{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T15:21:08Z","timestamp":1775575268183,"version":"3.50.1"},"reference-count":61,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:00:00Z","timestamp":1765843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Danube Allergy Research Cluster of the country of Lower Austria"},{"name":"INSPIRED (Innovative Strategies for Prevention, diagnosis and therapy of ragweed pollen Induced REspiratoryDiseases) project","award":["COP 2014\u20132020 92\/09.09.2016"],"award-info":[{"award-number":["COP 2014\u20132020 92\/09.09.2016"]}]},{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"crossref","award":["23-75-30016"],"award-info":[{"award-number":["23-75-30016"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"crossref","award":["P_37_747"],"award-info":[{"award-number":["P_37_747"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Allergen sensitization profiles are increasingly affected by environmental and climate changes. This study exemplifies fundamental differences in molecular IgE sensitization profiles in two nearby regions in Argentina with different climatic conditions (La Plata and Bah\u00eda Blanca). A cross-sectional study was conducted involving 155 patients with allergic symptoms from La Plata and Bah\u00eda Blanca (34.0 \u00b1 11.2 years, female\/male: 83\/72). Serum samples were analyzed for IgE reactivity using a chip containing 101 micro-arrayed allergen molecules. Statistical analyses were performed to compare allergen-specific IgE levels, sensitization prevalences and reported symptoms. Patients from La Plata\u2014with subtropical weather\u2014showed a higher prevalence of IgE reactivity to house dust mite (HDM) allergens (Der p 23: 74%; Der p 1: 53% and Der p 2: 56%) and more frequently reported asthma (AS) symptoms (40% vs. 24%) than patients from Bah\u00eda Blanca. In contrast, patients from Bah\u00eda Blanca, with dry and windy weather, exhibited higher sensitization rates to pollen allergens, particularly Phl p 1 (49%) and Ole e 1 (22%) as well as to Alternaria alternata (Alt a 1, 35%) and reported a significantly higher prevalence of skin manifestations (54% vs. 31%) than those from La Plata. Cat allergen Fel d 1 was an equally important sensitizer in both regions (La Plata 30% and Bah\u00eda Blanca 37%). Sensitization to class 1 food allergens was rare in both groups (1\u20138%), including non-specific lipid transfer proteins (peanut Ara h 9 and peach Pru p 3) but IgE sensitizations to genuine peanut allergens were almost absent. Important regional differences in allergen sensitization profiles were observed between two geographically close regions with different climatic conditions. Our findings underscore the relevance of region-specific allergen profiling and highlight the clinical utility of molecular allergy diagnosis for a more precise allergen identification and improved management of allergic diseases.<\/jats:p>","DOI":"10.3390\/ijms262412101","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T14:36:53Z","timestamp":1765895813000},"page":"12101","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Profound Impact of Local Climatic Conditions on IgE Sensitization Profiles: Evidence from Argentine Cities"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8109-312X","authenticated-orcid":false,"given":"Eszter","family":"Sarzsinszky","sequence":"first","affiliation":[{"name":"Division of Immunopathology, Department of Pathophysiology and Allergy Research, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2734-516X","authenticated-orcid":false,"given":"Paola","family":"Smaldini","sequence":"additional","affiliation":[{"name":"Instituto de Estudios Inmunol\u00f3gicos y Fisiopatol\u00f3gicos-IIFP, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), La Plata 1900, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9990-8602","authenticated-orcid":false,"given":"Marcela","family":"Chinigo","sequence":"additional","affiliation":[{"name":"Hospital San Juan de Dios, La Plata 1900, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Ardanaz","sequence":"additional","affiliation":[{"name":"Hospital San Juan de Dios, La Plata 1900, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Ben\u00edtez","sequence":"additional","affiliation":[{"name":"Hospital San Juan de Dios, La Plata 1900, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Ramos","sequence":"additional","affiliation":[{"name":"Hospital San Juan de Dios, La Plata 1900, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Eugenia","family":"Braviz Lopez","sequence":"additional","affiliation":[{"name":"Hospital San Juan de Dios, La Plata 1900, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gonzalo","family":"Ram\u00f3n","sequence":"additional","affiliation":[{"name":"Instituto de Alergia e Inmunolog\u00eda del Sur, Bah\u00eda Blanca 8000, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9990-8147","authenticated-orcid":false,"given":"Germ\u00e1n","family":"Ram\u00f3n","sequence":"additional","affiliation":[{"name":"Instituto de Alergia e Inmunolog\u00eda del Sur, Bah\u00eda Blanca 8000, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Schlederer","sequence":"additional","affiliation":[{"name":"Division of Immunopathology, Department of Pathophysiology and Allergy Research, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3338-9606","authenticated-orcid":false,"given":"Mikhail","family":"Tulaev","sequence":"additional","affiliation":[{"name":"Division of Immunopathology, Department of Pathophysiology and Allergy Research, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf","family":"Valenta","sequence":"additional","affiliation":[{"name":"Division of Immunopathology, Department of Pathophysiology and Allergy Research, Medical University of Vienna, 1090 Vienna, Austria"},{"name":"Laboratory of Immunopathology, Department of Clinical Immunology and Allergy, Sechenov First Moscow State Medical University, 119991 Moscow, Russia"},{"name":"Center for Molecular Allergology, Karl Landsteiner University for Healthcare Sciences, 3500 Krems, Austria"},{"name":"Life Improvement by Future Technologies (LIFT) Center, 121205 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huey-Jy","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Immunopathology, Department of Pathophysiology and Allergy Research, Medical University of Vienna, 1090 Vienna, Austria"},{"name":"Center for Molecular Allergology, Karl Landsteiner University for Healthcare Sciences, 3500 Krems, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4250-8243","authenticated-orcid":false,"given":"Susanne","family":"Vrtala","sequence":"additional","affiliation":[{"name":"Division of Immunopathology, Department of Pathophysiology and Allergy Research, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0092-3169","authenticated-orcid":false,"given":"Guillermo","family":"Docena","sequence":"additional","affiliation":[{"name":"Instituto de Estudios Inmunol\u00f3gicos y Fisiopatol\u00f3gicos-IIFP, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), La Plata 1900, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Allergochip Working 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