{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T02:55:36Z","timestamp":1769914536706,"version":"3.49.0"},"reference-count":62,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2022YFB3805902"],"award-info":[{"award-number":["2022YFB3805902"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22077118"],"award-info":[{"award-number":["22077118"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013314","name":"\u201c111\u201d Project","doi-asserted-by":"crossref","award":["B18012"],"award-info":[{"award-number":["B18012"]}],"id":[{"id":"10.13039\/501100013314","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Natural Science Foundation of Jilin Province","award":["20210101353JC"],"award-info":[{"award-number":["20210101353JC"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is a complex neurodegenerative disease. The pathogenesis of AD remains incompletely understood. It is characterized by a variety of neuropathological changes, including neuroinflammation, neuronal loss and synaptic damage. Multiple pathological changes make achieving good therapeutic effects with a single drug treatment difficult, and using multiple drugs for combination therapy is currently the most effective method. Currently, the mainstay drugs used for AD treatment are hydrophobic drugs, such as curcumin, donepezil, and resveratrol. Because hydrophobic drugs cannot dissolve in bodily fluids and often aggregate or precipitate, their efficacy is greatly reduced. Therefore, there is an urgent need for a drug carrier that can effectively load and continuously release drugs. However, currently, there are few drug carriers that can achieve efficient co-loading of multiple hydrophobic drugs. Therefore, three of two-dimensional imine covalent organic frameworks (COFs) with different monomers were synthesized through rational design and screening. These three synthesized COFs are simultaneously loaded with curcumin (CUR) and benzofurazan (BZ) to achieve combined therapy. The results indicate that among this series of synthesized COFs, the COF synthesized from 4,4\u2032,4\u2033-(1,3,5-Triazine-2,4,6-triyl) trianiline and benzene-1,3,5-tricarboxaldehyde (COF-TB) exhibits optimal hydrophobic drug-loading capacity, enabling effective co-loading of CUR and BZ (BC@COF-TB). After treatment with BC@COF-TB, the cognitive function of 5\u00d7FAD mice was significantly improved. The COF platform provides a new way to deliver hydrophobic drugs for AD treatment.<\/jats:p>","DOI":"10.3390\/ijms262110803","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T17:51:43Z","timestamp":1762451503000},"page":"10803","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hydrophobic Drug Delivery Platforms Based on Covalent Organic Frameworks for Combined Treatment of Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8845-5546","authenticated-orcid":false,"given":"Yun","family":"Zhao","sequence":"first","affiliation":[{"name":"Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education, Faculty of Chemistry, Northeast Normal University, Changchun 130024, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education, Faculty of Chemistry, Northeast Normal University, Changchun 130024, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6399-1398","authenticated-orcid":false,"given":"Enpeng","family":"Xi","sequence":"additional","affiliation":[{"name":"Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education, Faculty of Chemistry, Northeast Normal University, Changchun 130024, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuming","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education, Faculty of Chemistry, Northeast Normal University, Changchun 130024, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7700-1544","authenticated-orcid":false,"given":"Nan","family":"Gao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education, Faculty of Chemistry, Northeast Normal University, Changchun 130024, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S167","DOI":"10.37765\/ajmc.2020.88481","article-title":"Current and evolving treatment strategies for the Alzheimer disease continuum","volume":"26","author":"Marasco","year":"2020","journal-title":"Am. J. Manag. Care"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"4947","DOI":"10.1021\/acsami.2c19839","article-title":"Imine-Linked Covalent Organic Framework Modulates Oxidative Stress in Alzheimer\u2019s Disease","volume":"15","author":"Ren","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1002\/alz.12901","article-title":"The worldwide costs of dementia in 2019","volume":"19","author":"Wimo","year":"2023","journal-title":"Alzheimers Dement."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Lauretti, E., Dincer, O., and Pratico, D. (2020). Glycogen synthase kinase-3 signaling in Alzheimer\u2019s disease. Biochim. Biophys. Acta-Mol. Cell Res., 1867.","DOI":"10.1016\/j.bbamcr.2020.118664"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/alz.12578","article-title":"Projecting the long-term societal value of a disease-modifying treatment for Alzheimer\u2019s disease in the United States","volume":"18","author":"Prados","year":"2022","journal-title":"Alzheimers Dement."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.2174\/0929867330666230403125140","article-title":"Drugs to Treat Neuroinflammation in Neurodegenerative Disorders","volume":"31","author":"Wang","year":"2024","journal-title":"Curr. Med. Chem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/nrneurol.2011.2","article-title":"Epidemiology of Alzheimer disease","volume":"7","author":"Reitz","year":"2011","journal-title":"Nat. Rev. Neurol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"100036","DOI":"10.59717\/j.xinn-med.2023.100036","article-title":"The associations of energy adjusted dietary inflammatory index with brain structure and cognitive function","volume":"1","author":"Zheng","year":"2023","journal-title":"Innov. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"100026","DOI":"10.59717\/j.xinn-med.2023.100026","article-title":"ADpred: A non-invasive model for three types of dementia and mild cognitive impairment","volume":"1","author":"Xu","year":"2023","journal-title":"Innov. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"100020","DOI":"10.59717\/j.xinn-med.2023.100020","article-title":"Advancing the battle against Alzheimer\u2019s Disease: A focus ontargeting tau pathology by antisense oligonucleotide","volume":"1","author":"Lin","year":"2023","journal-title":"Innov. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"101619","DOI":"10.1016\/j.arr.2022.101619","article-title":"Oxidative stress: The core pathogenesis and mechanism of Alzheimer\u2019s disease","volume":"77","author":"Bai","year":"2022","journal-title":"Ageing Res. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"14476","DOI":"10.1038\/s41598-017-15251-6","article-title":"Identification of a peptide-peptide binding motif in the coating of nab-paclitaxel nanoparticles with clinical antibodies: Bevacizumab, rituximab, and trastuzumab","volume":"7","author":"Butterfield","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/j.2042-7158.1983.tb04831.x","article-title":"Reconstituted collagen nanoparticles, a novel drug carrier delivery system","volume":"35","author":"Rohdewald","year":"1983","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1615\/CritRevOncog.2014011455","article-title":"Development of nanoscale approaches for ovarian cancer therapeutics and diagnostics","volume":"19","author":"Engelberth","year":"2014","journal-title":"Crit. Rev. Oncog."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"7668","DOI":"10.1002\/anie.200902612","article-title":"Supramolecular Stacking of Doxorubicin on Carbon Nanotubes for In Vivo Cancer Therapy","volume":"48","author":"Liu","year":"2009","journal-title":"Angew. Chem.-Int. Edit."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.4103\/1673-5374.160063","article-title":"Dendrimer nanocarriers drug action: Perspective for neuronal pharmacology","volume":"10","author":"Vidal","year":"2015","journal-title":"Neural Regen. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1021\/nn901181c","article-title":"Exceptionally High Payload of Doxorubicin in Hollow Gold Nanospheres for Near-Infrared Light-Triggered Drug Release","volume":"4","author":"You","year":"2010","journal-title":"ACS Nano"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.foodchem.2019.04.096","article-title":"Fabrication of chitosan hydrochloride and carboxymethyl starch complex nanogels as potential delivery vehicles for curcumin","volume":"293","author":"Li","year":"2019","journal-title":"Food Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.foodhyd.2016.01.021","article-title":"Polysaccharide-based nanoparticles by chitosan and gum arabic polyelectrolyte complexation as carriers for curcumin","volume":"57","author":"Tan","year":"2016","journal-title":"Food Hydrocoll."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"42354","DOI":"10.1021\/acsami.3c10074","article-title":"Delivery of Small-Molecule Drugs and Protein Drugs by Injectable Acid-Responsive Self-Assembled COF Hydrogels for Combinatorial Lung Cancer Treatment","volume":"15","author":"Meng","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"4325","DOI":"10.1021\/acsabm.5c00436","article-title":"Advanced Postsynthetic Modification of COF: Elevating Hydrophilicity for Efficient Doxorubicin Delivery","volume":"8","author":"Asadi","year":"2025","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"8749","DOI":"10.1002\/adma.201603006","article-title":"Exploiting Noncovalent Interactions in an Imine-Based Covalent Organic Framework for Quercetin Delivery","volume":"28","author":"Vyas","year":"2016","journal-title":"Adv. Mater."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3218","DOI":"10.1021\/acs.nanolett.1c00488","article-title":"Light-Activated Hypoxia-Sensitive Covalent Organic Framework for Tandem-Responsive Drug Delivery","volume":"21","author":"Lei","year":"2021","journal-title":"Nano Lett."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1038\/s41467-018-04910-5","article-title":"Water-dispersible PEG-curcumin\/amine-functionalized covalent organic framework nanocomposites as smart carriers for in vivo drug delivery","volume":"9","author":"Zhang","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1021\/acsanm.9b02603","article-title":"Evolution of Nanocarrier Drug-Delivery Systems and Recent Advancements in Covalent Organic Framework\u2013Drug Systems","volume":"3","author":"Scicluna","year":"2020","journal-title":"ACS Appl. Nano Mater."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e202202538","DOI":"10.1002\/slct.202202538","article-title":"Covalent Organic Frameworks (COFs): A Necessary Choice For Drug Delivery","volume":"7","author":"Guo","year":"2022","journal-title":"ChemistrySelect"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/cjoc.201400550","article-title":"Synthesis of Microporous Nitrogen-Rich Covalent-Organic Framework and Its Application in CO2 Capture","volume":"33","author":"Gao","year":"2014","journal-title":"Chin. J. Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"16091","DOI":"10.1021\/acsnano.3c12167","article-title":"Probing Self-Diffusion of Guest Molecules in a Covalent Organic Framework: Simulation and Experiment","volume":"18","author":"Grunenberg","year":"2024","journal-title":"ACS Nano"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"28047","DOI":"10.1039\/C6RA01717G","article-title":"A new triazine functionalized luminescent covalent organic framework for nitroaromatic sensing and CO2 storage","volume":"6","author":"Gomes","year":"2016","journal-title":"RSC Adv."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"124352","DOI":"10.1016\/j.jssc.2023.124352","article-title":"N-doping and structural regularity of covalent organic frameworks (COFs) tune the catalytic activity for knoevenagel condensation reaction","volume":"328","author":"Chen","year":"2023","journal-title":"J. Solid. State Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"4570","DOI":"10.1021\/ja8096256","article-title":"A Crystalline Imine-Linked 3-D Porous Covalent Organic Framework","volume":"131","author":"Hunt","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"8680","DOI":"10.1021\/acsami.1c19754","article-title":"Covalent Organic Framework-Incorporated Nanofibrous Membrane as an Intelligent Platform for Wound Dressing","volume":"14","author":"Zou","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"4128","DOI":"10.1039\/C6CC00853D","article-title":"Nanoscale covalent organic frameworks as smart carriers for drug delivery","volume":"52","author":"Bai","year":"2016","journal-title":"Chem. Commun."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"24620","DOI":"10.1039\/D2TA07271H","article-title":"Bandgap engineering of covalent organic frameworks for boosting photocatalytic hydrogen evolution from water","volume":"10","author":"Chen","year":"2022","journal-title":"J. Mater. Chem. A"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"33121","DOI":"10.1021\/acsami.0c09173","article-title":"Ultralow Surface Tension Solvents Enable Facile COF Activation with Reduced Pore Collapse","volume":"12","author":"Zhu","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1021\/jacs.4c17520","article-title":"Uranium Extraction from Seawater via Hydrogen Bond Porous Organic Cages","volume":"147","author":"Wu","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e202420746","DOI":"10.1002\/anie.202420746","article-title":"Targeted Synthesis of Interpenetration-Free Mesoporous Aromatic Frameworks by Manipulating Catalysts as Templates","volume":"64","author":"Wang","year":"2025","journal-title":"Angew. Chem.-Int. Edit."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jechem.2024.12.044","article-title":"Pyridine-nitrogen conjugated covalent organic frameworks for high-efficiency gas-solid photocatalytic reduction of CO2 to CO","volume":"104","author":"Jiang","year":"2025","journal-title":"J. Energy Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jcis.2023.09.060","article-title":"Coralloid W18O49@covalent organic frameworks S-scheme heterojunction for high efficiency photocatalytic aerobic oxidation","volume":"653","author":"Zhao","year":"2024","journal-title":"J. Colloid. Interface Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"11976","DOI":"10.1039\/D4CC02583K","article-title":"Hydrogen storage in a sandwich structure by assembly of BNs and MOFs","volume":"60","author":"Sun","year":"2024","journal-title":"Chem. Commun."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"22930","DOI":"10.1021\/jacs.4c07945","article-title":"Constructing Isoreticular Metal-Organic Frameworks by Silver-Carbon Bonds","volume":"146","author":"Jiang","year":"2024","journal-title":"J. Am. Chem. Soc."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.chempr.2023.09.022","article-title":"Metal-carbon bond metal-organic frameworks with permanent porosity","volume":"10","author":"Jiang","year":"2024","journal-title":"Chem"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e202402095","DOI":"10.1002\/anie.202402095","article-title":"Rationally Designed Cyclooctatetrathiophene-Based Porous Aromatic Frameworks (COTh-PAFs) for Efficient Photocatalytic Hydrogen Peroxide Production","volume":"63","author":"Cao","year":"2024","journal-title":"Angew. Chem.-Int. Edit."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"4575","DOI":"10.1021\/acscatal.2c05568","article-title":"Selective Production of Glycolic Acid from Cellulose Promoted by Acidic\/Redox Polyoxometalates via Oxidative Hydrolysis","volume":"13","author":"Li","year":"2023","journal-title":"ACS Catal."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"4766","DOI":"10.1039\/D3CC00623A","article-title":"Ultrafine platinum nanoparticles anchored in porous aromatic frameworks for efficient hydrogen evolution reaction","volume":"59","author":"Li","year":"2023","journal-title":"Chem. Commun."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e202301129","DOI":"10.1002\/chem.202301129","article-title":"Preparation of Trimetallic-Organic Framework Film Electrodes via Secondary Growth for Efficient Oxygen Evolution Reaction","volume":"29","author":"Li","year":"2023","journal-title":"Chem.-Eur. J."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s12640-019-00030-0","article-title":"Effects of Curcumin on Microglial Cells","volume":"36","author":"Ghasemi","year":"2019","journal-title":"Neurotox. Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e2303016","DOI":"10.1002\/adhm.202303016","article-title":"Dual-ROS Sensitive Moieties Conjugate Inhibits Curcumin Oxidative Degradation for Colitis Precise Therapy","volume":"13","author":"Liang","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"187","DOI":"10.18632\/aging.101149","article-title":"Curcumin older adults by increasing nitric oxide bioavailability and reducing oxidative stress","volume":"9","author":"Strahler","year":"2017","journal-title":"Aging"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s00702-022-02480-x","article-title":"Pharmacological considerations for treating neuroinflammation with curcumin in Alzheimer\u2019s disease","volume":"129","author":"Zhou","year":"2022","journal-title":"J. Neural Transm."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.niox.2008.04.003","article-title":"Sustained release nitric oxide releasing nanoparticles: Characterization of a novel delivery platform based on nitrite containing hydrogel\/glass composites","volume":"19","author":"Friedman","year":"2008","journal-title":"Nitric Oxide"},{"key":"ref_52","first-page":"e202413108","article-title":"Multifunctional Microneedle Patches Loaded With Engineered Nitric Oxide-Releasing Nanocarriers for Targeted and Synergistic Chronic Wound Therapy","volume":"37","author":"Jin","year":"2025","journal-title":"Adv. Mater."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.freeradbiomed.2020.09.025","article-title":"Control of systemic inflammation through early nitric oxide supplementation with nitric oxide releasing nanoparticles","volume":"161","author":"Williams","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"7063","DOI":"10.1039\/D1TB00847A","article-title":"Recent advances in the development of nitric oxide-releasing biomaterials and their application potentials in chronic wound healing","volume":"9","author":"Wu","year":"2021","journal-title":"J. Mat. Chem. B"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.niox.2023.03.003","article-title":"Dual role of nitric oxide in Alzheimer\u2019s disease","volume":"134\u2013135","author":"Azargoonjahromi","year":"2023","journal-title":"Nitric Oxide"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Fershtat, L.L., and Zhilin, E.S. (2021). Recent Advances in the Synthesis and Biomedical Applications of Heterocyclic NO-Donors. Molecules, 26.","DOI":"10.3390\/molecules26185705"},{"key":"ref_57","first-page":"1786","article-title":"Furazans in Medicinal Chemistry","volume":"64","author":"Mancini","year":"2021","journal-title":"J. Mater. Chem."},{"key":"ref_58","first-page":"4412","article-title":"Furoxans as Nitric Oxide Donors. 4-Phenyl-3-furoxancarbonitrile: Thiol-Mediated Nitric Oxide Release and Biological Evaluation","volume":"37","author":"Medana","year":"1994","journal-title":"J. Mater. Chem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"e2403046","DOI":"10.1002\/adhm.202403046","article-title":"Enhanced Nitric Oxide Delivery Through Self-Assembling Nanoparticles for Eradicating Gram-Negative Bacteria","volume":"13","author":"Lai","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/cmdc.201700113","article-title":"Molecular Hybridization Tools in the Development of Furoxan-Based NO-Donor Prodrugs","volume":"12","author":"Fershtat","year":"2017","journal-title":"ChemMedChem"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2312275","DOI":"10.1002\/adma.202312275","article-title":"Microalgae-Based Hydrogel for Inflammatory Bowel Disease and Its Associated Anxiety and Depression","volume":"36","author":"Zhong","year":"2024","journal-title":"Adv. Mater."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/s41392-025-02426-1","article-title":"Rapid amyloid-\u03b2 clearance and cognitive recovery through multivalent modulation of blood\u2013brain barrier transport","volume":"10","author":"Chen","year":"2025","journal-title":"Sig. Transduct. Target. Ther."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/21\/10803\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T05:11:13Z","timestamp":1762578673000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/21\/10803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,6]]},"references-count":62,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["ijms262110803"],"URL":"https:\/\/doi.org\/10.3390\/ijms262110803","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,6]]}}}