{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:46:10Z","timestamp":1791773170619,"version":"4.3.4"},"reference-count":132,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T00:00:00Z","timestamp":1763164800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Antwerp BOF-grants Geconcerteerde Onderzoeksactie","award":["FFB180348"],"award-info":[{"award-number":["FFB180348"]}]},{"name":"Methusalem OEC grant\u2014\u201cGENOMED\u201d","award":["FFB190208"],"award-info":[{"award-number":["FFB190208"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The Paraoxonase (PON) gene family consists of three paralogues (PON1, PON2 and PON3) that are tandemly located on chromosome 7. In this review paper, the structure and function of the encoded proteins is summarized. In addition, an overview is given on the generated animal models. Finally, their involvement in the pathogenesis of different diseases is discussed, starting from an extended screening of the literature using PUBMED and Web of Science. PON1 and PON3 are mainly expressed in the liver and released into the bloodstream, bound to high-density lipoprotein. PON2 is expressed in various tissues, including the liver, lungs, heart, placenta and testes, but remains intracellular. The name of the enzyme family reflects PON1\u2032s ability to neutralize paraoxon, but they also exhibit lactonase and esterase activities. All three PON enzymes play a role in reducing lipid peroxides in High-Density Lipoprote\u00efne (HDL) and low-density lipoprotein(LDL), giving them antioxidant properties. This links them to Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD), a metabolic liver condition marked by the excessive accumulation of triglycerides (TG) in liver cells. In addition to their association with MASLD, the PON genes are, due to their antioxidant properties, also associated with other conditions including cardiovascular diseases, chronic kidney disease, neurological and immunological conditions up to some forms of cancer. In the latter, the antioxidant properties can result in tumor progression by protecting malignant cells from oxidative damage thus supporting survival, proliferation and metastasis indicating them as potential drug targets for treatment of cancer. Therefore, further research on this protein family can provide novel insights into their function and their potential therapeutic applicability.<\/jats:p>","DOI":"10.3390\/ijms262211054","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T10:24:58Z","timestamp":1763375098000},"page":"11054","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Paraoxonase (PON) Gene Family in Health, Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Other Diseases"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6501-6714","authenticated-orcid":false,"given":"Tammy","family":"Huybrechts","sequence":"first","affiliation":[{"name":"Department of Medical Genetics, University of Antwerp, 2000 Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristien","family":"Franck","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, University of Antwerp, 2000 Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Steenackers","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, University of Antwerp, 2000 Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5065-7858","authenticated-orcid":false,"given":"Wim","family":"Van Hul","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, University of Antwerp, 2000 Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.jhep.2021.11.009","article-title":"A new perspective on NAFLD: Focusing on lipid droplets","volume":"76","author":"Scorletti","year":"2022","journal-title":"J. Hepatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/s41575-021-00523-4","article-title":"Advancing the global public health agenda for NAFLD: A consensus statement","volume":"19","author":"Lazarus","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.jhep.2024.04.031","article-title":"EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD)","volume":"81","author":"Tacke","year":"2024","journal-title":"J. Hepatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/hep4.1479","article-title":"Pathogenesis of Nonalcoholic Steatohepatitis: An Overview","volume":"4","author":"Parthasarathy","year":"2020","journal-title":"Hepatol. Commun."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1002\/hep.24001","article-title":"Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis","volume":"52","author":"Tilg","year":"2010","journal-title":"Hepatology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"121185","DOI":"10.1016\/j.lfs.2022.121185","article-title":"Shedding light on non-alcoholic fatty liver disease: Pathogenesis, molecular mechanisms, models, and emerging therapeutics","volume":"312","author":"Khairnar","year":"2023","journal-title":"Life Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1053\/j.gastro.2014.11.039","article-title":"Nonalcoholic steatohepatitis is the second leading etiology of liver disease among adults awaiting liver transplantation in the United States","volume":"148","author":"Wong","year":"2015","journal-title":"Gastroenterology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s12944-024-02108-x","article-title":"Updated mechanisms of MASLD pathogenesis","volume":"23","author":"Li","year":"2024","journal-title":"Lipids Health Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00018-018-2947-0","article-title":"Molecular pathways of nonalcoholic fatty liver disease development and progression","volume":"76","author":"Bessone","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1056\/NEJMoa2309000","article-title":"A Phase 3, Randomized, Controlled Trial of Resmetirom in NASH with Liver Fibrosis","volume":"390","author":"Harrison","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1006\/geno.1995.1261","article-title":"The genetic mapping and gene structure of mouse paraoxonase\/arylesterase","volume":"30","author":"Sorenson","year":"1995","journal-title":"Genomics"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1006\/geno.1996.0225","article-title":"The human serum paraoxonase\/arylesterase gene (PON1) is one member of a multigene family","volume":"33","author":"Sorenson","year":"1996","journal-title":"Genomics"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.gene.2015.04.088","article-title":"Human paraoxonase-1 (PON1): Gene structure and expression, promiscuous activities and multiple physiological roles","volume":"567","author":"Mackness","year":"2015","journal-title":"Gene"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.numecd.2011.08.011","article-title":"Effect of dietary lipids on paraoxonase-1 activity and gene expression","volume":"22","author":"Ferretti","year":"2012","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"44444","DOI":"10.1074\/jbc.M105660200","article-title":"Paraoxonase-2 is a ubiquitously expressed protein with antioxidant properties and is capable of preventing cell-mediated oxidative modification of low density lipoprotein","volume":"276","author":"Ng","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1161\/01.ATV.21.4.542","article-title":"Human paraoxonase-3 is an HDL-associated enzyme with biological activity similar to paraoxonase-1 protein but is not regulated by oxidized lipids","volume":"21","author":"Reddy","year":"2001","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/ng1196-334","article-title":"The effect of the human serum paraoxonase polymorphism is reversed with diazoxon, soman and sarin","volume":"14","author":"Davies","year":"1996","journal-title":"Nat. Genet."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Mackness, B., Mackness, M., Aviram, M., and Paragh, G. (2008). Paraoxonase-1 in Chronic Liver Diseases, Neurological Diseases and HIV Infection. The Paraoxonases: Their Role in Disease Development and Xenobiotic Metabolism, Springer.","DOI":"10.1007\/978-1-4020-6561-3"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Milaciu, M.V., Vesa, S.C., Bocsan, I.C., Ciumarnean, L., Sampelean, D., Negrean, V., Pop, R.M., Matei, D.M., Pasca, S., and Rachisan, A.L. (2019). Paraoxonase-1 Serum Concentration and PON1 Gene Polymorphisms: Relationship with Non-Alcoholic Fatty Liver Disease. J. Clin. Med., 8.","DOI":"10.3390\/jcm8122200"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.3748\/wjg.15.1929","article-title":"Measurement of serum paraoxonase-1 activity in the evaluation of liver function","volume":"15","author":"Camps","year":"2009","journal-title":"World J. Gastroenterol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1021\/jacs.6b10801","article-title":"Active Site Hydrophobicity and the Convergent Evolution of Paraoxonase Activity in Structurally Divergent Enzymes: The Case of Serum Paraoxonase 1","volume":"139","author":"Kruger","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0024-3205(94)00422-O","article-title":"The role of calcium in the hydrolysis of the organophosphate paraoxon by human serum A-esterase","volume":"56","author":"Vitarius","year":"1995","journal-title":"Life Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1089\/ars.2010.3774","article-title":"The human paraoxonase gene cluster as a target in the treatment of atherosclerosis","volume":"16","author":"She","year":"2012","journal-title":"Antioxid. Redox Signal."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Taler-Vercic, A., Golicnik, M., and Bavec, A. (2020). The Structure and Function of Paraoxonase-1 and Its Comparison to Paraoxonase-2 and -3. Molecules, 25.","DOI":"10.3390\/molecules25245980"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"122","DOI":"10.11613\/BM.2011.020","article-title":"The paraoxonase 1, 2 and 3 in humans","volume":"21","author":"Rajkovic","year":"2011","journal-title":"Biochem. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s00210-003-0833-1","article-title":"Pharmacogenetics of paraoxonases: A brief review","volume":"369","author":"Draganov","year":"2004","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clinbiochem.2019.07.010","article-title":"The epigenetic regulation of paraoxonase 1 (PON1) as an important enzyme in HDL function: The missing link between environmental and genetic regulation","volume":"73","author":"Mahrooz","year":"2019","journal-title":"Clin. Biochem."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Van Dijck, E., Diels, S., Fransen, E., Cremers, T.C., Verrijken, A., Dirinck, E., Hoischen, A., Vandeweyer, G., Vanden Berghe, W., and Van Gaal, L. (2024). A Case-Control Study Supports Genetic Contribution of the PON Gene Family in Obesity and Metabolic Dysfunction Associated Steatotic Liver Disease. Antioxidants, 13.","DOI":"10.3390\/antiox13091051"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"7657","DOI":"10.1074\/jbc.M512595200","article-title":"The catalytic histidine dyad of high density lipoprotein-associated serum paraoxonase-1 (PON1) is essential for PON1-mediated inhibition of low density lipoprotein oxidation and stimulation of macrophage cholesterol efflux","volume":"281","author":"Rosenblat","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Meneses, M.J., Silvestre, R., Sousa-Lima, I., and Macedo, M.P. (2019). Paraoxonase-1 as a Regulator of Glucose and Lipid Homeostasis: Impact on the Onset and Progression of Metabolic Disorders. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20164049"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.1016\/j.jss.2011.06.033","article-title":"Toll-like receptor 4 mediates oxidized LDL-induced macrophage differentiation to foam cells","volume":"171","author":"Howell","year":"2011","journal-title":"J. Surg. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00011-013-0667-3","article-title":"OxLDL-induced IL-1beta secretion promoting foam cells formation was mainly via CD36 mediated ROS production leading to NLRP3 inflammasome activation","volume":"63","author":"Liu","year":"2014","journal-title":"Inflamm. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"137","DOI":"10.2147\/VHRM.S165173","article-title":"Paraoxonase (PON)-1: A brief overview on genetics, structure, polymorphisms and clinical relevance","volume":"14","author":"Shunmoogam","year":"2018","journal-title":"Vasc. Health Risk Manag."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Camps, J., Castane, H., Rodriguez-Tomas, E., Baiges-Gaya, G., Hernandez-Aguilera, A., Arenas, M., Iftimie, S., and Joven, J. (2021). On the Role of Paraoxonase-1 and Chemokine Ligand 2 (C-C motif) in Metabolic Alterations Linked to Inflammation and Disease. A 2021 Update. Biomolecules, 11.","DOI":"10.20944\/preprints202106.0023.v1"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0891-5849(91)90192-6","article-title":"Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes","volume":"11","author":"Esterbauer","year":"1991","journal-title":"Free Radic. Biol. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.freeradbiomed.2010.10.708","article-title":"Human carotid lesion linoleic acid hydroperoxide inhibits paraoxonase 1 (PON1) activity via reaction with PON1 free sulfhydryl cysteine 284","volume":"50","author":"Tavori","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Milkovic, L., Zarkovic, N., Marusic, Z., Zarkovic, K., and Jaganjac, M. (2023). The 4-Hydroxynonenal-Protein Adducts and Their Biological Relevance: Are Some Proteins Preferred Targets?. Antioxidants, 12.","DOI":"10.3390\/antiox12040856"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.bbrc.2006.10.059","article-title":"S-Glutathionylation regulates HDL-associated paraoxonase 1 (PON1) activity","volume":"351","author":"Rozenberg","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"R622","DOI":"10.1016\/j.cub.2012.07.004","article-title":"Unfolded protein response","volume":"22","author":"Cao","year":"2012","journal-title":"Curr. Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1007\/s12072-020-10094-2","article-title":"The Asian Pacific Association for the Study of the Liver clinical practice guidelines for the diagnosis and management of metabolic associated fatty liver disease","volume":"14","author":"Eslam","year":"2020","journal-title":"Hepatol. Int."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/28406","article-title":"Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis","volume":"394","author":"Shih","year":"1998","journal-title":"Nature"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1139\/cjpp-2014-0491","article-title":"Hyperhomocysteinemia: A missing link to dysfunctional HDL via paraoxanase-1","volume":"93","author":"Givvimani","year":"2015","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Khalaf, F.K., Mohammed, C.J., Dube, P., Connolly, J.A., Lad, A., Ashraf, U.M., Breidenbach, J.D., Su, R.C., Kleinhenz, A.L., and Malhotra, D. (2022). Paraoxonase-1 Regulation of Renal Inflammation and Fibrosis in Chronic Kidney Disease. Antioxidants, 11.","DOI":"10.3390\/antiox11050900"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Dube, P., Khalaf, F.K., DeRiso, A., Mohammed, C.J., Connolly, J.A., Battepati, D., Lad, A., Breidenbach, J.D., Kleinhenz, A.L., and Khatib-Shahidi, B. (2022). Cardioprotective Role for Paraoxonase-1 in Chronic Kidney Disease. Biomedicines, 10.","DOI":"10.3390\/biomedicines10092301"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.atherosclerosis.2013.03.005","article-title":"Paraoxonase 1 (PON1) reduces macrophage inflammatory responses","volume":"228","author":"Aharoni","year":"2013","journal-title":"Atherosclerosis"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"949","DOI":"10.4049\/jimmunol.1201828","article-title":"Paraoxonase-1 Suppresses Experimental Colitis via the Inhibition of IFN-\u03b3 Production from CD4 T Cells","volume":"191","author":"Yamashita","year":"2013","journal-title":"J. Immunol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Bai, L., Shi, G., Ma, Y., Zhang, L., Guan, F., Zhang, X., Xu, Y., Chen, H., and Zhang, L. (2018). Paraoxonase 1 knockout rats have impaired T cell development at the CD4\/CD8 double-negative to double-positive transition stage. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-32780-w"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1002\/art.21889","article-title":"Relationship of serum paraoxonase 1 activity and paraoxonase 1 genotype to risk of systemic lupus erythematosus","volume":"54","author":"Tripi","year":"2006","journal-title":"Arthritis Rheum."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.clinbiochem.2005.06.010","article-title":"Assessment of paraoxonase 1 activity and malondialdehyde levels in patients with rheumatoid arthritis","volume":"38","author":"Baskol","year":"2005","journal-title":"Clin. Biochem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/jnc.13240","article-title":"Serum paraoxonase and arylesterase activities of paraoxonase-1 (PON-1), mild cognitive impairment, and 2-year conversion to dementia: A pilot study","volume":"135","author":"Cervellati","year":"2015","journal-title":"J. Neurochem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/hmg\/ddi428","article-title":"Polymorphisms in the PON gene cluster are associated with Alzheimer disease","volume":"15","author":"Erlich","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"ref_52","first-page":"66","article-title":"Association of Paraoxonse1 (PON1) Genotypes with the Activity of PON1 in Patients with Parkinson\u2019s Disease","volume":"28","author":"Mota","year":"2019","journal-title":"Acta Neurol Taiwan"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Medina-Diaz, I.M., Ponce-Ruiz, N., Rojas-Garcia, A.E., Zambrano-Zargoza, J.F., Bernal-Hernandez, Y.Y., Gonzalez-Arias, C.A., Barron-Vivanco, B.S., and Herrera-Moreno, J.F. (2022). The Relationship between Cancer and Paraoxonase 1. Antioxidants, 11.","DOI":"10.3390\/antiox11040697"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"42817","DOI":"10.18632\/oncotarget.17069","article-title":"Paraoxonase-1 (PON1) induces metastatic potential and apoptosis escape via its antioxidative function in lung cancer cells","volume":"8","author":"Aldonza","year":"2017","journal-title":"Oncotarget"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1080\/10715762.2019.1645956","article-title":"A meta-analysis of the relationship between paraoxonase 1 polymorphisms and cancer","volume":"53","author":"Liu","year":"2019","journal-title":"Free Radic. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.31557\/APJCP.2021.22.8.2323","article-title":"Association of PON1, LEP and LEPR Polymorphisms with Susceptibility to Breast Cancer: A Meta-Analysis","volume":"22","author":"Sayad","year":"2021","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Kunachowicz, D., Sciskalska, M., and Kepinska, M. (2023). Modulatory Effect of Lifestyle-Related, Environmental and Genetic Factors on Paraoxonase-1 Activity: A Review. Int. J. Environ. Res. Public Health, 20.","DOI":"10.3390\/ijerph20042813"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/S0891-5849(02)01429-6","article-title":"Paraoxonase (PON1) deficiency is associated with increased macrophage oxidative stress: Studies in PON1-knockout mice","volume":"34","author":"Rozenberg","year":"2003","journal-title":"Free Radic. Biol. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"17527","DOI":"10.1074\/jbc.M910376199","article-title":"Combined serum paraoxonase knockout\/apolipoprotein E knockout mice exhibit increased lipoprotein oxidation and atherosclerosis","volume":"275","author":"Shih","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.freeradbiomed.2021.03.042","article-title":"Changes in redox plasma proteome of Pon1-\/- mice are exacerbated by a hyperhomocysteinemic diet","volume":"169","author":"Sikora","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"29491","DOI":"10.1074\/jbc.M605379200","article-title":"Paraoxonase-2 deficiency aggravates atherosclerosis in mice despite lower apolipoprotein-B-containing lipoproteins: Anti-atherogenic role for paraoxonase-2","volume":"281","author":"Ng","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.atherosclerosis.2009.07.057","article-title":"Paraoxonase 2 (PON2) decreases high glucose-induced macrophage triglycerides (TG) accumulation, via inhibition of NADPH-oxidase and DGAT1 activity: Studies in PON2-deficient mice","volume":"208","author":"Meilin","year":"2010","journal-title":"Atherosclerosis"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.taap.2011.02.014","article-title":"Paraoxonase 2 (PON2) in the mouse central nervous system: A neuroprotective role?","volume":"256","author":"Giordano","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1042\/BJ20101891","article-title":"Impaired hepatic insulin signalling in PON2-deficient mice: A novel role for the PON2\/apoE axis on the macrophage inflammatory response","volume":"436","author":"Bourquard","year":"2011","journal-title":"Biochem. J."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1182\/blood-2017-09-807040","article-title":"Paraoxonase-2 regulates coagulation activation through endothelial tissue factor","volume":"131","author":"Ebert","year":"2018","journal-title":"Blood"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.yjmcc.2019.02.008","article-title":"Paraoxonase 2 protects against acute myocardial ischemia-reperfusion injury by modulating mitochondrial function and oxidative stress via the PI3K\/Akt\/GSK-3beta RISK pathway","volume":"129","author":"Sulaiman","year":"2019","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Shih, D.M., Meng, Y., Sallam, T., Vergnes, L., Shu, M.L., Reue, K., Tontonoz, P., Fogelman, A.M., Lusis, A.J., and Reddy, S.T. (2019). PON2 Deficiency Leads to Increased Susceptibility to Diet-Induced Obesity. Antioxidants, 8.","DOI":"10.3390\/antiox8010019"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"107010","DOI":"10.1016\/j.ntt.2021.107010","article-title":"Paraoxonase 2 deficiency in mice alters motor behavior and causes region-specific transcript changes in the brain","volume":"87","author":"Garrick","year":"2021","journal-title":"Neurotoxicol. Teratol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"3917028","DOI":"10.1155\/2021\/3917028","article-title":"Deficiency of Antioxidative Paraoxonase 2 (Pon2) Leads to Increased Number of Phenotypic LT-HSCs and Disturbed Erythropoiesis","volume":"2021","author":"Spiecker","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Hagmann, H., Khayyat, N.H., Oezel, C., Papadakis, A., Kuczkowski, A., Benzing, T., Gulbins, E., Dryer, S., and Brinkkoetter, P.T. (2022). Paraoxonase 2 (PON2) Deficiency Reproduces Lipid Alterations of Diabetic and Inflammatory Glomerular Disease and Affects TRPC6 Signaling. Cells, 11.","DOI":"10.3390\/cells11223625"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Whitt, A.G., Neely, A.M., Sarkar, O.S., Meng, S., Arumugam, S., Yaddanapudi, K., and Li, C. (2023). Paraoxonase 2 (PON2) plays a limited role in murine lung tumorigenesis. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-37146-5"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Sreekumar, P.G., Su, F., Spee, C., Hong, E., Komirisetty, R., Araujo, E., Nusinowitz, S., Reddy, S.T., and Kannan, R. (2023). Paraoxonase 2 Deficiency Causes Mitochondrial Dysfunction in Retinal Pigment Epithelial Cells and Retinal Degeneration in Mice. Antioxidants, 12.","DOI":"10.3390\/antiox12101820"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"E103","DOI":"10.1152\/ajpendo.00357.2011","article-title":"Disruption of paraoxonase 3 impairs proliferation and antioxidant defenses in human A549 cells and causes embryonic lethality in mice","volume":"302","author":"Kempster","year":"2012","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1096\/fj.14-260570","article-title":"PON3 knockout mice are susceptible to obesity, gallstone formation, and atherosclerosis","volume":"29","author":"Shih","year":"2015","journal-title":"FASEB J."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Lamichhane, S., Mohammed, C.J., Haller, S.T., Kennedy, D.J., and Isailovic, D. (2022). Quantification of Cardiotonic Steroids Potentially Regulated by Paraoxonase 3 in a Rat Model of Chronic Kidney Disease Using UHPLC-Orbitrap-MS. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232113565"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1113\/JP285034","article-title":"Role of paraoxonase 3 in regulating ENaC-mediated Na(+) transport in the distal nephron","volume":"602","author":"Mutchler","year":"2024","journal-title":"J. Physiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.thromres.2008.03.004","article-title":"Paraoxonase 1 gene promoter polymorphisms are associated with the extent of stenosis in coronary arteries","volume":"123","author":"Najafi","year":"2009","journal-title":"Thromb. Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.cbi.2017.02.005","article-title":"Transcriptional regulation of human Paraoxonase 1 by nuclear receptors","volume":"268","author":"Mackness","year":"2017","journal-title":"Chem. Biol. Interact."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/ng0193-73","article-title":"The molecular basis of the human serum paraoxonase activity polymorphism","volume":"3","author":"Humbert","year":"1993","journal-title":"Nat. Genet."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1172\/JCI119134","article-title":"Paraoxonase polymorphism Met-Leu54 is associated with modified serum concentrations of the enzyme. A possible link between the paraoxonase gene and increased risk of cardiovascular disease in diabetes","volume":"99","author":"Garin","year":"1997","journal-title":"J. Clin. Investig."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cccn.2004.09.019","article-title":"Measurement of paraoxonase (PON1) status as a potential biomarker of susceptibility to organophosphate toxicity","volume":"352","author":"Costa","year":"2005","journal-title":"Clin. Chim. Acta"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"10141","DOI":"10.1021\/bi00106a010","article-title":"Characterization of cDNA clones encoding rabbit and human serum paraoxonase: The mature protein retains its signal sequence","volume":"30","author":"Hassett","year":"1991","journal-title":"Biochemistry"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0378-1119(98)00193-0","article-title":"Human PON2 gene at 7q21.3: Cloning, multiple mRNA forms, and missense polymorphisms in the coding sequence","volume":"213","author":"Mochizuki","year":"1998","journal-title":"Gene"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1161\/CIRCULATIONAHA.106.681700","article-title":"Paraoxonase-2 reduces oxidative stress in vascular cells and decreases endoplasmic reticulum stress-induced caspase activation","volume":"115","author":"Horke","year":"2007","journal-title":"Circulation"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"35564","DOI":"10.1074\/jbc.M109.051706","article-title":"A common mutation in paraoxonase-2 results in impaired lactonase activity","volume":"284","author":"Stoltz","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"24398","DOI":"10.1074\/jbc.M110.118604","article-title":"One enzyme, two functions: PON2 prevents mitochondrial superoxide formation and apoptosis independent from its lactonase activity","volume":"285","author":"Altenhofer","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1161\/01.ATV.19.9.2214","article-title":"Human serum Paraoxonase\/Arylesterase\u2019s retained hydrophobic N-terminal leader sequence associates with HDLs by binding phospholipids: Apolipoprotein A-I stabilizes activity","volume":"19","author":"Sorenson","year":"1999","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1096\/fj.13-240309","article-title":"Breaking the chain at the membrane: Paraoxonase 2 counteracts lipid peroxidation at the plasma membrane","volume":"28","author":"Hagmann","year":"2014","journal-title":"FASEB J."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1089\/ars.2010.3430","article-title":"Paraoxonase 2 deficiency alters mitochondrial function and exacerbates the development of atherosclerosis","volume":"14","author":"Devarajan","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"33741","DOI":"10.1074\/jbc.273.50.33741","article-title":"Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors","volume":"273","author":"Yoshida","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"e112","DOI":"10.1038\/cddis.2010.91","article-title":"Beyond reduction of atherosclerosis: PON2 provides apoptosis resistance and stabilizes tumor cells","volume":"2","author":"Witte","year":"2011","journal-title":"Cell Death Dis."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Shin, G.C., Lee, H.M., Kim, N., Yoo, S.K., Park, H.S., Choi, L.S., Kim, K.P., Lee, A.R., Seo, S.U., and Kim, K.H. (2022). Paraoxonase-2 contributes to promoting lipid metabolism and mitochondrial function via autophagy activation. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-25802-1"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"3717","DOI":"10.1111\/bph.16438","article-title":"Paraoxonase-2 agonist vutiglabridin promotes autophagy activation and mitochondrial function to alleviate non-alcoholic steatohepatitis","volume":"181","author":"Shin","year":"2024","journal-title":"Br. J. Pharmacol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.fct.2012.08.048","article-title":"Anti-obesity effects of glabridin-rich supercritical carbon dioxide extract of licorice in high-fat-fed obese mice","volume":"51","author":"Ahn","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S0021-9150(00)00440-8","article-title":"PON gene variants are associated with clinical manifestations of cardiovascular disease in familial hypercholesterolemia patients","volume":"154","author":"Leus","year":"2001","journal-title":"Atherosclerosis"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1161\/01.ATV.0000059385.95664.4D","article-title":"Mouse macrophage paraoxonase 2 activity is increased whereas cellular paraoxonase 3 activity is decreased under oxidative stress","volume":"23","author":"Rosenblat","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_97","first-page":"110","article-title":"Codon 311 (Cys \u2192 Ser) polymorphism of paraoxonase-2 gene is associated with apolipoprotein E4 allele in both Alzheimer\u2019s and vascular dementias","volume":"7","author":"Janka","year":"2002","journal-title":"Mol. Psychiatry"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41419-019-1354-2","article-title":"DJ-1 modulates the unfolded protein response and cell death via upregulation of ATF4 following ER stress","volume":"10","author":"Yang","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"577426","DOI":"10.1016\/j.jneuroim.2020.577426","article-title":"Protection induced by estradiol benzoate in the MPP(+) rat model of Parkinson\u2019s disease is associated with the regulation of the inflammatory cytokine profile in the nigro striatum","volume":"349","author":"Montes","year":"2020","journal-title":"J. Neuroimmunol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/ana.21993","article-title":"Paraoxonase gene mutations in amyotrophic lateral sclerosis","volume":"68","author":"Ticozzi","year":"2010","journal-title":"Ann. Neurol."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Bacchetti, T., Campagna, R., Sartini, D., Cecati, M., Morresi, C., Bellachioma, L., Martinelli, E., Rocchetti, G., Lucini, L., and Ferretti, G. (2022). C. spinosa L. subsp. rupestris Phytochemical Profile and Effect on Oxidative Stress in Normal and Cancer Cells. Molecules, 27.","DOI":"10.3390\/molecules27196488"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Campagna, R., Bacchetti, T., Salvolini, E., Pozzi, V., Molinelli, E., Brisigotti, V., Sartini, D., Campanati, A., Ferretti, G., and Offidani, A. (2020). Paraoxonase-2 Silencing Enhances Sensitivity of A375 Melanoma Cells to Treatment with Cisplatin. Antioxidants, 9.","DOI":"10.3390\/antiox9121238"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Campagna, R., Belloni, A., Pozzi, V., Salvucci, A., Notarstefano, V., Togni, L., Mascitti, M., Sartini, D., Giorgini, E., and Salvolini, E. (2022). Role Played by Paraoxonase-2 Enzyme in Cell Viability, Proliferation and Sensitivity to Chemotherapy of Oral Squamous Cell Carcinoma Cell Lines. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24010338"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1080\/16078454.2021.2009643","article-title":"PON2 blockade overcomes dexamethasone resistance in acute lymphoblastic leukemia","volume":"27","author":"Hui","year":"2022","journal-title":"Hematology"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"e13452","DOI":"10.1111\/eci.13452","article-title":"Paraoxonase-2: A potential biomarker for skin cancer aggressiveness","volume":"51","author":"Bacchetti","year":"2021","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Schiavoni, V., Emanuelli, M., Campagna, R., Cecati, M., Sartini, D., Milanese, G., Galosi, A.B., Pozzi, V., and Salvolini, E. (2024). Paraoxonase-2 shRNA-mediated gene silencing suppresses proliferation and migration, while promotes chemosensitivity in clear cell renal cell carcinoma cell lines. J. Cell. Biochem., 125.","DOI":"10.1002\/jcb.30572"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"342806","DOI":"10.1155\/2012\/342806","article-title":"Protectors or Traitors: The Roles of PON2 and PON3 in Atherosclerosis and Cancer","volume":"2012","author":"Witte","year":"2012","journal-title":"J. Lipids"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00432-025-06282-y","article-title":"Role of paraoxonase 2 (PON2) as a potential biomarker and therapeutic target in cancer treatment","volume":"151","author":"Agarwal","year":"2025","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Belloni, A., Campagna, R., Notarstefano, V., Pozzi, V., Orilisi, G., Pompei, V., Togni, L., Mascitti, M., Sartini, D., and Giorgini, E. (2025). Deepening Cisplatin sensitivity on Oral Squamous cell Carcinoma cell lines after PON2 knockdown: A FTIRM investigation. Spectrochim. Acta A Mol. Biomol. Spectrosc., 330.","DOI":"10.1016\/j.saa.2025.125726"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/j.1399-0004.1998.tb03752.x","article-title":"Genetic variation in paraoxonase-2 is associated with variation in plasma lipoproteins in Canadian Oji-Cree","volume":"54","author":"Hegele","year":"1998","journal-title":"Clin. Genet."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1600-0404.2007.00929.x","article-title":"The paraoxonase gene polymorphism in stroke patients and lipid profile","volume":"117","author":"Shin","year":"2008","journal-title":"Acta Neurol. Scand."},{"key":"ref_112","first-page":"159","article-title":"Human paraoxonase 2","volume":"9","author":"Porntadavity","year":"2010","journal-title":"EXCLI J."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/s41419-020-2504-2","article-title":"WTAP and BIRC3 are involved in the posttranscriptional mechanisms that impact on the expression and activity of the human lactonase PON2","volume":"11","author":"Carusone","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Mohammed, C.J., Lamichhane, S., Connolly, J.A., Soehnlen, S.M., Khalaf, F.K., Malhotra, D., Haller, S.T., Isailovic, D., and Kennedy, D.J. (2022). A PON for All Seasons: Comparing Paraoxonase Enzyme Substrates, Activity and Action including the Role of PON3 in Health and Disease. Antioxidants, 11.","DOI":"10.3390\/antiox11030590"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"33435","DOI":"10.1074\/jbc.M004543200","article-title":"Rabbit serum paraoxonase 3 (PON3) is a high density lipoprotein-associated lactonase and protects low density lipoprotein against oxidation","volume":"275","author":"Draganov","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.cbi.2016.05.036","article-title":"Paraoxonases-1, -2 and -3: What are their functions?","volume":"259","author":"Furlong","year":"2016","journal-title":"Chem. Biol. Interact."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1194\/jlr.M400511-JLR200","article-title":"Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities","volume":"46","author":"Draganov","year":"2005","journal-title":"J. Lipid Res."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.biopha.2008.08.023","article-title":"Protective effects of transgene expressed human PON3 against CCl4-induced subacute liver injury in mice","volume":"63","author":"Peng","year":"2009","journal-title":"Biomed. Pharmacother."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1161\/ATVBAHA.106.134189","article-title":"Adenovirus-mediated expression of human paraoxonase 3 protects against the progression of atherosclerosis in apolipoprotein E-deficient mice","volume":"27","author":"Ng","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1161\/01.RES.0000264499.48737.69","article-title":"Decreased obesity and atherosclerosis in human paraoxonase 3 transgenic mice","volume":"100","author":"Shih","year":"2007","journal-title":"Circ. Res."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1021\/pr5011586","article-title":"Paraoxonase-3 is depleted from the high-density lipoproteins of autoimmune disease patients with subclinical atherosclerosis","volume":"14","author":"Marsillach","year":"2015","journal-title":"J. Proteome Res."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"352857","DOI":"10.1155\/2012\/352857","article-title":"Paraoxonases-2 and -3 Are Important Defense Enzymes against Pseudomonas aeruginosa Virulence Factors due to Their Anti-Oxidative and Anti-Inflammatory Properties","volume":"2012","author":"Schweikert","year":"2012","journal-title":"J. Lipids"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/j.clinbiochem.2011.08.003","article-title":"Serum paraoxonase-3 concentration is associated with the severity of hepatic impairment in patients with chronic liver disease","volume":"44","author":"Marsillach","year":"2011","journal-title":"Clin. Biochem."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1194\/jlr.P018457","article-title":"Serum paraoxonase-3 concentration in HIV-infected patients. Evidence for a protective role against oxidation","volume":"53","author":"Aragones","year":"2012","journal-title":"J. Lipid Res."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.atherosclerosis.2011.11.021","article-title":"Serum paraoxonase-3 concentration is associated with insulin sensitivity in peripheral artery disease and with inflammation in coronary artery disease","volume":"220","author":"Rull","year":"2012","journal-title":"Atherosclerosis"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1194\/jlr.D014134","article-title":"Measurement of serum PON-3 concentration: Method evaluation, reference values, and influence of genotypes in a population-based study","volume":"52","author":"Aragones","year":"2011","journal-title":"J. Lipid Res."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"893212","DOI":"10.1155\/2014\/893212","article-title":"Association between paraoxonases gene expression and oxidative stress in hepatotoxicity induced by CCl4","volume":"2014","author":"Hafez","year":"2014","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Riedmaier, S., Klein, K., Winter, S., Hofmann, U., Schwab, M., and Zanger, U.M. (2011). Paraoxonase (PON1 and PON3) Polymorphisms: Impact on Liver Expression and Atorvastatin-Lactone Hydrolysis. Front. Pharmacol., 2.","DOI":"10.3389\/fphar.2011.00041"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1038\/cdd.2012.35","article-title":"PON3 is upregulated in cancer tissues and protects against mitochondrial superoxide-mediated cell death","volume":"19","author":"Schweikert","year":"2012","journal-title":"Cell Death Differ."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"70045","DOI":"10.18632\/oncotarget.12145","article-title":"Paraoxonase 3 inhibits cell proliferation and serves as a prognostic predictor in hepatocellular carcinoma","volume":"7","author":"Cai","year":"2016","journal-title":"Oncotarget"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"14193","DOI":"10.1007\/s13277-016-5247-z","article-title":"Downregulation of paraoxonase 3 contributes to aggressive human hepatocellular carcinoma progression and associates with poor prognosis","volume":"37","author":"Jin","year":"2016","journal-title":"Tumour Biol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.mrfmmm.2003.11.007","article-title":"Identification of paraoxonase 3 gene (PON3) missense mutations in a population of southern Italy","volume":"546","author":"Campo","year":"2004","journal-title":"Mutat. Res."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/22\/11054\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T10:26:44Z","timestamp":1763375204000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/22\/11054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,15]]},"references-count":132,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["ijms262211054"],"URL":"https:\/\/doi.org\/10.3390\/ijms262211054","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,15]]}}}