{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T05:40:28Z","timestamp":1788846028173,"version":"build-2803163510"},"reference-count":41,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008871","name":"Yunnan Province Science and Technology Department","doi-asserted-by":"publisher","award":["202301AU070047"],"award-info":[{"award-number":["202301AU070047"]}],"id":[{"id":"10.13039\/501100008871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Technology Talent and Platform Plan of Yunnan Province","award":["202305AF150160"],"award-info":[{"award-number":["202305AF150160"]}]},{"name":"Academician Expert Workstation of Yunnan Kunming","award":["YSZJGZZ-2022063"],"award-info":[{"award-number":["YSZJGZZ-2022063"]}]},{"name":"State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan","award":["2025KF001"],"award-info":[{"award-number":["2025KF001"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["3332028080"],"award-info":[{"award-number":["3332028080"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Yunnan Provincial Basic Research Project","award":["202101AY070001-195"],"award-info":[{"award-number":["202101AY070001-195"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Female reproductive aging precedes physical aging and is closely associated with the development of many aging-related diseases. With the delay in the human reproductive age, delaying reproductive aging and improving fertility have become important challenges for biomedical research. Arachidonic acid (AA) was found to significantly prolong the reproductive lifespan and enhance the quality of senescent oocytes in a cryptic nematode model. In a mouse model of senescence, AA supplementation improved the ovarian reserve, increased the oocyte number and quality, and restored fertility. Further analysis showed that AA delayed ovarian senescence by restoring lysosomal activity in the germ lines of senescent nematodes and mice and enhancing lysosomal functions in oocytes and ovarian granulosa cells. This study provides preliminary evidence that AA could serve as a potential intervention strategy for reproductive senescence and offers new ideas for improving reproductive health in older women.<\/jats:p>","DOI":"10.3390\/ijms262311332","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T10:24:17Z","timestamp":1763979857000},"page":"11332","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Arachidonic Acid Supplementation During Reproductive Aging Prevents Female Fertility Decline"],"prefix":"10.3390","volume":"26","author":[{"given":"Jie","family":"Tang","sequence":"first","affiliation":[{"name":"Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanli","family":"Chen","sequence":"additional","affiliation":[{"name":"Faculty of Basic Medicine, Kunming Medical University, Kunming 650500, China"},{"name":"State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Life Sciences, Yunnan University, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7425-084X","authenticated-orcid":false,"given":"Meng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhao","sequence":"additional","affiliation":[{"name":"Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Li","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxue","family":"Li","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengmei","family":"Yang","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanlong","family":"He","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8437-6333","authenticated-orcid":false,"given":"Longbao","family":"Lv","sequence":"additional","affiliation":[{"name":"Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.mce.2008.11.004","article-title":"Aging of the human ovary and testis","volume":"299","author":"Perheentupa","year":"2009","journal-title":"Mol. 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