{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T00:13:59Z","timestamp":1793664839193,"version":"4.5.1"},"reference-count":53,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32270991"],"award-info":[{"award-number":["32270991"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32400719"],"award-info":[{"award-number":["32400719"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Glucocorticoid drugs (GCs), while effective in systemic lupus erythematosus (SLE), cause severe systemic side effects due to lack of tissue-specificity. To overcome this bottleneck, we developed a CD74-directed antibody\u2013drug conjugate (Bud-ADC) to deliver budesonide, a potent GC drug, selectively to target CD74-expressing immune cells (e.g., B cells, dendritic cells), which play an important role in SLE pathogenesis. Bud-ADC combines a cross-species anti-CD74 antibody with budesonide via a cleavable linker, enabling immunosuppression on targeted cells. In vitro, Bud-ADC selectively inhibited CD74-high immune cell activation and cytokine production. In two SLE mouse models, Bud-ADC significantly alleviated disease hallmarks\u2014reducing autoantibodies, splenomegaly, and kidney damage\u2014while showing superior efficacy to free budesonide at equivalent doses. The therapeutic effects involved both direct targeting of CD74-high immune cells and indirect modulation of T cell responses despite low CD74 expression. This study establishes CD74-targeted ADC as a novel strategy to enhance GC efficacy in SLE, aiming at minimizing off-target toxicity while maintaining broad immunosuppressive activity. The translatable design supports further preclinical and clinical development for autoimmune diseases.<\/jats:p>","DOI":"10.3390\/ijms262311761","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T10:50:38Z","timestamp":1764931838000},"page":"11761","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["CD74-Targeting Antibody\u2013Drug Conjugate Enhances Immunosuppression of Glucocorticoid in Systemic Lupus Erythematosus"],"prefix":"10.3390","volume":"26","author":[{"given":"Qizhen","family":"Du","sequence":"first","affiliation":[{"name":"Key Laboratory of Multicellular Systems, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, 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Target. Ther."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"5628","DOI":"10.1002\/jcp.27419","article-title":"Antibody-Drug Conjugates (ADCs) for Cancer Therapy: Strategies, Challenges, and Successes","volume":"234","author":"Lotfinia","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/s41573-023-00709-2","article-title":"Antibody\u2013Drug Conjugates Come of Age in Oncology","volume":"22","author":"Dumontet","year":"2023","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13045-025-01704-3","article-title":"Antibody-Drug Conjugates (ADCs): Current and Future Biopharmaceuticals","volume":"18","author":"Wang","year":"2025","journal-title":"J. Hematol. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Gogia, P., Ashraf, H., Bhasin, S., and Xu, Y. (2023). Antibody\u2013Drug Conjugates: A Review of Approved Drugs and Their Clinical Level of Evidence. Cancers, 15.","DOI":"10.3390\/cancers15153886"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"883","DOI":"10.4049\/jimmunol.168.2.883","article-title":"Selective Intracellular Delivery of Dexamethasone into Activated Endothelial Cells Using an E-Selectin-Directed Immunoconjugate","volume":"168","author":"Everts","year":"2002","journal-title":"J. Immunol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.omtm.2016.11.004","article-title":"Antibody-Directed Glucocorticoid Targeting to CD163 in M2-Type Macrophages Attenuates Fructose-Induced Liver Inflammatory Changes","volume":"4","author":"Svendsen","year":"2017","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1021\/acs.bioconjchem.8b00312","article-title":"Development of Anti-CD74 Antibody\u2013Drug Conjugates to Target Glucocorticoids to Immune Cells","volume":"29","author":"Brandish","year":"2018","journal-title":"Bioconjug. Chem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"11958","DOI":"10.1021\/acs.jmedchem.1c00541","article-title":"Development of Novel Glucocorticoids for Use in Antibody\u2013Drug Conjugates for the Treatment of Inflammatory Diseases","volume":"64","author":"Han","year":"2021","journal-title":"J. Med. Chem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"12544","DOI":"10.1021\/acs.jmedchem.3c01174","article-title":"Discovery of ABBV-154, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody-Drug Conjugate (iADC)","volume":"66","author":"Hobson","year":"2023","journal-title":"J. Med. Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"F680","DOI":"10.1152\/ajprenal.00289.2015","article-title":"Human Anti-A3(IV)NC1 Antibody Drug Conjugates Target Glomeruli to Resolve Nephritis","volume":"309","author":"Kvirkvelia","year":"2015","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1136\/annrheumdis-2021-eular.2213","article-title":"Pos0365 Anti-Tnf Glucocorticoid Receptor Modulator Antibody Drug Conjugate for the Treatment of Autoimmune Diseases","volume":"80","author":"Stoffel","year":"2021","journal-title":"Annu. Rheum. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1038\/mt.2012.103","article-title":"Targeting the Hemoglobin Scavenger Receptor CD163 in Macrophages Highly Increases the Anti-Inflammatory Potency of Dexamethasone","volume":"20","author":"Graversen","year":"2012","journal-title":"Mol. Ther."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Theocharopoulos, C., Lialios, P.-P., Samarkos, M., Gogas, H., and Ziogas, D.C. (2021). Antibody-Drug Conjugates: Functional Principles and Applications in Oncology and Beyond. Vaccines, 9.","DOI":"10.3390\/vaccines9101111"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Pal, L.B., Bule, P., Khan, W., and Chella, N. (2023). An Overview of the Development and Preclinical Evaluation of Antibody\u2013Drug Conjugates for Non-Oncological Applications. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15071807"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1146\/annurev-med-043021-032611","article-title":"Systemic Lupus Erythematosus: New Diagnostic and Therapeutic Approaches","volume":"74","author":"Lazar","year":"2023","journal-title":"Annu. Rev. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.molmed.2017.05.006","article-title":"Pathogenesis of Human Systemic Lupus Erythematosus: A Cellular Perspective","volume":"23","author":"Moulton","year":"2017","journal-title":"Trends Mol. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/nrrheum.2016.186","article-title":"New Insights into the Immunopathogenesis of Systemic Lupus Erythematosus","volume":"12","author":"Tsokos","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41572-019-0141-9","article-title":"Lupus Nephritis","volume":"6","author":"Anders","year":"2020","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"16039","DOI":"10.1038\/nrdp.2016.39","article-title":"Systemic Lupus Erythematosus","volume":"2","author":"Kaul","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Enr\u00edquez-Merayo, E., and Cuadrado, M.J. (2023). Steroids in Lupus: Enemies or Allies. J. Clin. Med., 12.","DOI":"10.3390\/jcm12113639"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.otc.2010.04.003","article-title":"A Comprehensive Review of the Adverse Effects of Systemic Corticosteroids","volume":"43","author":"Poetker","year":"2010","journal-title":"Otolaryngol. Clin. N. Am."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41423-020-00526-2","article-title":"New Insights into the Cell- and Tissue-Specificity of Glucocorticoid Actions","volume":"18","author":"Quatrini","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"L\u00fchder, F., and Reichardt, H.M. (2017). Novel Drug Delivery Systems Tailored for Improved Administration of Glucocorticoids. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18091836"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/S0006-2952(03)00122-9","article-title":"Delivery of Pharmacologically Active Dexamethasone into Activated Endothelial Cells by Dexamethasone-Anti-E-Selectin Immunoconjugate","volume":"65","author":"Kok","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"ref_26","unstructured":"McPherson, M.J., Hobson, A.D., Hayes, M.E., Marvin, C.C., Schmidt, D., Waegell, W., Goess, C., OH, J.Z., Hernandez, A., and Randolph, J.T. (2017). Glucocorticoid Receptor Agonist and Immunoconjugates Thereof. (WO2017210471A1)."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1021\/acs.bioconjchem.6b00337","article-title":"Novel Phosphate Modified Cathepsin B Linkers: Improving Aqueous Solubility and Enhancing Payload Scope of ADCs","volume":"27","author":"Kern","year":"2016","journal-title":"Bioconjug. Chem."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Buttgereit, F., Singhal, A., Kivitz, A., Drescher, E., Taniguchi, Y., P\u00e9rez, R.M., Anderson, J., D\u2019Cunha, R., Zhao, W., and DeVogel, N. (2025). Efficacy and Safety of ABBV-154 for the Treatment of Active Rheumatoid Arthritis: A Phase 2b, Randomized, Placebo-Controlled Trial. Arthritis Rheumatol., 1\u20139.","DOI":"10.1002\/art.43266"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1002\/art.42415","article-title":"Efficacy and Safety of ABBV-3373, a Novel Anti\u2013Tumor Necrosis Factor Glucocorticoid Receptor Modulator Antibody\u2013Drug Conjugate, in Adults with Moderate-to-Severe Rheumatoid Arthritis Despite Methotrexate Therapy: A Randomized, Double-Blind, Active-Controlled Proof-of-Concept Phase IIa Trial","volume":"75","author":"Buttgereit","year":"2023","journal-title":"Arthritis Rheumatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"7395","DOI":"10.1073\/pnas.80.24.7395","article-title":"cDNA Clone for the Human Invariant Gamma Chain of Class II Histocompatibility Antigens and Its Implications for the Protein Structure","volume":"80","author":"Claesson","year":"1983","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1074\/jbc.M703265200","article-title":"Macrophage Migration Inhibitory Factor Induces B Cell Survival by Activation of a CD74-CD44 Receptor Complex","volume":"283","author":"Gore","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1073\/pnas.1612195114","article-title":"CD74 Is a Novel Transcription Regulator","volume":"114","author":"Radomir","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.bbamcr.2016.03.026","article-title":"The Multifaceted Roles of the Invariant Chain CD74\u2014More than Just a Chaperone","volume":"1863","year":"2016","journal-title":"Biochim. Biophys. Acta (BBA)\u2014Mol. Cell Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/s41584-019-0238-2","article-title":"The Immunobiology of MIF: Function, Genetics and Prospects for Precision Medicine","volume":"15","author":"Kang","year":"2019","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s00011-016-0995-1","article-title":"The Biological Function and Significance of CD74 in Immune Diseases","volume":"66","author":"Su","year":"2017","journal-title":"Inflamm. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1046\/j.1365-2567.1999.00868.x","article-title":"Cell Surface Expression and Metabolism of Major Histocompatibility Complex Class II Invariant Chain (CD74) by Diverse Cell Lines","volume":"98","author":"Ong","year":"1999","journal-title":"Immunology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"8581","DOI":"10.1073\/pnas.90.18.8581","article-title":"Cell Surface HLA-DR-Invariant Chain Complexes Are Targeted to Endosomes by Rapid Internalization","volume":"90","author":"Roche","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Lindner, R. (2017). Invariant Chain Complexes and Clusters as Platforms for MIF Signaling. Cells, 6.","DOI":"10.3390\/cells6010006"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0140-6736(10)61354-2","article-title":"Efficacy and Safety of Belimumab in Patients with Active Systemic Lupus Erythematosus: A Randomised, Placebo-Controlled, Phase 3 Trial","volume":"377","author":"Navarra","year":"2011","journal-title":"Lancet"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1136\/ard-2023-224854","article-title":"Telitacicept in Patients with Active Systemic Lupus Erythematosus: Results of a Phase 2b, Randomised, Double-Blind, Placebo-Controlled Trial","volume":"83","author":"Wu","year":"2024","journal-title":"Annu. Rheum. Dis."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1358\/dot.2022.58.1.3352743","article-title":"Telitacicept, a Novel Humanized, Recombinant TACI-Fc Fusion Protein, for the Treatment of Systemic Lupus Erythematosus","volume":"58","author":"Fan","year":"2022","journal-title":"Drugs Today"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e000910","DOI":"10.1136\/lupus-2023-000910","article-title":"Anifrolumab in Lupus Nephritis: Results from Second-Year Extension of a Randomised Phase II Trial","volume":"10","author":"Jayne","year":"2023","journal-title":"Lupus Sci. Med."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Lu, X., Chen, Z., Yi, C., Ling, Z., Ye, J., Chen, K., Cong, Y., Sonam, W., Cheng, S., and Wang, R. (2025). An Anti-CD47 Antibody Binds to a Distinct Epitope in a Novel Metal Ion-Dependent Manner to Minimize Cross-Linking of Red Blood Cells. J. Biol. Chem., 301.","DOI":"10.1016\/j.jbc.2025.110420"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"R54","DOI":"10.1186\/ar3767","article-title":"The Anti-CD74 Humanized Monoclonal Antibody, Milatuzumab, Which Targets the Invariant Chain of MHC II Complexes, Alters B-Cell Proliferation, Migration, and Adhesion Molecule Expression","volume":"14","author":"Reiter","year":"2012","journal-title":"Arthritis Res. Ther."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/jcag\/gwy018","article-title":"Budesonide for the Induction and Maintenance of Remission in Crohn\u2019s Disease: Systematic Review and Meta-Analysis for the Cochrane Collaboration","volume":"1","author":"Kuenzig","year":"2018","journal-title":"J. Can. Assoc. Gastroenterol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1080\/14656566.2016.1183648","article-title":"Budesonide for the Treatment of Ulcerative Colitis","volume":"17","author":"Abdalla","year":"2016","journal-title":"Expert Opin. Pharmacother."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0923-1811(94)00376-P","article-title":"Effects of Topical Treatment with Budesonide on Parameters for Epidermal Proliferation, Keratinization and Inflammation in Psoriasis","volume":"9","author":"Ferrier","year":"1995","journal-title":"J. Dermatol. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s40268-018-0253-9","article-title":"Efficacy and Safety of Budesonide in the Treatment of Eosinophilic Esophagitis: Updated Systematic Review and Meta-Analysis of Randomized and Non-Randomized Studies","volume":"18","author":"Rawla","year":"2018","journal-title":"Drugs R. D"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1183\/09031936.98.11061268","article-title":"Effects of Orally Inhaled Budesonide in Seasonal Allergic Rhinitis","volume":"11","author":"Greiff","year":"1998","journal-title":"Eur. Respir. J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/s000110050450","article-title":"A Comparison of the Inhibitory Effects of Budesonide, Beclomethasone Dipropionate, Dexamethasone, Hydrocortisone and Tixocortol Pivalate on Cytokine Release from Leukocytes Recovered from Human Bronchoalveolar Lavage","volume":"48","author":"Whelan","year":"1999","journal-title":"Inflamm. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0091-6749(99)70059-X","article-title":"Pharmacodynamics and Pharmacokinetics of Budesonide: A New Nebulized Corticosteroid","volume":"104","author":"Szefler","year":"1999","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_52","first-page":"53319","article-title":"The Bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL\/6 Mice","volume":"105","author":"Klarquist","year":"2015","journal-title":"J. Vis. Exp."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Yan, Y., Zhang, Z., Chen, Y., Hou, B., Liu, K., Qin, H., Fang, L., and Du, G. (2020). Coptisine Alleviates Pristane-Induced Lupus-Like Disease and Associated Kidney and Cardiovascular Complications in Mice. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.00929"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/23\/11761\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T05:13:46Z","timestamp":1764998026000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/23\/11761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,4]]},"references-count":53,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["ijms262311761"],"URL":"https:\/\/doi.org\/10.3390\/ijms262311761","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,4]]}}}