{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T13:59:07Z","timestamp":1771855147660,"version":"3.50.1"},"reference-count":78,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Karina Oliveira Santos has received a schorlaship from Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior \u2013 Brasil","award":["03\/2025"],"award-info":[{"award-number":["03\/2025"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Salivary biomarkers have been explored as potential non-invasive tools for the diagnosis and monitoring of inflammatory bowel diseases (IBD), including Crohn\u2019s Disease (CD) and Ulcerative Colitis (UC). This study presents a scoping review and evidence mapping on the use of saliva as a matrix in which biomarkers can be identified for these conditions. A systematic search of multiple databases and studies was conducted until 28 January 2025, resulting in the selection of 12 relevant articles. The quantified evidence synthesis identified eight molecular and microbial categories. Of these, four classes, including cytokines, microRNAs, calprotectin, and the microbiome, have demonstrated the most consistent potential. Alterations in these biomarkers, such as an increase in the Prevotella genus within the microbiome, and elevated PSMA7 levels, may reflect disruptions in intestinal barrier integrity and immune response. However, factors such as oral health status, hygiene habits, and medication must be carefully considered. Therefore, further clinical research is essential to validate specific biomarkers.<\/jats:p>","DOI":"10.3390\/ijms262211195","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T15:03:15Z","timestamp":1763564595000},"page":"11195","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Salivary Biomarkers in Crohn\u2019s Disease and Ulcerative Colitis: A Scoping Review and Evidence Map"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6979-0045","authenticated-orcid":false,"given":"Karina Oliveira","family":"Santos","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Bauru School of Dentistry (FOB), S\u00e3o Paulo University (USP), Bauru 17047-002, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7319-8906","authenticated-orcid":false,"given":"Ligia Yukie","family":"Sassaki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Medical School, S\u00e3o Paulo State University (UNESP), Campus Botucatu, Botucatu 18618-970, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1737-8918","authenticated-orcid":false,"given":"Maiara","family":"Brusco De Freitas","sequence":"additional","affiliation":[{"name":"Center for Molecular Prediction of Inflammatory Bowel Disease (PREDICT), Department of Clinical Medicine, Aalborg University (AAU), 2450 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4035-3113","authenticated-orcid":false,"given":"Julio Pinheiro","family":"Baima","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Medical School, S\u00e3o Paulo State University (UNESP), Campus Botucatu, Botucatu 18618-970, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2375-9330","authenticated-orcid":false,"given":"Murilo Henrique","family":"Faria","sequence":"additional","affiliation":[{"name":"Human Movement Research Laboratory (MOVI-LAB), Department of Physical Education, Faculty of Sciences, S\u00e3o Paulo State University (UNESP), Bauru 17033-360, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1526-2048","authenticated-orcid":false,"given":"Anna Luisa","family":"Bizotto","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Bauru School of Dentistry (FOB), S\u00e3o Paulo University (USP), Bauru 17047-002, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0936-7157","authenticated-orcid":false,"given":"J\u00falia Pardini","family":"Ben\u00edcio","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Bauru School of Dentistry (FOB), S\u00e3o Paulo University (USP), Bauru 17047-002, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6413-5348","authenticated-orcid":false,"given":"Ana Carolina","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Bauru School of Dentistry (FOB), S\u00e3o Paulo University (USP), Bauru 17047-002, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"ref_1","first-page":"11","article-title":"Salivaomics\u2014A promising future in early diagnosis of dental diseases","volume":"11","author":"Koneru","year":"2014","journal-title":"Dent. 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