{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:26:21Z","timestamp":1791894381304,"version":"4.3.4"},"reference-count":214,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"BIOMETRA","award":["Piano di sostegno alla ricerca BIOMETRA\u2013Linea B (grant PSR2023_Giussani)"],"award-info":[{"award-number":["Piano di sostegno alla ricerca BIOMETRA\u2013Linea B (grant PSR2023_Giussani)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Sphingolipids are a large group of molecules, crucial components of all mammalian cells, that are particularly abundant in the central and peripheral nervous system and associated with important human brain functions. Sphingolipids are necessary for membrane organization and driving functions. Ceramide, sphingosine-1-phosphate and GM1, show bioactive properties. Ceramide and sphingosine-1-phosphate play a crucial role in the regulation of physio-pathological conditions. Small changes in their levels, in the ratio sphingosine-1-phosphate\/ceramide as well as in chain length profiles of sphingolipids contribute to alter signaling pathways in neurons and glia, contributing to various neurological disorders. GM1 is considered a neurotrophic and neuroprotective compound and seems to be necessary for the correct functioning of neuronal membrane receptors, suggesting that a reduction in its level in the brain can be involved in neurodegenerative diseases. In this review, we give an overview of sphingolipid metabolism, summarizing the role of ceramide, sphingosine-1-phosphate, and GM1 in maintaining human health.<\/jats:p>","DOI":"10.3390\/ijms262211118","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T15:38:09Z","timestamp":1763393889000},"page":"11118","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Involvement of Ceramide, Sphingosine-1-Phosphate and Ganglioside GM1 in Regulating Some Nervous System Functions"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7793-1757","authenticated-orcid":false,"given":"Paola","family":"Giussani","sequence":"first","affiliation":[{"name":"Department of Medical Biotechnology and Translational Medicine, Universit\u00e0 degli Studi di Milano, LITA Segrate, Via Fratelli Cervi, 93, 20054 Segrate, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4194-4804","authenticated-orcid":false,"given":"Laura","family":"Mauri","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology and Translational Medicine, Universit\u00e0 degli Studi di Milano, LITA Segrate, Via Fratelli Cervi, 93, 20054 Segrate, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8180-5908","authenticated-orcid":false,"given":"Sandro","family":"Sonnino","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology and Translational Medicine, Universit\u00e0 degli Studi di Milano, LITA Segrate, Via Fratelli Cervi, 93, 20054 Segrate, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"109250","DOI":"10.1016\/j.celrep.2021.109250","article-title":"A reference map of sphingolipids in murine tissues","volume":"35","author":"Muralidharan","year":"2021","journal-title":"Cell Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4419-6741-1_1","article-title":"An overview of sphingolipid metabolism: From synthesis to breakdown","volume":"688","author":"Gault","year":"2010","journal-title":"Adv. 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