{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:56:45Z","timestamp":1791863805191,"version":"4.3.4"},"reference-count":51,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Korea Bio-health Technology R&D Project","award":["RS-2023-00267453"],"award-info":[{"award-number":["RS-2023-00267453"]}]},{"name":"Korea Health Technology R&D Project","award":["RS-2021-KH113822"],"award-info":[{"award-number":["RS-2021-KH113822"]}]},{"name":"Korea Health Technology R&D Project","award":["RS-2022-KH131231"],"award-info":[{"award-number":["RS-2022-KH131231"]}]},{"name":"Ministry of Health & Welfare, Republic of Korea"},{"name":"Bio&Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government","award":["RS-2023-00223559"],"award-info":[{"award-number":["RS-2023-00223559"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, amyloid-\u03b2 (A\u03b2) pathology, synaptic degeneration, impaired neurogenesis, and chronic neuroinflammation. KBN2202, a small-molecule salicylic acid derivative [2-[(2-naphthalen-1-yloxy)ethyl]amino]-4-hydroxybenzoic acid], was investigated for its potential as a multi-target therapeutic agent in advanced-stage AD. To this end, 9-month-old 5xFAD mice with established AD-like pathology received daily oral KBN2202 (5 or 20 mg\/kg) or vehicle for 12 weeks. KBN2202 demonstrated broad histopathological benefits. It preserved hippocampal CA1 cytoarchitecture and increased dendritic length in cortical neurons. Neurogenic activity was also enhanced, with elevated doublecortin (DCX) expression in the subventricular zone (SVZ). At the molecular level, KBN2202 reduced amyloid precursor protein C-terminal fragments (APP-CTFs), key intermediates in amyloidogenic processing, and histological staining confirmed a significant reduction in fibrillar and diffuse A\u03b2 plaque burden in the cortex and hippocampus. Furthermore, KBN2202 attenuated astrocytic and microglial activation, indicating suppression of chronic neuroinflammation. In behavioral assessments, KBN2202 significantly improved recognition memory in the novel object recognition (NOR) test, while Y-maze performance remained unchanged. Overall, the compound exhibited robust neuroprotective, pro-neurogenic, anti-amyloid, and anti-inflammatory effects. These findings support the therapeutic potential of KBN2202 as a multi-functional candidate for symptomatic-stage AD.<\/jats:p>","DOI":"10.3390\/ijms262210942","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T10:56:47Z","timestamp":1762945007000},"page":"10942","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["KBN2202, a Salicylic Acid Derivative, Preserves Neuronal Architecture, Enhances Neurogenesis, Attenuates Amyloid and Inflammatory Pathology, and Restores Recognition Memory in 5xFAD Mice at an Advanced Stage of AD Pathophysiology"],"prefix":"10.3390","volume":"26","author":[{"given":"Sun-Young","family":"Lee","sequence":"first","affiliation":[{"name":"Efficacy Test Center for Mental & Behavioral Disorders (MBD), Ajou University Hospital, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Chul","family":"Kim","sequence":"additional","affiliation":[{"name":"Preclinical Research Center, Daegu-Gyeongbuk Medical Innovation Foundation (K-MEDI hub), Daegu 41061, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Ran","family":"Choi","sequence":"additional","affiliation":[{"name":"Efficacy Test Center for Mental & Behavioral Disorders (MBD), Ajou University Hospital, Suwon 16499, Republic of Korea"},{"name":"Laboratory Animal Research Center, Ajou University School of Medicine, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiseo","family":"Song","sequence":"additional","affiliation":[{"name":"Efficacy Test Center for Mental & Behavioral Disorders (MBD), Ajou University Hospital, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moonhang","family":"Kim","sequence":"additional","affiliation":[{"name":"Efficacy Test Center for Mental & Behavioral Disorders (MBD), Ajou University Hospital, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok-Hwan","family":"Chang","sequence":"additional","affiliation":[{"name":"Efficacy Test Center for Mental & Behavioral Disorders (MBD), Ajou University Hospital, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Sung","family":"Kim","sequence":"additional","affiliation":[{"name":"Efficacy Test Center for Mental & Behavioral Disorders (MBD), Ajou University Hospital, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8661-8746","authenticated-orcid":false,"given":"Joon-Suk","family":"Park","sequence":"additional","affiliation":[{"name":"Preclinical Research Center, Daegu-Gyeongbuk Medical Innovation Foundation (K-MEDI hub), Daegu 41061, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Rae","family":"Lee","sequence":"additional","affiliation":[{"name":"Efficacy Test Center for Mental & Behavioral Disorders (MBD), Ajou University Hospital, Suwon 16499, Republic of Korea"},{"name":"Laboratory Animal Research Center, Ajou University School of Medicine, Suwon 16499, Republic of Korea"},{"name":"Department of Pharmacology, Ajou University School of Medicine, Suwon 16499, Republic of Korea"},{"name":"BK21 R&E Initiative for Advanced Precision Medicine, Suwon 16499, Republic of Korea"},{"name":"Department of Biomedical Sciences, Graduate School of Ajou University, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.cell.2015.12.056","article-title":"The Cellular Phase of Alzheimer\u2019s Disease","volume":"164","author":"Karran","year":"2016","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA-AA Research Framework: Toward a biological definition of Alzheimer\u2019s disease","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimers Dement."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41582-020-00435-y","article-title":"Neuroinflammation and microglial activation in Alzheimer disease: Where do we go from here?","volume":"17","author":"Leng","year":"2021","journal-title":"Nat. Rev. Neurol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/ni.3102","article-title":"Innate immunity in Alzheimer\u2019s disease","volume":"16","author":"Heneka","year":"2015","journal-title":"Nat. Immunol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/nrn3880","article-title":"Immune attack: The role of inflammation in Alzheimer disease","volume":"16","author":"Heppner","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Fruholz, I., and Meyer-Luehmann, M. (2024). The intricate interplay between microglia and adult neurogenesis in Alzheimer\u2019s disease. Front. Cell Neurosci., 18.","DOI":"10.3389\/fncel.2024.1456253"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Cummings, J., Zhou, Y., Lee, G., Zhong, K., Fonseca, J., and Cheng, F. (2023). Alzheimer\u2019s disease drug development pipeline: 2023. Alzheimers Dement., 9.","DOI":"10.1002\/trc2.12385"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/s41573-022-00391-w","article-title":"The amyloid hypothesis in Alzheimer disease: New insights from new therapeutics","volume":"21","author":"Karran","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","article-title":"Alzheimer\u2019s disease","volume":"397","author":"Scheltens","year":"2021","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nature19323","article-title":"The antibody aducanumab reduces Abeta plaques in Alzheimer\u2019s disease","volume":"537","author":"Sevigny","year":"2016","journal-title":"Nature"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1056\/NEJMoa2100708","article-title":"Donanemab in Early Alzheimer\u2019s Disease","volume":"384","author":"Mintun","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer\u2019s disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"5481","DOI":"10.1038\/s41380-021-01249-0","article-title":"The Amyloid-beta Pathway in Alzheimer\u2019s Disease","volume":"26","author":"Hampel","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.immuni.2017.06.006","article-title":"Reactive Astrocytes: Production, Function, and Therapeutic Potential","volume":"46","author":"Liddelow","year":"2017","journal-title":"Immunity"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"437","DOI":"10.4103\/1673-5374.245463","article-title":"Multitarget therapeutic strategies for Alzheimer\u2019s disease","volume":"14","author":"Ibrahim","year":"2019","journal-title":"Neural Regen. Res."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Gong, C.X., Dai, C.L., Liu, F., and Iqbal, K. (2022). Multi-Targets: An Unconventional Drug Development Strategy for Alzheimer\u2019s Disease. Front. Aging Neurosci., 14.","DOI":"10.3389\/fnagi.2022.837649"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Hossain, M.S., and Hussain, M.H. (2025). Multi-Target Drug Design in Alzheimer\u2019s Disease Treatment: Emerging Technologies, Advantages, Challenges, and Limitations. Pharmacol. Res. Perspect., 13.","DOI":"10.1002\/prp2.70131"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1002\/jnr.10851","article-title":"Antioxidant effect of acetylsalicylic and salicylic acid in rat brain slices subjected to hypoxia","volume":"75","author":"Guerrero","year":"2004","journal-title":"J. Neurosci. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1006\/phrs.2000.0717","article-title":"Effects of salicylic acid in glutamate- and kainic acid-induced neurotoxicity in cerebellar granular cell culture of rats","volume":"42","author":"Gepdiremen","year":"2000","journal-title":"Pharmacol. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.brainres.2010.05.010","article-title":"Salicylic acid protects against chronic L-DOPA-induced 6-OHDA generation in experimental model of parkinsonism","volume":"1344","author":"Borah","year":"2010","journal-title":"Brain Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/s002109900079","article-title":"Salicylate protects against MPTP-induced impairments in dopaminergic neurotransmission at the striatal and nigral level in mice","volume":"360","author":"Ferger","year":"1999","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Makhaeva, G.F., Kovaleva, N.V., Rudakova, E.V., Boltneva, N.P., Grishchenko, M.V., Lushchekina, S.V., Astakhova, T.Y., Serebryakova, O.G., Timokhina, E.N., and Zhilina, E.F. (2023). Conjugates of Tacrine and Salicylic Acid Derivatives as New Promising Multitarget Agents for Alzheimer\u2019s Disease. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24032285"},{"key":"ref_23","unstructured":"Kim, J., Heo, J.H., Kim, M., Choi, M.R., and Lee, S.R. (2024, January 5\u20139). Effect of a salicylic acid derivative, KBN-2202, on changes of Alzheimer\u2019s disease-related factors in murine neuroblastoma Neuro2a cells. Proceedings of the Society for Neuroscience Annual Meeting, Chicago, IL, USA."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"10129","DOI":"10.1523\/JNEUROSCI.1202-06.2006","article-title":"Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer\u2019s disease mutations: Potential factors in amyloid plaque formation","volume":"26","author":"Oakley","year":"2006","journal-title":"J. Neurosci."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Forner, S., Kawauchi, S., Balderrama-Gutierrez, G., Kramar, E.A., Matheos, D.P., Phan, J., Javonillo, D.I., Tran, K.M., Hingco, E., and da Cunha, C. (2021). Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer\u2019s disease. Sci. Data, 8.","DOI":"10.1038\/s41597-021-01054-y"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.neurobiolaging.2003.12.005","article-title":"Hippocampal neurons in pre-clinical Alzheimer\u2019s disease","volume":"25","author":"West","year":"2004","journal-title":"Neurobiol. Aging"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jns.2009.02.370","article-title":"Dendritic pathology in Alzheimer\u2019s disease","volume":"283","author":"Baloyannis","year":"2009","journal-title":"J. Neurol. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s12035-008-8018-z","article-title":"Dendritic spine loss and synaptic alterations in Alzheimer\u2019s disease","volume":"37","author":"Knobloch","year":"2008","journal-title":"Mol. Neurobiol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Mu, Y., and Gage, F.H. (2011). Adult hippocampal neurogenesis and its role in Alzheimer\u2019s disease. Mol. Neurodegener., 6.","DOI":"10.1186\/1750-1326-6-85"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Capilla-Gonzalez, V., Herranz-Perez, V., and Garcia-Verdugo, J.M. (2015). The aged brain: Genesis and fate of residual progenitor cells in the subventricular zone. Front. Cell Neurosci., 9.","DOI":"10.3389\/fncel.2015.00365"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/s41591-019-0375-9","article-title":"Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer\u2019s disease","volume":"25","author":"Rabano","year":"2019","journal-title":"Nat. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1126\/science.286.5440.735","article-title":"Beta-secretase cleavage of Alzheimer\u2019s amyloid precursor protein by the transmembrane aspartic protease BACE","volume":"286","author":"Vassar","year":"1999","journal-title":"Science"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"595","DOI":"10.15252\/emmm.201606210","article-title":"The amyloid hypothesis of Alzheimer\u2019s disease at 25 years","volume":"8","author":"Selkoe","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0306-4522(02)00056-8","article-title":"Stereologic assessment of the total cortical volume occupied by amyloid deposits and its relationship with cognitive status in aging and Alzheimer\u2019s disease","volume":"112","author":"Bussiere","year":"2002","journal-title":"Neuroscience"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/373523a0","article-title":"Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein","volume":"373","author":"Games","year":"1995","journal-title":"Nature"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Serrano-Pozo, A., Frosch, M.P., Masliah, E., and Hyman, B.T. (2011). Neuropathological alterations in Alzheimer disease. Cold Spring Harb. Perspect. Med., 1.","DOI":"10.1101\/cshperspect.a006189"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-1-4939-8994-2_10","article-title":"The Y-Maze for Assessment of Spatial Working and Reference Memory in Mice","volume":"1916","author":"Kraeuter","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1126\/science.aau0437","article-title":"Alzheimer\u2019s disease: The right drug, the right time","volume":"362","author":"Golde","year":"2018","journal-title":"Science"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1096\/fj.12-217497","article-title":"A truncated peptide from p35, a Cdk5 activator, prevents Alzheimer\u2019s disease phenotypes in model mice","volume":"27","author":"Shukla","year":"2013","journal-title":"FASEB J."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.biopsych.2020.02.001","article-title":"The beta-Secretase BACE1 in Alzheimer\u2019s Disease","volume":"89","author":"Hampel","year":"2021","journal-title":"Biol. Psychiatry"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1460-9568.2004.03813.x","article-title":"Doublecortin expression levels in adult brain reflect neurogenesis","volume":"21","author":"Winner","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1073\/pnas.2634794100","article-title":"Increased hippocampal neurogenesis in Alzheimer\u2019s disease","volume":"101","author":"Jin","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Knoth, R., Singec, I., Ditter, M., Pantazis, G., Capetian, P., Meyer, R.P., Horvat, V., Volk, B., and Kempermann, G. (2010). Murine features of neurogenesis in the human hippocampus across the lifespan from 0 to 100 years. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0008809"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/s41583-019-0132-6","article-title":"Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease","volume":"20","author":"Butterfield","year":"2019","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.trci.2019.05.008","article-title":"Alzheimer\u2019s disease drug development pipeline: 2019","volume":"5","author":"Cummings","year":"2019","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1126\/science.1088417","article-title":"Inflammatory blockade restores adult hippocampal neurogenesis","volume":"302","author":"Monje","year":"2003","journal-title":"Science"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Cao, J., Hou, J., Ping, J., and Cai, D. (2018). Advances in developing novel therapeutic strategies for Alzheimer\u2019s disease. Mol. Neurodegener., 13.","DOI":"10.1186\/s13024-018-0299-8"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"8631","DOI":"10.1073\/pnas.1708106114","article-title":"BACE inhibition-dependent repair of Alzheimer\u2019s pathophysiology","volume":"114","author":"Keskin","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Jawhar, S., Trawicka, A., Jenneckens, C., Bayer, T.A., and Wirths, O. (2012). Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Abeta aggregation in the 5XFAD mouse model of Alzheimer\u2019s disease. Neurobiol. Aging, 33.","DOI":"10.1016\/j.neurobiolaging.2010.05.027"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Klessig, D.F., Tian, M., and Choi, H.W. (2016). Multiple Targets of Salicylic Acid and Its Derivatives in Plants and Animals. Front. Immunol., 7.","DOI":"10.3389\/fimmu.2016.00206"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.tem.2013.06.002","article-title":"AMPK: Mediating the metabolic effects of salicylate-based drugs?","volume":"24","author":"Steinberg","year":"2013","journal-title":"Trends Endocrinol. Metab."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/22\/10942\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T10:57:40Z","timestamp":1762945060000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/22\/10942"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,12]]},"references-count":51,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["ijms262210942"],"URL":"https:\/\/doi.org\/10.3390\/ijms262210942","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,12]]}}}