{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:45:09Z","timestamp":1788309909114,"version":"build-2803163510"},"reference-count":99,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["21-73-30010P"],"award-info":[{"award-number":["21-73-30010P"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>To reduce the time of postoperative recovery and to prevent post-surgical complications, biocompatible synthetic materials with osteoconductive and osteoinductive properties are used as bone substitutes in large bone defect management. A simplified biomimetic approach to similar materials is based on the use of an inorganic filler, a polymer matrix, and a compatibilizer, mimicking the composition of the natural bone. Based on plate-like micro-sized carbonated hydroxyapatite (pCAp), we prepared compression-molded samples optionally containing an additional polyester component (poly(\u03b5-caprolactone) PCL, poly(L-lactide) PLLA, or poly(L-methylglycolide) PLMG); syntheticblock copolymers comprising fragments of the corresponding polyester and poly(ethylene phosphoric acid) (PEPA) were also prepared and studied asa \u2018two-in-one\u2019 polymer matrix\/compatibilizer. Bone regeneration experiments involving a three-month rat tibial defect model were conducted with 250\u2013500 \u03bcm granules of the composites. Comparative studies of the introduction of the polyester-b-PEPA copolymer into composites revealed a positive effect, which manifests itself in accelerated bone regeneration, which further intensified for pCAp\/PEPA-b-PLMG. The latter composite formulation was used to study the results of the introduction of cerium into the filler. One-month experiments with pCAp, CePO4-doped pCAp, and composites of these inorganic fillers with PEPA-b-PLMG were conducted. For the first time, a positive synergistic effect of the presence of cerium and PEPA in the composite, which appeared in substitution of the implant material by two-thirds of newly formed partly matured bone, was observed four weeks after surgery.<\/jats:p>","DOI":"10.3390\/ijms262211113","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T14:04:07Z","timestamp":1763388247000},"page":"11113","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Synergistic Effect of Poly(ethylenephosphoric Acid) and Cerium in Bone Substitute Composites on Tissue Response and Bone Remodeling"],"prefix":"10.3390","volume":"26","author":[{"given":"Victoria","family":"Besprozvannykh","sequence":"first","affiliation":[{"name":"A.V. Topchiev Institute of Petrochemical Synthesis RAS, Leninsky Pr. 29, 119991 Moscow, Russia"},{"name":"Faculty of Chemistry, National Research University Higher School of Economics, Myasnitskaya St. 20, 101100 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Ryndyk","sequence":"additional","affiliation":[{"name":"A.V. Topchiev Institute of Petrochemical Synthesis RAS, Leninsky Pr. 29, 119991 Moscow, Russia"},{"name":"Faculty of Chemistry, National Research University Higher School of Economics, Myasnitskaya St. 20, 101100 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilya","family":"Nifant\u2019ev","sequence":"additional","affiliation":[{"name":"A.V. Topchiev Institute of Petrochemical Synthesis RAS, Leninsky Pr. 29, 119991 Moscow, Russia"},{"name":"Faculty of Chemistry, National Research University Higher School of Economics, Myasnitskaya St. 20, 101100 Moscow, Russia"},{"name":"Chemistry Department, M.V. Lomonosov Moscow State University, Leninskie Gory 1\u20133, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Tavtorkin","sequence":"additional","affiliation":[{"name":"A.V. Topchiev Institute of Petrochemical Synthesis RAS, Leninsky Pr. 29, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry","family":"Gavrilov","sequence":"additional","affiliation":[{"name":"A.V. Topchiev Institute of Petrochemical Synthesis RAS, Leninsky Pr. 29, 119991 Moscow, Russia"},{"name":"Chemistry Department, M.V. Lomonosov Moscow State University, Leninskie Gory 1\u20133, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0121-1232","authenticated-orcid":false,"given":"Yulia","family":"Lukina","sequence":"additional","affiliation":[{"name":"N.N. Priorov National Medical Research Center for Traumatology and Orthopedics, Ministry of Health of the Russian Federation, Priorova St. 10, 127299 Moscow, Russia"},{"name":"Faculty of Digital Technologies and Chemical Engineering, Mendeleev University of Chemical Technology of Russia, Miusskaya Sq. 9, 125047 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1326-6794","authenticated-orcid":false,"given":"Leonid","family":"Bionyshev-Abramov","sequence":"additional","affiliation":[{"name":"N.N. Priorov National Medical Research Center for Traumatology and Orthopedics, Ministry of Health of the Russian Federation, Priorova St. 10, 127299 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4097-1552","authenticated-orcid":false,"given":"Natalya","family":"Serejnikova","sequence":"additional","affiliation":[{"name":"N.N. Priorov National Medical Research Center for Traumatology and Orthopedics, Ministry of Health of the Russian Federation, Priorova St. 10, 127299 Moscow, Russia"},{"name":"Institute for Regenerative Medicine, Sechenov First Moscow State Medical University, Trubetskaya St. 8, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitriiy","family":"Smolentsev","sequence":"additional","affiliation":[{"name":"N.N. Priorov National Medical Research Center for Traumatology and Orthopedics, Ministry of Health of the Russian Federation, Priorova St. 10, 127299 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0181-5952","authenticated-orcid":false,"given":"Pavel","family":"Ivchenko","sequence":"additional","affiliation":[{"name":"A.V. Topchiev Institute of Petrochemical Synthesis RAS, Leninsky Pr. 29, 119991 Moscow, Russia"},{"name":"Chemistry Department, M.V. Lomonosov Moscow State University, Leninskie Gory 1\u20133, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Santoro, A., Voto, A., Fortino, L., Guida, R., Laudisio, C., Cillo, M., and D\u2019Ursi, A.M. (2025). Bone Defect Treatment in Regenerative Medicine: Exploring Natural and Synthetic Bone Substitutes. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26073085"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2041731418776819","DOI":"10.1177\/2041731418776819","article-title":"Bone substitutes: A review of their characteristics, clinical use, and perspectives for large bone defects management","volume":"9","author":"Keller","year":"2018","journal-title":"J. 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