{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T14:08:23Z","timestamp":1793110103532,"version":"4.5.0"},"reference-count":152,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Post-viral neuroinflammatory syndromes, particularly those occurring after SARS-CoV-2 infection, have received increasing attention due to their complex and persistent neurological manifestations. The aim of this narrative review is to integrate current evidence on the molecular and cellular mechanisms underlying chronic neuroinflammation following viral infections, with a focus on dysregulated innate immune responses, macrophage\u2013microglia interactions, oxidative\u2013mitochondrial stress, and impaired inflammation resolution pathways. Our synthesis shows that prolonged activation of macrophages and glial cells promotes the continuous release of pro-inflammatory mediators, while defective phagocytosis and inadequate clearance of cellular debris maintain an inflammatory microenvironment. Mitochondrial dysfunction further amplifies immune activation by stimulating metabolic stress and reactive oxygen species production. In parallel, deficiencies in mediators specialized in inflammation resolution impede the transition from inflammation to resolution, allowing neuroimmune imbalance and nociceptive sensitization to persist long after virus clearance. Key conclusions indicate that these interconnected mechanisms collectively contribute to the long-term neurological symptoms observed in post-viral states, including cognitive impairment, neuropathic pain, and fatigue. Emerging therapeutic strategies targeting cytokine signaling, microglial reactivity, mitochondrial function, and resolution pathways are promising, but remain insufficiently validated in clinical practice. Overall, evidence suggests that post-viral neuroinflammation results from the convergence of sustained immune activation and failure of endogenous resolution mechanisms, highlighting the need for further mechanistic studies and targeted interventions.<\/jats:p>","DOI":"10.3390\/ijms262311383","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T10:46:18Z","timestamp":1764067578000},"page":"11383","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Dysregulated Resolution of Inflammation After Respiratory Viral Infections: Molecular Pathways Linking Neuroinflammation to Post-Viral Neuropathic Pain\u2014A Narrative Review"],"prefix":"10.3390","volume":"26","author":[{"given":"Andrei Emilian","family":"Popa","sequence":"first","affiliation":[{"name":"Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"},{"name":"2nd Internal Medicine Department, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2207-5129","authenticated-orcid":false,"given":"Elena","family":"Popa","sequence":"additional","affiliation":[{"name":"Preventive Medicine and Interdisciplinarity Department, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Dramba","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"},{"name":"2nd Internal Medicine Department, \u201cGrigore T. 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Biol., 13.","DOI":"10.3389\/fcell.2025.1600149"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"107879","DOI":"10.1016\/j.pharmthera.2021.107879","article-title":"Resolution of Inflammation: An Organizing Principle in Biology and Medicine","volume":"227","author":"Panigrahy","year":"2021","journal-title":"Pharmacol. Ther."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Futokoro, R., Hijioka, M., Arata, M., and Kitamura, Y. (2022). Lipoxin A4 Receptor Stimulation Attenuates Neuroinflammation in a Mouse Model of Intracerebral Hemorrhage. Brain Sci., 12.","DOI":"10.3390\/brainsci12020162"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Popa, E., Popa, A.E., Poroch, M., Poroch, V., Ungureanu, M.I., Slanina, A.M., Bacusca, A., and Coman, E.A. (2025). The Molecular Mechanisms of Cognitive Dysfunction in Long COVID: A Narrative Review. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26115102"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S1474-4422(20)30221-0","article-title":"Neurological Associations of COVID-19","volume":"19","author":"Ellul","year":"2020","journal-title":"Lancet Neurol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Pa\u0219a, V., Popa, E., Poroch, M., Cosmescu, A., Bacusca, A.I., Slanina, A.M., Ceasovschih, A., Stoica, A., Petroaie, A., and Ungureanu, M. (2023). The \u201cViral\u201d Form of Polyarteritis Nodosa (PAN)\u2014A Distinct Entity: A Case Based Review. Medicina, 59.","DOI":"10.3390\/medicina59061162"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1111\/bph.16323","article-title":"Resolution Pharmacology and the Treatment of Infectious Diseases","volume":"181","author":"Costa","year":"2024","journal-title":"Br. J. Pharmacol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Valente, M., Dentoni, M., Bellizzi, F., Kuris, F., and Gigli, G.L. (2022). Specialized Pro-Resolving Mediators in Neuroinflammation: Overview of Studies and Perspectives of Clinical Applications. Molecules, 27.","DOI":"10.3390\/molecules27154836"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Sodero, G., Gentili, C., Mariani, F., Pulcinelli, V., Valentini, P., and Buonsenso, D. (2024). Procalcitonin and Presepsin as Markers of Infectious Respiratory Diseases in Children: A Scoping Review of the Literature. Children, 11.","DOI":"10.3390\/children11030350"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s41073-019-0064-8","article-title":"SANRA\u2014A Scale for the Quality Assessment of Narrative Review Articles","volume":"4","author":"Baethge","year":"2019","journal-title":"Res. Integr. Peer Rev."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Kallaste, A., Kisand, K., Aart, A., Salumets, A., Kisand, K., Peterson, P., and Lember, M. (2025). Long COVID and Biomarker Dysregulation\u2014A Shift Toward Immune Exhaustion?. Medicina, 61.","DOI":"10.3390\/medicina61060996"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Ge, Y., Huang, M., and Yao, Y. (2022). Efferocytosis and Its Role in Inflammatory Disorders. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.839248"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.exger.2017.12.002","article-title":"Pioglitazone Attenuates Aging-Related Disorders in Aged Apolipoprotein E Deficient Mice","volume":"102","author":"Shen","year":"2018","journal-title":"Exp. Gerontol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/s41573-022-00470-y","article-title":"Drugging the Efferocytosis Process: Concepts and Opportunities","volume":"21","author":"Mehrotra","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"7221","DOI":"10.1074\/jbc.RA118.006628","article-title":"MERTK Tyrosine Kinase Receptor Together with TIM4 Phosphatidylserine Receptor Mediates Distinct Signal Transduction Pathways for Efferocytosis and Cell Proliferation","volume":"294","author":"Nishi","year":"2019","journal-title":"J. Biol. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"107300","DOI":"10.1016\/j.phrs.2024.107300","article-title":"PI3K\/AKT Signaling Pathway: Molecular Mechanisms and Therapeutic Potential in Depression","volume":"206","author":"Guo","year":"2024","journal-title":"Pharmacol. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"eaaz5267","DOI":"10.1126\/scisignal.aaz5267","article-title":"Kinetics of Receptor Tyrosine Kinase Activation Define ERK Signaling Dynamics","volume":"13","author":"Kiyatkin","year":"2020","journal-title":"Sci. Signal."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.immuni.2024.03.002","article-title":"DAMPs and DAMP-Sensing Receptors in Inflammation and Diseases","volume":"57","author":"Ma","year":"2024","journal-title":"Immunity"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12950-015-0081-4","article-title":"The PPAR-\u03b3 Antagonist GW9662 Elicits Differentiation of M2c-like Cells and Upregulation of the MerTK\/Gas6 Axis: A Key Role for PPAR-\u03b3 in Human Macrophage Polarization","volume":"12","author":"Zizzo","year":"2015","journal-title":"J. Inflamm."},{"key":"ref_21","first-page":"427","article-title":"Flow Cytometry Analysis of Ppar\u03b1 Receptors in Metabolic Syndrome\/Studiul Receptorilor Ppar\u03b1 Prin Metoda Citometriei \u00cen Flux \u00cen Sindromul Metabolic","volume":"22","author":"Popa","year":"2014","journal-title":"Rev. Romana Med. Lab."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Zheng, W., Zhou, Z., Guo, X., Zuo, X., Zhang, J., An, Y., Zheng, H., Yue, Y., Wang, G., and Wang, F. (2023). Efferocytosis and Respiratory Disease. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241914871"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.imlet.2023.02.001","article-title":"Cellular Mechanisms Underlying the Impairment of Macrophage Efferocytosis","volume":"254","author":"Ma","year":"2023","journal-title":"Immunol. Lett."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1038\/cdd.2013.82","article-title":"Milk Fat Globule-EGF Factor 8 Mediates the Enhancement of Apoptotic Cell Clearance by Glucocorticoids","volume":"20","author":"Lauber","year":"2013","journal-title":"Cell Death Differ."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Wang, Y., Zhang, W., Xu, Y., Wu, D., Gao, Z., Zhou, J., Qian, H., He, B., and Wang, G. (2022). Extracellular HMGB1 Impairs Macrophage-Mediated Efferocytosis by Suppressing the Rab43-Controlled Cell Surface Transport of CD91. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.767630"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s12974-025-03428-0","article-title":"Microglia Efferocytosis: An Emerging Mechanism for the Resolution of Neuroinflammation in Alzheimer\u2019s Disease","volume":"22","author":"Chen","year":"2025","journal-title":"J. Neuroinflamm."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Bohan, D., Ert, H.V., Ruggio, N., Rogers, K.J., Badreddine, M., Brise\u00f1o, J.A.A., Elliff, J.M., Chavez, R.A.R., Gao, B., and Stokowy, T. (2021). Phosphatidylserine Receptors Enhance SARS-CoV-2 Infection. PLoS Pathog., 17.","DOI":"10.1371\/journal.ppat.1009743"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Rizzi, M., Tonello, S., D\u2019Onghia, D., and Sainaghi, P.P. (2023). Gas6\/TAM Axis Involvement in Modulating Inflammation and Fibrosis in COVID-19 Patients. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24020951"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Lekshmi, V.S., Asha, K., Sanicas, M., Asi, A., Arya, U.M., and Kumar, B. (2023). PI3K\/Akt\/Nrf2 Mediated Cellular Signaling and Virus-Host Interactions: Latest Updates on the Potential Therapeutic Management of SARS-CoV-2 Infection. Front. Mol. Biosci., 10.","DOI":"10.3389\/fmolb.2023.1158133"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.cytogfr.2022.01.002","article-title":"Before the \u201cCytokine Storm\u201d: Boosting Efferocytosis as an Effective Strategy against SARS-CoV-2 Infection and Associated Complications","volume":"63","author":"Dutta","year":"2022","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Xie, J., Yuan, C., Yang, S., Ma, Z., Li, W., Mao, L., Jiao, P., and Liu, W. (2024). The Role of Reactive Oxygen Species in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) Infection-Induced Cell Death. Cell Mol. Biol. Lett., 29.","DOI":"10.1186\/s11658-024-00659-6"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/s41577-021-00588-x","article-title":"Inflammasome Activation at the Crux of Severe COVID-19","volume":"21","author":"Vora","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00018-025-05648-2","article-title":"Microglia Regulate Myelin Clearance and Cholesterol Metabolism after Demyelination via Interferon Regulatory Factor 5","volume":"82","author":"Montilla","year":"2025","journal-title":"Cell Mol. Life Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.cmet.2018.12.004","article-title":"Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair","volume":"29","author":"Zhang","year":"2019","journal-title":"Cell Metab."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Li, K., Wang, R., Zhu, H., Wen, B., Xu, L., and Huang, Y. (2025). Biomarker Signatures in Time-Course Progression of Neuropathic Pain at Spinal Cord Level Based on Bioinformatics and Machine Learning Analysis. Biomolecules, 15.","DOI":"10.3390\/biom15091254"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1186\/s12974-022-02629-1","article-title":"Trem2 Deficiency Impairs Recovery and Phagocytosis and Dysregulates Myeloid Gene Expression during Virus-Induced Demyelination","volume":"19","author":"Hwang","year":"2022","journal-title":"J. Neuroinflamm."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.cell.2015.01.049","article-title":"TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer\u2019s Disease Model","volume":"160","author":"Wang","year":"2015","journal-title":"Cell"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.tins.2020.10.002","article-title":"Microglial Phagocytosis: A Disease-Associated Process Emerging from Alzheimer\u2019s Disease Genetics","volume":"43","author":"Marcora","year":"2020","journal-title":"Trends Neurosci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s13024-022-00588-y","article-title":"TREM2 Dependent and Independent Functions of Microglia in Alzheimer\u2019s Disease","volume":"17","author":"Hou","year":"2022","journal-title":"Mol. Neurodegener."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Coman, A.E., Ceasovschih, A., Petroaie, A.D., Popa, E., Lionte, C., Bologa, C., Haliga, R.E., Cosmescu, A., Sl\u0103nin\u0103, A.M., and Bacu\u0219c\u0103, A.I. (2023). The Significance of Low Magnesium Levels in COVID-19 Patients. Medicina, 59.","DOI":"10.3390\/medicina59020279"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Koutsiaris, A.G., and Karakousis, K. (2025). Long COVID Mechanisms, Microvascular Effects, and Evaluation Based on Incidence. Life, 15.","DOI":"10.20944\/preprints202505.1240.v1"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nrn.2016.7","article-title":"TREM2 Variants: New Keys to Decipher Alzheimer Disease Pathogenesis","volume":"17","author":"Colonna","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Mecca, C., Giambanco, I., Donato, R., and Arcuri, C. (2018). Microglia and Aging: The Role of the TREM2\u2013DAP12 and CX3CL1-CX3CR1 Axes. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19010318"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1038\/s41418-024-01347-w","article-title":"Cell Autonomous Functions of CD47 in Regulating Cellular Plasticity and Metabolic Plasticity","volume":"31","author":"Polara","year":"2024","journal-title":"Cell Death Differ."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Zhang, W., Huang, Q., Xiao, W., Zhao, Y., Pi, J., Xu, H., Zhao, H., Xu, J., Evans, C.E., and Jin, H. (2020). Advances in Anti-Tumor Treatments Targeting the CD47\/SIRP\u03b1 Axis. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.00018"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Zhao, W., Ma, L., Deng, D., Zhang, T., Han, L., Xu, F., Huang, S., Ding, Y., and Chen, X. (2023). M2 Macrophage Polarization: A Potential Target in Pain Relief. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1243149"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"3224","DOI":"10.1093\/hmg\/ddaa209","article-title":"Trem2 Promotes Anti-Inflammatory Responses in Microglia and Is Suppressed under pro-Inflammatory Conditions","volume":"29","author":"Liu","year":"2020","journal-title":"Hum. Mol. Genet."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1021\/acsptsci.9b00075","article-title":"New Advances in Targeting the Resolution of Inflammation: Implications for Specialized Pro-Resolving Mediator GPCR Drug Discovery","volume":"3","author":"Park","year":"2020","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1002\/art.42510","article-title":"Efficacy and Safety of Lenabasum, a Cannabinoid Type 2 Receptor Agonist, in a Phase 3 Randomized Trial in Diffuse Cutaneous Systemic Sclerosis","volume":"75","author":"Spiera","year":"2023","journal-title":"Arthritis Rheumatol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1186\/s12933-024-02501-x","article-title":"Lipoxin A4 Improves Cardiac Remodeling and Function in Diabetes-Associated Cardiac Dysfunction","volume":"23","author":"Fu","year":"2024","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.bbrc.2020.02.032","article-title":"Insufficient Efferocytosis by M2-like Macrophages as a Possible Mechanism of Neuropathic Pain Induced by Nerve Injury","volume":"525","author":"Kobayashi","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e60223","DOI":"10.7554\/eLife.60223","article-title":"Analysis of the Immune Response to Sciatic Nerve Injury Identifies Efferocytosis as a Key Mechanism of Nerve Debridement","volume":"9","author":"Kalinski","year":"2020","journal-title":"eLife"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1186\/s12974-023-02940-5","article-title":"Efferocytosis Is Restricted by Axon Guidance Molecule EphA4 via ERK\/Stat6\/MERTK Signaling Following Brain Injury","volume":"20","author":"Soliman","year":"2023","journal-title":"J. Neuroinflamm."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/s41419-021-03770-0","article-title":"Ligand-Dependent Kinase Activity of MERTK Drives Efferocytosis in Human iPSC-Derived Macrophages","volume":"12","author":"Wanke","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Ruan, S., Jia, R., Hu, L., Liu, Y., Tian, Q., Jiang, K., Xia, X., Tao, X., Liu, W.-T., and Pan, Y. (2024). Ozone Promotes Macrophage Efferocytosis and Alleviates Neuropathic Pain by Activating the AMPK\/Gas6-MerTK\/SOCS3 Signaling Pathway. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1455771"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.37358\/RC.17.10.5897","article-title":"The Impact of Ozone Therapy on Antioxidant Status and Quality of Life in Palliative Care\u2014Exploratory Study","volume":"68","author":"Totolici","year":"2017","journal-title":"Rev. Chim."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"108532","DOI":"10.1016\/j.intimp.2022.108532","article-title":"Baicalin Clears Inflammation by Enhancing Macrophage Efferocytosis via Inhibition of the RhoA\/ROCK Signaling Pathway and Regulating Macrophage Polarization","volume":"105","author":"Cai","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Grossini, E., Concina, D., Rinaldi, C., Russotto, S., Garhwal, D., Zeppegno, P., Gramaglia, C., Kul, S., and Panella, M. (2021). Association Between Plasma Redox State\/Mitochondria Function and a Flu-Like Syndrome\/COVID-19 in the Elderly Admitted to a Long-Term Care Unit. Front. Physiol., 12.","DOI":"10.3389\/fphys.2021.707587"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Lee, Y.-J., Kim, B.-M., Ahn, Y.-H., Choi, J.H., Choi, Y.-H., and Kang, J.L. (2021). STAT6 Signaling Mediates PPAR\u03b3 Activation and Resolution of Acute Sterile Inflammation in Mice. Cells, 10.","DOI":"10.3390\/cells10030501"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Noonong, K., Chatatikun, M., Surinkaew, S., Kotepui, M., Hossain, R., Bunluepuech, K., Noothong, C., Tedasen, A., Klangbud, W.K., and Imai, M. (2023). Mitochondrial Oxidative Stress, Mitochondrial ROS Storms in Long COVID Pathogenesis. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1275001"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"104731","DOI":"10.1016\/j.dci.2023.104731","article-title":"The Acute Inflammatory Response of Teleost Fish","volume":"146","author":"Soliman","year":"2023","journal-title":"Dev. Comp. Immunol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.cmet.2020.01.001","article-title":"Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury","volume":"31","author":"Yurdagul","year":"2020","journal-title":"Cell Metab."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1038\/s42255-021-00471-y","article-title":"Non-Canonical Glutamine Transamination Sustains Efferocytosis by Coupling Redox Buffering to Oxidative Phosphorylation","volume":"3","author":"Merlin","year":"2021","journal-title":"Nat. Metab."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1074\/jbc.RA118.006691","article-title":"cAMP-Dependent Activation of the Rac Guanine Exchange Factor P-REX1 by Type I Protein Kinase A (PKA) Regulatory Subunits","volume":"294","author":"Gutkind","year":"2019","journal-title":"J. Biol. Chem."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"e2024358118","DOI":"10.1073\/pnas.2024358118","article-title":"Redox Imbalance Links COVID-19 and Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome","volume":"118","author":"Paul","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Xu, S., Li, H., Ai, Z., Guo, R., Cheng, H., and Wang, Y. (2024). Exploring Viral Neuropathic Pain: Molecular Mechanisms and Therapeutic Implications. PLoS Pathog., 20.","DOI":"10.1371\/journal.ppat.1012397"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"e131355","DOI":"10.1172\/jci.insight.131355","article-title":"STAT6\/Arg1 Promotes Microglia\/Macrophage Efferocytosis and Inflammation Resolution in Stroke Mice","volume":"4","author":"Cai","year":"2019","journal-title":"JCI Insight"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.bbi.2017.11.001","article-title":"Stress Disinhibits Microglia via Down-Regulation of CD200R: A Mechanism of Neuroinflammatory Priming","volume":"69","author":"Frank","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e20202135","DOI":"10.1084\/jem.20202135","article-title":"Neuroinvasion of SARS-CoV-2 in Human and Mouse Brain","volume":"218","author":"Song","year":"2021","journal-title":"J. Exp. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"106089","DOI":"10.1016\/j.bbi.2025.106089","article-title":"LXR-\u03b2 Regulates Microglial Efferocytosis and Neuroinflammation in CPSP via STAT6 Activation","volume":"130","author":"Zang","year":"2025","journal-title":"Brain Behav. Immun."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1111\/bph.14647","article-title":"The Specialised Pro-resolving Lipid Mediator Maresin 1 Reduces Inflammatory Pain with a Long-lasting Analgesic Effect","volume":"176","author":"Fattori","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.scib.2024.07.049","article-title":"Specialized Pro-Resolving Lipid Mediators: A Key Player in Resolving Inflammation in Autoimmune Diseases","volume":"70","author":"Zhang","year":"2025","journal-title":"Sci. Bull."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s40001-025-02424-7","article-title":"Resolvin D1 Accelerates Resolution of Neuroinflammation by Inhibiting Microglia Activation through the BDNF\/TrkB Signaling Pathway","volume":"30","author":"Bo","year":"2025","journal-title":"Eur. J. Med. Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"5294","DOI":"10.1172\/JCI129448","article-title":"Maresin 1 Activates LGR6 Receptor Promoting Phagocyte Immunoresolvent Functions","volume":"129","author":"Chiang","year":"2019","journal-title":"J. Clin. Investig."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nature13479","article-title":"Novel Pro-Resolving Lipid Mediators in Inflammation Are Leads for Resolution Physiology","volume":"510","author":"Serhan","year":"2014","journal-title":"Nature"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s12974-016-0540-8","article-title":"Lipoxin A4 Inhibits Microglial Activation and Reduces Neuroinflammation and Neuropathic Pain after Spinal Cord Hemisection","volume":"13","author":"Martini","year":"2016","journal-title":"J. Neuroinflamm."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"106380","DOI":"10.1016\/j.prostaglandins.2019.106380","article-title":"Lipoxin A4 Inhibited the Activation of Hepatic Stellate Cells -T6 Cells by Modulating Profibrotic Cytokines and NF-\u03baB Signaling Pathway","volume":"146","author":"Zhang","year":"2020","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"e185299","DOI":"10.1172\/jci.insight.185299","article-title":"12-Lipoxygenase Inhibition Delays Onset of Autoimmune Diabetes in Human Gene Replacement Mice","volume":"9","author":"Nargis","year":"2024","journal-title":"JCI Insight"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/s41467-023-43554-y","article-title":"15-Lipoxygenase Promotes Resolution of Inflammation in Lymphedema by Controlling Treg Cell Function through IFN-\u03b2","volume":"15","author":"Zamora","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Recchiuti, A., Mattoscio, D., and Isopi, E. (2019). Roles, Actions, and Therapeutic Potential of Specialized Pro-Resolving Lipid Mediators for the Treatment of Inflammation in Cystic Fibrosis. Front. Pharmacol., 10.","DOI":"10.3389\/fphar.2019.00252"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"S\u00e1nchez-Garc\u00eda, S., Ja\u00e9n, R.I., Lozano-Rodr\u00edguez, R., Avenda\u00f1o-Ortiz, J., Pascual-Iglesias, A., Hurtado-Navarro, L., L\u00f3pez-Collazo, E., Bosc\u00e1, L., and Prieto, P. (2025). Lipoxin A4 Levels Correlate with Severity in a Spanish COVID-19 Cohort: Potential Use of Endogenous pro-Resolving Mediators as Biomarkers. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1509188"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Jin, J., Xie, Y., Shi, C., Ma, J., Wang, Y., Qiao, L., Li, K., and Sun, T. (2020). Lipoxin A4 Inhibits NLRP3 Inflammasome Activation in Rats With Non-Compressive Disc Herniation Through the JNK1\/Beclin-1\/PI3KC3 Pathway. Front. Neurosci., 14, Erratum in Front. Neurosci. 2020, 14, 608184.","DOI":"10.3389\/fnins.2020.00799"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Ir\u00fan, P., Gracia, R., Piazuelo, E., Pardo, J., Morte, E., Pa\u00f1o, J.R., Boza, J., Carrera-Lasfuentes, P., Higuera, G.A., and Lanas, A. (2023). Serum Lipid Mediator Profiles in COVID-19 Patients and Lung Disease Severity: A Pilot Study. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-33682-2"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Gomes-da-Silva, N.C., Xavier-de-Britto, I., Soares, M.A.G., Yoshihara, N.M.A., Ilem \u00d6zdemir, D., Ricci-Junior, E., Fechine, P.B.A., Alencar, L.M.R., de Oliveira Henriques, M.D.G.M., and Barja-Fidalgo, T.C. (2025). Nanostructured Lipoxin A4: Understanding Its Biological Behavior and Impact on Alzheimer\u2019s Disease (Proof of Concept). Pharmaceutics, 17.","DOI":"10.3390\/pharmaceutics17050649"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"177254","DOI":"10.1016\/j.ejphar.2025.177254","article-title":"da Aspirin-Triggered Lipoxin A4 Reduces Neuropathic Pain and Anxiety-like Behaviours in Male Diabetic Rats: Antinociceptive Enhancement by Cannabinoid Receptor Agonists","volume":"989","author":"Ferreira","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s43450-021-00213-x","article-title":"Assessment of Polyunsaturated Fatty Acids on COVID-19-Associated Risk Reduction","volume":"32","author":"Baral","year":"2022","journal-title":"Rev. Bras. Farmacogn."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Chi, J., Cheng, J., Wang, S., Li, C., and Chen, M. (2023). Promising Anti-Inflammatory Tools: Biomedical Efficacy of Lipoxins and Their Synthetic Pathways. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241713282"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.arcmed.2020.03.004","article-title":"Can Bioactive Lipids Inactivate Coronavirus (COVID-19)?","volume":"51","author":"Das","year":"2020","journal-title":"Arch. Med. Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s41983-024-00853-5","article-title":"Repercussions of Microglial Efferocytosis on Neurodegeneration in Alzheimer\u2019s Disease (AD): A Double-Edged Sword and Perplexing Factor Warranting Scrutiny in AD Research","volume":"60","author":"Kanuri","year":"2024","journal-title":"Egypt. J. Neurol. Psychiatry Neurosurg."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Liu, C., Fan, D., Lei, Q., Lu, A., and He, X. (2022). Roles of Resolvins in Chronic Inflammatory Response. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232314883"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Libreros, S., Shay, A.E., Nshimiyimana, R., Fichtner, D., Martin, M.J., Wourms, N., and Serhan, C.N. (2021). A New E-Series Resolvin: RvE4 Stereochemistry and Function in Efferocytosis of Inflammation-Resolution. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.631319"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Gracia Aznar, A., Moreno Egea, F., Gracia Banzo, R., Gutierrez, R., Rizo, J.M., Rodriguez-Ledo, P., Nerin, I., and Regidor, P.-A. (2024). Pro-Resolving Inflammatory Effects of a Marine Oil Enriched in Specialized Pro-Resolving Mediators (SPMs) Supplement and Its Implication in Patients with Post-COVID Syndrome (PCS). Biomedicines, 12.","DOI":"10.20944\/preprints202407.2492.v1"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"e21441","DOI":"10.1096\/fj.202001952R","article-title":"Resolvin D1 and D2 Reduce SARS-CoV-2-Induced Inflammatory Responses in Cystic Fibrosis Macrophages","volume":"35","author":"Recchiuti","year":"2021","journal-title":"FASEB J."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Yasmeen, N., Selvaraj, H., Lakhawat, S.S., Datta, M., Sharma, P.K., Jain, A., Khanna, R., Srinivasan, J., and Kumar, V. (2023). Possibility of Averting Cytokine Storm in SARS-COV 2 Patients Using Specialized pro-Resolving Lipid Mediators. Biochem. Pharmacol., 209.","DOI":"10.1016\/j.bcp.2023.115437"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Pang, J., Xin, P., Kong, Y., Wang, Z., and Wang, X. (2023). Resolvin D2 Reduces Chronic Neuropathic Pain and Bone Cancer Pain via Spinal Inhibition of IL-17 Secretion, CXCL1 Release and Astrocyte Activation in Mice. Brain Sci., 13.","DOI":"10.3390\/brainsci13010152"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1182\/blood.2021013422","article-title":"Resolvin T-Series Reduce Neutrophil Extracellular Traps","volume":"139","author":"Chiang","year":"2022","journal-title":"Blood"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s12931-023-02650-9","article-title":"What Is the Actual Relationship between Neutrophil Extracellular Traps and COVID-19 Severity? A Longitudinal Study","volume":"25","author":"Lasierra","year":"2024","journal-title":"Respir. Res."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.1039\/D0OB02136A","article-title":"A New Synthetic Protectin D1 Analog 3-Oxa-PD1n-3 DPA Reduces Neuropathic Pain and Chronic Itch in Mice","volume":"19","author":"Nesman","year":"2021","journal-title":"Org. Biomol. Chem."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Walker, K.H., Krishnamoorthy, N., Br\u00fcggemann, T.R., Shay, A.E., Serhan, C.N., and Levy, B.D. (2021). Protectins PCTR1 and PD1 Reduce Viral Load and Lung Inflammation During Respiratory Syncytial Virus Infection in Mice. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.704427"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Navarini, L., Vomero, M., Currado, D., Berardicurti, O., Biaggi, A., Marino, A., Bearzi, P., Corberi, E., Rigon, A., and Arcarese, L. (2023). The Specialized Pro-Resolving Lipid Mediator Protectin D1 Affects Macrophages Differentiation and Activity in Adult-Onset Still\u2019s Disease and COVID-19, Two Hyperinflammatory Diseases Sharing Similar Transcriptomic Profiles. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1148268"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.5114\/aoms\/135703","article-title":"Bioactive Lipid-Based Therapeutic Approach to COVID-19 and Other Similar Infections","volume":"19","author":"Das","year":"2023","journal-title":"Arch. Med. Sci."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"e29484","DOI":"10.1002\/jmv.29484","article-title":"A Protectin DX (PDX) Analog with in Vitro Activity against Influenza A(H1N1) Viruses","volume":"96","author":"Fortin","year":"2024","journal-title":"J. Med. Virol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1515\/cclm-2021-0644","article-title":"Quantitative Profiling of Inflammatory and Pro-Resolving Lipid Mediators in Human Adolescents and Mouse Plasma Using UHPLC-MS\/MS","volume":"59","author":"Hartling","year":"2021","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/nm.3911","article-title":"Elucidation of Novel 13-Series Resolvins That Increase with Atorvastatin and Clear Infections","volume":"21","author":"Dalli","year":"2015","journal-title":"Nat. Med."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Zahoor, I., Nematullah, M., Ahmed, M.E., Fatma, M., Sajad, M., Ayasolla, K., Cerghet, M., Palaniyandi, S., Ceci, V., and Carrera, G. (2025). Maresin-1 Promotes Neuroprotection and Modulates Metabolic and Inflammatory Responses in Disease-Associated Cell Types in Preclinical Models of Multiple Sclerosis. J. Biol. Chem., 301.","DOI":"10.1016\/j.jbc.2025.108226"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.bja.2018.10.062","article-title":"Maresin 1 Attenuates Neuroinflammation in a Mouse Model of Perioperative Neurocognitive Disorders","volume":"122","author":"Yang","year":"2019","journal-title":"Br. J. Anaesth."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12974-022-02405-1","article-title":"Maresin 1 Promotes Nerve Regeneration and Alleviates Neuropathic Pain after Nerve Injury","volume":"19","author":"Wei","year":"2022","journal-title":"J. Neuroinflamm."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Lopes, R.V., Baggio, D.F., Ferraz, C.R., Bertozzi, M.M., Saraiva-Santos, T., Verri Junior, W.A., and Chichorro, J.G. (2023). Maresin-2 Inhibits Inflammatory and Neuropathic Trigeminal Pain and Reduces Neuronal Activation in the Trigeminal Ganglion. Curr. Res. Neurobiol., 4.","DOI":"10.1016\/j.crneur.2023.100093"},{"key":"ref_109","first-page":"3130","article-title":"N-3 Docosapentaenoic Acid-Derived Protectin D1 Promotes Resolution of Neuroinflammation and Arrests Epileptogenesis","volume":"141","author":"Frigerio","year":"2018","journal-title":"Brain"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3892\/ijmm.2021.4919","article-title":"Lipoxin A4 Protects against Paraquat-induced Acute Lung Injury by Inhibiting the TLR4\/MyD88-mediated Activation of the NF-\u03baB and PI3K\/AKT Pathways","volume":"47","author":"Li","year":"2021","journal-title":"Int. J. Mol. Med."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"5267","DOI":"10.1007\/s11357-024-01165-5","article-title":"Mitochondrial Dysfunction in Long COVID: Mechanisms, Consequences, and Potential Therapeutic Approaches","volume":"46","author":"Molnar","year":"2024","journal-title":"GeroScience"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"112034","DOI":"10.1016\/j.exger.2022.112034","article-title":"Elevated Plasma CAF22 Are Incompletely Restored Six Months after COVID-19 Infection in Older Men","volume":"171","author":"Karim","year":"2023","journal-title":"Exp. Gerontol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"103471","DOI":"10.1016\/j.isci.2021.103471","article-title":"Immune System Cells from COVID-19 Patients Display Compromised Mitochondrial-Nuclear Expression Co-Regulation and Rewiring toward Glycolysis","volume":"24","author":"Medini","year":"2021","journal-title":"iScience"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"e157","DOI":"10.1002\/mco2.157","article-title":"COVID-19 Metabolism: Mechanisms and Therapeutic Targets","volume":"3","author":"Wang","year":"2022","journal-title":"MedComm"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"SC11","DOI":"10.12659\/MSM.881699","article-title":"Increased Plasma Peroxides as a Marker of Oxidative Stress in Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS)","volume":"17","author":"Maes","year":"2011","journal-title":"Med. Sci. Monit."},{"key":"ref_116","first-page":"715","article-title":"Increased 8-Hydroxy-Deoxyguanosine, a Marker of Oxidative Damage to DNA, in Major Depression and Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome","volume":"30","author":"Maes","year":"2009","journal-title":"Neuro Endocrinol. Lett."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.redox.2015.03.002","article-title":"New Insights into Lyme Disease","volume":"5","author":"Peacock","year":"2015","journal-title":"Redox Biol."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Vernon, S.D., Whistler, T., Cameron, B., Hickie, I.B., Reeves, W.C., and Lloyd, A. (2006). Preliminary Evidence of Mitochondrial Dysfunction Associated with Post-Infective Fatigue after Acute Infection with Epstein Barr Virus. BMC Infect. Dis., 6.","DOI":"10.1186\/1471-2334-6-15"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s12967-019-1906-3","article-title":"A Possible Role for Mitochondrial-Derived Peptides Humanin and MOTS-c in Patients with Q Fever Fatigue Syndrome and Chronic Fatigue Syndrome","volume":"17","author":"Raijmakers","year":"2019","journal-title":"J. Transl. Med."},{"key":"ref_120","first-page":"e31331","article-title":"The Effects of the COVID-19 Pandemic on Mental Health: A Web-Based Study Among Romanian Adults","volume":"14","author":"Popa","year":"2022","journal-title":"Cureus"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/s41577-021-00597-w","article-title":"Resolving Inflammation","volume":"21","author":"Gilroy","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/s41577-024-01104-7","article-title":"Neuroinflammation in Alzheimer Disease","volume":"25","author":"Heneka","year":"2025","journal-title":"Nat. Rev. Immunol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12974-022-02397-y","article-title":"Gas6 Induces Inflammation and Reduces Plaque Burden but Worsens Behavior in a Sex-Dependent Manner in the APP\/PS1 Model of Alzheimer\u2019s Disease","volume":"19","author":"Owlett","year":"2022","journal-title":"J. Neuroinflamm."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"101605","DOI":"10.1016\/j.smim.2022.101605","article-title":"Specialized Pro-Resolving Mediators as Modulators of Immune Responses","volume":"59","author":"Julliard","year":"2022","journal-title":"Semin. Immunol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"102542","DOI":"10.1016\/j.plefa.2023.102542","article-title":"Over-the-Counter Fish Oil Supplementation and Pro-Resolving and Pro-Inflammatory Lipid Mediators in Rheumatoid Arthritis","volume":"190","author":"Marchand","year":"2023","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"17448069221124920","DOI":"10.1177\/17448069221124920","article-title":"Dimethyl Fumarate Attenuates Pain Behaviors in Osteoarthritis Rats via Induction of Nrf2-Mediated Mitochondrial Biogenesis","volume":"18","author":"Gao","year":"2022","journal-title":"Mol. Pain"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.3324\/haematol.2019.219519","article-title":"Specialized Pro-Resolving Lipid Mediators Are Differentially Altered in Peripheral Blood of Patients with Multiple Sclerosis and Attenuate Monocyte and Blood-Brain Barrier Dysfunction","volume":"105","author":"Kooij","year":"2020","journal-title":"Haematologica"},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Liotti, F., Marotta, M., Melillo, R.M., and Prevete, N. (2022). The Impact of Resolution of Inflammation on Tumor Microenvironment: Exploring New Ways to Control Cancer Progression. Cancers, 14.","DOI":"10.3390\/cancers14143333"},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Teixeira-Santos, L., Martins, S., Sousa, T., Albino-Teixeira, A., and Pinho, D. (2023). The Pro-Resolving Lipid Mediator Maresin 1 Ameliorates Pain Responses and Neuroinflammation in the Spared Nerve Injury-Induced Neuropathic Pain: A Study in Male and Female Mice. PLoS ONE, 18.","DOI":"10.1371\/journal.pone.0287392"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"2500128","DOI":"10.1002\/advs.202500128","article-title":"Synergistic Modulating of Mitochondrial Transfer and Immune Microenvironment to Attenuate Discogenic Pain","volume":"12","author":"Wang","year":"2025","journal-title":"Adv. Sci."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.jpain.2022.12.013","article-title":"Sex Dimorphism in Resolvin D5-Induced Analgesia in Rat Models of Trigeminal Pain","volume":"24","author":"Baggio","year":"2023","journal-title":"J. Pain"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Demuth, L., Ohm, M., Michaelsen-Preusse, K., Schulze, K., Riese, P., Guzm\u00e1n, C.A., Korte, M., and Hosseini, S. (2023). Influenza Vaccine Is Able to Prevent Neuroinflammation Triggered by H7N7 IAV Infection. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1142639"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"e175401","DOI":"10.1172\/jci.insight.175401","article-title":"Modulation of Innate Immune Response to mRNA Vaccination after SARS-CoV-2 Infection or Sequential Vaccination in Humans","volume":"9","author":"Hellgren","year":"2024","journal-title":"JCI Insight"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.bbi.2025.05.021","article-title":"Intravenous SARS-CoV-2 Spike Protein Induces Neuroinflammation and Alpha-Synuclein Accumulation in Brain Regions Relevant to Parkinson\u2019s Disease","volume":"129","author":"Schreiber","year":"2025","journal-title":"Brain Behav. Immun."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41541-025-01124-x","article-title":"Ionizable Lipid Nanoparticles of mRNA Vaccines Elicit NF-\u03baB and IRF Responses through Toll-like Receptor 4","volume":"10","author":"Zelkoski","year":"2025","journal-title":"NPJ Vaccines"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"577765","DOI":"10.1016\/j.jneuroim.2021.577765","article-title":"A Systematic Review of Cases of CNS Demyelination Following COVID-19 Vaccination","volume":"362","author":"Ismail","year":"2022","journal-title":"J. Neuroimmunol."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Bahramy, M.A., Hashempour, Z., and Shahriarirad, R. (2024). Chronic Inflammatory Demyelinating Polyneuropathy Following COVID-19 Vaccination: A Case Report and Literature Review. BMC Neurol., 24.","DOI":"10.1186\/s12883-024-03756-3"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"123536","DOI":"10.1016\/j.jns.2025.123536","article-title":"Small Fiber Neuropathy Following COVID-19 Vaccination: A Case Series","volume":"474","author":"Primicerio","year":"2025","journal-title":"J. Neurol. Sci."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"104141","DOI":"10.1016\/j.msard.2022.104141","article-title":"Onset of Various CNS Inflammatory Demyelination Diseases Following COVID-19 Vaccinations","volume":"68","author":"Kim","year":"2022","journal-title":"Mult. Scler. Relat. Disord."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1038\/s41591-021-01556-7","article-title":"Neurological Complications after First Dose of COVID-19 Vaccines and SARS-CoV-2 Infection","volume":"27","author":"Patone","year":"2021","journal-title":"Nat. Med."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Rinaldi, V., Bellucci, G., Buscarinu, M.C., Reni\u00e8, R., Marrone, A., Nasello, M., Zancan, V., Nistri, R., Palumbo, R., and Salerno, A. (2022). CNS Inflammatory Demyelinating Events after COVID-19 Vaccines: A Case Series and Systematic Review. Front. Neurol., 13.","DOI":"10.3389\/fneur.2022.1018785"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"703","DOI":"10.3233\/JAD-221231","article-title":"The Impact of Routine Vaccinations on Alzheimer\u2019s Disease Risk in Persons 65 Years and Older: A Claims-Based Cohort Study Using Propensity Score Matching","volume":"95","author":"Harris","year":"2023","journal-title":"J. Alzheimers Dis."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/s41541-025-01247-1","article-title":"DNA Vaccine Targeting Betacoronavirus Spike Protein Blocks Neuroinvasion and Neuroinflammation in Swine via Dual Antiviral-Immunomodulatory Action","volume":"10","author":"Yu","year":"2025","journal-title":"NPJ Vaccines"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s11940-025-00827-9","article-title":"Vaccine Based Approaches for the Prevention and Treatment of Neurological Disease","volume":"27","author":"Aderinto","year":"2025","journal-title":"Curr. Treat. Options Neurol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"e4748","DOI":"10.1002\/ejp.4748","article-title":"Moving towards the Use of Artificial Intelligence in Pain Management","volume":"29","author":"Antel","year":"2025","journal-title":"Eur. J. Pain Lond. Engl."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"110725","DOI":"10.1016\/j.diabres.2023.110725","article-title":"Machine Learning Analysis of the UK Biobank Reveals Prognostic and Diagnostic Immune Biomarkers for Polyneuropathy and Neuropathic Pain in Diabetes","volume":"201","author":"Allwright","year":"2023","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s12985-024-02400-3","article-title":"Development and Validation of a Prognostic Model for Assessing Long COVID Risk Following Omicron Wave\u2014A Large Population-Based Cohort Study","volume":"21","author":"Fang","year":"2024","journal-title":"Virol. J."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"3332","DOI":"10.1212\/WNL.0000000000203193","article-title":"Use of Individual Measure and Z-Scores to Monitor Disease Course in Relapsing Multiple Sclerosis: A 1-Year Prospective Study in a Single Center (P5-3.012)","volume":"100","author":"Reddam","year":"2023","journal-title":"Neurology"},{"key":"ref_149","unstructured":"National Institutes of Health (NIH) (2025, October 05). NIH RECOVER Makes Long COVID Data Easier to Access, Available online: https:\/\/www.nih.gov\/news-events\/news-releases\/nih-recover-makes-long-covid-data-easier-access."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"100007","DOI":"10.1016\/j.inhs.2025.100007","article-title":"A Review Article on \u201cAI-Guided Discovery of Novel Anti-Inflammatory Agents for Cancer Therapy: A New Era in Drug Development","volume":"1","author":"Paithankar","year":"2025","journal-title":"\u201d Intell. Hosp."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1","DOI":"10.33425\/2639-846X.1051","article-title":"Personalized Pain Therapy: An Artificial Intelligence (AI) Method and Web-Tool to Predict Patient Response to OTC Topical Analgesics","volume":"5","author":"Gudin","year":"2021","journal-title":"Anesth. Pain Res."},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Froicu, E.-M., Onicescu, O.-M., Creang\u0103-Murariu, I., Dasc\u0103lu, C., Gafton, B., Afr\u0103s\u00e2nie, V.-A., Alexa-Stratulat, T., Marinca, M.-V., Pu\u0219ca\u0219u, D.-M., and Miron, L. (2025). Modeling Pain Dynamics and Opioid Response in Oncology Inpatients: A Retrospective Study with Application to AI-Guided Analgesic Strategies in Colorectal Cancer. Medicina, 61.","DOI":"10.3390\/medicina61101741"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/23\/11383\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T15:03:23Z","timestamp":1764774203000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/23\/11383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,25]]},"references-count":152,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["ijms262311383"],"URL":"https:\/\/doi.org\/10.3390\/ijms262311383","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,25]]}}}