and Regeneration","volume":"453","author":"Gurtner","year":"2008","journal-title":"Nature"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Gushiken, L.F.S., Beserra, F.P., Bastos, J.K., Jackson, C.J., and Pellizzon, C.H. (2021). 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