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Adverse left ventricular remodeling (LVR), which refers to a progressive dilation of left ventricular (LV) end-diastolic and end-systolic volumes, usually accompanied by a deterioration in LV systolic function, occurs frequently and underlies most cases of HF development after AMI. In this review, we discuss the current definitions of post-AMI LVR, the most appropriate imaging modalities for its detection, and the pathophysiological mechanisms by which Cardiac Rehabilitation (CR) can improve LVR\u2014including exercise interventions, cardiovascular risk factors control, and pharmacological therapy optimization. Finally, we provide up-to-date recommendations for the follow-up and management of LVR in post-AMI patients enrolled in CR and outline future prospects on this topic.<\/jats:p>","DOI":"10.3390\/ijms262210964","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T09:10:45Z","timestamp":1763025045000},"page":"10964","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Left Ventricular Remodeling After Myocardial Infarction\u2014Pathophysiology, Diagnostic Approach and Management During Cardiac Rehabilitation"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5565-5547","authenticated-orcid":false,"given":"V\u00edctor","family":"Marcos-Garc\u00e9s","sequence":"first","affiliation":[{"name":"Department of Cardiology, Hospital Clinico Universitario de Valencia, 46010 Valencia, Spain"},{"name":"INCLIVA Health Research Institute, 46010 Valencia, Spain"},{"name":"Network Biomedical Research Center for Cardiovascular Diseases (CIBER-CV), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4751-5859","authenticated-orcid":false,"given":"Carlos","family":"Bertol\u00edn-Boronat","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Clinico Universitario de Valencia, 46010 Valencia, Spain"},{"name":"INCLIVA Health Research Institute, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1734-0381","authenticated-orcid":false,"given":"H\u00e9ctor","family":"Merenciano-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Clinico Universitario de Valencia, 46010 Valencia, Spain"},{"name":"INCLIVA Health Research Institute, 46010 Valencia, Spain"},{"name":"Network Biomedical Research Center for Cardiovascular Diseases (CIBER-CV), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Luz","family":"Mart\u00ednez Mas","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Clinico Universitario de Valencia, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josefa In\u00e9s","family":"Climent Alberola","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Hospital Clinico Universitario de Valencia, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4024-0418","authenticated-orcid":false,"given":"Laura","family":"L\u00f3pez-Bueno","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Hospital Clinico Universitario de Valencia, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Pay\u00e1 Rubio","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Hospital Clinico Universitario de Valencia, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3527-0337","authenticated-orcid":false,"given":"Nerea","family":"P\u00e9rez-Sol\u00e9","sequence":"additional","affiliation":[{"name":"INCLIVA Health Research Institute, 46010 Valencia, Spain"},{"name":"Network Biomedical Research Center for Cardiovascular Diseases (CIBER-CV), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6405-6279","authenticated-orcid":false,"given":"C\u00e9sar","family":"R\u00edos-Navarro","sequence":"additional","affiliation":[{"name":"INCLIVA Health Research Institute, 46010 Valencia, Spain"},{"name":"Network Biomedical Research Center for Cardiovascular Diseases (CIBER-CV), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"de Dios","sequence":"additional","affiliation":[{"name":"Network Biomedical Research Center for Cardiovascular Diseases (CIBER-CV), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3483-7066","authenticated-orcid":false,"given":"Jose","family":"Gavara","sequence":"additional","affiliation":[{"name":"INCLIVA Health Research Institute, 46010 Valencia, Spain"},{"name":"Network Biomedical Research Center for Cardiovascular Diseases (CIBER-CV), 28029 Madrid, Spain"},{"name":"Centre for Biomaterials and Tissue Engineering, Universitat Polit\u00e8cnica de Val\u00e8ncia, 46022 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2825-3646","authenticated-orcid":false,"given":"David","family":"Moratal","sequence":"additional","affiliation":[{"name":"Network Biomedical Research Center for Cardiovascular Diseases (CIBER-CV), 28029 Madrid, Spain"},{"name":"Centre for Biomaterials and Tissue Engineering, Universitat Polit\u00e8cnica de Val\u00e8ncia, 46022 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7229-9780","authenticated-orcid":false,"given":"Jose F.","family":"Rodriguez-Palomares","sequence":"additional","affiliation":[{"name":"Network Biomedical Research Center for Cardiovascular Diseases (CIBER-CV), 28029 Madrid, Spain"},{"name":"Department of Medicine, Universitat Aut\u00f2noma de Barcelona, 08193 Barcelona, Spain"},{"name":"Department of Cardiology, Hospital Universitari Vall d\u2019Hebron, 08035 Barcelona, Spain"},{"name":"Vall d\u2019Hebron Institut de Recerca, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8043-6055","authenticated-orcid":false,"given":"Jose 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Bodi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Clinico Universitario de Valencia, 46010 Valencia, Spain"},{"name":"INCLIVA Health Research Institute, 46010 Valencia, Spain"},{"name":"Network Biomedical Research Center for Cardiovascular Diseases (CIBER-CV), 28029 Madrid, Spain"},{"name":"Department of Medicine, Faculty of Medicine and Odontology, University of Valencia, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,12]]},"reference":[{"key":"ref_1","first-page":"e41","article-title":"2025 Heart Disease and Stroke Statistics: A Report of US and Global Data from the American Heart Association","volume":"151","author":"Martin","year":"2025","journal-title":"Circulation"},{"key":"ref_2","unstructured":"(2025, August 11). 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