{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T05:21:14Z","timestamp":1765862474903,"version":"3.48.0"},"reference-count":19,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T00:00:00Z","timestamp":1765670400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA243547"],"award-info":[{"award-number":["R01 CA243547"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA202752"],"award-info":[{"award-number":["R01 CA202752"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA072720"],"award-info":[{"award-number":["P30 CA072720"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"US Department of Defense","doi-asserted-by":"publisher","award":["W81XWH1910821"],"award-info":[{"award-number":["W81XWH1910821"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002338","name":"Val Skinner Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100002338","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Hugs for Brady Foundation"},{"DOI":"10.13039\/100001006","name":"Breast Cancer Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001006","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Gertrude Fogarty Trust"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>A growing body of recent work suggests the possibility of heterogeneous ribosomal composition. We recently observed subtype-specific mRNA and copy number variation signatures of human ribosomal proteins (RPs) in cancers from human adults, but whether such subtype-specific RP mRNA signatures are also present in human pediatric cancers is currently unknown. In this study, we analyzed mRNA expression data from multiple large pediatric cancer datasets to test for heterogeneity in RP mRNA signatures. We found that different pediatric cancer types have different RP mRNA signatures, sometimes multiple RP mRNA signatures within the same pediatric cancer type, which can be subgroup\/subtype-specific (e.g., in Medulloblastoma) or cell-of-origin-specific (e.g., in Acute Lymphoblastic Leukemia (ALL)). In B-cell ALL, we found two RP mRNA subtypes with significantly different prognoses. Consistent with our recent findings in adult cancers, the RP mRNA signature in pediatric cancer is heterogeneous and subtype-specific and may have clinical relevance.<\/jats:p>","DOI":"10.3390\/ijms262412036","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T09:36:39Z","timestamp":1765791399000},"page":"12036","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Subtype-Specific mRNA Signatures of Human Ribosomal Proteins in Pediatric Cancers"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7917-0317","authenticated-orcid":false,"given":"Anshuman","family":"Panda","sequence":"first","affiliation":[{"name":"Perlmutter Cancer Center, New York, NY 10016, USA"},{"name":"NYU Grossman School of Medicine, New York, NY 10016, USA"},{"name":"Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anupama","family":"Yadav","sequence":"additional","affiliation":[{"name":"Dana-Farber Cancer Institute, Boston, MA 02215, USA"},{"name":"Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyan","family":"Bhanot","sequence":"additional","affiliation":[{"name":"Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA"},{"name":"Departments of Molecular Biology & Physics, Rutgers University, Piscataway, NJ 08854, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shridar","family":"Ganesan","sequence":"additional","affiliation":[{"name":"Perlmutter Cancer Center, New York, NY 10016, USA"},{"name":"NYU Grossman School of Medicine, New York, NY 10016, USA"},{"name":"Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA"},{"name":"Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"eaao0665","DOI":"10.1126\/sciadv.aao0665","article-title":"Variant ribosomal RNA alleles are conserved and exhibit tissue-specific expression","volume":"4","author":"Parks","year":"2018","journal-title":"Sci. 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