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Hormonal shifts are the driving force of the ovulation cycle; however, several other factors are able to fine-tune the occurrence of follicular rupture. Prior to the follicular rupture, the pre-ovulatory luteinizing hormone (LH) surge triggers a self-generating local inflammatory and redox cascade, which is responsible for the release of several inflammatory and redox signaling mediators. Eicosanoids are one of the key regulators of the initiation of the local inflammation within the follicle, while the balance of reactive oxygen species and antioxidants is fundamental to maintaining the physiologically coordinated redox state during the ovulation process. In this review, we aim to provide a summary of the human menstrual and rat estrus cycles and demonstrate the LH-induced inflammatory and redox cascade involved in follicle rupture through the details of lipid-derived and redox signaling mediators.<\/jats:p>","DOI":"10.3390\/ijms262411979","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T11:13:33Z","timestamp":1765538013000},"page":"11979","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Inflammatory and Redox Mediators in Rat and Human Ovulation"],"prefix":"10.3390","volume":"26","author":[{"given":"Dorottya","family":"Varga","sequence":"first","affiliation":[{"name":"Department of Pharmacodynamics and Biopharmacy, University of Szeged, 6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1408-3286","authenticated-orcid":false,"given":"P\u00e9ter","family":"Szatm\u00e1ri","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics and Biopharmacy, University of Szeged, 6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5219-8491","authenticated-orcid":false,"given":"Eszter","family":"Ducza","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics and Biopharmacy, University of Szeged, 6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Zhao, Y., Feng, H., Zhang, Y., Zhang, J.V., Wang, X., Liu, D., Wang, T., Li, R.H.W., Ng, E.H.Y., and Yeung, W.S.B. 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