{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:20:56Z","timestamp":1792603256526,"version":"4.5.0"},"reference-count":268,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>It has been demonstrated that prolonged exposure to stress engenders a plethora of neuropsychiatric, immune and metabolic disorders. However, its pathophysiology transcends the conventional hypothalamic\u2013pituitary\u2013adrenal (HPA) axis. This review addresses the central question of how integrated neural and microbial pathways regulate stress responses and resilience. We present a model in which the parasympathetic nervous system (particularly the vagus nerve) and the gut microbiota interact to form a bidirectional neuroimmune network that modulates the HPA axis, immune function, neurotransmitter balance, and metabolic adaptation. Key molecular pathways include nitric oxide synthesis via the classical nitric oxide synthase (NOS)-dependent and microbiota-mediated nitrate\u2013nitrite routes, inducible nitric oxide synthase (iNOS) regulation, nuclear factor erythroid 2-related factor 2 (Nrf2) signalling, lysosomal function, autophagy and the cholinergic anti-inflammatory reflex. Other pathways include the gamma-aminobutyric acid (GABA) and serotonin (5-HT) systems, NF-\u03baB (nuclear factor kappa-light-chain-enhancer of activated B cells) signalling, polyamine metabolism and peroxisome proliferator-activated receptor gamma (PPAR\u03b3). Intermittent hypoxia training (IHT) enhances mitochondrial function, oxidative stress responses, autonomic balance and gut microbiota composition. This promotes parasympathetic activity and stress resilience that is tailored to the individual. These adaptations support the concept of personalised stress response profiles based on hypoxic adaptability. Clinical implications include combining IHT with vagus nerve stimulation, probiotics, dietary strategies, and stress reduction techniques. Monitoring vagal tone and microbiota composition could also serve as predictive biomarkers for personalised interventions in stress-related disorders. This integrative framework highlights the therapeutic potential of targeting the parasympathetic system and the gut microbiota to modulate stress.<\/jats:p>","DOI":"10.3390\/ijms262311706","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T10:34:01Z","timestamp":1764758041000},"page":"11706","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Integrative Neuroimmune Role of the Parasympathetic Nervous System, Vagus Nerve and Gut Microbiota in Stress Modulation: A Narrative Review"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4669-1092","authenticated-orcid":false,"given":"Natalia","family":"Kurhaluk","sequence":"first","affiliation":[{"name":"Institute of Biology, Pomeranian University in S\u0142upsk, Arciszewski St. 22 B, 76-200 S\u0142upsk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7277-721X","authenticated-orcid":false,"given":"Renata","family":"Ko\u0142odziejska","sequence":"additional","affiliation":[{"name":"Department of Medical Biology and Biochemistry, Collegium Medicum in Bydgoszcz, Nicholaus Copernicus University, M. Kar\u0142owicz St. 24, 85-092 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1978-6018","authenticated-orcid":false,"given":"Piotr","family":"Kami\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Medical Biology and Biochemistry, Division of Ecology and Environmental Protection, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toru\u0144, M. Sk\u0142odowska-Curie St. 9, 85-094 Bydgoszcz, Poland"},{"name":"Department of Biotechnology, Institute of Biological Sciences, Faculty of Biological Sciences, University of Zielona G\u00f3ra, Prof. Z. Szafran St. 1, 65-516 Zielona G\u00f3ra, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3951-9005","authenticated-orcid":false,"given":"Halina","family":"Tkaczenko","sequence":"additional","affiliation":[{"name":"Institute of Biology, Pomeranian University in S\u0142upsk, Arciszewski St. 22 B, 76-200 S\u0142upsk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Knezevic, E., Nenic, K., Milanovic, V., and Knezevic, N.N. (2023). The Role of Cortisol in Chronic Stress, Neurodegenerative Diseases, and Psychological Disorders. Cells, 12.","DOI":"10.3390\/cells12232726"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/mds.26069","article-title":"Gut Microbiota Are Related to Parkinson\u2019s Disease and Clinical Phenotype","volume":"30","author":"Scheperjans","year":"2015","journal-title":"Mov. Disord."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e143768","DOI":"10.1172\/JCI143768","article-title":"The Gut, Its Microbiome, and the Brain: Connections and Communications","volume":"131","author":"Gershon","year":"2021","journal-title":"J. Clin. Investig."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Chang, X., Zhang, Y., Chen, X., Li, S., Mei, H., Xiao, H., Ma, X., Liu, Z., and Li, R. (2024). Gut Microbiome and Serum Amino Acid Metabolome Alterations in Autism Spectrum Disorder. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-54717-2"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.4103\/1673-5374.373673","article-title":"Gut-Microbiome-Brain Axis: The Crosstalk between the Vagus Nerve, Alpha-Synuclein and the Brain in Parkinson\u2019s Disease","volume":"18","author":"Oliveira","year":"2023","journal-title":"Neural Regen. Res."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Bauer, K.C., Trehan, R., Ruf, B., Myojin, Y., Benmebarek, M.R., Ma, C., Seifert, M., Nur, A., Qi, J., and Huang, P. (2024). The Gut Microbiome Controls Liver Tumors via the Vagus Nerve. bioRxiv.","DOI":"10.1101\/2024.01.23.576951"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1038\/bjp.2008.185","article-title":"Acetylcholine beyond Neurons: The Non-Neuronal Cholinergic System in Humans","volume":"154","author":"Wessler","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/s41575-019-0157-3","article-title":"The Role of Short-Chain Fatty Acids in Microbiota-Gut-Brain Communication","volume":"16","author":"Dalile","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"4923","DOI":"10.1113\/JP276431","article-title":"Short-Chain Fatty Acids: Microbial Metabolites That Alleviate Stress-Induced Brain-Gut Axis Alterations","volume":"596","author":"Boehme","year":"2018","journal-title":"J. Physiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"6213","DOI":"10.2147\/JIR.S384949","article-title":"Vagus Nerve and Underlying Impact on the Gut Microbiota-Brain Axis in Behavior and Neurodegenerative Diseases","volume":"15","author":"Han","year":"2022","journal-title":"J. Inflamm. Res."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Tan, C., Yan, Q., Ma, Y., Fang, J., and Yang, Y. (2022). Recognizing the Role of the Vagus Nerve in Depression from Microbiota-Gut-Brain Axis. Front. Neurol., 13.","DOI":"10.3389\/fneur.2022.1015175"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Ullah, H., Arbab, S., Tian, Y., Liu, C.Q., Chen, Y., Qijie, L., Khan, M.I.U., Hassan, I.U., and Li, K. (2023). The Gut Microbiota-Brain Axis in Neurological Disorder. Front. Neurosci., 17.","DOI":"10.3389\/fnins.2023.1225875"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Rutsch, A., Kantsj\u00f6, J.B., and Ronchi, F. (2020). The Gut-Brain Axis: How Microbiota and Host Inflammasome Influence Brain Physiology and Pathology. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.604179"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Silva, Y.P., Bernardi, A., and Frozza, R.L. (2020). The Role of Short-Chain Fatty Acids from Gut Microbiota in Gut-Brain Communication. Front. Endocrinol., 11.","DOI":"10.3389\/fendo.2020.00025"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/j.2040-4603.2016.tb00694.x","article-title":"Regulation of the Hypothalamic-Pituitary-Adrenocortical Stress Response","volume":"6","author":"Herman","year":"2016","journal-title":"Compr. Physiol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Kinlein, S.A., and Karatsoreos, I.N. (2020). The Hypothalamic-Pituitary-Adrenal Axis as a Substrate for Stress Resilience: Interactions with the Circadian Clock. Front. Neuroendocrinol., 56.","DOI":"10.1016\/j.yfrne.2019.100819"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Bonaz, B., Sinniger, V., and Pellissier, S. (2017). The Vagus Nerve in the Neuro-Immune Axis: Implications in the Pathology of the Gastrointestinal Tract. Front. Immunol., 8.","DOI":"10.3389\/fimmu.2017.01452"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Bonaz, B., Bazin, T., and Pellissier, S. (2018). The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis. Front. Neurosci., 12.","DOI":"10.3389\/fnins.2018.00049"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Kim, M.E., and Lee, J.S. (2025). Advances in the Regulation of Inflammatory Mediators in Nitric Oxide Synthase: Implications for Disease Modulation and Therapeutic Approaches. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26031204"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Hong, P.P., Zhu, X.X., Yuan, W.J., Niu, G.J., and Wang, J.X. (2021). Nitric Oxide Synthase Regulates Gut Microbiota Homeostasis by ERK-NF-\u03baB Pathway in Shrimp. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.778098"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Huang, Y., Chen, Y., Xie, H., Feng, Y., Chen, S., and Bao, B. (2024). Effects of Inducible Nitric Oxide Synthase (iNOS) Gene Knockout on the Diversity, Composition, and Function of Gut Microbiota in Adult Zebrafish. Biology, 13.","DOI":"10.3390\/biology13060372"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Shi, Y., and Wu, W. (2023). Multimodal Non-Invasive Non-Pharmacological Therapies for Chronic Pain: Mechanisms and Progress. BMC Med., 21.","DOI":"10.1186\/s12916-023-03076-2"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1146\/annurev-publhealth-052120-101420","article-title":"Environmental Factors Influencing COVID-19 Incidence and Severity","volume":"43","author":"Weaver","year":"2022","journal-title":"Annu. Rev. Public Health"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e825","DOI":"10.1016\/S2542-5196(22)00174-7","article-title":"Interactions between Climate and COVID-19","volume":"6","author":"Ford","year":"2022","journal-title":"Lancet Planet. Health"},{"key":"ref_25","unstructured":"Tindle, J., and Tadi, P. (2025, May 30). Neuroanatomy, Parasympathetic Nervous System, StatPearls, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK553141\/."},{"key":"ref_26","unstructured":"Waxenbaum, J.A., Reddy, V., and Varacallo, M.A. (2025). Anatomy, Autonomic Nervous System. StatPearls, StatPearls Publishing. [Updated 24 July 2023]."},{"key":"ref_27","unstructured":"S\u00e1nchez-Manso, J.C., Gujarathi, R., and Varacallo, M.A. (2025). Autonomic Dysfunction. StatPearls, StatPearls Publishing. [Updated 4 August 2023]."},{"key":"ref_28","unstructured":"Carlson, A.B., and Kraus, G.P. (2025, May 30). Physiology, Cholinergic Receptors, StatPearls, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK526134\/."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Tanahashi, Y., Komori, S., Matsuyama, H., Kitazawa, T., and Unno, T. (2021). Functions of Muscarinic Receptor Subtypes in Gastrointestinal Smooth Muscle: A Review of Studies with Receptor-Knockout Mice. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22020926"},{"key":"ref_30","unstructured":"Sam, C., and Bordoni, B. (2025, May 30). Physiology, Acetylcholine, StatPearls, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK557825\/."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Tizabi, Y., Getachew, B., Tsytsarev, V., Csoka, A.B., Copeland, R.L., and Heinbockel, T. (2023). Central Nicotinic and Muscarinic Receptors in Health and Disease. Acetylcholine\u2014Recent Advances and New Perspectives, IntechOpen.","DOI":"10.5772\/intechopen.112447"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Tsimpili, H., and Zoidis, G. (2025). A New Era of Muscarinic Acetylcholine Receptor Modulators in Neurological Diseases, Cancer and Drug Abuse. Pharmaceuticals, 18.","DOI":"10.3390\/ph18030369"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1097\/00001756-199404000-00013","article-title":"Modulation of Cholinergic Transmission by Nitric Oxide, VIP and ATP in the Gastric Muscle","volume":"5","author":"Baccari","year":"1994","journal-title":"Neuroreport"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1006\/jsre.1999.5590","article-title":"Role of Nitric Oxide, Vasoactive Intestinal Polypeptide, and ATP in Inhibitory Neurotransmission in Human Jejunum","volume":"84","author":"Murr","year":"1999","journal-title":"J. Surg. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/978-1-4939-0897-4_9","article-title":"Neuropeptides and the Microbiota-Gut-Brain Axis","volume":"817","author":"Holzer","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1152\/physiol.00023.2021","article-title":"Targeting Parasympathetic Activity to Improve Autonomic Tone and Clinical Outcomes","volume":"37","author":"Kay","year":"2022","journal-title":"Physiology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.bbi.2005.03.015","article-title":"The Cholinergic Anti-Inflammatory Pathway","volume":"19","author":"Pavlov","year":"2005","journal-title":"Brain Behav. Immun."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/nature01321","article-title":"The Inflammatory Reflex","volume":"420","author":"Tracey","year":"2002","journal-title":"Nature"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1177\/09680519030090060401","article-title":"Neural Inhibition of Inflammation: The Cholinergic Anti-Inflammatory Pathway","volume":"9","author":"Czura","year":"2003","journal-title":"J. Endotoxin Res."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Breit, S., Kupferberg, A., Rogler, G., and Hasler, G. (2018). Vagus Nerve as Modulator of the Brain-Gut Axis in Psychiatric and Inflammatory Disorders. Front. Psychiatry, 9.","DOI":"10.3389\/fpsyt.2018.00044"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1111\/cns.14207","article-title":"Anti-Neuroinflammation Effects of Transcutaneous Auricular Vagus Nerve Stimulation Against Depression-Like Behaviors via Hypothalamic \u03b17nAchR\/JAK2\/STAT3\/NF-\u03baB Pathway in Rats Exposed to Chronic Unpredictable Mild Stress","volume":"29","author":"Chen","year":"2023","journal-title":"CNS Neurosci. Ther."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"567","DOI":"10.2119\/2008-00079.Parrish","article-title":"Modulation of TNF Release by Choline Requires Alpha7 Subunit Nicotinic Acetylcholine Receptor-Mediated Signaling","volume":"14","author":"Parrish","year":"2008","journal-title":"Mol. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"106790","DOI":"10.1016\/j.phrs.2023.106790","article-title":"Autoimmunity to Neuronal Nicotinic Acetylcholine Receptors","volume":"192","author":"Pechlivanidou","year":"2023","journal-title":"Pharmacol. Res."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Mashimo, M., Moriwaki, Y., Misawa, H., Kawashima, K., and Fujii, T. (2021). Regulation of Immune Functions by Non-Neuronal Acetylcholine (ACh) via Muscarinic and Nicotinic ACh Receptors. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22136818"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.intimp.2015.04.015","article-title":"Non-Neuronal Cholinergic System in Regulation of Immune Function with a Focus on \u03b17 nAChRs","volume":"29","author":"Kawashima","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Reale, M., and Costantini, E. (2021). Cholinergic Modulation of the Immune System in Neuroinflammatory Diseases. Diseases, 9.","DOI":"10.3390\/diseases9020029"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.bbi.2024.11.023","article-title":"The Vagus Nerve: An Old but New Player in Brain-Body Communication","volume":"124","author":"Ma","year":"2025","journal-title":"Brain Behav. Immun."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Che Mohd Nassir, C.M.N., Che Ramli, M.D., Mohamad Ghazali, M., Jaffer, U., Abdul Hamid, H., Mehat, M.Z., and Hein, Z.M. (2024). The Microbiota-Gut-Brain Axis: Key Mechanisms Driving Glymphopathy and Cerebral Small Vessel Disease. Life, 15.","DOI":"10.20944\/preprints202411.0255.v1"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Kurhaluk, N. (2024). Tricarboxylic Acid Cycle Intermediates and Individual Ageing. Biomolecules, 14.","DOI":"10.3390\/biom14030260"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.pharmthera.2007.03.010","article-title":"Effects of Exercise Training on the Cardiovascular System: Pharmacological Approaches","volume":"114","author":"Zanesco","year":"2007","journal-title":"Pharmacol. Ther."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Hadad, R., Akobe, S.F., Weber, P., Madsen, C.V., Larsen, B.S., Madsbad, S., Nielsen, O.W., Dominguez, M.H., Haugaard, S.B., and Sajadieh, A. (2022). Parasympathetic Tonus in Type 2 Diabetes and Pre-Diabetes and Its Clinical Implications. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-22675-2"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e160721189770","DOI":"10.2174\/1573403X16999201231203854","article-title":"Analysis of Heart Rate Variability and Implication of Different Factors on Heart Rate Variability","volume":"17","author":"Tiwari","year":"2021","journal-title":"Curr. Cardiol. Rev."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Laborde, S., Mosley, E., and Thayer, J.F. (2017). Heart Rate Variability and Cardiac Vagal Tone in Psychophysiological Research\u2014Recommendations for Experiment Planning, Data Analysis, and Data Reporting. Front. Psychol., 8.","DOI":"10.3389\/fpsyg.2017.00213"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e13174","DOI":"10.1111\/eci.13174","article-title":"Heart Rate Variability in Atrial Fibrillation: The Balance between Sympathetic and Parasympathetic Nervous System","volume":"49","author":"Khan","year":"2019","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Sic, A., Bogicevic, M., Brezic, N., Nemr, C., and Knezevic, N.N. (2025). Chronic Stress and Headaches: The Role of the HPA Axis and Autonomic Nervous System. Biomedicines, 13.","DOI":"10.3390\/biomedicines13020463"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/head.12650","article-title":"Vagus Nerve and Vagus Nerve Stimulation, a Comprehensive Review: Part II","volume":"56","author":"Yuan","year":"2016","journal-title":"Headache"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.neuron.2021.12.020","article-title":"Internal Senses of the Vagus Nerve","volume":"110","author":"Prescott","year":"2022","journal-title":"Neuron"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1007\/s11910-023-01323-w","article-title":"Vagus Nerve Stimulation in Ischemic Stroke","volume":"23","author":"Andalib","year":"2023","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Hwang, Y.K., and Oh, J.S. (2025). Interaction of the Vagus Nerve and Serotonin in the Gut-Brain Axis. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26031160"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"78","DOI":"10.5688\/aj710478","article-title":"Physiology of the Autonomic Nervous System","volume":"71","author":"McCorry","year":"2007","journal-title":"Am. J. Pharm. Educ."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1016\/j.lfs.2007.01.002","article-title":"Neuro-Immune Interactions via the Cholinergic Anti-Inflammatory Pathway","volume":"80","author":"Pavlov","year":"2007","journal-title":"Life Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/s41390-018-0270-y","article-title":"Absence of Gut Microbial Colonization Attenuates the Sympathoadrenal Response to Hypoglycemic Stress in Mice: Implications for Human Neonates","volume":"85","author":"Giri","year":"2019","journal-title":"Pediatr. Res."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"LaGamma, E.F., Hu, F., Pena Cruz, F., Bouchev, P., and Nankova, B.B. (2021). Bacteria-Derived Short Chain Fatty Acids Restore Sympathoadrenal Responsiveness to Hypoglycemia after Antibiotic-Induced Gut Microbiota Depletion. Neurobiol. Stress, 15.","DOI":"10.1016\/j.ynstr.2021.100376"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1053\/j.gastro.2020.10.066","article-title":"The Microbiota-Gut-Brain Axis: From Motility to Mood","volume":"160","author":"Margolis","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/978-3-642-23274-9_20","article-title":"Activation of Muscarinic Receptors by Non-Neuronal Acetylcholine","volume":"208","author":"Wessler","year":"2012","journal-title":"Handb. Exp. Pharmacol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/jnc.13953","article-title":"Non-Neuronal Acetylcholine Involved in Reproduction in Mammals and Honeybees","volume":"142","author":"Wessler","year":"2017","journal-title":"J. Neurochem."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.2741\/1390","article-title":"Expression of Non-Neuronal Acetylcholine in Lymphocytes and Its Contribution to the Regulation of Immune Function","volume":"9","author":"Kawashima","year":"2004","journal-title":"Front. Biosci."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Fujii, T., Mashimo, M., Moriwaki, Y., Misawa, H., Ono, S., Horiguchi, K., and Kawashima, K. (2017). Expression and Function of the Cholinergic System in Immune Cells. Front. Immunol., 8.","DOI":"10.3389\/fimmu.2017.01085"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Shelukhina, I., Siniavin, A., Kasheverov, I., Ojomoko, L., Tsetlin, V., and Utkin, Y. (2023). \u03b17- and \u03b19-Containing Nicotinic Acetylcholine Receptors in the Functioning of Immune System and in Pain. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24076524"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"103678","DOI":"10.1016\/j.autrev.2024.103678","article-title":"Neuroimmune Communication of the Cholinergic System in Gut Inflammation and Autoimmunity","volume":"23","author":"Halder","year":"2024","journal-title":"Autoimmun. Rev."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jneuroim.2013.12.003","article-title":"SLURP-1, an Endogenous \u03b17 Nicotinic Acetylcholine Receptor Allosteric Ligand, Is Expressed in CD205(+) Dendritic Cells in Human Tonsils and Potentiates Lymphocytic Cholinergic Activity","volume":"267","author":"Fujii","year":"2014","journal-title":"J. Neuroimmunol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/nrendo.2012.189","article-title":"The Vagus Nerve and the Inflammatory Reflex\u2014Linking Immunity and Metabolism","volume":"8","author":"Pavlov","year":"2012","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jphs.2017.05.002","article-title":"Physiological Functions of the Cholinergic System in Immune Cells","volume":"134","author":"Fujii","year":"2017","journal-title":"J. Pharmacol. Sci."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Mashimo, M., Komori, M., Matsui, Y.Y., Murase, M.X., Fujii, T., Takeshima, S., Okuyama, H., Ono, S., Moriwaki, Y., and Misawa, H. (2019). Distinct Roles of \u03b17 nAChRs in Antigen-Presenting Cells and CD4+ T Cells in the Regulation of T Cell Differentiation. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.01102"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.conb.2020.01.017","article-title":"Functions of Acetylcholine-Producing Lymphocytes in Immunobiology","volume":"62","author":"Malin","year":"2020","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s11154-020-09584-3","article-title":"Therapeutic Potential of \u03b17 Nicotinic Acetylcholine Receptor Agonists to Combat Obesity, Diabetes, and Inflammation","volume":"21","author":"Xie","year":"2020","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1038\/nbt.3663","article-title":"Blood Pressure Regulation by CD4+ Lymphocytes Expressing Choline Acetyltransferase","volume":"34","author":"Olofsson","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/s41577-019-0160-5","article-title":"Immune Mechanisms of Hypertension","volume":"19","author":"Drummond","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"G920","DOI":"10.1152\/ajpgi.00114.2016","article-title":"Acetylcholine-Producing T Cells in the Intestine Regulate Antimicrobial Peptide Expression and Microbial Diversity","volume":"311","author":"Dhawan","year":"2016","journal-title":"Am. J. Physiol.-Gastrointest. Liver Physiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"9059601","DOI":"10.1155\/2021\/9059601","article-title":"The Regulation Effect of \u03b17nAChRs and M1AChRs on Inflammation and Immunity in Sepsis","volume":"2021","author":"Hu","year":"2021","journal-title":"Mediat. Inflamm."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1038\/sj.ijo.0801278","article-title":"The Role of Stress and the Hypothalamic-Pituitary-Adrenal Axis in the Pathogenesis of the Metabolic Syndrome: Neuro-Endocrine and Target Tissue-Related Causes","volume":"24","author":"Chrousos","year":"2000","journal-title":"Int. J. Obes."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0022-3999(02)00429-4","article-title":"Hypothalamic-Pituitary-Adrenal Axis, Neuroendocrine Factors and Stress","volume":"53","author":"Tsigos","year":"2002","journal-title":"J. Psychosom. Res."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Park, S., and Wu, X. (2022). Modulation of the Gut Microbiota in Memory Impairment and Alzheimer\u2019s Disease via the Inhibition of the Parasympathetic Nervous System. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232113574"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3892\/mi.2025.236","article-title":"Harnessing Non-Invasive Vagal Neuromodulation: HRV Biofeedback and SSP for Cardiovascular and Autonomic Regulation (Review)","volume":"5","author":"Gitler","year":"2025","journal-title":"Med. Int."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"e12643","DOI":"10.1111\/jne.12643","article-title":"The Role of the Vagus Nerve in Appetite Control: Implications for the Pathogenesis of Obesity","volume":"30","author":"Cork","year":"2018","journal-title":"J. Neuroendocrinol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1007\/s00592-023-02088-x","article-title":"Microbiota-Gut-Brain Axis: Relationships among the Vagus Nerve, Gut Microbiota, Obesity, and Diabetes","volume":"60","author":"Longo","year":"2023","journal-title":"Acta Diabetol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1177\/10738584241259702","article-title":"Vagus Nerve and Gut-Brain Communication","volume":"31","author":"Wang","year":"2025","journal-title":"Neuroscientist"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/s12964-023-01219-9","article-title":"Short-Chain Fatty Acids in Diseases","volume":"21","author":"Zhang","year":"2023","journal-title":"Cell Commun. Signal."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"111572","DOI":"10.1016\/j.mce.2022.111572","article-title":"Short Chain Fatty Acids: Microbial Metabolites for Gut-Brain Axis Signalling","volume":"546","author":"Collins","year":"2022","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"2102878","DOI":"10.1080\/19490976.2022.2102878","article-title":"Microbiota-Derived Metabolites as Drivers of Gut-Brain Communication","volume":"14","author":"Ahmed","year":"2022","journal-title":"Gut Microbes"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Guzel, T., and Mirowska-Guzel, D. (2022). The Role of Serotonin Neurotransmission in Gastrointestinal Tract and Pharmacotherapy. Molecules, 27.","DOI":"10.3390\/molecules27051680"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1093\/procel\/pwad026","article-title":"The Microbiota-Gut-Brain Axis and Neurodevelopmental Disorders","volume":"14","author":"Wang","year":"2023","journal-title":"Protein Cell"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"e656","DOI":"10.1002\/mco2.656","article-title":"The gut microbiota-brain axis in neurological disorders","volume":"5","author":"You","year":"2024","journal-title":"MedComm"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"102515","DOI":"10.1016\/j.arr.2024.102515","article-title":"Microglia and Gut Microbiota: A Double-Edged Sword in Alzheimer\u2019s Disease","volume":"101","author":"Bano","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"ref_95","first-page":"3","article-title":"The Higher the Basal Vagal Tone the Better the Motor Imagery Ability","volume":"157","author":"Sebastiani","year":"2019","journal-title":"Arch. Ital. Biol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.semcdb.2023.02.004","article-title":"The Gut-Brain Axis and Cognitive Control: A Role for the Vagus Nerve","volume":"156","author":"Hayes","year":"2024","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"107794","DOI":"10.1016\/j.pharmthera.2020.107794","article-title":"The Evolving Obesity Challenge: Targeting the Vagus Nerve and the Inflammatory Reflex in the Response","volume":"222","author":"Pavlov","year":"2021","journal-title":"Pharmacol. Ther."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ijpsycho.2021.01.015","article-title":"Correlation of Sympathetic and Parasympathetic Nervous System Activity during Rest and Acute Stress Tasks","volume":"162","author":"Weissman","year":"2021","journal-title":"Int. J. Psychophysiol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1093\/nutrit\/nuad131","article-title":"Supplementation with L-Arginine and Nitrates vs Age and Individual Physiological Reactivity","volume":"82","author":"Kurhaluk","year":"2024","journal-title":"Nutr. Rev."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Kurhaluk, N. (2023). The Effectiveness of L-Arginine in Clinical Conditions Associated with Hypoxia. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24098205"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1161\/CIRCRESAHA.116.305484","article-title":"The Ins and Outs of Mitochondrial Calcium","volume":"116","author":"Finkel","year":"2015","journal-title":"Circ. Res."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/19490976.2021.1900996","article-title":"Intestinal Cetobacterium and Acetate Modify Glucose Homeostasis via Parasympathetic Activation in Zebrafish","volume":"13","author":"Wang","year":"2021","journal-title":"Gut Microbes"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"226","DOI":"10.33594\/000000705","article-title":"Adaptive Effects of Intermittent Hypoxia Training on Oxygen-Dependent Processes as a Potential Therapeutic Strategy Tool","volume":"58","author":"Kurhaluk","year":"2024","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Kurhaluk, N., Lukash, O., Kami\u0144ski, P., and Tkaczenko, H. (2024). L-Arginine and Intermittent Hypoxia Are Stress-Limiting Factors in Male Wistar Rat Models. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252212364"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"112154","DOI":"10.1016\/j.exger.2023.112154","article-title":"Alpha-Ketoglutarate as a Potent Regulator for Lifespan and Healthspan: Evidences and Perspectives","volume":"175","author":"Naeini","year":"2023","journal-title":"Exp. Gerontol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1089\/15270290260131939","article-title":"Intermittent Hypoxia Research in the Former Soviet Union and the Commonwealth of Independent States: History and Review of the Concept and Selected Applications","volume":"3","author":"Serebrovskaya","year":"2002","journal-title":"High Alt. Med. Biol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1002\/med.20151","article-title":"Nitrite as Regulator of Hypoxic Signaling in Mammalian Physiology","volume":"29","author":"Bahrami","year":"2009","journal-title":"Med. Res. Rev."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1177\/1535370216657614","article-title":"Intermittent Hypoxia Training as Non-Pharmacologic Therapy for Cardiovascular Diseases: Practical Analysis on Methods and Equipment","volume":"241","author":"Serebrovskaya","year":"2016","journal-title":"Exp. Biol. Med."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1046\/j.1440-1681.1999.03016.x","article-title":"The Cholinergic \u2018Pitfall\u2019: Acetylcholine, a Universal Cell Molecule in Biological Systems, Including Humans","volume":"26","author":"Wessler","year":"1999","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1254\/jjp.85.2","article-title":"The Biological Role of Non-Neuronal Acetylcholine in Plants and Humans","volume":"85","author":"Wessler","year":"2001","journal-title":"Jpn. J. Pharmacol."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Bellocchi, C., Carandina, A., Montinaro, B., Targetti, E., Furlan, L., Rodrigues, G.D., Tobaldini, E., and Montano, N. (2022). The Interplay between Autonomic Nervous System and Inflammation across Systemic Autoimmune Diseases. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23052449"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Gergalova, G., Lykhmus, O., Kalashnyk, O., Koval, L., Chernyshov, V., Kryukova, E., Tsetlin, V., Komisarenko, S., and Skok, M. (2012). Mitochondria Express \u03b17 Nicotinic Acetylcholine Receptors to Regulate Ca2+ Accumulation and Cytochrome c Release: Study on Isolated Mitochondria. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0031361"},{"key":"ref_113","first-page":"e1290","article-title":"Nicotinic Acetylcholine Receptors in Mitochondria: Subunit Composition, Function and Signaling","volume":"3","author":"Skok","year":"2016","journal-title":"Neurotransmitter"},{"key":"ref_114","first-page":"2860","article-title":"Neuroprotective Effect of Intermittent Hypobaric Hypoxia Preconditioning on Cerebral Ischemia\/Reperfusion in Rats","volume":"13","author":"Yue","year":"2020","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.7150\/ijms.86622","article-title":"Intermittent Hypoxia Conditioning: A Potential Multi-Organ Protective Therapeutic Strategy","volume":"20","author":"Zhang","year":"2023","journal-title":"Int. J. Med. Sci."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Bekker, I., Kooistra, A., van Dijk, P.R., Lefrandt, J.D., Veeger, N.J.G.M., and van Beek, A.P. (2025). The Influence of Exercise and Physical Activity on Autonomic Nervous System Function Measured by Heart Rate Variability in Individuals with Type 1 Diabetes Mellitus\u2014A Systematic Review. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26157096"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s11556-021-00278-6","article-title":"Effects of Different Exercise Interventions on Heart Rate Variability and Cardiovascular Health Factors in Older Adults: A Systematic Review","volume":"18","author":"Thielmann","year":"2021","journal-title":"Eur. Rev. Aging Phys. Act."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"El-Malahi, O., Mohajeri, D., Mincu, R., B\u00e4uerle, A., Rothenaicher, K., Knuschke, R., Rammos, C., Rassaf, T., and Lortz, J. (2024). Beneficial Impacts of Physical Activity on Heart Rate Variability: A Systematic Review and Meta-Analysis. PLoS ONE, 19.","DOI":"10.1371\/journal.pone.0299793"},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Ristori, S., Bertoni, G., Bientinesi, E., and Monti, D. (2025). The Role of Nutraceuticals and Functional Foods in Mitigating Cellular Senescence and Its Related Aspects: A Key Strategy for Delaying or Preventing Aging and Neurodegenerative Disorders. Nutrients, 17.","DOI":"10.20944\/preprints202504.0821.v1"},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Tkaczenko, H., and Kurhaluk, N. (2025). Antioxidant-Rich Functional Foods and Exercise: Unlocking Metabolic Health Through Nrf2 and Related Pathways. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26031098"},{"key":"ref_121","first-page":"355","article-title":"Mild Intermittent Hypoxia Exposure Alters Gut Microbiota Composition in Men with Overweight and Obesity. Benef","volume":"13","author":"Venema","year":"2022","journal-title":"Microbes"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Van Meijel, R.L.J., Wang, P., Bouwman, F., Blaak, E.E., Mariman, E.C.M., and Goossens, G.H. (2022). The Effects of Mild Intermittent Hypoxia Exposure on the Abdominal Subcutaneous Adipose Tissue Proteome in Overweight and Obese Men: A First-in-Human Randomized, Single-Blind, and Cross-Over Study. Front. Physiol., 12.","DOI":"10.3389\/fphys.2021.791588"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.5665\/sleep.6176","article-title":"Normoxic Recovery Mimicking Treatment of Sleep Apnea Does Not Reverse Intermittent Hypoxia-Induced Bacterial Dysbiosis and Low-Grade Endotoxemia in Mice","volume":"39","author":"Torres","year":"2016","journal-title":"Sleep"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.2147\/NSS.S484377","article-title":"Associations of Intermittent Hypoxia Burden with Gut Microbiota Dysbiosis in Adult Patients with Obstructive Sleep Apnea","volume":"16","author":"Guo","year":"2024","journal-title":"Nat. Sci. Sleep"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.chom.2021.07.004","article-title":"Alterations in the Gut Microbiota Contribute to Cognitive Impairment Induced by the Ketogenic Diet and Hypoxia","volume":"29","author":"Olson","year":"2021","journal-title":"Cell Host Microbe"},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Zhou, D., Xue, J., Miyamoto, Y., Poulsen, O., Eckmann, L., and Haddad, G.G. (2021). Microbiota Modulates Cardiac Transcriptional Responses to Intermittent Hypoxia and Hypercapnia. Front. Physiol., 12.","DOI":"10.3389\/fphys.2021.680275"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"517","DOI":"10.2147\/NSS.S454297","article-title":"Reoxygenation Mitigates Intermittent Hypoxia-Induced Systemic Inflammation and Gut Microbiota Dysbiosis in High-Fat Diet-Induced Obese Rats","volume":"16","author":"Dong","year":"2024","journal-title":"Nat. Sci. Sleep"},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Li, C., and Shi, S. (2024). Gut Microbiota and Metabolic Profiles in Chronic Intermittent Hypoxia-Induced Rats: Disease-Associated Dysbiosis and Metabolic Disturbances. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1224396"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/s41390-021-01707-z","article-title":"Neonatal Intermittent Hypoxia, Fish Oil, and\/or Antioxidant Supplementation on Gut Microbiota in Neonatal Rats","volume":"92","author":"Bodkin","year":"2022","journal-title":"Pediatr. Res."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Kurhaluk, N., Kami\u0144ski, P., Bilski, R., Ko\u0142odziejska, R., Wo\u017aniak, A., and Tkaczenko, H. (2025). Role of Antioxidants in Modulating the Microbiota-Gut-Brain Axis and Their Impact on Neurodegenerative Diseases. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26083658"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.neuron.2016.06.033","article-title":"GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits","volume":"91","author":"Tremblay","year":"2016","journal-title":"Neuron"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1111\/j.1365-2982.2011.01796.x","article-title":"The Anxiolytic Effect of Bifidobacterium longum NCC3001 Involves Vagal Pathways for Gut-Brain Communication","volume":"23","author":"Bercik","year":"2011","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Lei, A.A., Phang, V.W.X., Lee, Y.Z., Kow, A.S.F., Tham, C.L., Ho, Y.C., and Lee, M.T. (2025). Chronic Stress-Associated Depressive Disorders: The Impact of HPA Axis Dysregulation and Neuroinflammation on the Hippocampus\u2014A Mini Review. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26072940"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"e33214","DOI":"10.1016\/j.heliyon.2024.e33214","article-title":"Therapeutic Effects and Mechanisms of Fecal Microbiota Transplantation on EAE Partly through HPA Axis-Mediated Neuroendocrine Regulation","volume":"10","author":"Xu","year":"2024","journal-title":"Heliyon"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/s41398-025-03326-2","article-title":"Dynamic Alterations of Depressive-Like Behaviors, Gut Microbiome, and Fecal Metabolome in Social Defeat Stress Mice","volume":"15","author":"Li","year":"2025","journal-title":"Transl. Psychiatry"},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Borrego-Ruiz, A., and Borrego, J.J. (2024). An Updated Overview on the Relationship between Human Gut Microbiome Dysbiosis and Psychiatric and Psychological Disorders. Prog. Neuro-Psychopharmacol. Biol. Psychiatry, 128.","DOI":"10.1016\/j.pnpbp.2023.110861"},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Warren, A., Nyavor, Y., Beguelin, A., and Frame, L.A. (2024). Dangers of the Chronic Stress Response in the Context of the Microbiota-Gut-Immune-Brain Axis and Mental Health: A Narrative Review. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1365871"},{"key":"ref_138","first-page":"e67595","article-title":"Hypothalamic-Pituitary-Adrenal (HPA) Axis: Unveiling the Potential Mechanisms Involved in Stress-Induced Alzheimer\u2019s Disease and Depression","volume":"16","author":"P","year":"2024","journal-title":"Cureus"},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Huo, R., Zeng, B., Zeng, L., Cheng, K., Li, B., Luo, Y., Wang, H., Zhou, C., Fang, L., and Li, W. (2017). Microbiota Modulate Anxiety-Like Behavior and Endocrine Abnormalities in Hypothalamic-Pituitary-Adrenal Axis. Front. Cell. Infect. Microbiol., 7.","DOI":"10.3389\/fcimb.2017.00489"},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Saturio, S., Nogacka, A.M., Alvarado-Jasso, G.M., Salazar, N., de Los Reyes-Gavil\u00e1n, C.G., Gueimonde, M., and Arboleya, S. (2021). Role of Bifidobacteria on Infant Health. Microorganisms, 9.","DOI":"10.3390\/microorganisms9122415"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"5393","DOI":"10.1016\/j.cell.2024.07.019","article-title":"Stress-Sensitive Neural Circuits Change the Gut Microbiome via Duodenal Glands","volume":"187","author":"Chang","year":"2024","journal-title":"Cell"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nature18309","article-title":"Acetate Mediates a Microbiome-Brain-\u03b2-Cell Axis to Promote Metabolic Syndrome","volume":"534","author":"Perry","year":"2016","journal-title":"Nature"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.4103\/0366-6999.190667","article-title":"Gut Microbiota-Brain Axis","volume":"129","author":"Wang","year":"2016","journal-title":"Chin. Med. J."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Yang, Y., Eguchi, A., Wan, X., Chang, L., Wang, X., Qu, Y., Mori, C., and Hashimoto, K. (2023). A Role of Gut-Microbiota-Brain Axis via Subdiaphragmatic Vagus Nerve in Depression-Like Phenotypes in Chrna7 Knock-Out Mice. Prog. Neuro-Psychopharmacol. Biol. Psychiatry, 120.","DOI":"10.1016\/j.pnpbp.2022.110652"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Ortega, V.A., Mercer, E.M., Giesbrecht, G.F., and Arrieta, M.C. (2021). Evolutionary Significance of the Neuroendocrine Stress Axis on Vertebrate Immunity and the Influence of the Microbiome on Early-Life Stress Regulation and Health Outcomes. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.634539"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s11011-025-01554-5","article-title":"Gut Microbiota-Derived Short Chain Fatty Acids Act as Mediators of the Gut-Liver-Brain Axis","volume":"40","author":"Li","year":"2025","journal-title":"Metab. Brain Dis."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1868-7083-4-4","article-title":"The Epigenetic Effects of Butyrate: Potential Therapeutic Implications for Clinical Practice","volume":"4","author":"Leone","year":"2012","journal-title":"Clin. Epigenet."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/ame2.12464","article-title":"Role of Short-Chain Fatty Acids in Host Physiology","volume":"7","author":"Liu","year":"2024","journal-title":"Anim. Models Exp. Med."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"R121","DOI":"10.1530\/JME-18-0152","article-title":"Stress and Glucocorticoid Receptor Regulation of Mitochondrial Gene Expression","volume":"62","author":"Lapp","year":"2019","journal-title":"J. Mol. Endocrinol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.bbi.2006.11.006","article-title":"An Inflammatory Review of Glucocorticoid Actions in the CNS","volume":"21","author":"Sorrells","year":"2007","journal-title":"Brain Behav. Immun."},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Nikoli\u0107, T., Bogosavljevi\u0107, M.V., Stojkovi\u0107, T., Kanazir, S., Lon\u010darevi\u0107-Vasiljkovi\u0107, N., Radonji\u0107, N.V., Popi\u0107, J., and Petronijevi\u0107, N. (2024). Effects of Antipsychotics on the Hypothalamus-Pituitary-Adrenal Axis in a Phencyclidine Animal Model of Schizophrenia. Cells, 13.","DOI":"10.3390\/cells13171425"},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Strehl, C., Ehlers, L., Gaber, T., and Buttgereit, F. (2019). Glucocorticoids\u2014All-Rounders Tackling the Versatile Players of the Immune System. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.01744"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s12079-022-00695-x","article-title":"Role of Interleukin-6-Mediated Inflammation in the Pathogenesis of Inflammatory Bowel Disease: Focus on the Available Therapeutic Approaches and Gut Microbiome","volume":"17","author":"Shahini","year":"2023","journal-title":"J. Cell Commun. Signal."},{"key":"ref_154","first-page":"11","article-title":"Involvement and Role of Antidepressant Drugs of the Hypothalamic-Pituitary-Adrenal Axis and Glucocorticoid Receptor Function","volume":"30","author":"Nikisch","year":"2009","journal-title":"Neuro Endocrinol. Lett."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Rusch, J.A., Layden, B.T., and Dugas, L.R. (2023). Signalling Cognition: The Gut Microbiota and Hypothalamic-Pituitary-Adrenal Axis. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1130689"},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Kasarello, K., Cudnoch-Jedrzejewska, A., and Czarzasta, K. (2023). Communication of Gut Microbiota and Brain via Immune and Neuroendocrine Signaling. Front. Microbiol., 14.","DOI":"10.3389\/fmicb.2023.1118529"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"e0041523","DOI":"10.1128\/msystems.00415-23","article-title":"Sodium Butyrate Facilitates CRHR2 Expression to Alleviate HPA Axis Hyperactivity in Autism-Like Rats Induced by Prenatal Lipopolysaccharides through Histone Deacetylase Inhibition","volume":"8","author":"Wang","year":"2023","journal-title":"mSystems"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.arr.2005.03.003","article-title":"The Stress System in the Human Brain in Depression and Neurodegeneration","volume":"4","author":"Swaab","year":"2005","journal-title":"Ageing Res. Rev."},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Savulescu-Fiedler, I., Benea, S.N., C\u0103runtu, C., Nancoff, A.S., Homentcovschi, C., and Bucurica, S. (2025). Rewiring the Brain Through the Gut: Insights into Microbiota-Nervous System Interactions. Curr. Issues Mol. Biol., 47.","DOI":"10.3390\/cimb47070489"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.molmet.2018.03.004","article-title":"Enterochromaffin 5-HT Cells\u2014A Major Target for GLP-1 and Gut Microbial Metabolites","volume":"11","author":"Lund","year":"2018","journal-title":"Mol. Metab."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"5261","DOI":"10.1113\/JP282064","article-title":"Vagus Nerve Stimulation Activates Nucleus of Solitary Tract Neurons via Supramedullary Pathways","volume":"599","author":"Cooper","year":"2021","journal-title":"J. Physiol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"e12904","DOI":"10.1111\/nmo.12904","article-title":"GABA-Producing Bifidobacterium dentium Modulates Visceral Sensitivity in the Intestine","volume":"29","author":"Pokusaeva","year":"2017","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.3390\/cimb44040096","article-title":"Therapeutic Anti-Depressant Potential of Microbial GABA Produced by Lactobacillus rhamnosus Strains for GABAergic Signaling Restoration and Inhibition of Addiction-Induced HPA Axis Hyperactivity","volume":"44","author":"Tette","year":"2022","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/sj.bjp.0707264","article-title":"The Alpha7 Nicotinic Acetylcholine Receptor as a Pharmacological Target for Inflammation","volume":"151","author":"Ulloa","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.chom.2018.05.003","article-title":"Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease","volume":"23","author":"Agus","year":"2018","journal-title":"Cell Host Microbe"},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Savelieva, K.V., Zhao, S., Pogorelov, V.M., Rajan, I., Yang, Q., Cullinan, E., and Lanthorn, T.H. (2008). Genetic Disruption of Both Tryptophan Hydroxylase Genes Dramatically Reduces Serotonin and Affects Behavior in Models Sensitive to Antidepressants. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0003301"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.jpsychires.2015.05.007","article-title":"Kynurenine Pathway Dysfunction in the Pathophysiology and Treatment of Depression: Evidences from Animal and Human Studies","volume":"68","author":"Jansen","year":"2015","journal-title":"J. Psychiatr. Res."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1093\/advances\/nmz127","article-title":"Tryptophan Metabolism: A Link Between the Gut Microbiota and Brain","volume":"11","author":"Gao","year":"2020","journal-title":"Adv. Nutr."},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Shaw, C., Hess, M., and Weimer, B.C. (2023). Microbial-Derived Tryptophan Metabolites and Their Role in Neurological Disease: Anthranilic Acid and Anthranilic Acid Derivatives. Microorganisms, 11.","DOI":"10.3390\/microorganisms11071825"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1111\/j.1471-4159.1991.tb08211.x","article-title":"Two Forms of the Gamma-Aminobutyric Acid Synthetic Enzyme Glutamate Decarboxylase Have Distinct Intraneuronal Distributions and Cofactor Interactions","volume":"56","author":"Kaufman","year":"1991","journal-title":"J. Neurochem."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.anaerobe.2016.10.011","article-title":"GABA Production and Structure of gadB\/gadC Genes in Lactobacillus and Bifidobacterium Strains from Human Microbiota","volume":"42","author":"Yunes","year":"2016","journal-title":"Anaerobe"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.bbi.2018.08.010","article-title":"Resilience and Immunity","volume":"74","author":"Dantzer","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1001\/jamapediatrics.2024.2626","article-title":"Bifidobacterium and Lactobacillus Probiotics and Gut Dysbiosis in Preterm Infants: The PRIMAL Randomized Clinical Trial","volume":"178","author":"Knoll","year":"2024","journal-title":"JAMA Pediatr."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.cobeha.2019.01.011","article-title":"Stress, Depression, Diet, and the Gut Microbiota: Human-Bacteria Interactions at the Core of Psychoneuroimmunology and Nutrition","volume":"28","author":"Madison","year":"2019","journal-title":"Curr. Opin. Behav. Sci."},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Zhang, C., Xue, P., Zhang, H., Tan, C., Zhao, S., Li, X., Sun, L., Zheng, H., Wang, J., and Zhang, B. (2022). Gut Brain Interaction Theory Reveals Gut Microbiota Mediated Neurogenesis and Traditional Chinese Medicine Research Strategies. Front. Cell. Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.1072341"},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Brun, P., Akbarali, H.I., and Castagliuolo, I. (2021). Editorial: The Gut Microbiota Orchestrates the Neuronal-Immune System. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.672685"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1080\/19490976.2019.1638722","article-title":"Gut Microbes and Metabolites as Modulators of Blood-Brain Barrier Integrity and Brain Health","volume":"11","author":"Parker","year":"2020","journal-title":"Gut Microbes"},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Missiego-Beltr\u00e1n, J., and Beltr\u00e1n-Velasco, A.I. (2024). The Role of Microbial Metabolites in the Progression of Neurodegenerative Diseases\u2014Therapeutic Approaches: A Comprehensive Review. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms251810041"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"101982","DOI":"10.1016\/j.xcrm.2025.101982","article-title":"The Gut Microbiota-Immune-Brain Axis: Therapeutic Implications","volume":"6","author":"Moloney","year":"2025","journal-title":"Cell Rep. Med."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1128\/CMR.16.4.637-646.2003","article-title":"Role of Toll-Like Receptors in Pathogen Recognition","volume":"16","author":"Janssens","year":"2003","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Sameer, A.S., and Nissar, S. (2021). Toll-Like Receptors (TLRs): Structure, Functions, Signaling, and Role of Their Polymorphisms in Colorectal Cancer Susceptibility. BioMed Res. Int., 2021.","DOI":"10.1155\/2021\/1157023"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.immuni.2017.12.012","article-title":"Regulation of the Immune Response by the Aryl Hydrocarbon Receptor","volume":"48","author":"Quintana","year":"2018","journal-title":"Immunity"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/978-1-4939-3139-2_16","article-title":"The Aryl Hydrocarbon Receptor in Immunity: Tools and Potential","volume":"1371","author":"Esser","year":"2016","journal-title":"Methods Mol. Biol."},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Facchin, S., Bertin, L., Bonazzi, E., Lorenzon, G., De Barba, C., Barberio, B., Zingone, F., Maniero, D., Scarpa, M., and Ruffolo, C. (2024). Short-Chain Fatty Acids and Human Health: From Metabolic Pathways to Current Therapeutic Implications. Life, 14.","DOI":"10.20944\/preprints202403.1638.v1"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1097\/SAP.0000000000003044","article-title":"The Role of Interleukin 10 in Keloid Therapy: A Literature Review","volume":"88","author":"Harsono","year":"2022","journal-title":"Ann. Plast. Surg."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1365-2982.2008.01252.x","article-title":"The Vagus Nerve as a Modulator of Intestinal Inflammation","volume":"21","author":"Boeckxstaens","year":"2009","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.bbi.2009.10.016","article-title":"The Vagus Nerve Modulates CD4+ T Cell Activity","volume":"24","author":"Karimi","year":"2010","journal-title":"Brain Behav. Immun."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"e2212476120","DOI":"10.1073\/pnas.2212476120","article-title":"Cholinergic Regulation of Vascular Endothelial Function by Human ChAT+ T Cells","volume":"120","author":"Tarnawski","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1002\/j.2040-4603.2014.tb00587.x","article-title":"Central Nervous System Control of Gastrointestinal Motility and Secretion and Modulation of Gastrointestinal Functions","volume":"4","author":"Browning","year":"2014","journal-title":"Compr. Physiol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.freeradbiomed.2020.02.001","article-title":"Nitrate from Diet Might Fuel Gut Microbiota Metabolism: Minding the Gap Between Redox Signaling and Inter-Kingdom Communication","volume":"149","author":"Rocha","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1080\/15548627.2020.1739442","article-title":"Sulforaphane Activates a Lysosome-Dependent Transcriptional Program to Mitigate Oxidative Stress","volume":"17","author":"Li","year":"2021","journal-title":"Autophagy"},{"key":"ref_192","doi-asserted-by":"crossref","unstructured":"Chen, Y., Xu, J., and Chen, Y. (2021). Regulation of Neurotransmitters by the Gut Microbiota and Effects on Cognition in Neurological Disorders. Nutrients, 13.","DOI":"10.3390\/nu13062099"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"e37114","DOI":"10.1097\/MD.0000000000037114","article-title":"The Correlation Between Gut Microbiota and Both Neurotransmitters and Mental Disorders: A Narrative Review","volume":"103","author":"Mhanna","year":"2024","journal-title":"Medicine"},{"key":"ref_194","doi-asserted-by":"crossref","unstructured":"Ning, P., Lin, S., Shi, Y., and Liu, T. (2025). Potential Role of Gut-Related Factors in the Pathology of Cartilage in Osteoarthritis. Front. Nutr., 11.","DOI":"10.3389\/fnut.2024.1515806"},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"Li, S., Feng, W., Wu, J., Cui, H., Wang, Y., Liang, T., An, J., Chen, W., Guo, Z., and Lei, H. (2024). A Narrative Review: Immunometabolic Interactions of Host-Gut Microbiota and Botanical Active Ingredients in Gastrointestinal Cancers. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25169096"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s10072-022-06413-0","article-title":"Role of Neurotransmitters in Immune-Mediated Inflammatory Disorders: A Crosstalk Between the Nervous and Immune Systems","volume":"44","author":"Oshaghi","year":"2023","journal-title":"Neurol. Sci."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1177\/1535370216654228","article-title":"Inhibitory Neurotransmission Regulates Vagal Efferent Activity and Gastric Motility","volume":"241","author":"McMenamin","year":"2016","journal-title":"Exp. Biol. Med."},{"key":"ref_198","first-page":"54","article-title":"Vagus Nerve Stimulation (VNS) and Treatment of Depression: To the Brainstem and Beyond","volume":"3","author":"Cristancho","year":"2006","journal-title":"Psychiatry"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1007\/s13311-017-0537-8","article-title":"Vagal Nerve Stimulation for Treatment-Resistant Depression","volume":"14","author":"Carreno","year":"2017","journal-title":"Neurotherapeutics"},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Liu, N., Sun, S., Wang, P., Sun, Y., Hu, Q., and Wang, X. (2021). The Mechanism of Secretion and Metabolism of Gut-Derived 5-Hydroxytryptamine. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22157931"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.neuroimage.2010.12.060","article-title":"Chronic Stress Is Linked to 5-HT(1A) Receptor Changes and Functional Disintegration of the Limbic Networks","volume":"55","author":"Jovanovic","year":"2011","journal-title":"NeuroImage"},{"key":"ref_202","doi-asserted-by":"crossref","unstructured":"Browning, K.N. (2015). Role of Central Vagal 5-HT3 Receptors in Gastrointestinal Physiology and Pathophysiology. Front. Neurosci., 9.","DOI":"10.3389\/fnins.2015.00413"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.autneu.2009.10.002","article-title":"Neuroanatomic Relationships Between the GABAergic and Serotonergic Systems in the Developing Human Medulla","volume":"154","author":"Broadbelt","year":"2010","journal-title":"Auton. Neurosci."},{"key":"ref_204","doi-asserted-by":"crossref","unstructured":"Thompson, S.L., O\u2019Leary, G.H., Austelle, C.W., Gruber, E., Kahn, A.T., Manett, A.J., Short, B., and Badran, B.W. (2021). A Review of Parameter Settings for Invasive and Non-Invasive Vagus Nerve Stimulation (VNS) Applied in Neurological and Psychiatric Disorders. Front. Neurosci., 15.","DOI":"10.3389\/fnins.2021.709436"},{"key":"ref_205","doi-asserted-by":"crossref","unstructured":"G\u00f3ralczyk-Bi\u0144kowska, A., Szmajda-Krygier, D., and Koz\u0142owska, E. (2022). The Microbiota-Gut-Brain Axis in Psychiatric Disorders. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231911245"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.clnu.2018.04.010","article-title":"Effect of Probiotic and Prebiotic vs Placebo on Psychological Outcomes in Patients with Major Depressive Disorder: A Randomized Clinical Trial","volume":"38","author":"Kazemi","year":"2019","journal-title":"Clin. Nutr."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.bbi.2021.11.023","article-title":"Bifidobacterium breve CCFM1025 Attenuates Major Depression Disorder via Regulating Gut Microbiome and Tryptophan Metabolism: A Randomized Clinical Trial","volume":"100","author":"Tian","year":"2022","journal-title":"Brain Behav. Immun."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jare.2022.05.003","article-title":"Multi-Probiotics Ameliorate Major Depressive Disorder and Accompanying Gastrointestinal Syndromes via Serotonergic System Regulation","volume":"45","author":"Tian","year":"2023","journal-title":"J. Adv. Res."},{"key":"ref_209","doi-asserted-by":"crossref","unstructured":"Guo, X., Lin, F., Yang, F., Chen, J., Cai, W., and Zou, T. (2022). Gut Microbiome Characteristics of Comorbid Generalized Anxiety Disorder and Functional Gastrointestinal Disease: Correlation with Alexithymia and Personality Traits. Front. Psychiatry, 13.","DOI":"10.3389\/fpsyt.2022.946808"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"e00314","DOI":"10.1128\/mSphere.00314-20","article-title":"Distinct Fecal and Plasma Metabolites in Children with Autism Spectrum Disorders and Their Modulation after Microbiota Transfer Therapy","volume":"5","author":"Kang","year":"2020","journal-title":"mSphere"},{"key":"ref_211","doi-asserted-by":"crossref","unstructured":"Nirmalkar, K., Qureshi, F., Kang, D.W., Hahn, J., Adams, J.B., and Krajmalnik-Brown, R. (2022). Shotgun Metagenomics Study Suggests Alteration in Sulfur Metabolism and Oxidative Stress in Children with Autism and Improvement after Microbiota Transfer Therapy. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232113481"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s13195-024-01482-z","article-title":"Effects of Intensive Lifestyle Changes on the Progression of Mild Cognitive Impairment or Early Dementia Due to Alzheimer\u2019s Disease: A Randomized, Controlled Clinical Trial","volume":"16","author":"Ornish","year":"2024","journal-title":"Alzheimers Res. Ther."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"8221","DOI":"10.1096\/fj.201900071R","article-title":"APOE Genotype Influences the Gut Microbiome Structure and Function in Humans and Mice: Relevance for Alzheimer\u2019s Disease Pathophysiology","volume":"33","author":"Tran","year":"2019","journal-title":"FASEB J."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1136\/gutjnl-2022-329201","article-title":"Gut Microbiome Modulates the Effects of a Personalised Postprandial-Targeting (PPT) Diet on Cardiometabolic Markers: A Diet Intervention in Pre-Diabetes","volume":"72","author":"Godneva","year":"2023","journal-title":"Gut"},{"key":"ref_215","doi-asserted-by":"crossref","unstructured":"Mei, L., Yang, Z., Zhang, X., Liu, Z., Wang, M., Wu, X., Chen, X., Huang, Q., and Huang, R. (2021). Sustained Drug Treatment Alters the Gut Microbiota in Rheumatoid Arthritis. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.704089"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1053\/j.gastro.2019.09.024","article-title":"Effects of Low FODMAP Diet on Symptoms, Fecal Microbiome, and Markers of Inflammation in Patients with Quiescent Inflammatory Bowel Disease in a Randomized Trial","volume":"158","author":"Cox","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.cmet.2018.05.006","article-title":"Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota","volume":"27","author":"Cignarella","year":"2018","journal-title":"Cell Metab."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1210\/clinem\/dgaa644","article-title":"Intermittent Fasting Improves Cardiometabolic Risk Factors and Alters Gut Microbiota in Metabolic Syndrome Patients","volume":"106","author":"Guo","year":"2021","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jad.2007.01.028","article-title":"Cardiac Vagal Control in the Severity and Course of Depression: The Importance of Symptomatic Heterogeneity","volume":"103","author":"Rottenberg","year":"2007","journal-title":"J. Affect. Disord."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s11689-017-9197-6","article-title":"Reduced Vagal Tone in Women with the FMR1 Premutation Is Associated with FMR1 mRNA but Not Depression or Anxiety","volume":"9","author":"Klusek","year":"2017","journal-title":"J. Neurodev. Disord."},{"key":"ref_221","doi-asserted-by":"crossref","unstructured":"Zheng, F., Zhang, X., Wang, S., Jia, G., and Cheng, L. (2025). Vagus Nerve Stimulation Regulates the Th17\/Treg Balance and Alleviates Lung Injury in Acute Respiratory Distress Syndrome by Upregulating \u03b17nAChR. Biomedicines, 13.","DOI":"10.3390\/biomedicines13061294"},{"key":"ref_222","doi-asserted-by":"crossref","unstructured":"Komaroff, A.L., and Lipkin, W.I. (2023). ME\/CFS and Long COVID Share Similar Symptoms and Biological Abnormalities: Road Map to the Literature. Front. Med., 10.","DOI":"10.3389\/fmed.2023.1187163"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.neubiorev.2020.06.031","article-title":"Advances in Understanding Mechanisms and Therapeutic Targets to Treat Comorbid Depression and Cardiovascular Disease","volume":"116","author":"Pope","year":"2020","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_224","doi-asserted-by":"crossref","unstructured":"Iida, T., Yokoyama, Y., Wagatsuma, K., Hirayama, D., and Nakase, H. (2018). Impact of Autophagy of Innate Immune Cells on Inflammatory Bowel Disease. Cells, 8.","DOI":"10.3390\/cells8010007"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"2338933","DOI":"10.1080\/0886022X.2024.2338933","article-title":"TXNIP Deficiency Attenuates Renal Fibrosis by Modulating mTORC1\/TFEB-Mediated Autophagy in Diabetic Kidney Disease","volume":"46","author":"Du","year":"2024","journal-title":"Ren. Fail."},{"key":"ref_226","doi-asserted-by":"crossref","unstructured":"Ulfig, A., Bader, V., Varatnitskaya, M., Lupilov, N., Winklhofer, K.F., and Leichert, L.I. (2021). Hypochlorous Acid-Modified Human Serum Albumin Suppresses MHC Class II-Dependent Antigen Presentation in Pro-Inflammatory Macrophages. Redox Biol., 43.","DOI":"10.1016\/j.redox.2021.101981"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"tkad004","DOI":"10.1093\/burnst\/tkad004","article-title":"Targeting Macrophage Autophagy for Inflammation Resolution and Tissue Repair in Inflammatory Bowel Disease","volume":"11","author":"Wang","year":"2023","journal-title":"Burn. Trauma"},{"key":"ref_228","doi-asserted-by":"crossref","unstructured":"Kiraly, S., Stanley, J., and Eden, E.R. (2025). Lysosome-Mitochondrial Crosstalk in Cellular Stress and Disease. Antioxidants, 14.","DOI":"10.3390\/antiox14020125"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"5007","DOI":"10.1074\/jbc.M114.621771","article-title":"Polysaccharide A from the Capsule of Bacteroides fragilis Induces Clonal CD4+ T Cell Expansion","volume":"290","author":"Johnson","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_230","doi-asserted-by":"crossref","unstructured":"Alula, K.M., and Theiss, A.L. (2023). Autophagy in Crohn\u2019s Disease: Converging on Dysfunctional Innate Immunity. Cells, 12.","DOI":"10.3390\/cells12131779"},{"key":"ref_231","doi-asserted-by":"crossref","unstructured":"Ramos-Molina, B., Queipo-Ortu\u00f1o, M.I., Lambertos, A., Tinahones, F.J., and Pe\u00f1afiel, R. (2019). Dietary and Gut Microbiota Polyamines in Obesity- and Age-Related Diseases. Front. Nutr., 6.","DOI":"10.3389\/fnut.2019.00024"},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.cll.2015.02.002","article-title":"Salmonella, Shigella, and Yersinia","volume":"35","author":"Dekker","year":"2015","journal-title":"Clin. Lab. Med."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.3748\/wjg.v16.i10.1258","article-title":"T300A Polymorphism of ATG16L1 and Susceptibility to Inflammatory Bowel Diseases: A Meta-Analysis","volume":"16","author":"Cheng","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1161\/CIRCRESAHA.119.315248","article-title":"Impaired Autophagy in CD11b+ Dendritic Cells Expands CD4+ Regulatory T Cells and Limits Atherosclerosis in Mice","volume":"125","author":"Clement","year":"2019","journal-title":"Circ. Res."},{"key":"ref_235","doi-asserted-by":"crossref","unstructured":"Miao, Z.X., Meng, H., Wang, J., Hou, X.T., Cheng, W.W., Liu, B.H., Zhang, Q.G., and Yuan, S. (2025). Autophagy in Inflammatory Bowel Disease: Immunization, Etiology, and Therapeutic Potential. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1543040"},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/nrd.2017.22","article-title":"Pharmacological Modulation of Autophagy: Therapeutic Potential and Persisting Obstacles","volume":"16","author":"Galluzzi","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1186\/s12974-020-01916-z","article-title":"Ingestion of Lactobacillus intestinalis and Lactobacillus reuteri Causes Depression- and Anhedonia-Like Phenotypes in Antibiotic-Treated Mice via the Vagus Nerve","volume":"17","author":"Wang","year":"2020","journal-title":"J. Neuroinflamm."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.4014\/jmb.1907.07044","article-title":"Lactobacillus mucosae and Bifidobacterium longum Synergistically Alleviate Immobilization Stress-Induced Anxiety\/Depression in Mice by Suppressing Gut Dysbiosis","volume":"29","author":"Han","year":"2019","journal-title":"J. Microbiol. Biotechnol."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"1178646920928984","DOI":"10.1177\/1178646920928984","article-title":"Tryptophan Metabolites Along the Microbiota-Gut-Brain Axis: An Interkingdom Communication System Influencing the Gut in Health and Disease","volume":"13","author":"Bosi","year":"2020","journal-title":"Int. J. Tryptophan Res."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jcmgh.2024.01.024","article-title":"Advances in Brain-Gut-Microbiome Interactions: A Comprehensive Update on Signaling Mechanisms, Disorders, and Therapeutic Implications","volume":"18","author":"Dong","year":"2024","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s11739-023-03374-w","article-title":"Gut Microbiota, Intestinal Permeability, and Systemic Inflammation: A Narrative Review","volume":"19","author":"Petito","year":"2024","journal-title":"Intern. Emerg. Med."},{"key":"ref_242","doi-asserted-by":"crossref","unstructured":"Li, L., Wang, D., Pan, H., Huang, L., Sun, X., He, C., and Wei, Q. (2022). Non-Invasive Vagus Nerve Stimulation in Cerebral Stroke: Current Status and Future Perspectives. Front. Neurosci., 16.","DOI":"10.3389\/fnins.2022.820665"},{"key":"ref_243","doi-asserted-by":"crossref","unstructured":"Yan, L., Li, H., Qian, Y., Zhang, J., Cong, S., Zhang, X., Wu, L., Wang, Y., Wang, M., and Yu, T. (2024). Transcutaneous Vagus Nerve Stimulation: A New Strategy for Alzheimer\u2019s Disease Intervention Through the Brain-Gut-Microbiota Axis?. Front. Aging Neurosci., 16.","DOI":"10.3389\/fnagi.2024.1334887"},{"key":"ref_244","doi-asserted-by":"crossref","unstructured":"Faraji, N., Payami, B., Ebadpour, N., and Gorji, A. (2025). Vagus Nerve Stimulation and Gut Microbiota Interactions: A Novel Therapeutic Avenue for Neuropsychiatric Disorders. Neurosci. Biobehav. Rev., 169.","DOI":"10.1016\/j.neubiorev.2024.105990"},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"2470547017711912","DOI":"10.1177\/2470547017711912","article-title":"Biobehavioral Mechanisms of Mindfulness as a Treatment for Chronic Stress: An RDoC Perspective","volume":"1","author":"Garland","year":"2017","journal-title":"Chronic Stress"},{"key":"ref_246","doi-asserted-by":"crossref","unstructured":"Gerritsen, R.J.S., and Band, G.P.H. (2018). Breath of Life: The Respiratory Vagal Stimulation Model of Contemplative Activity. Front. Hum. Neurosci., 12.","DOI":"10.3389\/fnhum.2018.00397"},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"2492377","DOI":"10.1080\/19490976.2025.2492377","article-title":"Multi-Species Probiotic Supplement Enhances Vagal Nerve Function\u2014Results of a Randomized Controlled Trial in Patients with Depression and Healthy Controls","volume":"17","author":"Narrath","year":"2025","journal-title":"Gut Microbes"},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.brs.2017.05.006","article-title":"Non-Invasive Vagus Nerve Stimulation Acutely Improves Spontaneous Cardiac Baroreflex Sensitivity in Healthy Young Men: A Randomized Placebo-Controlled Trial","volume":"10","author":"Antonino","year":"2017","journal-title":"Brain Stimul."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.brs.2014.07.031","article-title":"Non-Invasive Vagus Nerve Stimulation in Healthy Humans Reduces Sympathetic Nerve Activity","volume":"7","author":"Clancy","year":"2014","journal-title":"Brain Stimul."},{"key":"ref_250","doi-asserted-by":"crossref","unstructured":"Ansari, F., Neshat, M., Pourjafar, H., Jafari, S.M., Samakkhah, S.A., and Mirzakhani, E. (2023). The Role of Probiotics and Prebiotics in Modulating of the Gut-Brain Axis. Front. Nutr., 10.","DOI":"10.3389\/fnut.2023.1173660"},{"key":"ref_251","doi-asserted-by":"crossref","unstructured":"Zhou, P., Chen, C., Patil, S., and Dong, S. (2024). Unveiling the Therapeutic Symphony of Probiotics, Prebiotics, and Postbiotics in Gut-Immune Harmony. Front. Nutr., 11.","DOI":"10.3389\/fnut.2024.1355542"},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"3831972","DOI":"10.1155\/2017\/3831972","article-title":"Exercise Modifies the Gut Microbiota with Positive Health Effects","volume":"2017","author":"Monda","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_253","doi-asserted-by":"crossref","unstructured":"Strasser, B., Wolters, M., Weyh, C., Kr\u00fcger, K., and Ticinesi, A. (2021). The Effects of Lifestyle and Diet on Gut Microbiota Composition, Inflammation and Muscle Performance in Our Aging Society. Nutrients, 13.","DOI":"10.3390\/nu13062045"},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"244","DOI":"10.3390\/pathophysiology31020019","article-title":"Neuromodulation and the Gut-Brain Axis: Therapeutic Mechanisms and Implications for Gastrointestinal and Neurological Disorders","volume":"31","author":"Aljeradat","year":"2024","journal-title":"Pathophysiology"},{"key":"ref_255","doi-asserted-by":"crossref","unstructured":"Mohebali, N., Weigel, M., Hain, T., S\u00fctel, M., Bull, J., Kreikemeyer, B., and Breitr\u00fcck, A. (2023). Faecalibacterium prausnitzii, Bacteroides faecis and Roseburia intestinalis Attenuate Clinical Symptoms of Experimental Colitis by Regulating Treg\/Th17 Cell Balance and Intestinal Barrier Integrity. Biomed. Pharmacother., 167.","DOI":"10.1016\/j.biopha.2023.115568"},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1183\/09031936.00184314","article-title":"Intermittent Hypoxia Alters Gut Microbiota Diversity in a Mouse Model of Sleep Apnoea","volume":"45","author":"Torres","year":"2015","journal-title":"Eur. Respir. J."},{"key":"ref_257","doi-asserted-by":"crossref","unstructured":"Shabani, M., Ghoshehy, A., Mottaghi, A.M., Chegini, Z., Kerami, A., Shariati, A., and Taati Moghadam, M. (2025). The Relationship Between Gut Microbiome and Human Diseases: Mechanisms, Predisposing Factors and Potential Intervention. Front. Cell. Infect. Microbiol., 15.","DOI":"10.3389\/fcimb.2025.1516010"},{"key":"ref_258","doi-asserted-by":"crossref","unstructured":"Pasqualette, L., Fidalgo, T.K.D.S., Freitas-Fernandes, L.B., Souza, G.G.L., Imbiriba, L.A., Lobo, L.A., Volchan, E., Domingues, R.M.C.P., Valente, A.P., and Miranda, K.R. (2024). Alterations in Vagal Tone Are Associated with Changes in the Gut Microbiota of Adults with Anxiety and Depression Symptoms: Analysis of Fecal Metabolite Profiles. Metabolites, 14.","DOI":"10.3390\/metabo14080450"},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"426","DOI":"10.33594\/000000669","article-title":"Do the Effects of Krebs Cycle Intermediates on Oxygen-Dependent Processes in Hypoxia Mediated by the Nitric Oxide System Have Reciprocal or Competitive Relationships?","volume":"57","author":"Kurhaluk","year":"2023","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"597","DOI":"10.33594\/000000734","article-title":"Nitric Oxide-Dependent Regulation of Oxygen-Related Processes in a Rat Model of Lead Neurotoxicity: Influence of the Hypoxia Resistance Factor","volume":"58","author":"Kurhaluk","year":"2024","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"336","DOI":"10.33594\/000000716","article-title":"Elucidation of the Role of L-Arginine and N\u03c9-Nitro-L-Arginine in the Treatment of Rats with Different Levels of Hypoxic Tolerance and Exposure to Lead Nitrate","volume":"58","author":"Tkaczenko","year":"2024","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1080\/15374416.2013.843464","article-title":"Low Vagal Tone Magnifies the Association Between Psychosocial Stress Exposure and Internalizing Psychopathology in Adolescents","volume":"44","author":"McLaughlin","year":"2015","journal-title":"J. Clin. Child Adolesc. Psychol."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1093\/advances\/nmac075","article-title":"Perspective: Leveraging the Gut Microbiota to Predict Personalized Responses to Dietary, Prebiotic, and Probiotic Interventions","volume":"13","author":"Gibbons","year":"2022","journal-title":"Adv. Nutr."},{"key":"ref_264","doi-asserted-by":"crossref","unstructured":"Matsuura, N., Kanayama, M., Watanabe, Y., Yamada, H., Lili, L., and Torii, A. (2024). Effect of Personalized Prebiotic and Probiotic Supplements on the Symptoms of Irritable Bowel Syndrome: An Open-Label, Single-Arm, Multicenter Clinical Trial. Nutrients, 16.","DOI":"10.3390\/nu16193333"},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"9816","DOI":"10.1080\/10408398.2022.2076064","article-title":"Dietary polyphenols: Regulate the advanced glycation end products-RAGE axis and the microbiota-gut-brain axis to prevent neurodegenerative diseases","volume":"63","author":"Li","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_266","doi-asserted-by":"crossref","unstructured":"Fernandes, A., Mateus, N., and de Freitas, V. (2023). Polyphenol-Dietary Fiber Conjugates from Fruits and Vegetables: Nature and Biological Fate in a Food and Nutrition Perspective. Foods, 12.","DOI":"10.3390\/foods12051052"},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"138739","DOI":"10.1016\/j.foodchem.2024.138739","article-title":"Dietary polyphenols regulate appetite mechanism via gut-brain axis and gut homeostasis","volume":"446","author":"Liu","year":"2024","journal-title":"Food Chem."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"142932","DOI":"10.1016\/j.foodchem.2025.142932","article-title":"Advances in dietary polyphenols: Regulation of inflammatory bowel disease (IBD) via bile acid metabolism and the gut-brain axis","volume":"472","author":"Jiang","year":"2025","journal-title":"Food Chem."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/23\/11706\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T10:35:57Z","timestamp":1764758157000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/23\/11706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,3]]},"references-count":268,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["ijms262311706"],"URL":"https:\/\/doi.org\/10.3390\/ijms262311706","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,3]]}}}