{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:12:51Z","timestamp":1790291571418,"version":"4.1.0"},"reference-count":87,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Statutory Theme 3 of MMRI PAS"},{"name":"National Science Centre, Poland","award":["2018\/31\/B\/NZ4\/01379"],"award-info":[{"award-number":["2018\/31\/B\/NZ4\/01379"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Maternal immune activation (MIA) is a recognized environmental risk factor for altered brain development, yet its early molecular consequences remain unclear. In this study, we examined total Tau, site-specific Tau phosphorylation, and selected synaptic proteins in one-month-old female mouse offspring exposed prenatally to MIA evoked by poly(I:C), a synthetic mimetic of viral dsRNA. Our analyses revealed a consistent reduction in Tau phosphorylation at Ser416 across multiple brain regions, including the cortex, hippocampus, and cerebellum, without changes in total Tau levels or other phosphorylation sites. Among synaptic markers, only Shank3 levels were decreased, and this effect was confined to the cerebellum. No additional robust alterations were detected at this stage of development. These findings suggest that Tau hypophosphorylation at Ser416 may represent an early and widespread molecular footprint of MIA, whereas cerebellar Shank3 downregulation points to a region-specific vulnerability of synaptic pathways. While the study is limited to female offspring and a single postnatal time point, the data provide new insights into subtle molecular signatures that could precede or accompany later functional outcomes. Our results highlight Tau phosphorylation and Shank3 expression as potential molecular markers of prenatal immune stress, warranting further longitudinal and sex-comparative studies to clarify their relevance for neurodevelopmental trajectories.<\/jats:p>","DOI":"10.3390\/ijms262110778","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T17:06:06Z","timestamp":1762362366000},"page":"10778","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Tau Hypophosphorylation at Ser416 as the Early Molecular Imprint of Maternal Immune Activation: Insights from Female Mice Offspring"],"prefix":"10.3390","volume":"26","author":[{"given":"Ewelina","family":"Bielska","sequence":"first","affiliation":[{"name":"Department of Cellular Signalling, Mossakowski Medical Research Institute, Polish Academy of Sciences, ul. Pawi\u0144skiego 5, 02-106 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5996-7799","authenticated-orcid":false,"given":"Marta","family":"Matuszewska","sequence":"additional","affiliation":[{"name":"Department of Cellular Signalling, Mossakowski Medical Research Institute, Polish Academy of Sciences, ul. Pawi\u0144skiego 5, 02-106 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"W\u00f3jcik","sequence":"additional","affiliation":[{"name":"Department of Cellular Signalling, Mossakowski Medical Research Institute, Polish Academy of Sciences, ul. Pawi\u0144skiego 5, 02-106 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1121-5168","authenticated-orcid":false,"given":"Anna","family":"Wilkaniec","sequence":"additional","affiliation":[{"name":"Department of Cellular Signalling, Mossakowski Medical Research Institute, Polish Academy of Sciences, ul. Pawi\u0144skiego 5, 02-106 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7604-4371","authenticated-orcid":false,"given":"Magdalena","family":"Cie\u015blik","sequence":"additional","affiliation":[{"name":"Department of Cellular Signalling, Mossakowski Medical Research Institute, Polish Academy of Sciences, ul. Pawi\u0144skiego 5, 02-106 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9777-1378","authenticated-orcid":false,"given":"Magdalena","family":"G\u0105ssowska-Dobrowolska","sequence":"additional","affiliation":[{"name":"Department of Cellular Signalling, Mossakowski Medical Research Institute, Polish Academy of Sciences, ul. Pawi\u0144skiego 5, 02-106 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1697-8164","authenticated-orcid":false,"given":"Dorota","family":"Sulejczak","sequence":"additional","affiliation":[{"name":"Department of Experimental Pharmacology, Mossakowski Medical Research Institute, Polish Academy of Sciences, ul. Pawi\u0144skiego 5, 02-106 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7541-1571","authenticated-orcid":false,"given":"Grzegorz A.","family":"Czapski","sequence":"additional","affiliation":[{"name":"Department of Cellular Signalling, Mossakowski Medical Research Institute, Polish Academy of Sciences, ul. Pawi\u0144skiego 5, 02-106 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6867-9377","authenticated-orcid":false,"given":"Agata","family":"Adamczyk","sequence":"additional","affiliation":[{"name":"Department of Cellular Signalling, Mossakowski Medical Research Institute, Polish Academy of Sciences, ul. Pawi\u0144skiego 5, 02-106 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Khan, S.S., and Bloom, G.S. (2016). Tau: The Center of a Signaling Nexus in Alzheimer\u2019s Disease. Front. Neurosci., 10.","DOI":"10.3389\/fnins.2016.00031"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3184","DOI":"10.1038\/s41598-018-21596-3","article-title":"A Role for Tau in Learning, Memory and Synaptic Plasticity","volume":"8","author":"Biundo","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s40478-021-01246-y","article-title":"Synaptic Tau: A Pathological or Physiological Phenomenon?","volume":"9","author":"Robbins","year":"2021","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.bbi.2019.07.026","article-title":"IL-17A Exacerbates Neuroinflammation and Neurodegeneration by Activating Microglia in Rodent Models of Parkinson\u2019s Disease","volume":"81","author":"Liu","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1186\/s40001-023-01360-8","article-title":"SNAP25 Is a Potential Target for Early Stage Alzheimer\u2019s Disease and Parkinson\u2019s Disease","volume":"28","author":"Wang","year":"2023","journal-title":"Eur. J. Med. Res."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Margiotta, A. (2021). Role of SNAREs in Neurodegenerative Diseases. Cells, 10.","DOI":"10.3390\/cells10050991"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"15295","DOI":"10.1038\/ncomms15295","article-title":"Tau Association with Synaptic Vesicles Causes Presynaptic Dysfunction","volume":"8","author":"Zhou","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"7277","DOI":"10.1038\/s41467-023-43130-4","article-title":"Tau Forms Synaptic Nano-Biomolecular Condensates Controlling the Dynamic Clustering of Recycling Synaptic Vesicles","volume":"14","author":"Longfield","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"4941","DOI":"10.1523\/JNEUROSCI.1945-22.2023","article-title":"Postsynaptic Protein Shank3a Deficiency Synergizes with Alzheimer\u2019s Disease Neuropathology to Impair Cognitive Performance in the 3xTg-AD Murine Model","volume":"43","author":"Landry","year":"2023","journal-title":"J. Neurosci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1007\/s10571-021-01054-x","article-title":"Association of SHANK Family with Neuropsychiatric Disorders: An Update on Genetic and Animal Model Discoveries","volume":"42","author":"Wan","year":"2022","journal-title":"Cell Mol. Neurobiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"10695","DOI":"10.1523\/JNEUROSCI.2178-07.2007","article-title":"Maternal Immune Activation Alters Fetal Brain Development through Interleukin-6","volume":"27","author":"Smith","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.neulet.2018.06.004","article-title":"Alterations in Neuronal Cytoskeletal and Astrocytic Proteins Content in the Brain of the Autistic-like Mouse Strain C58\/J","volume":"682","author":"Haro","year":"2018","journal-title":"Neurosci. Lett."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.neuron.2020.01.038","article-title":"Tau Reduction Prevents Key Features of Autism in Mouse Models","volume":"106","author":"Tai","year":"2020","journal-title":"Neuron"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.bbi.2013.12.016","article-title":"The Different Effects of LPS and Poly I:C Prenatal Immune Challenges on the Behavior, Development and Inflammatory Responses in Pregnant Mice and Their Offspring","volume":"38","author":"Arsenault","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"R99","DOI":"10.1152\/ajpregu.00087.2021","article-title":"LPS versus Poly I:C Model: Comparison of Long-Term Effects of Bacterial and Viral Maternal Immune Activation on the Offspring","volume":"322","author":"Bao","year":"2022","journal-title":"Am. J. Physiol.-Regul. Integr. Comp. Physiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1084\/jem.20080091","article-title":"Length-Dependent Recognition of Double-Stranded Ribonucleic Acids by Retinoic Acid-Inducible Gene-I and Melanoma Differentiation-Associated Gene 5","volume":"205","author":"Kato","year":"2008","journal-title":"J. Exp. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.bbagrm.2009.06.005","article-title":"The Toll-like Receptor 3:dsRNA Signaling Complex","volume":"1789","author":"Botos","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1177\/1753425912459975","article-title":"TLR3 Activation Efficiency by High or Low Molecular Mass Poly I:C","volume":"19","author":"Zhou","year":"2013","journal-title":"Innate. Immun."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.bbi.2012.07.008","article-title":"Maternal Immune Activation Causes Age- and Region-Specific Changes in Brain Cytokines in Offspring throughout Development","volume":"31","author":"Garay","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"13931","DOI":"10.3390\/ijms140713931","article-title":"Role of Cytokine Signaling during Nervous System Development","volume":"14","author":"Mousa","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/0304-3940(89)90600-9","article-title":"Interleukin-6 as a Neurotrophic Factor for Promoting the Survival of Cultured Basal Forebrain Cholinergic Neurons from Postnatal Rats","volume":"104","author":"Hama","year":"1989","journal-title":"Neurosci. Lett."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1006\/exnr.1995.1082","article-title":"Interleukin-1 Beta Enhances Survival and Interleukin-6 Protects against MPP+ Neurotoxicity in Cultures of Fetal Rat Dopaminergic Neurons","volume":"136","author":"Akaneya","year":"1995","journal-title":"Exp. Neurol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Gonzalez Caldito, N. (2023). Role of Tumor Necrosis Factor-Alpha in the Central Nervous System: A Focus on Autoimmune Disorders. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1213448"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.it.2024.04.004","article-title":"Beyond Antiviral: Role of IFN-I in Brain Development","volume":"45","author":"Baker","year":"2024","journal-title":"Trends Immunol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1126\/science.1088417","article-title":"Inflammatory Blockade Restores Adult Hippocampal Neurogenesis","volume":"302","author":"Monje","year":"2003","journal-title":"Science"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/j.1460-9568.2007.05309.x","article-title":"Microglia-Derived Interleukin-6 and Leukaemia Inhibitory Factor Promote Astrocytic Differentiation of Neural Stem\/Progenitor Cells","volume":"25","author":"Nakanishi","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Cie\u015blik, M., G\u0105ssowska-Dobrowolska, M., J\u0119\u015bko, H., Czapski, G.A., Wilkaniec, A., Zawadzka, A., Dominiak, A., Polowy, R., Filipkowski, R.K., and Boguszewski, P.M. (2020). Maternal Immune Activation Induces Neuroinflammation and Cortical Synaptic Deficits in the Adolescent Rat Offspring. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21114097"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/2040-2392-2-13","article-title":"Increased Midgestational IFN-\u03b3, IL-4 and IL-5 in Women Bearing a Child with Autism: A Case-Control Study","volume":"2","author":"Goines","year":"2011","journal-title":"Mol. Autism"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Brynge, M., Gardner, R.M., Sj\u00f6qvist, H., Lee, B.K., Dalman, C., and Karlsson, H. (2022). Maternal Levels of Cytokines in Early Pregnancy and Risk of Autism Spectrum Disorders in Offspring. Front. Public Health, 10.","DOI":"10.3389\/fpubh.2022.917563"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S2215-0366(20)30006-7","article-title":"Cytokine Levels throughout Pregnancy and Risk for Psychosis in Adult Offspring: A Case-Control Study","volume":"7","author":"Allswede","year":"2020","journal-title":"Lancet Psychiatry"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Cie\u015blik, M., Gassowska-Dobrowolska, M., Zawadzka, A., Frontczak-Baniewicz, M., Gewartowska, M., Dominiak, A., Czapski, G.A., and Adamczyk, A. (2020). The Synaptic Dysregulation in Adolescent Rats Exposed to Maternal Immune Activation. Front. Mol. Neurosci., 13.","DOI":"10.3389\/fnmol.2020.555290"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/nrn.2015.1","article-title":"Tau in Physiology and Pathology","volume":"17","author":"Wang","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1126\/science.aag3194","article-title":"Maternal Immune Activation: Implications for Neuropsychiatric Disorders","volume":"353","author":"Estes","year":"2016","journal-title":"Science"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.tins.2019.08.001","article-title":"Neurodevelopmental Resilience and Susceptibility to Maternal Immune Activation","volume":"42","author":"Meyer","year":"2019","journal-title":"Trends Neurosci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1093\/brain\/awv081","article-title":"Reactive Microglia Drive Tau Pathology and Contribute to the Spreading of Pathological Tau in the Brain","volume":"138","author":"Maphis","year":"2015","journal-title":"Brain"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"105844","DOI":"10.1016\/j.neubiorev.2024.105844","article-title":"Maternal Immune Activation and Its Multifaceted Effects on Learning and Memory in Rodent Offspring: A Systematic Review","volume":"164","author":"Conejo","year":"2024","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Xu, J., Zhao, R., Yan, M., Zhou, M., Liu, H., Wang, X., Lu, C., Li, Q., Mo, Y., and Zhang, P. (2024). Sex-Specific Behavioral and Molecular Responses to Maternal Lipopolysaccharide-Induced Immune Activation in a Murine Model: Implications for Neurodevelopmental Disorders. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25189885"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Liu, Y., Hang, X., Zhang, Y., Fang, Y., Yuan, S., Zhang, Y., Wu, B., Kong, Y., Kuang, Z., and Sun, W. (2024). Maternal Immune Activation Induces Sex-Dependent Behavioral Differences in a Rat Model of Schizophrenia. Front. Psychiatry, 15.","DOI":"10.3389\/fpsyt.2024.1375999"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Matuszewska, M., Wilkaniec, A., G\u0105ssowska-Dobrowolska, M., Cie\u015blik, M., Olech-Kocha\u0144czyk, G., Pa\u0142asz, E., Gawinek, E., Strawski, M., and Czapski, G.A. (2025). Inhibition of BET Proteins Modulates Amyloid-Beta Accumulation and Cognitive Performance in Middle-Aged Mice Prenatally Exposed to Maternal Immune Activation. Front. Mol. Neurosci., 18.","DOI":"10.3389\/fnmol.2025.1619583"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"577813","DOI":"10.1016\/j.jneuroim.2022.577813","article-title":"Maternal Immune Activation with High Molecular Weight Poly(I:C) in Wistar Rats Leads to Elevated Immune Cell Chemoattractants","volume":"364","author":"Brown","year":"2022","journal-title":"J. Neuroimmunol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"21378","DOI":"10.1038\/s41598-020-78294-2","article-title":"Maternal Immune Activation Induces Sustained Changes in Fetal Microglia Motility","volume":"10","author":"Ozaki","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.bbi.2016.11.020","article-title":"Long-Term Altered Immune Responses Following Fetal Priming in a Non-Human Primate Model of Maternal Immune Activation","volume":"63","author":"Rose","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.bbi.2014.02.007","article-title":"Maternal Immune Activation Leads to Activated Inflammatory Macrophages in Offspring","volume":"38","author":"Onore","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"ENEURO.0058-20.2020","DOI":"10.1523\/ENEURO.0058-20.2020","article-title":"Increased Tau Expression Correlates with Neuronal Maturation in the Developing Human Cerebral Cortex","volume":"7","author":"Fiock","year":"2020","journal-title":"eNeuro"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1093\/hmg\/ddr603","article-title":"Tau\u2019s Role in the Developing Brain: Implications for Intellectual Disability","volume":"21","author":"Sapir","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13024-021-00460-5","article-title":"\u201cDon\u2019t Phos Over Tau\u201d: Recent Developments in Clinical Biomarkers and Therapies Targeting Tau Phosphorylation in Alzheimer\u2019s Disease and Other Tauopathies","volume":"16","author":"Xia","year":"2021","journal-title":"Mol. Neurodegener."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1093\/jnen\/nlz073","article-title":"Tau Phosphorylation and Aggregation in the Developing Human Brain","volume":"78","author":"Hefti","year":"2019","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1111\/j.1471-4159.2009.05882.x","article-title":"Developmental Regulation of Tau Phosphorylation, Tau Kinases, and Tau Phosphatases","volume":"108","author":"Yu","year":"2009","journal-title":"J. Neurochem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1111\/j.1471-4159.2005.03307.x","article-title":"Phosphorylation of Tau at Serine 416 by Ca2+\/Calmodulin-Dependent Protein Kinase II in Neuronal Soma in Brain","volume":"94","author":"Yamamoto","year":"2005","journal-title":"J. Neurochem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1007\/s00127-023-02471-7","article-title":"Do Prenatal Factors Shape the Risk for Dementia?: A Systematic Review of the Epidemiological Evidence for the Prenatal Origins of Dementia","volume":"60","author":"Wiegersma","year":"2025","journal-title":"Soc. Psychiatry Psychiatr. Epidemiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/bdr2.1416","article-title":"Maternal Immune Activation, Central Nervous System Development and Behavioral Phenotypes","volume":"110","author":"Minakova","year":"2018","journal-title":"Birth Defects Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/nrneurol.2014.187","article-title":"Maternal Immune Activation and Abnormal Brain Development across CNS Disorders","volume":"10","author":"Knuesel","year":"2014","journal-title":"Nat. Rev. Neurol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/s41386-018-0185-7","article-title":"Maternal Immune Activation: Reporting Guidelines to Improve the Rigor, Reproducibility, and Transparency of the Model","volume":"44","author":"Kentner","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.neubiorev.2010.07.002","article-title":"Sex Bias in Neuroscience and Biomedical Research","volume":"35","author":"Beery","year":"2011","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e2014464118","DOI":"10.1073\/pnas.2014464118","article-title":"Impact of Prenatal Maternal Cytokine Exposure on Sex Differences in Brain Circuitry Regulating Stress in Offspring 45 Years Later","volume":"118","author":"Goldstein","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s12974-024-03106-7","article-title":"Impact of Maternal Immune Activation and Sex on Placental and Fetal Brain Cytokine and Gene Expression Profiles in a Preclinical Model of Neurodevelopmental Disorders","volume":"21","author":"Osman","year":"2024","journal-title":"J. Neuroinflamm."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.bbi.2005.11.003","article-title":"Immunological Stress at the Maternal\u2013Foetal Interface: A Link between Neurodevelopment and Adult Psychopathology","volume":"20","author":"Meyer","year":"2006","journal-title":"Brain Behav. Immun."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1186\/s13287-023-03579-y","article-title":"The Effect of TLR3 Priming Conditions on MSC Immunosuppressive Properties","volume":"14","author":"Tolstova","year":"2023","journal-title":"Stem Cell Res. Ther."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Magatti, M., Stefani, F.R., Papait, A., Cargnoni, A., Masserdotti, A., Silini, A.R., and Parolini, O. (2019). Perinatal Mesenchymal Stromal Cells and Their Possible Contribution to Fetal-Maternal Tolerance. Cells, 8.","DOI":"10.3390\/cells8111401"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Abu-Raya, B., Michalski, C., Sadarangani, M., and Lavoie, P.M. (2020). Maternal Immunological Adaptation During Normal Pregnancy. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.575197"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.placenta.2017.04.003","article-title":"Immunomodulatory Properties of Human Placental Mesenchymal Stem\/Stromal Cells","volume":"59","author":"Abumaree","year":"2017","journal-title":"Placenta"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/j.1600-0897.2010.00955.x","article-title":"Effect of Human Endometrial Stromal Cell-Derived Conditioned Medium on Uterine Natural Killer (uNK) Cells\u2019 Proliferation and Cytotoxicity","volume":"65","author":"Chen","year":"2011","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.3727\/096368914X683016","article-title":"Undifferentiated Wharton\u2019s Jelly Mesenchymal Stem Cell Transplantation Induces Insulin-Producing Cell Differentiation and Suppression of T-Cell-Mediated Autoimmunity in Nonobese Diabetic Mice","volume":"24","author":"Tsai","year":"2015","journal-title":"Cell Transplant."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/jcmm.12715","article-title":"Amniotic Mesenchymal Cells from Pre-eclamptic Placentae Maintain Immunomodulatory Features as Healthy Controls","volume":"20","author":"Pianta","year":"2016","journal-title":"J. Cell Mol. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.cellimm.2010.11.001","article-title":"Human Mesenchymal Stem Cells and Renal Tubular Epithelial Cells Differentially Influence Monocyte-Derived Dendritic Cell Differentiation and Maturation","volume":"267","author":"Kronsteiner","year":"2011","journal-title":"Cell Immunol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Rossi, D., Pianta, S., Magatti, M., Sedlmayr, P., and Parolini, O. (2012). Characterization of the Conditioned Medium from Amniotic Membrane Cells: Prostaglandins as Key Effectors of Its Immunomodulatory Activity. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0046956"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"270","DOI":"10.9758\/cpn.2020.18.2.270","article-title":"High Serum Levels of Serum 100 Beta Protein, Neuron-Specific Enolase, Tau, Active Caspase-3, M30 and M65 in Children with Autism Spectrum Disorders","volume":"18","author":"Kirmit","year":"2020","journal-title":"Clin. Psychopharmacol. Neurosci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/s41398-020-00904-4","article-title":"Tauopathy in the Young Autistic Brain: Novel Biomarker and Therapeutic Target","volume":"10","author":"Grigg","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"G\u0105ssowska-Dobrowolska, M., Kolasa-Wo\u0142osiuk, A., Cie\u015blik, M., Dominiak, A., Friedland, K., and Adamczyk, A. (2021). Alterations in Tau Protein Level and Phosphorylation State in the Brain of the Autistic-Like Rats Induced by Prenatal Exposure to Valproic Acid. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22063209"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"G\u0105ssowska-Dobrowolska, M., Kolasa, A., Beversdorf, D.Q., and Adamczyk, A. (2022). Alterations in Cerebellar Microtubule Cytoskeletal Network in a Valproic Acid-Induced Rat Model of Autism Spectrum Disorders. Biomedicines, 10.","DOI":"10.3390\/biomedicines10123031"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"G\u0105ssowska-Dobrowolska, M., Czapski, G.A., Cie\u015blik, M., Zajdel, K., Frontczak-Baniewicz, M., Babiec, L., and Adamczyk, A. (2023). Microtubule Cytoskeletal Network Alterations in a Transgenic Model of Tuberous Sclerosis Complex: Relevance to Autism Spectrum Disorders. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24087303"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"3429","DOI":"10.1111\/j.1460-9568.2007.05955.x","article-title":"Site-Specific Effects of Tau Phosphorylation on Its Microtubule Assembly Activity and Self-Aggregation","volume":"26","author":"Liu","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1523\/JNEUROSCI.2068-16.2017","article-title":"A Novel Human CAMK2A Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors","volume":"37","author":"Stephenson","year":"2017","journal-title":"J. Neurosci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"jcs248187","DOI":"10.1242\/jcs.248187","article-title":"Protein Phosphatase 2A\u2014Structure, Function and Role in Neurodevelopmental Disorders","volume":"134","author":"Sandal","year":"2021","journal-title":"J. Cell Sci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.1038\/s41380-025-02905-5","article-title":"Lara Ord\u00f3\u00f1ez, A.J.; C\u00e1novas, M.; Mart\u00edn-Oliva, D.; Gonz\u00e1lez-Maeso, J.; Cutillas, P.R.; L\u00f3pez-Gim\u00e9nez, J.F. Maternal immune activation imprints translational dysregulation and differential MAP2 phosphorylation in descendant neural stem cells","volume":"30","year":"2025","journal-title":"Mol. Psychiatry"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s13229-020-00393-8","article-title":"Altered Synaptic Ultrastructure in the Prefrontal Cortex of Shank3-Deficient Rats","volume":"11","author":"Keshav","year":"2020","journal-title":"Mol. Autism"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"8801","DOI":"10.1523\/JNEUROSCI.0925-21.2021","article-title":"Excessive Laughter-like Vocalizations, Microcephaly, and Translational Outcomes in the Ube3a Deletion Rat Model of Angelman Syndrome","volume":"41","author":"Berg","year":"2021","journal-title":"J. Neurosci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1159\/000334260","article-title":"The 22q13.3 Deletion Syndrome (Phelan-McDermid Syndrome)","volume":"2","author":"Phelan","year":"2012","journal-title":"Mol. Syndromol."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Vyas, Y., Cheyne, J.E., Lee, K., Jung, Y., Cheung, P.Y., and Montgomery, J.M. (2021). Shankopathies in the Developing Brain in Autism Spectrum Disorders. Front. Neurosci., 15.","DOI":"10.3389\/fnins.2021.775431"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/nrn.2016.183","article-title":"SHANK Proteins: Roles at the Synapse and in Autism Spectrum Disorder","volume":"18","author":"Monteiro","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Leblond, C.S., Nava, C., Polge, A., Gauthier, J., Huguet, G., Lumbroso, S., Giuliano, F., Stordeur, C., Depienne, C., and Mouzat, K. (2014). Meta-Analysis of SHANK Mutations in Autism Spectrum Disorders: A Gradient of Severity in Cognitive Impairments. PLoS Genet., 10.","DOI":"10.1371\/journal.pgen.1004580"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Woelfle, S., Pedro, M.T., Wagner, J., Sch\u00f6n, M., and Boeckers, T.M. (2023). Expression Profiles of the Autism-Related SHANK Proteins in the Human Brain. BMC Biol., 21.","DOI":"10.1186\/s12915-023-01712-0"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1002\/aur.1925","article-title":"Developmental Social Communication Deficits in the Shank3 Rat Model of Phelan-Mcdermid Syndrome and Autism Spectrum Disorder","volume":"11","author":"Berg","year":"2018","journal-title":"Autism Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13229-022-00532-3","article-title":"Immune Activation during Pregnancy Exacerbates ASD-Related Alterations in Shank3-Deficient Mice","volume":"14","author":"Atanasova","year":"2023","journal-title":"Mol. Autism"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.bbi.2019.04.019","article-title":"Influence of Poly(I:C) Variability on Thermoregulation, Immune Responses and Pregnancy Outcomes in Mouse Models of Maternal Immune Activation","volume":"80","author":"Mueller","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/1742-2094-9-151","article-title":"Systemic Immune Challenges Trigger and Drive Alzheimer-like Neuropathology in Mice","volume":"9","author":"Krstic","year":"2012","journal-title":"J. Neuroinflamm."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Czapski, G.A., Babiec, L., J\u0119\u015bko, H., G\u0105ssowska-Dobrowolska, M., Cie\u015blik, M., Matuszewska, M., Frontczak-Baniewicz, M., Zajdel, K., and Adamczyk, A. (2021). Synaptic Alterations in a Transgenic Model of Tuberous Sclerosis Complex: Relevance to Autism Spectrum Disorders. Int. J. Mol. 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