{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:33:50Z","timestamp":1785890030135,"version":"3.56.0"},"reference-count":65,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["25-14-00162"],"award-info":[{"award-number":["25-14-00162"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Here we elucidated the effects of natural protoberberine alkaloids (rotundine, berberine, and nitidine) and cinnamic acid derivatives (ethyl-4-methoxycinnamate and osthole) found in Vietnamese medicinal plants, on the boundary potential of lipid bilayers and phase behavior of membrane lipids. Lipid bilayers were composed of neutral phosphatidylcholines (PC) and negatively charged phosphatidylserines (PS). Tested compounds did not produce any noticeable changes in the boundary potential with the exception of osthole, which caused a potential drop by about 30 mV independently of the membrane phospholipid composition. Protoberberine alkaloids did not demonstrate an ability to greatly influence phase transition of PC, while they dramatically disturbed PS melting by integrating two different lipid states by merging the low-melting component into the higher one. Ethyl-4-methoxycinnamate and osthole were able to decrease the temperature and sharpness of the PC and PS phase transition, although the effect on PS was higher. We also revealed that ethyl-4-methoxycinnamate and osthole diminished the melting point of both components of PS transition without the changes in their relative impacts. The observed membrane activity of the tested compounds may be related to their physiological and pharmacological potential.<\/jats:p>","DOI":"10.3390\/ijms262211237","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T08:59:46Z","timestamp":1763715586000},"page":"11237","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Effects of Several Natural Protoberberine Alkaloids and Cinnamic Acid Derivatives Used for Traditional Medicine on the Membrane Boundary Potential and Lipid Packing Stress"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2429-2007","authenticated-orcid":false,"given":"Svetlana S.","family":"Efimova","sequence":"first","affiliation":[{"name":"Institute of Cytology of Russian Academy of Science, Tikhoretsky Ave. 4, St. Petersburg 194064, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5674-9844","authenticated-orcid":false,"given":"Polina D.","family":"Zlodeeva","sequence":"additional","affiliation":[{"name":"Institute of Cytology of Russian Academy of Science, Tikhoretsky Ave. 4, St. Petersburg 194064, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6922-1627","authenticated-orcid":false,"given":"Quan Minh","family":"Pham","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Vietnamese Academic of Science and Technology (ICH, VAST), 18 Hoang Quoc Viet, Hanoi 113000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huong Thi Thu","family":"Trinh","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Vietnamese Academic of Science and Technology (ICH, VAST), 18 Hoang Quoc Viet, Hanoi 113000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha Minh","family":"Le","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Vietnamese Academic of Science and Technology (ICH, VAST), 18 Hoang Quoc Viet, Hanoi 113000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Van Th\u1ecb Hong","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Vietnamese Academic of Science and Technology (ICH, VAST), 18 Hoang Quoc Viet, Hanoi 113000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long Quoc","family":"Pham","sequence":"additional","affiliation":[{"name":"Laboratory of Biophysics, Institute for Advanced Study in Technology, Ton Duc Thang University, 19 Nguyen Huu Tho Street, Ho Chi Minh City 700000, Vietnam"},{"name":"Faculty of Pharmacy, Ton Duc Thang University, 19 Nguyen Huu Tho Street, Ho Chi Minh City 700000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga S.","family":"Ostroumova","sequence":"additional","affiliation":[{"name":"Institute of Cytology of Russian Academy of Science, Tikhoretsky Ave. 4, St. Petersburg 194064, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/j.nut.2009.06.014","article-title":"Bioactive compounds: Safety and efficacy","volume":"25","author":"Biesalski","year":"2009","journal-title":"Nutrition"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.jep.2014.04.024","article-title":"Ethnobotany, phytochemistry and pharmacology of Stephania rotunda Lour","volume":"154","author":"Desgrouas","year":"2014","journal-title":"J. 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