{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T01:37:01Z","timestamp":1789522621456,"version":"build-2803163510"},"reference-count":80,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>TRPV4 (transient receptor potential vanilloid 4) is a non-selective, multifunctional cationic channel that is expressed in numerous cells in the body. It can be activated by temperature, mechanical forces, and chemical and biochemical molecules. Functionally, TRPV4 participates in maintaining osmotic homeostasis, blood pressure, and hypoxic preconditioning. As far as we know, the presence of TRPV4 has never been reported in the carotid body despite the overlap that exists between some biological functions of TRPV4 and the physiology of the carotid body. In the present work, immunofluorescence associated with confocal laser microscopy, associated with quantitative analysis (area occupied by immunofluorescence), has been used to examine the occurrence of TRPV4 in the human carotid body. The results demonstrated the presence of TRPV4 in a subpopulation of chemoreceptor type I cells (approximately 65\u201368%), a subpopulation of type II supporting cells, and in nerve terminals in the human carotid body. Its function, if any, in this multisensory organ must be demonstrated, but it is in line with the functions attributed to the carotid body.<\/jats:p>","DOI":"10.3390\/ijms262110689","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:15:14Z","timestamp":1762175714000},"page":"10689","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Transient Receptor Potential Vanilloid 4 (TRPV4) in the Human Carotid Body"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1442-1095","authenticated-orcid":false,"given":"Yolanda","family":"Garc\u00eda-Mesa","sequence":"first","affiliation":[{"name":"Grupo SINPOS, Departamento de Morfolog\u00eda y Biolog\u00eda Celular, Universidad de Oviedo, 33003 Oviedo, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias, ISPA, 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7993-3943","authenticated-orcid":false,"given":"Elda","family":"Alba","sequence":"additional","affiliation":[{"name":"Instituto de Neurociencias Vithas, 28010 Madrid, Spain"},{"name":"Servicio de Neurolog\u00eda, Hospital Cl\u00ednico San Carlos, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2758-930X","authenticated-orcid":false,"given":"Graciela","family":"Mart\u00ednez-Barbero","sequence":"additional","affiliation":[{"name":"Grupo SINPOS, Departamento de Morfolog\u00eda y Biolog\u00eda Celular, Universidad de Oviedo, 33003 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iv\u00e1n","family":"Suazo","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Aut\u00f3noma de Chile, Santiago 8330015, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Cuendias","sequence":"additional","affiliation":[{"name":"Grupo SINPOS, Departamento de Morfolog\u00eda y Biolog\u00eda Celular, Universidad de Oviedo, 33003 Oviedo, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias, ISPA, 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4496-6582","authenticated-orcid":false,"given":"Jos\u00e9","family":"Mart\u00edn-Cruces","sequence":"additional","affiliation":[{"name":"Grupo SINPOS, Departamento de Morfolog\u00eda y Biolog\u00eda Celular, Universidad de Oviedo, 33003 Oviedo, Spain"},{"name":"Master ENDORE, Universidad de Santiago de Compostela, 15705 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirian","family":"Teul\u00e9-Trull","sequence":"additional","affiliation":[{"name":"Grupo SINPOS, Departamento de Morfolog\u00eda y Biolog\u00eda Celular, Universidad de Oviedo, 33003 Oviedo, Spain"},{"name":"Master ENDORE, Universidad de Santiago de Compostela, 15705 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1276-0018","authenticated-orcid":false,"given":"Jos\u00e9 A.","family":"Vega","sequence":"additional","affiliation":[{"name":"Grupo SINPOS, Departamento de Morfolog\u00eda y Biolog\u00eda Celular, Universidad de Oviedo, 33003 Oviedo, Spain"},{"name":"Facultad de Ciencias de la Salud, Universidad Aut\u00f3noma de Chile, Santiago 8330015, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Garc\u00eda-Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Grupo SINPOS, Departamento de Morfolog\u00eda y Biolog\u00eda Celular, Universidad de Oviedo, 33003 Oviedo, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias, ISPA, 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3244-1049","authenticated-orcid":false,"given":"Teresa","family":"Cobo","sequence":"additional","affiliation":[{"name":"Departamento de Cirug\u00eda y Especialidades M\u00e9dico-Quir\u00fargicas, Universidad de Oviedo, 33003 Oviedo, Spain"},{"name":"Instituto Asturiano de Odontolog\u00eda, 33006 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1146\/annurev-physiol-020518-114427","article-title":"Physiology of the Carotid Body: From Molecules to Disease","volume":"82","year":"2020","journal-title":"Annu. 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