{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T11:20:03Z","timestamp":1765538403063,"version":"3.48.0"},"reference-count":88,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["FONDECYT\/ANID Regular 1250984"],"award-info":[{"award-number":["FONDECYT\/ANID Regular 1250984"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Many familial diseases are caused by genetic accidents, which affect the genome and its epigenetic environment, summarized as an interaction network between genes. We wish to study the existence or absence of robustness for such genetic interaction networks centered on the gene SP1 and involved in three familial diseases: familial angioedema, osteogenesis imperfecta, and biliary atresia. The updating of gene states at the vertices of the interaction graph of the genetic network (1 if a gene is activated, 0 if it is inhibited) can be performed in multiple ways that have been well-studied over the last 20 years: parallel, block-parallel, sequential, block-sequential, random, etc. We add to these classic updating modes two new ones, the intricate and the state-dependent. We have studied the robustness of three particular interaction graphs related to the familial diseases chosen as examples. The comparison of the interaction graphs and dynamics of the chosen familial diseases of different etiology shows common points in their interaction graphs and similarities in their dynamics according to their expression clock.<\/jats:p>","DOI":"10.3390\/ijms262411976","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T11:13:33Z","timestamp":1765538013000},"page":"11976","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Boolean Networks with Classic and New Updating Modes Applied to Genetic Regulation in Some Familial Diseases"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8335-9240","authenticated-orcid":false,"given":"Jacques","family":"Demongeot","sequence":"first","affiliation":[{"name":"Laboratory AGEIS, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Grenoble Alpes, Avenue des Maquis du Graisivaudan, 38700 La Tronche, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdoul Khadir","family":"Diallo","sequence":"additional","affiliation":[{"name":"Laboratory AGEIS, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Grenoble Alpes, Avenue des Maquis du Graisivaudan, 38700 La Tronche, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hana","family":"Hazgui","sequence":"additional","affiliation":[{"name":"CHS Montperrin, Assistance Publique H\u00f4pitaux de Marseille, 109 Avenue du Petit Barth\u00e9l\u00e9my, 13090 Aix-en-Provence, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariem","family":"Jelassi","sequence":"additional","affiliation":[{"name":"ENSI-Ecole Nationale des Sciences de l\u2019Informatique, Campus Universitaire de la Manouba, La Manouba 2010, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatine","family":"Kelloufi","sequence":"additional","affiliation":[{"name":"Laboratory AGEIS, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Grenoble Alpes, Avenue des Maquis du Graisivaudan, 38700 La Tronche, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9860-1729","authenticated-orcid":false,"given":"Houssem","family":"ben Khalfallah","sequence":"additional","affiliation":[{"name":"Laboratory AGEIS, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Grenoble Alpes, Avenue des Maquis du Graisivaudan, 38700 La Tronche, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4643-5003","authenticated-orcid":false,"given":"Alonso","family":"Espinoza","sequence":"additional","affiliation":[{"name":"Faculty of Engineering and Science, Universidad Adolfo Ib\u00e1\u00f1ez, Av. Diagonal Las Torres 2640, Pe\u00f1alol\u00e9n 7910133, Santiago, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7264-9840","authenticated-orcid":false,"given":"Marco","family":"Montalva-Medel","sequence":"additional","affiliation":[{"name":"Faculty of Engineering and Science, Universidad Adolfo Ib\u00e1\u00f1ez, Av. Diagonal Las Torres 2640, Pe\u00f1alol\u00e9n 7910133, Santiago, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Zhang, G., Shi, H., Wang, L., Zhou, M., Wang, Z., Liu, X., Cheng, L., Li, W., and Li, X. (2015). MicroRNA and transcription factor mediated regulatory network analysis reveals critical regulators and regulatory modules in myocardial infarction. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0135339"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1016\/j.jaci.2016.02.021","article-title":"Plasmin is a natural trigger for bradykinin production in patients with hereditary angioedema with factor XII mutations","volume":"138","author":"Suffritti","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Caccia, S., Suffritti, C., Carzaniga, T., Berardelli, R., Berra, S., Martorana, V., Fra, A., Drouet, C., and Cicardi, M. (2018). Intermittent C1-inhibitor deficiency associated with recessive inheritance: Functional and structural insight. Sci. Rep., 8.","DOI":"10.1038\/s41598-017-16667-w"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/all.13270","article-title":"Hereditary angioedema with a mutation in the plasminogen gene","volume":"73","author":"Bork","year":"2018","journal-title":"Allergy"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.bbrc.2017.12.060","article-title":"A missense mutation in the plasminogen gene, within the plasminogen kringle 3 domain, in hereditary angioedema with normal C1 inhibitor","volume":"498","author":"Dewald","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"40014","DOI":"10.1074\/jbc.C000508200","article-title":"Regulation of plasminogen activator inhibitor-1 expression by transforming growth factor-beta -induced physical and functional interactions between smads and Sp1","volume":"275","author":"Datta","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.jaci.2017.05.020","article-title":"Mutation of the angiopoietin-1 gene (ANGPT1) associates with a new type of hereditary angioedema","volume":"141","author":"Bafunno","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1080\/07853890.2018.1449959","article-title":"Hereditary angioedema due to C1-inhibitor deficiency in Macedonia: Clinical characteristics, novel SERPING1 mutations and genetic factors modifying the clinical phenotype","volume":"50","author":"Andrejevic","year":"2018","journal-title":"Ann. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.jaci.2018.03.016","article-title":"A transcriptomics study of hereditary angioedema attacks","volume":"142","author":"Castellano","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/humu.23917","article-title":"SERPING1 mutation update: Mutation spectrum and C1 Inhibitor phenotypes","volume":"41","author":"Ponard","year":"2020","journal-title":"Hum. Mutat."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.gendis.2019.07.002","article-title":"An update on the genetics and pathogenesis of hereditary angioedema","volume":"7","author":"Banday","year":"2020","journal-title":"Genes Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/cei.13516","article-title":"Epigenetic alterations on C1-inhibitor expression may influence hereditary angioedema attack frequency and C4 levels","volume":"202","author":"Khan","year":"2020","journal-title":"Clin. Exp. Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.alit.2019.12.009","article-title":"A novel deep intronic SERPING1 variantas a cause of hereditary angioedema due to C1-inhibitor deficiency","volume":"69","author":"Vatsiou","year":"2020","journal-title":"Allergol. Int."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s10875-020-00753-2","article-title":"Deep intronic mutation in SERPING1 caused hereditary angioedema through pseudoexon activation","volume":"40","author":"Soucek","year":"2020","journal-title":"J. Clin. Immunoogyl."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Kajd\u00e1csi, E., Jandrasics, Z., Veszeli, N., Mak\u00f3, V., Koncz, A., Guly\u00e1s, D., K\u00f6halmi, K.V., Temesszentandr\u00e1si, G., Cervenak, L., and G\u00e1l, P. (2020). Patterns of C1-Inhibitor\/Plasma Serine Protease Complexes in Healthy Humans and in Hereditary Angioedema Patients. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.00794"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Corvillo, F., de la Morena Barrio, M.E., Marcos Bravo, C., L\u00f3pez-Trascasa, M., Vicente, V., Emsley, J., Caballero, T., Corral, J., and Lopez Lera, A. (2020). The FXII c.-4T>C Polymorphism as a Disease Modifier in Patients with Hereditary Angioedema Due to the FXIIp.Thr328Lys Variant. Front. Genet., 11.","DOI":"10.3389\/fgene.2020.01033"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Santacroce, R., D\u2019Andrea, G., Maffione, A.B., Margaglione, M., and d\u2019Apolito, M. (2021). The Genetics of Hereditary Angioedema: A Review. J. Clin. Med., 10.","DOI":"10.3390\/jcm10092023"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1016\/j.jaip.2023.04.035","article-title":"A National Survey of Hereditary Angioedema and Acquired C1 Inhibitor Deficiency in the United Kingdom","volume":"11","author":"Yong","year":"2023","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"100223","DOI":"10.1016\/j.jacig.2024.100223","article-title":"Hereditary angioedema with normal C1 inhibitor associated with carboxypeptidase N deficiency","volume":"3","author":"Vincent","year":"2024","journal-title":"J. Allergy Clin. Immunol. Glob."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.anai.2024.02.017","article-title":"Plasma microRNAs as biomarkers in hereditary angioedema","volume":"132","author":"Craig","year":"2024","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"49","DOI":"10.17161\/kjm.vol18.22749","article-title":"Phenotypic Heterogeny of Hereditary Angioedema Within a Single Family","volume":"18","author":"Fails","year":"2025","journal-title":"Kans. J. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1242\/dev.017905","article-title":"Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode","volume":"135","author":"Jayasena","year":"2008","journal-title":"Development"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1089\/scd.2013.0280","article-title":"Notch1 signaling antagonizes transforming growth factor-\u03b2 pathway and induces apoptosis in rabbit trophoblast stem cells","volume":"23","author":"Tan","year":"2014","journal-title":"Stem Cells Dev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"103","DOI":"10.2147\/BTT.S27566","article-title":"Hereditary angioedema: Epidemiology, management, and role of icatibant","volume":"7","author":"Ghazi","year":"2013","journal-title":"Biol. Targets Ther."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.anai.2018.05.031","article-title":"SERPING1 and F12 combined variants in a hereditary angioedema family","volume":"121","author":"Charignon","year":"2018","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/nm.3544","article-title":"Excessive transforming growth factor-\u03b2 signaling is a common mechanism in osteogenesis imperfecta","volume":"20","author":"Grafe","year":"2014","journal-title":"Nat. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1097\/MED.0000000000000367","article-title":"Osteogenesis imperfecta: Diagnosis and treatment","volume":"24","author":"Palomo","year":"2017","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"ref_28","first-page":"13","article-title":"c-Met as a Target for Personalized Therapy","volume":"23","author":"Giovannetti","year":"2015","journal-title":"Transl. Oncogen."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.bpobgyn.2019.02.007","article-title":"Fetal stem cell transplantation and gene therapy","volume":"58","author":"Sagar","year":"2019","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1097\/MOP.0000000000000813","article-title":"Osteogenesis imperfecta: Advancements in genetics and treatment","volume":"31","author":"Rossi","year":"2019","journal-title":"Curr. Opin. Pediatr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e10377","DOI":"10.1002\/jbm4.10377","article-title":"Gene Expression Profile and Acute Gene Expression Response to Sclerostin Inhibition in Osteogenesis Imperfecta Bone","volume":"4","author":"Surowiec","year":"2020","journal-title":"JBMR Plus"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3278","DOI":"10.1002\/art.34566","article-title":"Chondrocyte-intrinsic Smad3 represses Runx2-inducible matrix metalloproteinase 13 expression to maintain articular cartilage and prevent osteoarthritis","volume":"64","author":"Chen","year":"2012","journal-title":"Arthritis Rheum."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1186\/s13075-017-1454-2","article-title":"New insights on the MMP-13 regulatory network in the pathogenesis of early osteoarthritis","volume":"19","author":"Li","year":"2017","journal-title":"Arthritis Res. Ther."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1089\/hum.2024.191","article-title":"Comprehensive Review of Osteogenesis Imperfecta: Current Treatments and Future Innovations","volume":"36","author":"Chaugule","year":"2025","journal-title":"Hum. Gene Ther."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/S0168-8278(00)00048-9","article-title":"Expression and cellular localization of fibrillin-1 in normal and pathological human liver","volume":"34","author":"Dubuisson","year":"2001","journal-title":"J. Hepatol."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Li, L., Huang, J., and Liu, Y. (2024). The extracellular matrix glycoprotein fibrillin-1 in health and disease. Front. Cell Dev. Biol., 11.","DOI":"10.3389\/fcell.2023.1302285"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.cyto.2012.10.035","article-title":"Interleukin-33 overexpression is associated with gamma-glutamyl transferase in biliary atresia","volume":"61","author":"Dong","year":"2013","journal-title":"Cytokine"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/hep.27045","article-title":"Gene expression signature for biliary atresia and a role for interleukin-8 in pathogenesis of experimental disease","volume":"60","author":"Bessho","year":"2014","journal-title":"Hepatology"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.humpath.2014.09.010","article-title":"Elaboration of tubules with active hedgehog drives parenchymal fibrogenesis in gestational alloimmune liver disease","volume":"46","author":"Asai","year":"2015","journal-title":"Hum. Pathol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/gm154","article-title":"Staging of biliary atresia at diagnosis by molecular profiling of the liver","volume":"2","author":"Moyer","year":"2010","journal-title":"Genome Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1097\/MPG.0000000000001194","article-title":"Identification of circulating MicroRNAs in biliary atresia by next-generation sequencing","volume":"63","author":"Peng","year":"2016","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/labinvest.2015.149","article-title":"Inhibition of notch signaling pathway prevents cholestatic liver fibrosis by decreasing the differentiation of hepatic progenitor cells into cholangiocytes","volume":"96","author":"Zhang","year":"2016","journal-title":"Lab Investig."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Kanta, J. (2016). Elastin in the liver. Front. Physiol., 7.","DOI":"10.3389\/fphys.2016.00491"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1142\/S0192415X17500070","article-title":"Huang Qi decoction prevents bdl-induced liver fibrosis through inhibition of notch signaling activation","volume":"45","author":"Zhang","year":"2017","journal-title":"Am. J. Chin. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1159\/000493290","article-title":"Inhibition of the notch signaling pathway reduces the differentiation of hepatic progenitor cells into cholangiocytes in biliary atresia","volume":"49","author":"Mao","year":"2018","journal-title":"Cell Physiol. Biochem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e20190902","DOI":"10.1542\/peds.2019-0902","article-title":"Serum MMP-7 in the diagnosis of biliary atresia","volume":"144","author":"Jiang","year":"2019","journal-title":"Pediatrics"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Verhulst, S., Roskams, T., Sancho-Bru, P., and van Grunsven, L.A. (2019). Meta-analysis of human and mouse biliary epithelial cell gene profiles. Cells, 8.","DOI":"10.3390\/cells8101117"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.biochi.2020.05.014","article-title":"Functional role of annexins in zebrafish caudal fin regeneration\u2014A gene knockdown approach in regenerating tissue","volume":"175","author":"Quoseena","year":"2020","journal-title":"Biochimie"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e30232","DOI":"10.1097\/MD.0000000000030232","article-title":"Identification of signature of gene expression in biliary atresia using weighted gene co-expression network analysis","volume":"101","author":"Wang","year":"2022","journal-title":"Medicine"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"392","DOI":"10.3346\/jkms.2003.18.3.392","article-title":"The pattern of differentially expressed genes in biliary atresia","volume":"18","author":"Choe","year":"2003","journal-title":"J. Korean Med. Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.clinre.2015.11.010","article-title":"Biliary atresia: Clinical advances and perspectives","volume":"40","author":"Nizery","year":"2016","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s12098-024-05241-8","article-title":"Machine Learning in Biliary Atresia: Taking a Cautious Step into the Future","volume":"92","author":"Bolia","year":"2025","journal-title":"Indian J. Pediatr."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0022-0396(75)90065-0","article-title":"Limit sets for axiom A diffeomorphisms","volume":"18","author":"Bowen","year":"1975","journal-title":"J. Differ. Equ."},{"key":"ref_54","first-page":"151","article-title":"Sur Les courbes d\u00e9finies par une \u00e9quation diff\u00e9rentielle","volume":"2","year":"1886","journal-title":"J. Math. Pures Appliqu\u00e9es"},{"key":"ref_55","unstructured":"Hilbert, D. (1990). Sur les Probl\u00e8mes Futurs des Math\u00e9matiques: Les 23 Probl\u00e8mes, J. Gabay."},{"key":"ref_56","first-page":"33","article-title":"Unit\u00e9s biologiques dou\u00e9es de continuit\u00e9 g\u00e9n\u00e9tique","volume":"8","year":"1949","journal-title":"Colloques Int. CNRS"},{"key":"ref_57","unstructured":"(2025, February 15). BoolNet. Available online: https:\/\/sysbio.uni-ulm.de."},{"key":"ref_58","unstructured":"(2025, May 05). Network-Design. Available online: https:\/\/github.com\/houssembk30\/Network-Design."},{"key":"ref_59","unstructured":"Espinoza, A. (2025, July 15). Available online: https:\/\/github.com\/aer-neo\/Frustration-and-Energy-Tool-Boolean-Networks\/tree\/5c9e7fe."},{"key":"ref_60","unstructured":"(2025, January 15). Metacore. Available online: https:\/\/clarivate.com\/life-sciences-healthcare."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e324","DOI":"10.1038\/emm.2017.11","article-title":"Writing, erasing and reading histone lysine methylations","volume":"49","author":"Hyun","year":"2017","journal-title":"Exp. Mol. Med."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Szczepanek, J., and Tretyn, A. (2023). MicroRNA-Mediated Regulation of Histone-Modifying Enzymes in Cancer: Mechanisms and Therapeutic Implications. Biomolecules, 13.","DOI":"10.3390\/biom13111590"},{"key":"ref_63","unstructured":"(2025, February 22). Medscape. Available online: https:\/\/emedicine.medscape.com\/article\/135604-overview?form=fpf."},{"key":"ref_64","unstructured":"(2025, February 23). NCBI, Available online: https:\/\/www.ncbi.nlm.nih.gov\/nucleotide?cmd=search."},{"key":"ref_65","unstructured":"(2025, February 22). Signor. Available online: https:\/\/signor.uniroma2.it\/relation_result.php?id=SIGNOR-ST11&organism=human."},{"key":"ref_66","unstructured":"Thom, R. (1972). Stabilit\u00e9 Structurelle et Morphogen\u00e8se, Benjamin."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/BFb0076414","article-title":"On the definitions of attractors","volume":"1163","author":"Cosnard","year":"1985","journal-title":"Lect. Notes Maths"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/224177a0","article-title":"Homeostasis and Differentiation in Random Genetic Control Networks","volume":"224","author":"Kauffman","year":"1969","journal-title":"Nature"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/0022-5193(73)90247-6","article-title":"Boolean formalization of genetic control circuits","volume":"42","author":"Thomas","year":"1973","journal-title":"J. Theor. Biol."},{"key":"ref_70","first-page":"1","article-title":"On the relation between the logical structure of systems and their ability to generate multiple steady states or sustained oscillations","volume":"Volume 9","author":"Thomas","year":"1980","journal-title":"Numerical Methods in the Study of Critical Phenomena, Proceedings of a Colloquium, Carry-le-Rouet, France, 2\u20134 June 1980"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.dam.2011.11.005","article-title":"Combinatorics of Boolean automata circuits dynamics","volume":"160","author":"Demongeot","year":"2012","journal-title":"Discret. Appl. Math."},{"key":"ref_72","unstructured":"Tran, Q.N., and Arabnia, H.R. (2015). Genetic regulatory networks: Focus on attractors of their dynamics. Computational Biology, Bioinformatics and Systems Biology, Elsevier."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Demongeot, J., Jelassi, M., Hazgui, H., Ben Miled, S., Bellamine Ben Saoud, N., and Taramasco, C. (2016). Biological Networks Entropies: Examples in Neural Memory Networks, Genetic Regulation Networks and Social Epidemic Networks. Entropy, 20.","DOI":"10.3390\/e20010036"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Goles, E., and Martinez, S. (2001). Dynamical systems and biological regulations. Complex Systems, Kluwer.","DOI":"10.1007\/978-94-010-0920-1"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.tcs.2004.03.010","article-title":"On limit cycles of monotone functions with symmetric connection graphs","volume":"322","author":"Aracena","year":"2005","journal-title":"Theor. Comp. Sci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s10441-008-9029-x","article-title":"Robustness in neural and genetic networks","volume":"56","author":"Demongeot","year":"2008","journal-title":"Acta Biotheoretica"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"4437","DOI":"10.3390\/ijms10104437","article-title":"Robustness of regulatory networks. A Generic Approach with Applications at Different Levels: Physiologic, Metabolic and Genetic","volume":"10","author":"Demongeot","year":"2009","journal-title":"Int. J. Mol. Sci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.mbs.2013.01.007","article-title":"On the number of different dynamics in Boolean networks with deterministic update schedules","volume":"242","author":"Aracena","year":"2013","journal-title":"Math. Biosci."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/j.dam.2012.12.018","article-title":"On the number of update digraphs and its relation with the feedback arc sets and tournaments","volume":"161","author":"Aracena","year":"2013","journal-title":"Discret. Appl. Math."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s11047-019-09779-x","article-title":"About block-parallel Boolean networks: A position paper","volume":"19","author":"Demongeot","year":"2020","journal-title":"Nat. Comput."},{"key":"ref_81","first-page":"9","article-title":"On Boolean Isolated Cycles and Tangential Double-Cycles Dynamics","volume":"Volume 42","author":"Adamatzky","year":"2022","journal-title":"Automata and Complexity"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"116601","DOI":"10.1016\/j.chaos.2025.116601","article-title":"Impact of (a) synchronism on ECA: Towards a new classification","volume":"199","author":"Goles","year":"2025","journal-title":"Chaos Solitons Fractals"},{"key":"ref_83","unstructured":"Demongeot, J., Goles, E., ben Khalfallah, H., Montalva-Medel, M., and Sen\u00e9, S. (2025). Robustness of Boolean networks to update modes: An application to hereditary angioedema. arXiv."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0895-7177(97)00212-4","article-title":"Frustration and overblocking on graphs","volume":"26","author":"Combe","year":"1997","journal-title":"Math. Comp. Model."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.crma.2012.01.019","article-title":"Robustness in biological regulatory networks II: Application to genetic threshold Boolean random regulatory networks","volume":"350","author":"Demongeot","year":"2012","journal-title":"Comptes Rendus Math\u00e9matique I"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.disc.2024.114258","article-title":"Critically 3-frustrated signed graphs","volume":"348","author":"Cappello","year":"2025","journal-title":"Discret. Math."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"147401","DOI":"10.1103\/PhysRevLett.134.147401","article-title":"Statistical Mechanics of Frustrated Assemblies and Incompatible Graphs","volume":"134","author":"Yang","year":"2025","journal-title":"Phys. Rev. Lett."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1039\/D5LC00020C","article-title":"Machine learning-assisted flexible dual modal sensor for multi-sensing detection and target object recognition in the grasping process","volume":"25","author":"Dong","year":"2025","journal-title":"Lab Chip"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/24\/11976\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T11:15:05Z","timestamp":1765538105000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/24\/11976"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,12]]},"references-count":88,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["ijms262411976"],"URL":"https:\/\/doi.org\/10.3390\/ijms262411976","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,12]]}}}