{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T12:21:08Z","timestamp":1793449268149,"version":"4.5.0"},"reference-count":73,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003827","name":"National Research, Development and Innovation Fund","doi-asserted-by":"publisher","award":["2024-2.1.1-EK\u00d6P-2024-0004 (203)"],"award-info":[{"award-number":["2024-2.1.1-EK\u00d6P-2024-0004 (203)"]}],"id":[{"id":"10.13039\/501100003827","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Semmelweis 250+ Excellence Ph.D. Scholarship","award":["EFOP-3.6.3-VEKOP-16-2017-00009"],"award-info":[{"award-number":["EFOP-3.6.3-VEKOP-16-2017-00009"]}]},{"DOI":"10.13039\/501100003827","name":"Ruprecht Karls University","doi-asserted-by":"publisher","award":["EFOP-3.6.3.-VEKOP-16-2017-00009"],"award-info":[{"award-number":["EFOP-3.6.3.-VEKOP-16-2017-00009"]}],"id":[{"id":"10.13039\/501100003827","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is characterized by mitochondrial dysfunction, oxidative stress, insulin resistance, and aberrant protein aggregation. Neurodegeneration model with neuronal insulin resistance was induced in SH-SY5Y human neuroblastoma cells by streptozotocin (STZ). We evaluated the neuroprotective effects of resveratrol (RZV) and three structural analogs: oxyresveratrol (OXI), monomethyl resveratrol (MONO), and trimethyl resveratrol (TRI). Mitochondrial function, plasma membrane integrity, oxidative stress) and autophagy were studied by fluorescent assays. Phosphorylated GSK3 levels were measured by ELISA as an indicator of insulin sensitivity. TRI exhibited significant mitochondrial protective effects and strongly induced autophagy. OXI demonstrated excellent antioxidant activity but showed no detectable mitochondrial protective or autophagy-inducing effects. RZV and MONO exhibited moderate antioxidant effects along with strong insulin-sensitizing and autophagy-inducing properties. Insulin sensitivity was most potently restored by RZV (IC50 = 54 pM) and MONO (IC50 = 50 pM), whereas TRI (IC50 = 160 pM) was less potent, and OXI (IC50 = 97 pM) showed moderate potency. Our findings suggest that the neuroprotective effects of resveratrol analogs significantly depend on their molecular structure and that they exert their beneficial effects through distinct mechanisms. This research may contribute to the development of novel, multi-target compounds for the treatment of neurodegenerative diseases.<\/jats:p>","DOI":"10.3390\/ijms262110787","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T10:08:51Z","timestamp":1762423731000},"page":"10787","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Resveratrol Analogs Ameliorate Mitochondrial Impairment and Insulin Resistance in a Streptozotocin-Induced In Vitro Model of Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"26","author":[{"given":"Alexandra","family":"Pasztern\u00e1k","sequence":"first","affiliation":[{"name":"Department of Pharmacodynamics, Semmelweis University, 4 Nagyv\u00e1rad t\u00e9r, H-1089 Budapest, Hungary"},{"name":"Center for Pharmacology and Drug Research & Development, Semmelweis University, 26 \u00dcll\u0151i \u00fat, H-1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4533-0404","authenticated-orcid":false,"given":"Kamilla","family":"Varga","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics, Semmelweis University, 4 Nagyv\u00e1rad t\u00e9r, H-1089 Budapest, Hungary"},{"name":"Center for Pharmacology and Drug Research & Development, Semmelweis University, 26 \u00dcll\u0151i \u00fat, H-1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00e1","family":"Gy\u00f6ngy\u00f6ssy","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics, Semmelweis University, 4 Nagyv\u00e1rad t\u00e9r, H-1089 Budapest, Hungary"},{"name":"Center for Pharmacology and Drug Research & Development, Semmelweis University, 26 \u00dcll\u0151i \u00fat, H-1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7755-0237","authenticated-orcid":false,"given":"Katinka","family":"Tarn\u00f3czi","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics, Semmelweis University, 4 Nagyv\u00e1rad t\u00e9r, H-1089 Budapest, Hungary"},{"name":"Center for Pharmacology and Drug Research & Development, Semmelweis University, 26 \u00dcll\u0151i \u00fat, H-1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"No\u00e9mi","family":"Sikur","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics, Semmelweis University, 4 Nagyv\u00e1rad t\u00e9r, H-1089 Budapest, Hungary"},{"name":"Center for Pharmacology and Drug Research & Development, Semmelweis University, 26 \u00dcll\u0151i \u00fat, H-1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1464-6403","authenticated-orcid":false,"given":"\u00c9va","family":"Sz\u00f6k\u0151","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics, Semmelweis University, 4 Nagyv\u00e1rad t\u00e9r, H-1089 Budapest, Hungary"},{"name":"Center for Pharmacology and Drug Research & Development, Semmelweis University, 26 \u00dcll\u0151i \u00fat, H-1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5343-0205","authenticated-orcid":false,"given":"Tam\u00e1s","family":"T\u00e1bi","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics, Semmelweis University, 4 Nagyv\u00e1rad t\u00e9r, H-1089 Budapest, Hungary"},{"name":"Center for Pharmacology and Drug Research & Development, Semmelweis University, 26 \u00dcll\u0151i \u00fat, H-1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3969","DOI":"10.1093\/brain\/awad159","article-title":"The amyloid cascade hypothesis: An updated critical review","volume":"146","author":"Kepp","year":"2023","journal-title":"Brain"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Behl, C. (2024). In 2024, the amyloid-cascade-hypothesis still remains a working hypothesis, no less but certainly no more. Front. Aging Neurosci., 16.","DOI":"10.3389\/fnagi.2024.1459224"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/j.bbadis.2014.06.010","article-title":"Elevated risk of type 2 diabetes for development of Alzheimer disease: A key role for oxidative stress in brain","volume":"1842","author":"Butterfield","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1007\/s11064-020-03031-0","article-title":"Role of Insulin Resistance in the Alzheimer\u2019s Disease Progression","volume":"45","author":"Nguyen","year":"2020","journal-title":"Neurochem. Res."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Carvalho, C., and Moreira, P.I. (2023). Metabolic defects shared by Alzheimer\u2019s disease and diabetes: A focus on mitochondria. Curr. Opin. Neurobiol., 79.","DOI":"10.1016\/j.conb.2023.102694"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Sedzikowska, A., and Szablewski, L. (2021). Insulin and Insulin Resistance in Alzheimer\u2019s Disease. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22189987"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Burillo, J., Marques, P., Jimenez, B., Gonzalez-Blanco, C., Benito, M., and Guillen, C. (2021). Insulin Resistance and Diabetes Mellitus in Alzheimer\u2019s Disease. Cells, 10.","DOI":"10.3390\/cells10051236"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1007\/s11064-021-03269-2","article-title":"The Impact of Differentiation on Cytotoxicity and Insulin Sensitivity in Streptozotocin Treated SH-SY5Y Cells","volume":"46","author":"Bagamery","year":"2021","journal-title":"Neurochem. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.2353\/ajpath.2009.090157","article-title":"Dysregulation of insulin signaling, glucose transporters, O-GlcNAcylation, and phosphorylation of tau and neurofilaments in the brain: Implication for Alzheimer\u2019s disease","volume":"175","author":"Deng","year":"2009","journal-title":"Am. J. Pathol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.cell.2012.02.040","article-title":"Alzheimer mechanisms and therapeutic strategies","volume":"148","author":"Huang","year":"2012","journal-title":"Cell"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s12264-013-1423-y","article-title":"Oxidative stress in Alzheimer\u2019s disease","volume":"30","author":"Chen","year":"2014","journal-title":"Neurosci. Bull."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/imcb.12301","article-title":"The role of innate immune responses and neuroinflammation in amyloid accumulation and progression of Alzheimer\u2019s disease","volume":"98","author":"Webers","year":"2020","journal-title":"Immunol. Cell Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"100056","DOI":"10.1016\/j.nbas.2022.100056","article-title":"Compromised autophagy and mitophagy in brain ageing and Alzheimer\u2019s diseases","volume":"2","author":"Caponio","year":"2022","journal-title":"Aging Brain"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Bisi, N., Feni, L., Peqini, K., Perez-Pena, H., Ongeri, S., Pieraccini, S., and Pellegrino, S. (2021). alpha-Synuclein: An All-Inclusive Trip Around its Structure, Influencing Factors and Applied Techniques. Front. Chem., 9.","DOI":"10.3389\/fchem.2021.666585"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Liu, J., Li, T., Zhong, G., Pan, Y., Gao, M., Su, S., Liang, Y., Ma, C., Liu, Y., and Wang, Q. (2023). Exploring the therapeutic potential of natural compounds for Alzheimer\u2019s disease: Mechanisms of action and pharmacological properties. Biomed. Pharmacother., 166.","DOI":"10.1016\/j.biopha.2023.115406"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"114242","DOI":"10.1016\/j.ejmech.2022.114242","article-title":"Resveratrol-based compounds and neurodegeneration: Recent insight in multitarget therapy","volume":"233","author":"Fantacuzzi","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Stacchiotti, A., and Corsetti, G. (2020). Natural Compounds and Autophagy: Allies Against Neurodegeneration. Front. Cell Dev. Biol., 8.","DOI":"10.3389\/fcell.2020.555409"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.bbrc.2004.05.075","article-title":"The retinoic acid and brain-derived neurotrophic factor differentiated SH-SY5Y cell line as a model for Alzheimer\u2019s disease-like tau phosphorylation","volume":"319","author":"Jamsa","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/nyas.13431","article-title":"Resveratrol for Alzheimer\u2019s disease","volume":"1403","author":"Sawda","year":"2017","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"107202","DOI":"10.1016\/j.ejps.2025.107202","article-title":"Resveratrol restores insulin signaling and balances mitochondrial biogenesis and autophagy in streptozotocin-induced neurodegeneration in vitro","volume":"212","author":"Varga","year":"2025","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1093\/nutrit\/nuae161","article-title":"The Metabolic Characteristics and Bioavailability of Resveratrol Based on Metabolic Enzymes","volume":"83","author":"Yang","year":"2025","journal-title":"Nutr. Rev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/biof.1410","article-title":"Metabolism and pharmacokinetics of resveratrol and pterostilbene","volume":"44","author":"Wang","year":"2018","journal-title":"Biofactors"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Varga, K., Paszternak, A., Kovacs, V., Guczogi, A., Sikur, N., Patakfalvi, D., Bagamery, F., Szoko, E., and Tabi, T. (2024). Differential Cytoprotective Effect of Resveratrol and Its Derivatives: Focus on Antioxidant and Autophagy-Inducing Effects. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252011274"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12986-024-00792-1","article-title":"Unraveling the therapeutic efficacy of resveratrol in Alzheimer\u2019s disease: An umbrella review of systematic evidence","volume":"21","author":"Azargoonjahromi","year":"2024","journal-title":"Nutr. Metab."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Rahman, M.A., Cho, Y., Nam, G., and Rhim, H. (2021). Antioxidant Compound, Oxyresveratrol, Inhibits APP Production through the AMPK\/ULK1\/mTOR-Mediated Autophagy Pathway in Mouse Cortical Astrocytes. Antioxidants, 10.","DOI":"10.3390\/antiox10030408"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3233\/JAD-2006-9102","article-title":"Intracerebral streptozotocin model of type 3 diabetes: Relevance to sporadic Alzheimer\u2019s disease","volume":"9","author":"Rivera","year":"2006","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Kaur, D., Grewal, A.K., Almasoudi, S.H., Almehmadi, A.H., Alsfouk, B.A., Kumar, A., Singh, V., Alexiou, A., Papadakis, M., and Welson, N.N. (2025). Neuroprotective effect of Tozasertib in Streptozotocin-induced alzheimer\u2019s mice model. Sci. Rep., 15.","DOI":"10.1038\/s41598-025-13920-5"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.bbadis.2014.09.011","article-title":"Neuroprotective action of resveratrol","volume":"1852","author":"Bastianetto","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"16229","DOI":"10.1007\/s12035-025-05234-4","article-title":"Resveratrol\u2019s Multifaceted Potential in Alzheimer\u2019s Disease: Insights from Preclinical and Clinical Evidence","volume":"62","author":"Patel","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Mathew, L.S., Marathe, A., Aman, A., Vats, A., Joy, T., and Rao, Y.L. (2025). Bridging the molecular and clinical aspects of resveratrol in Alzheimer\u2019s disease: A review. 3 Biotech, 15.","DOI":"10.1007\/s13205-025-04451-x"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Huang, J., Huang, N., Mao, Q., Shi, J., and Qiu, Y. (2023). Natural bioactive compounds in Alzheimer\u2019s disease: From the perspective of type 3 diabetes mellitus. Front. Aging Neurosci., 15.","DOI":"10.3389\/fnagi.2023.1130253"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0014-5793(93)81066-9","article-title":"Glycogen synthase kinase 3 beta is identical to tau protein kinase I generating several epitopes of paired helical filaments","volume":"325","author":"Ishiguro","year":"1993","journal-title":"FEBS Lett."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"19547","DOI":"10.1074\/jbc.272.31.19547","article-title":"Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons","volume":"272","author":"Hong","year":"1997","journal-title":"J. Biol. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nature01640","article-title":"GSK-3alpha regulates production of Alzheimer\u2019s disease amyloid-beta peptides","volume":"423","author":"Phiel","year":"2003","journal-title":"Nature"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.expneurol.2009.09.011","article-title":"GSK3: A possible link between beta amyloid peptide and tau protein","volume":"223","author":"Hernandez","year":"2010","journal-title":"Exp. Neurol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/sj.bjp.0703397","article-title":"Inhibition of mitochondrial proton F0F1-ATPase\/ATP synthase by polyphenolic phytochemicals","volume":"130","author":"Zheng","year":"2000","journal-title":"Br. J. Pharmacol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1006\/bbrc.1999.1063","article-title":"Piceatannol, a stilbene phytochemical, inhibits mitochondrial F0F1-ATPase activity by targeting the F1 complex","volume":"261","author":"Zheng","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_38","first-page":"87","article-title":"Effects of resveratrol on the rat brain respiratory chain","volume":"25","author":"Zini","year":"1999","journal-title":"Drugs Exp. Clin. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ejps.2018.07.039","article-title":"The role of autophagy induction in the mechanism of cytoprotective effect of resveratrol","volume":"123","author":"Ulakcsai","year":"2018","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.bbrc.2008.06.104","article-title":"Stimulation of muscle cell glucose uptake by resveratrol through sirtuins and AMPK","volume":"374","author":"Breen","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"7217","DOI":"10.1073\/pnas.0610068104","article-title":"Resveratrol stimulates AMP kinase activity in neurons","volume":"104","author":"Dasgupta","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"24194","DOI":"10.1074\/jbc.M802869200","article-title":"Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and Akt","volume":"283","author":"Chan","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.2337\/db05-1188","article-title":"Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice","volume":"55","author":"Zang","year":"2006","journal-title":"Diabetes"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Chung, Y.C., and Hyun, C.G. (2021). Inhibitory Effects of Pinostilbene on Adipogenesis in 3T3-L1 Adipocytes: A Study of Possible Mechanisms. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222413446"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Kou, X., and Chen, N. (2017). Resveratrol as a Natural Autophagy Regulator for Prevention and Treatment of Alzheimer\u2019s Disease. Nutrients, 9.","DOI":"10.3390\/nu9090927"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1186\/s40001-023-01424-9","article-title":"Crosstalk between autophagy and insulin resistance: Evidence from different tissues","volume":"28","author":"Sadeghi","year":"2023","journal-title":"Eur. J. Med. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1038\/sj.bjp.0704637","article-title":"The protective effect of resveratrols on ischaemia-reperfusion injuries of rat hearts is correlated with antioxidant efficacy","volume":"135","author":"Hung","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"H1876","DOI":"10.1152\/ajpheart.00375.2009","article-title":"Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells","volume":"297","author":"Ungvari","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s11010-008-9756-y","article-title":"EPR studies on the superoxide-scavenging capacity of the nutraceutical resveratrol","volume":"313","author":"Jia","year":"2008","journal-title":"Mol. Cell. Biochem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/biof.1399","article-title":"Role of resveratrol in regulation of cellular defense systems against oxidative stress","volume":"44","author":"Truong","year":"2018","journal-title":"Biofactors"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.bbrc.2005.03.237","article-title":"Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cells","volume":"331","author":"Chen","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"H18","DOI":"10.1152\/ajpheart.00260.2010","article-title":"Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2","volume":"299","author":"Ungvari","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.jnutbio.2009.02.004","article-title":"Protective effects of pinostilbene, a resveratrol methylated derivative, against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells","volume":"21","author":"Chao","year":"2010","journal-title":"J. Nutr. Biochem."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Tsuji, G., Yumine, A., Kawamura, K., Takemura, M., and Nakahara, T. (2024). Induction of Semaphorin 3A by Resveratrol and Pinostilbene via Activation of the AHR-NRF2 Axis in Human Keratinocytes. Antioxidants, 13.","DOI":"10.3390\/antiox13060732"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Treml, J., Lelakova, V., Smejkal, K., Paulickova, T., Labuda, S., Granica, S., Havlik, J., Jankovska, D., Padrtova, T., and Hosek, J. (2019). Antioxidant Activity of Selected Stilbenoid Derivatives in a Cellular Model System. Biomolecules, 9.","DOI":"10.3390\/biom9090468"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1007\/s11095-010-0090-1","article-title":"Resveratrol and resveratrol analogues--structure-activity relationship","volume":"27","author":"Szekeres","year":"2010","journal-title":"Pharm. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"306","DOI":"10.4062\/biomolther.2012.20.3.306","article-title":"Effects of Resveratrol and trans-3,5,4\u2032-Trimethoxystilbene on Glutamate-Induced Cytotoxicity, Heme Oxygenase-1, and Sirtuin 1 in HT22 Neuronal Cells","volume":"20","author":"Kim","year":"2012","journal-title":"Biomol. Ther."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Zhou, C., Tan, Y., Xu, B., Wang, Y., and Cheang, W.S. (2022). 3,4\u2032,5-Trimethoxy-trans-stilbene Alleviates Endothelial Dysfunction in Diabetic and Obese Mice via Activation of the AMPK\/SIRT1\/eNOS Pathway. Antioxidants, 11.","DOI":"10.3390\/antiox11071286"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1039\/D3FO04158A","article-title":"3,4\u2032,5-Trimethoxy-trans-stilbene ameliorates hepatic insulin resistance and oxidative stress in diabetic obese mice through insulin and Nrf2 signaling pathways","volume":"15","author":"Tan","year":"2024","journal-title":"Food Funct."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.bcp.2004.12.001","article-title":"Antioxidant, prooxidant and cytotoxic activity of hydroxylated resveratrol analogues: Structure-activity relationship","volume":"69","author":"Murias","year":"2005","journal-title":"Biochem. Pharmacol."},{"key":"ref_61","first-page":"617","article-title":"Antioxidant activity of resveratrol, piceatannol and 3,3\u2032,4,4\u2032,5,5\u2032-hexahydroxy-trans-stilbene in three leukemia cell lines","volume":"16","author":"Ovesna","year":"2006","journal-title":"Oncol. Rep."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1080\/14786410902990797","article-title":"Comparative antioxidant activities and synergism of resveratrol and oxyresveratrol","volume":"24","author":"Aftab","year":"2010","journal-title":"Nat. Prod. Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.cbi.2015.06.024","article-title":"Oxyresveratrol abrogates oxidative stress by activating ERK-Nrf2 pathway in the liver","volume":"245","author":"Choi","year":"2016","journal-title":"Chem. Biol. Interact."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jphs.2019.01.003","article-title":"Oxyresveratrol protects human lens epithelial cells against hydrogen peroxide-induced oxidative stress and apoptosis by activation of Akt\/HO-1 pathway","volume":"139","author":"Hu","year":"2019","journal-title":"J. Pharmacol. Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.bbagen.2016.10.025","article-title":"Oxyresveratrol activates parallel apoptotic and autophagic cell death pathways in neuroblastoma cells","volume":"1861","author":"Rahman","year":"2017","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1080\/19768354.2019.1620853","article-title":"Effects of resveratrol and oxyresveratrol on hippocampal cell death induced by kainic acid","volume":"23","author":"Lee","year":"2019","journal-title":"Anim. Cells Syst."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1248\/bpb.29.2419","article-title":"Neuroprotective effect of oxyresveratrol from smilacis chinae rhizome on amyloid Beta protein (25\u201335)-induced neurotoxicity in cultured rat cortical neurons","volume":"29","author":"Ban","year":"2006","journal-title":"Biol. Pharm. Bull."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.neuro.2015.05.005","article-title":"Ammonia-induced oxidative damage in neurons is prevented by resveratrol and lipoic acid with participation of heme oxygenase 1","volume":"49","author":"Bobermin","year":"2015","journal-title":"Neurotoxicology"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Monahan, D.S., Flaherty, E., Hameed, A., and Duffy, G.P. (2021). Resveratrol significantly improves cell survival in comparison to dexrazoxane and carvedilol in a h9c2 model of doxorubicin induced cardiotoxicity. Biomed. Pharmacother., 140.","DOI":"10.1016\/j.biopha.2021.111702"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"13632","DOI":"10.1073\/pnas.0706290104","article-title":"Mechanism of inhibition of bovine F1-ATPase by resveratrol and related polyphenols","volume":"104","author":"Gledhill","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1021\/acs.jafc.8b05982","article-title":"Resveratrol Analogs with Antioxidant Activity Inhibit Intestinal Epithelial Cancer Caco-2 Cell Growth by Modulating Arachidonic Acid Cascade","volume":"67","author":"Storniolo","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jnutbio.2017.10.015","article-title":"Resveratrol and pinostilbene confer neuroprotection against aging-related deficits through an ERK1\/2-dependent mechanism","volume":"54","author":"Allen","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Likhitwitayawuid, K. (2021). Oxyresveratrol: Sources, Productions, Biological Activities, Pharmacokinetics, and Delivery Systems. Molecules, 26.","DOI":"10.3390\/molecules26144212"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/21\/10787\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T10:10:21Z","timestamp":1762423821000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/21\/10787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,6]]},"references-count":73,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["ijms262110787"],"URL":"https:\/\/doi.org\/10.3390\/ijms262110787","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,6]]}}}