{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T19:06:38Z","timestamp":1785870398821,"version":"3.56.0"},"reference-count":79,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100024390","name":"ICMR National Institute of Nutrition","doi-asserted-by":"crossref","award":["23-BS08"],"award-info":[{"award-number":["23-BS08"]}],"id":[{"id":"10.13039\/501100024390","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The pathogenesis of knee osteoarthritis (OA) is multifaceted and involves the complete joint microenvironment. Despite beneficial evidence of curcumin, the mechanistic insights of nanoemulsified curcumin (n-Cur) delivery to the knee-OA microenvironment are limited. The study aimed to establish localized delivery of curcumin nanoemulsion in the knee joint of OA rats and to examine detailed histopathological changes. n-Cur was prepared using a neutral dietary oil and a surfactant. Adult (5 mo) male SD rats were intra-articularly delivered 40 mg\/mL of monoiodoacetate (MIA) to induce OA in the left knee and further treated with n-Cur (30 mg\/mL). The effect of n-Cur on macrophage recruitment was evaluated using a co-culture model of CHON 001 and RAW 264.7 cells. In the MIA model, localized delivery of n-Cur significantly reduced knee joint edema and joint space narrowing in the target site. Curcumin ameliorated cartilage degeneration by reducing fibrillation, hypocellularity, and restoring matrix proteoglycan, as evidenced by histology. Reduced synovial inflammation displays the effect of curcumin on the synovium, possibly by lowering the recruitment of macrophages in chemoattractant-stimulated chondrocytes. Thus, curcumin nanoemulsion can act as a chondroprotective agent, modulating the OA microenvironment by reducing joint edema, synovial inflammation, and oxidative stress in the OA model.<\/jats:p>","DOI":"10.3390\/ijms262211212","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T09:44:53Z","timestamp":1763631893000},"page":"11212","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Intra-Articular Delivery of Nanoemulsified Curcumin Ameliorates Joint Degeneration in a Chemically Induced Model of Osteoarthritis"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1451-7169","authenticated-orcid":false,"given":"Kota Sri Naga","family":"Hridayanka","sequence":"first","affiliation":[{"name":"Molecular Biology Division, National Institute of Nutrition, Indian Council of Medical Research, Hyderabad 500007, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibsekhar","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University College of Science, Osmania University, Hyderabad 500007, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2081-2391","authenticated-orcid":false,"given":"Saikanth","family":"Varma","sequence":"additional","affiliation":[{"name":"Molecular Biology Division, National Institute of Nutrition, Indian Council of Medical Research, Hyderabad 500007, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4056-431X","authenticated-orcid":false,"given":"Navya Sree","family":"Boga","sequence":"additional","affiliation":[{"name":"Molecular Biology Division, National Institute of Nutrition, Indian Council of Medical Research, Hyderabad 500007, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana","family":"Molangiri","sequence":"additional","affiliation":[{"name":"Molecular Biology Division, National Institute of Nutrition, Indian Council of Medical Research, Hyderabad 500007, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7638-5558","authenticated-orcid":false,"given":"Pradeep B.","family":"Patil","sequence":"additional","affiliation":[{"name":"Division of Animal Facility, National Institute of Nutrition, Indian Council of Medical Research, Hyderabad 500007, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myadara","family":"Srinivas","sequence":"additional","affiliation":[{"name":"Division of Animal Facility, National Institute of Nutrition, Indian Council of Medical Research, Hyderabad 500007, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1619-3778","authenticated-orcid":false,"given":"Asim K.","family":"Duttaroy","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, 0316 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8161-5597","authenticated-orcid":false,"given":"Sanjay","family":"Basak","sequence":"additional","affiliation":[{"name":"Molecular Biology Division, National Institute of Nutrition, Indian Council of Medical Research, Hyderabad 500007, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Karpi\u0144ski, R., Prus, A., Baj, J., Radej, S., Prz\u0105dka, M., Krakowski, P., and Jonak, K. 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