{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T17:33:14Z","timestamp":1774891994419,"version":"3.50.1"},"reference-count":49,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Grants-in-Aid for Scientific Research","doi-asserted-by":"crossref","award":["20H00333"],"award-info":[{"award-number":["20H00333"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Grants-in-Aid for Scientific Research","doi-asserted-by":"crossref","award":["24K01298"],"award-info":[{"award-number":["24K01298"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Grants-in-Aid for Scientific Research","doi-asserted-by":"crossref","award":["24K08200"],"award-info":[{"award-number":["24K08200"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Grant-in-Aid for Early-Career Scientists","award":["21K14495"],"award-info":[{"award-number":["21K14495"]}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004442","name":"National Science Centre","doi-asserted-by":"crossref","award":["2017\/26\/E\/ST4\/00987"],"award-info":[{"award-number":["2017\/26\/E\/ST4\/00987"]}],"id":[{"id":"10.13039\/501100004442","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>We investigated the adsorption and aggregation properties of 2,13-bis(hydroxymethyl)-[7]thiaheterohelicene ([7]TH-diol) on the Ag(111) surface by scanning tunneling microscopy (STM) and molecular dynamics (MD) simulation. STM observation revealed that both racemic and enantiopure [7]TH-diol formed apparently similar \u201czigzag\u201d chain structures. To elucidate the molecular arrangements in these structures, MD simulation successfully differentiates the formation mechanisms of these structures, demonstrating that hetero-chiral chains are stabilized primarily by van der Waals forces, whereas homo-chiral chains are stabilized through hydrogen bonding. The formation of homo-chiral chains is driven by the alignment of hydroxymethyl groups between the neighboring molecules, whereas the steric hindrance of helical skeletons affects chain growth. These findings highlight the critical role of inter-molecular interactions\u2014particularly hydrogen bonding\u2014in the self-assembly of helicene molecules.<\/jats:p>","DOI":"10.3390\/ijms262311458","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T15:56:41Z","timestamp":1764172601000},"page":"11458","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Chiral Recognition Mechanism of 2,13-Bis(hydroxymethyl)-[7]thiaheterohelicene on Ag(111) Investigated by STM and MD Simulation"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8133-9168","authenticated-orcid":false,"given":"Changqing","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Precision Engineering, Graduate School of Engineering, The University of Osaka, 2-1 Yamada-oka, Suita 565-0871, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0339-1847","authenticated-orcid":false,"given":"Takuma","family":"Hattori","sequence":"additional","affiliation":[{"name":"Department of Precision Engineering, Graduate School of Engineering, The University of Osaka, 2-1 Yamada-oka, Suita 565-0871, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4377-7015","authenticated-orcid":false,"given":"Yuji","family":"Hamamoto","sequence":"additional","affiliation":[{"name":"Department of Precision Engineering, Graduate School of Engineering, The University of Osaka, 2-1 Yamada-oka, Suita 565-0871, Osaka, Japan"},{"name":"Department of Communication Engineering, Okayama Prefectural University, 111 Kuboki, Soja 719-1197, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1368-6908","authenticated-orcid":false,"given":"Pawel","family":"Krukowski","sequence":"additional","affiliation":[{"name":"Department of Solid State Physics, Faculty of Physics and Applied Informatics, University of Lodz, Pomorska 149\/152, 90-236 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3859-5575","authenticated-orcid":false,"given":"Akira","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Precision Engineering, Graduate School of Engineering, The University of Osaka, 2-1 Yamada-oka, Suita 565-0871, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8910-7469","authenticated-orcid":false,"given":"Hideji","family":"Osuga","sequence":"additional","affiliation":[{"name":"Faculty of Systems Engineering, Wakayama University, 930 Sakaedani, Wakayama 640-8510, Wakayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4895-4121","authenticated-orcid":false,"given":"Yoshitada","family":"Morikawa","sequence":"additional","affiliation":[{"name":"Department of Precision Engineering, Graduate School of Engineering, The University of Osaka, 2-1 Yamada-oka, Suita 565-0871, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8140-7877","authenticated-orcid":false,"given":"Yuji","family":"Kuwahara","sequence":"additional","affiliation":[{"name":"Department of Precision Engineering, Graduate School of Engineering, The University of Osaka, 2-1 Yamada-oka, Suita 565-0871, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1038\/s41557-020-00561-6","article-title":"Exploiting attractive non-covalent interactions for the enantioselective catalysis of reactions involving radical intermediates","volume":"12","author":"Proctor","year":"2020","journal-title":"Nat. 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