{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T22:17:52Z","timestamp":1780525072204,"version":"3.54.1"},"reference-count":116,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Vitamin D exists in various forms and plays a central role in the absorption and regulation of calcium and phosphate. In chronic kidney disease, vitamin D concentrations become progressively reduced with the deterioration of kidney function, which becomes even more pronounced in end-stage kidney disease. Herein, we aim to summarize existing data regarding the pathogenetic role of vitamin D in dialysis and the potential effect of supplementation of various forms of vitamin D on hard and surrogate clinical endpoints. We performed a narrative review, gathering existing observational and clinical studies from 2001 to 2025 in English in the Medline\/PubMed database, along with current guidelines and consensus statements regarding the use of vitamin D and D analogues in end-stage kidney disease patients. Vitamin D should be monitored and corrected, but supraphysiologic doses should be avoided, as well as very high levels of vitamin D to avoid toxicity. In dialysis, native D is used only to correct vitamin D deficiency; the real target here is secondary hyperparathyroidism, where vitamin D analogues and calcimimetics should be administered.<\/jats:p>","DOI":"10.3390\/ijms262311550","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T11:19:51Z","timestamp":1764328791000},"page":"11550","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Vitamin D and Vitamin D Analogues in Hemodialysis Patients: A Review of the Literature"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9366-7466","authenticated-orcid":false,"given":"Konstantia","family":"Kantartzi","sequence":"first","affiliation":[{"name":"Department of Nephrology, University Hospital of Alexandroupolis, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9423-649X","authenticated-orcid":false,"given":"Stefanos","family":"Roumeliotis","sequence":"additional","affiliation":[{"name":"2nd Department of Nephrology, AHEPA University Hospital Medical School, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Polychronidis","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University Hospital of Alexandroupolis, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Zafeiri","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University Hospital of Alexandroupolis, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0314-9794","authenticated-orcid":false,"given":"Athanasios","family":"Roumeliotis","sequence":"additional","affiliation":[{"name":"2nd Department of Nephrology, AHEPA University Hospital Medical School, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Leivaditis","sequence":"additional","affiliation":[{"name":"2nd Department of Nephrology, AHEPA University Hospital Medical School, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7564-2724","authenticated-orcid":false,"given":"Vassilios","family":"Liakopoulos","sequence":"additional","affiliation":[{"name":"2nd Department of Nephrology, AHEPA University Hospital Medical School, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S117","DOI":"10.1016\/j.kint.2023.10.018","article-title":"KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease","volume":"105","author":"Stevens","year":"2024","journal-title":"Kidney Int."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Saponaro, F., Saba, A., and Zucchi, R. 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