{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T08:06:48Z","timestamp":1788250008793,"version":"build-2803163510"},"reference-count":48,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>In the current research a series of new copper(II) complexes with novel acylhydrazone ligands were synthesized and their antibacterial and anticancer activities were determined. The complexes were characterized by molecular spectroscopy (FT-IR and UV-Vis) and conductivity measurements. Additionally, their structure was confirmed by single-crystal X-ray analysis. The crystallographic data revealed that all compounds are mononuclear Cu(II) species. The Cu(II) ion is four-coordinated by the ONO donor set from mono-deprotonated hydrazone ligand and one Cl\u00af anion, forming distorted square-planar geometry. The biological studies revealed that the compounds exhibit high antimicrobial activity, especially against Gram-positive bacteria, in some cases greater than the reference substances, and better activity than free ligands. The tested complexes possessed the lowest MIC and MBC values towards Staphylococcus epidermidis ATCC 12228 and Micrococcus luteus ATCC 10240. Furthermore, they showed no toxicity towards normal cell lines.<\/jats:p>","DOI":"10.3390\/ijms262210980","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T09:10:45Z","timestamp":1763025045000},"page":"10980","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Copper(II) Complexes of Selected Acylhydrazones as Potential Biological Agents"],"prefix":"10.3390","volume":"26","author":[{"given":"Izabela","family":"Czy\u017cewska","sequence":"first","affiliation":[{"name":"Chair and Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Lublin, 4A Chod\u017aki Street, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8283-3484","authenticated-orcid":false,"given":"Liliana","family":"Mazur","sequence":"additional","affiliation":[{"name":"Institute of Chemical Sciences, Faculty of Chemistry, Maria Curie-Sk\u0142odowska University, Maria Curie-Sk\u0142odowska Sq. 2, 20-031 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Mroczka","sequence":"additional","affiliation":[{"name":"Laboratory of X-ray Optics, Centre for Interdisciplinary Research, The John Paul II Catholic University of Lublin, 1J Konstantyn\u00f3w Street, 20-708 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2844-9876","authenticated-orcid":false,"given":"Anna","family":"Biernasiuk","sequence":"additional","affiliation":[{"name":"Chair and Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Medical University of Lublin, 1 Chod\u017aki Street, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3104-8464","authenticated-orcid":false,"given":"Anna","family":"Hordyjewska","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Faculty of Medical Sciences, Medical University of Lublin, 4A Chod\u017aki Street, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0141ukasz","family":"Popio\u0142ek","sequence":"additional","affiliation":[{"name":"Chair and Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Lublin, 4A Chod\u017aki Street, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s12223-021-00910-z","article-title":"Mechanism of drug resistance in bacteria: Efflux pump modulation for designing of new antibiotic enhancers","volume":"66","author":"Mohanty","year":"2021","journal-title":"Folia Microbiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1128\/microbiolspec.VMBF-0016-2015","article-title":"Mechanisms of Antibiotic Resistance","volume":"4","author":"Munita","year":"2016","journal-title":"Microbiol. 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