{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T13:15:12Z","timestamp":1789046112150,"version":"build-2803163510"},"reference-count":171,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82070318"],"award-info":[{"award-number":["82070318"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Cardiovascular disease remains the leading global cause of death. Pathological cardiac hypertrophy is a key precursor to heart failure (HF), a condition with high morbidity and mortality. Extracellular vesicles (EVs) have emerged as crucial mediators of intercellular communication, carrying bioactive cargoes that reflect cellular state and influence recipient cell function. This review provides a focused and integrative perspective distinct from broader overviews, by dissecting the dynamic, cell-type-specific roles of EVs across the continuum from pathological hypertrophy to overt HF. We critically synthesize evidence on how EVs derived from cardiomyocytes, fibroblasts, immune cells, and adipocytes orchestrate maladaptive remodeling. Furthermore, we evaluate their dual utility as emerging diagnostic biomarkers and as engineerable therapeutic vectors. By highlighting recent advances in EV engineering for targeted delivery and discussing persistent translational challenges, this article offers a unique mechanistic-to-translational viewpoint aimed at advancing the therapeutic application of EVs in cardiovascular medicine.<\/jats:p>","DOI":"10.3390\/ijms27010095","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T03:06:02Z","timestamp":1766718362000},"page":"95","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Potential Biomarker and Therapeutic Tools for Pathological Cardiac Hypertrophy and Heart Failure: Extracellular Vesicles"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5350-6033","authenticated-orcid":false,"given":"Jinpeng","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"},{"name":"Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"},{"name":"Hubei Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongli","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"},{"name":"Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"},{"name":"Hubei Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0378-8385","authenticated-orcid":false,"given":"Min","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"},{"name":"Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"},{"name":"Hubei Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41569-018-0007-y","article-title":"Mechanisms of physiological and pathological cardiac hypertrophy","volume":"15","author":"Nakamura","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/s41580-022-00460-3","article-title":"Challenges and directions in studying cell-cell communication by extracellular vesicles","volume":"23","author":"Carter","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.cytogfr.2023.09.006","article-title":"Extracellular vesicles in cardiovascular diseases: From pathophysiology to diagnosis and therapy","volume":"74","author":"Du","year":"2023","journal-title":"Cytokine Growth Factor. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e948948","DOI":"10.12659\/MSM.948948","article-title":"Extracellular Vesicles as Emerging Regulators in Ischemic and Hypertrophic Cardiovascular Diseases: A Review of Pathogenesis and Therapeutics","volume":"31","author":"Chen","year":"2025","journal-title":"Med. Sci. Monit."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Guerricchio, L., Barile, L., and Bollini, S. (2024). Evolving Strategies for Extracellular Vesicles as Future Cardiac Therapeutics: From Macro- to Nano-Applications. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25116187"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Hu, H., Wang, X., Yu, H., and Wang, Z. (2024). Extracellular vesicular microRNAs and cardiac hypertrophy. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1444940"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e12404","DOI":"10.1002\/jev2.12404","article-title":"Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches","volume":"13","author":"Welsh","year":"2024","journal-title":"J. Extracell. Vesicles"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41392-024-01735-1","article-title":"Extracellular vesicles as tools and targets in therapy for diseases","volume":"9","author":"Kumar","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0005-2736(81)90512-5","article-title":"Exfoliation of membrane ecto-enzymes in the form of micro-vesicles","volume":"645","author":"Trams","year":"1981","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/0092-8674(83)90040-5","article-title":"Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: Selective externalization of the receptor","volume":"33","author":"Pan","year":"1983","journal-title":"Cell"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1126\/science.1153124","article-title":"Ceramide triggers budding of exosome vesicles into multivesicular endosomes","volume":"319","author":"Trajkovic","year":"2008","journal-title":"Science"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1146\/annurev-cellbio-101512-122326","article-title":"Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles","volume":"30","author":"Colombo","year":"2014","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"a016766","DOI":"10.1101\/cshperspect.a016766","article-title":"Molecular mechanisms of the membrane sculpting ESCRT pathway","volume":"5","author":"Henne","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_15","first-page":"5553","article-title":"Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles","volume":"126","author":"Colombo","year":"2013","journal-title":"J. Cell Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1038\/ncomms3712","article-title":"Ongoing activation of sphingosine 1-phosphate receptors mediates maturation of exosomal multivesicular endosomes","volume":"4","author":"Kajimoto","year":"2013","journal-title":"Nat. Commun."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.15252\/embj.201592484","article-title":"ESCRTs are everywhere","volume":"34","author":"Hurley","year":"2015","journal-title":"EMBO J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"4336","DOI":"10.1182\/blood-2003-03-0871","article-title":"Lipid raft-associated protein sorting in exosomes","volume":"102","author":"Geminard","year":"2003","journal-title":"Blood"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1042\/BST0390559","article-title":"Exosome target cell selection and the importance of exosomal tetraspanins: A hypothesis","volume":"39","author":"Rana","year":"2011","journal-title":"Biochem. Soc. Trans."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e07197","DOI":"10.7554\/eLife.07197","article-title":"KRAS-dependent sorting of miRNA to exosomes","volume":"4","author":"Cha","year":"2015","journal-title":"Elife"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"6917","DOI":"10.2147\/IJN.S264498","article-title":"Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications","volume":"15","author":"Zhang","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Doyle, L.M., and Wang, M.Z. (2019). Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis. Cells, 8.","DOI":"10.3390\/cells8070727"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Tschuschke, M., Kocherova, I., Bryja, A., Mozdziak, P., Angelova Volponi, A., Janowicz, K., Sibiak, R., Piotrowska-Kempisty, H., Izycki, D., and Bukowska, D. (2020). Inclusion Biogenesis, Methods of Isolation and Clinical Application of Human Cellular Exosomes. J. Clin. Med., 9.","DOI":"10.3390\/jcm9020436"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"a016857","DOI":"10.1101\/cshperspect.a016857","article-title":"The complex ultrastructure of the endolysosomal system","volume":"6","author":"Klumperman","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1083\/jcb.200911018","article-title":"Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C","volume":"189","author":"Hsu","year":"2010","journal-title":"J. Cell Biol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1111\/j.1600-0854.2009.00920.x","article-title":"Multivesicular endosome biogenesis in the absence of ESCRTs","volume":"10","author":"Stuffers","year":"2009","journal-title":"Traffic"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1373\/clinchem.2010.150730","article-title":"Intracellular and extracellular microRNAs in breast cancer","volume":"57","author":"Corcoran","year":"2011","journal-title":"Clin. Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s10549-010-0980-2","article-title":"Relevance of circulating tumor cells, extracellular nucleic acids, and exosomes in breast cancer","volume":"123","author":"Friel","year":"2010","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2174\/2211738511666230523114311","article-title":"A Comprehensive Review on Exosome: Recent Progress and Outlook","volume":"12","author":"Agarwal","year":"2023","journal-title":"Pharm. Nanotechnol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1161\/CIRCRESAHA.117.309417","article-title":"Methodological Guidelines to Study Extracellular Vesicles","volume":"120","author":"Coumans","year":"2017","journal-title":"Circ. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"6548","DOI":"10.7150\/thno.74305","article-title":"Small extracellular vesicles isolation and separation: Current techniques, pending questions and clinical applications","volume":"12","author":"Jia","year":"2022","journal-title":"Theranostics"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1007\/s00018-017-2452-x","article-title":"The role of neuropeptides in adverse myocardial remodeling and heart failure","volume":"74","author":"Widiapradja","year":"2017","journal-title":"Cell Mol. Life Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1440-1681.2007.04585.x","article-title":"Differences between pathological and physiological cardiac hypertrophy: Novel therapeutic strategies to treat heart failure","volume":"34","author":"McMullen","year":"2007","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.pharmthera.2010.04.005","article-title":"Molecular distinction between physiological and pathological cardiac hypertrophy: Experimental findings and therapeutic strategies","volume":"128","author":"Bernardo","year":"2010","journal-title":"Pharmacol. Ther."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"108025","DOI":"10.1016\/j.pharmthera.2021.108025","article-title":"Extracellular vesicles in cardiovascular disease: Biological functions and therapeutic implications","volume":"233","author":"Han","year":"2022","journal-title":"Pharmacol. Ther."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/ejhf.2333","article-title":"2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) With the special contribution of the Heart Failure Association (HFA) of the ESC","volume":"24","author":"McDonagh","year":"2022","journal-title":"Eur. J. Heart Fail."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1161\/CIRCRESAHA.117.311059","article-title":"Hypertrophic Cardiomyopathy: Genetics, Pathogenesis, Clinical Manifestations, Diagnosis, and Therapy","volume":"121","author":"Marian","year":"2017","journal-title":"Circ. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1016\/S0140-6736(21)01205-8","article-title":"Hypertrophic cardiomyopathy: A practical approach to guideline directed management","volume":"398","author":"Ommen","year":"2021","journal-title":"Lancet"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.amjmed.2003.05.009","article-title":"Prevalence of idiopathic hypertrophic cardiomyopathy in China: A population-based echocardiographic analysis of 8080 adults","volume":"116","author":"Zou","year":"2004","journal-title":"Am. J. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.jacc.2021.12.002","article-title":"Diagnosis and Evaluation of Hypertrophic Cardiomyopathy: JACC State-of-the-Art Review","volume":"79","author":"Maron","year":"2022","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/j.amjcard.2004.03.007","article-title":"Prevalence of hypertrophic cardiomyopathy in a population-based sample of American Indians aged 51 to 77 years (the Strong Heart Study)","volume":"93","author":"Maron","year":"2004","journal-title":"Am. J. Cardiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1161\/01.CIR.92.4.785","article-title":"Prevalence of hypertrophic cardiomyopathy in a general population of young adults. Echocardiographic analysis of 4111 subjects in the CARDIA Study. Coronary Artery Risk Development in (Young) Adults","volume":"92","author":"Maron","year":"1995","journal-title":"Circulation"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"365","DOI":"10.7326\/0003-4819-150-6-200903170-00004","article-title":"B-type natriuretic peptide testing, clinical outcomes, and health services use in emergency department patients with dyspnea: A randomized trial","volume":"150","author":"Schneider","year":"2009","journal-title":"Ann. Intern. Med."},{"key":"ref_44","first-page":"e895","article-title":"2022 AHA\/ACC\/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"145","author":"Heidenreich","year":"2022","journal-title":"Circulation"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"H1385","DOI":"10.1152\/ajpheart.01167.2011","article-title":"Cross talk between cardiac myocytes and fibroblasts: From multiscale investigative approaches to mechanisms and functional consequences","volume":"303","author":"Zhang","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Crocco, P., Montesanto, A., La Grotta, R., Paparazzo, E., Soraci, L., Dato, S., Passarino, G., and Rose, G. (2024). The Potential Contribution of MyomiRs miR-133a-3p, -133b, and -206 Dysregulation in Cardiovascular Disease Risk. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252312772"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Li, N., Zhou, H., and Tang, Q. (2018). miR-133: A Suppressor of Cardiac Remodeling?. Front. Pharmacol., 9.","DOI":"10.3389\/fphar.2018.00903"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells","volume":"9","author":"Valadi","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"10937","DOI":"10.1093\/nar\/gks832","article-title":"Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion-infected neuronal cells","volume":"40","author":"Bellingham","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1055\/s-0030-1267044","article-title":"Microparticles: Key protagonists in cardiovascular disorders","volume":"36","author":"Amabile","year":"2010","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12943-019-0999-x","article-title":"Exosomal let-7d-3p and miR-30d-5p as diagnostic biomarkers for non-invasive screening of cervical cancer and its precursors","volume":"18","author":"Zheng","year":"2019","journal-title":"Mol. Cancer"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1530\/EJE-19-0524","article-title":"Identification of exosomal miRNA biomarkers for diagnosis of papillary thyroid cancer by small RNA sequencing","volume":"182","author":"Dai","year":"2020","journal-title":"Eur. J. Endocrinol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1194\/jlr.R034991","article-title":"Extracellular communication via microRNA: Lipid particles have a new message","volume":"54","author":"Rayner","year":"2013","journal-title":"J. Lipid Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"7223","DOI":"10.1093\/nar\/gkr254","article-title":"Characterization of extracellular circulating microRNA","volume":"39","author":"Turchinovich","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1016\/j.ymthe.2022.01.031","article-title":"miR-486 attenuates cardiac ischemia\/reperfusion injury and mediates the beneficial effect of exercise for myocardial protection","volume":"30","author":"Bei","year":"2022","journal-title":"Mol. Ther."},{"key":"ref_56","first-page":"1372","article-title":"Roles of exosomes in cardioprotection","volume":"38","author":"Barile","year":"2017","journal-title":"Eur. Heart J."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Gilyazova, I., Asadullina, D., Kagirova, E., Sikka, R., Mustafin, A., Ivanova, E., Bakhtiyarova, K., Gilyazova, G., Gupta, S., and Khusnutdinova, E. (2023). MiRNA-146a-A Key Player in Immunity and Diseases. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241612767"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Beg, F., Wang, R., Saeed, Z., Devaraj, S., Masoor, K., and Nakshatri, H. (2017). Inflammation-associated microRNA changes in circulating exosomes of heart failure patients. BMC Res. Notes, 10.","DOI":"10.1186\/s13104-017-3090-y"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"6211","DOI":"10.21037\/jtd.2018.10.52","article-title":"Circulating exosomal miR-92b-5p is a promising diagnostic biomarker of heart failure with reduced ejection fraction patients hospitalized for acute heart failure","volume":"10","author":"Wu","year":"2018","journal-title":"J. Thorac. Dis."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1161\/CIRCULATIONAHA.119.045115","article-title":"High-Resolution Transcriptomic Profiling of the Heart During Chronic Stress Reveals Cellular Drivers of Cardiac Fibrosis and Hypertrophy","volume":"142","author":"McLellan","year":"2020","journal-title":"Circulation"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.addr.2021.03.021","article-title":"Cardiac fibrosis: Myofibroblast-mediated pathological regulation and drug delivery strategies","volume":"173","author":"Liu","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.kjms.2018.05.008","article-title":"Reduced exosome miR-425 and miR-744 in the plasma represents the progression of fibrosis and heart failure","volume":"34","author":"Wang","year":"2018","journal-title":"Kaohsiung J. Med. Sci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1161\/CIRCRESAHA.113.301209","article-title":"Circulating p53-responsive microRNAs are predictive indicators of heart failure after acute myocardial infarction","volume":"113","author":"Matsumoto","year":"2013","journal-title":"Circ. Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1093\/eurjhf\/hfq145","article-title":"Prognostic value of endothelial microparticles in patients with heart failure","volume":"12","author":"Nozaki","year":"2010","journal-title":"Eur. J. Heart Fail."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.bbacli.2014.11.006","article-title":"The predictive role of circulating microparticles in patients with chronic heart failure","volume":"3","author":"Berezin","year":"2015","journal-title":"BBA Clin."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.jjcc.2014.06.014","article-title":"Predictive value of apoptotic microparticles to mononuclear progenitor cells ratio in advanced chronic heart failure patients","volume":"65","author":"Berezin","year":"2015","journal-title":"J. Cardiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1172\/JCI64365","article-title":"MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy","volume":"123","author":"Halkein","year":"2013","journal-title":"J. Clin. Investig."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1161\/CIRCRESAHA.118.312751","article-title":"miR-146a Suppresses SUMO1 Expression and Induces Cardiac Dysfunction in Maladaptive Hypertrophy","volume":"123","author":"Oh","year":"2018","journal-title":"Circ. Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"H124","DOI":"10.1152\/ajpheart.00375.2025","article-title":"Human fetal circulating factors from pregnancies complicated by obesity upregulate genes associated with pathological hypertrophy in neonatal rat cardiomyocytes","volume":"330","author":"Vaughan","year":"2026","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1350088","DOI":"10.1080\/20013078.2017.1350088","article-title":"Circulating exosome microRNA associated with heart failure secondary to myxomatous mitral valve disease in a naturally occurring canine model","volume":"6","author":"Yang","year":"2017","journal-title":"J. Extracell. Vesicles"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12933-023-01755-1","article-title":"The interplay of inflammation, exosomes and Ca(2+) dynamics in diabetic cardiomyopathy","volume":"22","author":"Sanganalmath","year":"2023","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.yjmcc.2014.05.001","article-title":"Cardiomyocytes mediate anti-angiogenesis in type 2 diabetic rats through the exosomal transfer of miR-320 into endothelial cells","volume":"74","author":"Wang","year":"2014","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Huang, J.P., Chang, C.C., Kuo, C.Y., Huang, K.J., Sokal, E.M., Chen, K.H., and Hung, L.M. (2022). Exosomal microRNAs miR-30d-5p and miR-126a-5p Are Associated with Heart Failure with Preserved Ejection Fraction in STZ-Induced Type 1 Diabetic Rats. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23147514"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"110944","DOI":"10.1016\/j.mce.2020.110944","article-title":"Value of circulating miRNA-21 in the diagnosis of subclinical diabetic cardiomyopathy","volume":"518","author":"Tao","year":"2020","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1089\/scd.2021.0202","article-title":"Transcriptomic Analysis of Cardiomyocyte Extracellular Vesicles in Hypertrophic Cardiomyopathy Reveals Differential snoRNA Cargo","volume":"30","author":"James","year":"2021","journal-title":"Stem Cells Dev."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"109458","DOI":"10.1016\/j.jnutbio.2023.109458","article-title":"Revealing the contribution of iron overload-brown adipocytes to iron overload cardiomyopathy: Insights from RNA-seq and exosomes coculture technology","volume":"122","author":"Zhang","year":"2023","journal-title":"J. Nutr. Biochem."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"103016","DOI":"10.1016\/j.redox.2023.103016","article-title":"M2 macrophage exosome-derived lncRNA AK083884 protects mice from CVB3-induced viral myocarditis through regulating PKM2\/HIF-1\u03b1 axis mediated metabolic reprogramming of macrophages","volume":"69","author":"Zhang","year":"2024","journal-title":"Redox Biol."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Song, H.Y., Chien, C.S., Yarmishyn, A.A., Chou, S.J., Yang, Y.P., Wang, M.L., Wang, C.Y., Leu, H.B., Yu, W.C., and Chang, Y.L. (2019). Generation of GLA-Knockout Human Embryonic Stem Cell Lines to Model Autophagic Dysfunction and Exosome Secretion in Fabry Disease-Associated Hypertrophic Cardiomyopathy. Cells, 8.","DOI":"10.3390\/cells8040327"},{"key":"ref_79","first-page":"e2022066","article-title":"Plasma-derived exosomes implement miR-126-associated regulation of cytokines secretion in PBMCs of CHF patients in vitro","volume":"93","author":"Natrus","year":"2022","journal-title":"Acta Biomed."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1152\/physrev.1999.79.1.215","article-title":"Molecular mechanisms of myocardial remodeling","volume":"79","author":"Swynghedauw","year":"1999","journal-title":"Physiol. Rev."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"H8","DOI":"10.1152\/ajpheart.01303.2004","article-title":"Does load-induced ventricular hypertrophy progress to systolic heart failure?","volume":"289","author":"Berenji","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/S0140-6736(06)68074-4","article-title":"Controversies in ventricular remodelling","volume":"367","author":"Opie","year":"2006","journal-title":"Lancet"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1161\/CIRCRESAHA.113.302501","article-title":"Solving the cardiac hypertrophy riddle: The angiotensin II-mechanical stress connection","volume":"113","author":"Zablocki","year":"2013","journal-title":"Circ. Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1161\/01.HYP.0000255946.55091.24","article-title":"Interruption of Wnt signaling attenuates the onset of pressure overload-induced cardiac hypertrophy","volume":"49","author":"Strzelecka","year":"2007","journal-title":"Hypertension"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Bupha-Intr, T., Haizlip, K.M., and Janssen, P.M. (2012). Role of endothelin in the induction of cardiac hypertrophy in vitro. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0043179"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.autneu.2012.08.002","article-title":"Baroreflex control of renal sympathetic nerve activity in mice with cardiac hypertrophy","volume":"170","author":"Gava","year":"2012","journal-title":"Auton. Neurosci."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0898-6568(98)00036-9","article-title":"Signalling pathways for cardiac hypertrophy","volume":"10","author":"Yamazaki","year":"1998","journal-title":"Cell Signal"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"115462","DOI":"10.1016\/j.bcp.2023.115462","article-title":"Serum exosomes derived from spontaneously hypertensive rats induce cardiac hypertrophy in vitro and in vivo by increasing autocrine release of angiotensin II in cardiomyocytes","volume":"210","author":"Yu","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1161\/CIRCRESAHA.123.321759","article-title":"Cardiac Metabolism in Heart Failure and Implications for Uremic Cardiomyopathy","volume":"132","author":"Nguyen","year":"2023","journal-title":"Circ. Res."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"D\u2019Agostino, M., Mauro, D., Zicarelli, M., Carullo, N., Greco, M., Andreucci, M., Coppolino, G., and Bolignano, D. (2023). miRNAs in Uremic Cardiomyopathy: A Comprehensive Review. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24065425"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.18632\/aging.202385","article-title":"RNA interactions in right ventricular dysfunction induced type II cardiorenal syndrome","volume":"13","author":"Chen","year":"2021","journal-title":"Aging"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.freeradbiomed.2025.09.040","article-title":"Exosomal miR-27a-5p inhibits indoxyl sulfate-induced cardiac dysfunction by targeting the USF2\/FUT8 axis","volume":"241","author":"Xiao","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Wu, R., Gao, W., Yao, K., and Ge, J. (2019). Roles of Exosomes Derived From Immune Cells in Cardiovascular Diseases. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.00648"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Yu, H., Qin, L., Peng, Y., Bai, W., and Wang, Z. (2020). Exosomes Derived From Hypertrophic Cardiomyocytes Induce Inflammation in Macrophages via miR-155 Mediated MAPK Pathway. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.606045"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.yjmcc.2020.07.001","article-title":"Pleiotropic cardiac functions controlled by ischemia-induced lncRNA H19","volume":"146","author":"Hobuss","year":"2020","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"H928","DOI":"10.1152\/ajpheart.00602.2017","article-title":"Myocardial infarction-induced microRNA-enriched exosomes contribute to cardiac Nrf2 dysregulation in chronic heart failure","volume":"314","author":"Tian","year":"2018","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.yjmcc.2020.04.032","article-title":"Extracellular vesicular MicroRNA-27a* contributes to cardiac hypertrophy in chronic heart failure","volume":"143","author":"Tian","year":"2020","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.2337\/db19-1176","article-title":"Autophagy Inhibition Enables Nrf2 to Exaggerate the Progression of Diabetic Cardiomyopathy in Mice","volume":"69","author":"Zang","year":"2020","journal-title":"Diabetes"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/nrendo.2015.216","article-title":"Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy","volume":"12","author":"Jia","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.molcel.2010.10.006","article-title":"The heat shock response: Life on the verge of death","volume":"40","author":"Richter","year":"2010","journal-title":"Mol. Cell"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Bellini, S., Barutta, F., Mastrocola, R., Imperatore, L., Bruno, G., and Gruden, G. (2017). Heat Shock Proteins in Vascular Diabetic Complications: Review and Future Perspective. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18122709"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.2337\/db15-1563","article-title":"Hsp20-Mediated Activation of Exosome Biogenesis in Cardiomyocytes Improves Cardiac Function and Angiogenesis in Diabetic Mice","volume":"65","author":"Wang","year":"2016","journal-title":"Diabetes"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"e00611-16","DOI":"10.1128\/MCB.00611-16","article-title":"Myocyte-Derived Hsp90 Modulates Collagen Upregulation via Biphasic Activation of STAT-3 in Fibroblasts during Cardiac Hypertrophy","volume":"37","author":"Datta","year":"2017","journal-title":"Mol. Cell Biol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"H3052","DOI":"10.1152\/ajpheart.01355.2006","article-title":"HSP60 trafficking in adult cardiac myocytes: Role of the exosomal pathway","volume":"292","author":"Gupta","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"H2238","DOI":"10.1152\/ajpheart.00740.2007","article-title":"HSP60 in heart failure: Abnormal distribution and role in cardiac myocyte apoptosis","volume":"293","author":"Lin","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1161\/CIRCRESAHA.109.209643","article-title":"Extracellular heat shock protein 60, cardiac myocytes, and apoptosis","volume":"105","author":"Kim","year":"2009","journal-title":"Circ. Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1113\/JP278864","article-title":"Neuroinflammation in heart failure: New insights for an old disease","volume":"598","author":"Toledo","year":"2020","journal-title":"J. Physiol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/0735-1097(95)00332-0","article-title":"Adverse consequences of high sympathetic nervous activity in the failing human heart","volume":"26","author":"Kaye","year":"1995","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nrcardio.2016.163","article-title":"Neurohormonal activation in heart failure with reduced ejection fraction","volume":"14","author":"Hartupee","year":"2017","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1161\/CIRCRESAHA.113.300308","article-title":"Adrenergic nervous system in heart failure: Pathophysiology and therapy","volume":"113","author":"Lymperopoulos","year":"2013","journal-title":"Circ. Res."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/S0735-1097(01)01433-4","article-title":"Important role of endogenous norepinephrine and epinephrine in the development of in vivo pressure-overload cardiac hypertrophy","volume":"38","author":"Rapacciuolo","year":"2001","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/S0008-6363(02)00772-1","article-title":"Differential regulation of p38 mitogen-activated protein kinase mediates gender-dependent catecholamine-induced hypertrophy","volume":"57","author":"Dash","year":"2003","journal-title":"Cardiovasc. Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.freeradbiomed.2019.06.002","article-title":"Upregulating Nrf2 in the RVLM ameliorates sympatho-excitation in mice with chronic heart failure","volume":"141","author":"Ma","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/1742-2094-9-212","article-title":"Neuroinflammation and oxidative stress in rostral ventrolateral medulla contribute to neurogenic hypertension induced by systemic inflammation","volume":"9","author":"Wu","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Saint-Pol, J., Gosselet, F., Duban-Deweer, S., Pottiez, G., and Karamanos, Y. (2020). Targeting and Crossing the Blood-Brain Barrier with Extracellular Vesicles. Cells, 9.","DOI":"10.3390\/cells9040851"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1007\/s12265-022-10266-5","article-title":"The Peripheral Circulating Exosomal microRNAs Related to Central Inflammation in Chronic Heart Failure","volume":"15","author":"Xiao","year":"2022","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.cbi.2018.07.008","article-title":"New insights into TGF-\u03b2\/Smad signaling in tissue fibrosis","volume":"292","author":"Hu","year":"2018","journal-title":"Chem. Biol. Interact."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1161\/CIRCULATIONAHA.120.046372","article-title":"Loss of Phosphatase and Tensin Homolog Promotes Cardiomyocyte Proliferation and Cardiac Repair After Myocardial Infarction","volume":"142","author":"Liang","year":"2020","journal-title":"Circulation"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1161\/CIRCULATIONAHA.112.000882","article-title":"MiR-378 controls cardiac hypertrophy by combined repression of mitogen-activated protein kinase pathway factors","volume":"127","author":"Ganesan","year":"2013","journal-title":"Circulation"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.7150\/thno.22878","article-title":"MicroRNA-378 suppresses myocardial fibrosis through a paracrine mechanism at the early stage of cardiac hypertrophy following mechanical stress","volume":"8","author":"Yuan","year":"2018","journal-title":"Theranostics"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1172\/JCI70577","article-title":"Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy","volume":"124","author":"Bang","year":"2014","journal-title":"J. Clin. Investig."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.yjmcc.2015.10.022","article-title":"A critical role of cardiac fibroblast-derived exosomes in activating renin angiotensin system in cardiomyocytes","volume":"89","author":"Lyu","year":"2015","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.omtn.2018.05.013","article-title":"miR-217 Promotes Cardiac Hypertrophy and Dysfunction by Targeting PTEN","volume":"12","author":"Nie","year":"2018","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.yjmcc.2014.11.006","article-title":"Pellino1-mediated TGF-\u03b21 synthesis contributes to mechanical stress induced cardiac fibroblast activation","volume":"79","author":"Song","year":"2015","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"e22699","DOI":"10.1096\/fj.202200597R","article-title":"Cardiomyocyte-specific Peli1 contributes to the pressure overload-induced cardiac fibrosis through miR-494-3p-dependent exosomal communication","volume":"37","author":"Tang","year":"2023","journal-title":"FASEB J."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"e89908","DOI":"10.1172\/jci.insight.89908","article-title":"Adipocyte-specific loss of PPARgamma attenuates cardiac hypertrophy","volume":"1","author":"Fang","year":"2016","journal-title":"JCI Insight"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1161\/CIRCRESAHA.118.312657","article-title":"Induced Pluripotent Stem Cell (iPSC)-Derived Exosomes for Precision Medicine in Heart Failure","volume":"122","author":"Yang","year":"2018","journal-title":"Circ. Res."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1161\/CIRCRESAHA.116.304360","article-title":"Identification of therapeutic covariant microRNA clusters in hypoxia-treated cardiac progenitor cell exosomes using systems biology","volume":"116","author":"Gray","year":"2015","journal-title":"Circ. Res."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1172\/JCI123135","article-title":"microRNA-21-5p dysregulation in exosomes derived from heart failure patients impairs regenerative potential","volume":"129","author":"Qiao","year":"2019","journal-title":"J. Clin. Investig."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1161\/CIRCRESAHA.117.311769","article-title":"Induced Pluripotent Stem Cell (iPSC)-Derived Extracellular Vesicles Are Safer and More Effective for Cardiac Repair Than iPSCs","volume":"122","author":"Adamiak","year":"2018","journal-title":"Circ. Res."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"13144","DOI":"10.1073\/pnas.1616168113","article-title":"VEGF-B gene therapy inhibits doxorubicin-induced cardiotoxicity by endothelial protection","volume":"113","author":"Degerman","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.7150\/ijbs.58786","article-title":"Potential of exosomes as diagnostic biomarkers and therapeutic carriers for doxorubicin-induced cardiotoxicity","volume":"17","author":"Tian","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1186\/s12951-020-00733-z","article-title":"Human trophoblast-derived exosomes attenuate doxorubicin-induced cardiac injury by regulating miR-200b and downstream Zeb1","volume":"18","author":"Ni","year":"2020","journal-title":"J. Nanobiotechnol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s12012-022-09774-2","article-title":"Trophoblast Stem-Cell-Derived Exosomes Alleviate Cardiotoxicity of Doxorubicin via Improving Mfn2-Mediated Mitochondrial Fusion","volume":"23","author":"Duan","year":"2023","journal-title":"Cardiovasc. Toxicol."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Pang, Y., Ma, M., Wang, D., Xia, J., Wang, X., Hou, L., Wang, Z., and Li, X. (2021). Embryonic Stem Cell-Derived Exosomes Attenuate Transverse Aortic Constriction Induced Heart Failure by Increasing Angiogenesis. Front. Cardiovasc. Med., 8.","DOI":"10.3389\/fcvm.2021.638771"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1186\/s12967-024-05204-9","article-title":"Unlocking cardioprotection: iPSC exosomes deliver Nec-1 to target PARP1\/AIFM1 axis, alleviating HF oxidative stress and mitochondrial dysfunction","volume":"22","author":"Lv","year":"2024","journal-title":"J. Transl. Med."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1161\/CIRCRESAHA.114.305673","article-title":"Exosomal microRNA clusters are important for the therapeutic effect of cardiac progenitor cells","volume":"116","author":"Sluijter","year":"2015","journal-title":"Circ. Res."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.bbrc.2013.01.015","article-title":"Cardiac progenitor-derived exosomes protect ischemic myocardium from acute ischemia\/reperfusion injury","volume":"431","author":"Chen","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"e2277","DOI":"10.1038\/cddis.2016.181","article-title":"Cardiac progenitor cell-derived exosomes prevent cardiomyocytes apoptosis through exosomal miR-21 by targeting PDCD4","volume":"7","author":"Xiao","year":"2016","journal-title":"Cell Death Dis."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/75037","article-title":"TAK1 is activated in the myocardium after pressure overload and is sufficient to provoke heart failure in transgenic mice","volume":"6","author":"Zhang","year":"2000","journal-title":"Nat. Med."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1186\/s12951-022-01630-3","article-title":"Heart-targeting exosomes from human cardiosphere-derived cells improve the therapeutic effect on cardiac hypertrophy","volume":"20","author":"Mao","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1161\/CIRCRESAHA.119.315829","article-title":"Interleukin-10 Deficiency Alters Endothelial Progenitor Cell-Derived Exosome Reparative Effect on Myocardial Repair via Integrin-Linked Kinase Enrichment","volume":"126","author":"Yue","year":"2020","journal-title":"Circ. Res."},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Huang, Y., Chen, L., Feng, Z., Chen, W., Yan, S., Yang, R., Xiao, J., Gao, J., Zhang, D., and Ke, X. (2021). EPC-Derived Exosomal miR-1246 and miR-1290 Regulate Phenotypic Changes of Fibroblasts to Endothelial Cells to Exert Protective Effects on Myocardial Infarction by Targeting ELF5 and SP1. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.647763"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/978-981-10-4397-0_12","article-title":"Therapeutic Effects of Mesenchymal Stem Cell-Derived Exosomes in Cardiovascular Disease","volume":"998","author":"Suzuki","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"685","DOI":"10.7150\/thno.73568","article-title":"Therapeutic delivery of microRNA-125a-5p oligonucleotides improves recovery from myocardial ischemia\/reperfusion injury in mice and swine","volume":"13","author":"Gao","year":"2023","journal-title":"Theranostics"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"5579904","DOI":"10.1155\/2021\/5579904","article-title":"The Application Potential and Advance of Mesenchymal Stem Cell-Derived Exosomes in Myocardial Infarction","volume":"2021","author":"Wang","year":"2021","journal-title":"Stem Cells Int."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"4041","DOI":"10.1172\/JCI129193","article-title":"Interorgan communication by exosomes, adipose tissue, and adiponectin in metabolic syndrome","volume":"129","author":"Kita","year":"2019","journal-title":"J. Clin. Investig."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1016\/j.ymthe.2020.06.026","article-title":"Adiponectin Stimulates Exosome Release to Enhance Mesenchymal Stem-Cell-Driven Therapy of Heart Failure in Mice","volume":"28","author":"Nakamura","year":"2020","journal-title":"Mol. Ther."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"111969","DOI":"10.1016\/j.ejmech.2019.111969","article-title":"Novel linked butanolide dimer compounds increase adiponectin production during adipogenesis in human mesenchymal stem cells through peroxisome proliferator-activated receptor \u03b3 modulation","volume":"187","author":"Ahn","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/bmb\/ldw025","article-title":"Heart failure-potential new targets for therapy","volume":"119","author":"Nabeebaccus","year":"2016","journal-title":"Br. Med. Bull."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1002\/cbin.11664","article-title":"Exosomal microRNA-1246 from human umbilical cord mesenchymal stem cells potentiates myocardial angiogenesis in chronic heart failure","volume":"45","author":"Wang","year":"2021","journal-title":"Cell Biol. Int."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/ehf2.13144","article-title":"Heart failure after myocardial infarction: Incidence and predictors","volume":"8","author":"Stehlik","year":"2021","journal-title":"ESC Heart Fail."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nrcardio.2016.5","article-title":"Ischaemic conditioning and reperfusion injury","volume":"13","author":"Hausenloy","year":"2016","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.bja.2022.08.040","article-title":"Plasma exosomes generated by ischaemic preconditioning are cardioprotective in a rat heart failure model","volume":"130","author":"Luo","year":"2023","journal-title":"Br. J. Anaesth."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"218","DOI":"10.7150\/thno.38198","article-title":"Mononuclear phagocyte system blockade improves therapeutic exosome delivery to the myocardium","volume":"10","author":"Wan","year":"2020","journal-title":"Theranostics"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"e2102547","DOI":"10.1002\/adhm.202102547","article-title":"Recent Progress in Microneedles-Mediated Diagnosis, Therapy, and Theranostic Systems","volume":"11","author":"Yang","year":"2022","journal-title":"Adv. Healthc. Mater."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"e2202959","DOI":"10.1002\/adhm.202202959","article-title":"Microneedle Patch Loaded with Exosomes Containing MicroRNA-29b Prevents Cardiac Fibrosis after Myocardial Infarction","volume":"12","author":"Yuan","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Akhmerov, A., and Parimon, T. (2022). Extracellular Vesicles, Inflammation, and Cardiovascular Disease. Cells, 11.","DOI":"10.3390\/cells11142229"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.cardfail.2014.11.004","article-title":"Exaggerated inflammation and monocytosis associate with diastolic dysfunction in heart failure with preserved ejection fraction: Evidence of M2 macrophage activation in disease pathogenesis","volume":"21","author":"Glezeva","year":"2015","journal-title":"J. Card. Fail."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/s41565-021-00931-2","article-title":"Extracellular vesicles as a next-generation drug delivery platform","volume":"16","author":"Herrmann","year":"2021","journal-title":"Nat. Nanotechnol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"30087","DOI":"10.3402\/jev.v4.30087","article-title":"Applying extracellular vesicles based therapeutics in clinical trials\u2014An ISEV position paper","volume":"4","author":"Lener","year":"2015","journal-title":"J. Extracell. Vesicles"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.yjmcc.2023.09.006","article-title":"Current optimized strategies for stem cell-derived extracellular vesicle\/exosomes in cardiac repair","volume":"184","author":"Wu","year":"2023","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1186\/s12951-023-02081-0","article-title":"Targeted therapy using engineered extracellular vesicles: Principles and strategies for membrane modification","volume":"21","author":"Liu","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"122976","DOI":"10.1016\/j.biomaterials.2024.122976","article-title":"Myocardial delivery of miR30d with peptide-functionalized milk-derived extracellular vesicles for targeted treatment of hypertrophic heart failure","volume":"316","author":"Tong","year":"2025","journal-title":"Biomaterials"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"9407","DOI":"10.2147\/IJN.S522157","article-title":"Targeted Delivery of Exosome-Derived miRNA-185-5p Inhibitor via Liposomes Alleviates Apoptosis and Cuproptosis in Dilated Cardiomyopathy","volume":"20","author":"Xu","year":"2025","journal-title":"Int. J. Nanomed."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1039\/D2NH00070A","article-title":"Engineered extracellular vesicles as intelligent nanosystems for next-generation nanomedicine","volume":"7","author":"Fan","year":"2022","journal-title":"Nanoscale Horiz."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/s12951-025-03289-y","article-title":"Stem cells derived exosome laden oxygen generating hydrogel composites with good electrical conductivity for the tissue-repairing process of post-myocardial infarction","volume":"23","author":"Xu","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"e12182","DOI":"10.1002\/jev2.12182","article-title":"Updating MISEV: Evolving the minimal requirements for studies of extracellular vesicles","volume":"10","author":"Witwer","year":"2021","journal-title":"J. Extracell. Vesicles"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/s41569-020-0389-5","article-title":"Native and bioengineered extracellular vesicles for cardiovascular therapeutics","volume":"17","author":"Fernandes","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/s41440-022-01111-y","article-title":"A novel circ_0018553 protects against angiotensin-induced cardiac hypertrophy in cardiomyocytes by modulating the miR-4731\/SIRT2 signaling pathway","volume":"46","author":"Zuo","year":"2023","journal-title":"Hypertens. Res."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.omtn.2021.04.014","article-title":"Exosomally derived Y RNA fragment alleviates hypertrophic cardiomyopathy in transgenic mice","volume":"24","author":"Huang","year":"2021","journal-title":"Mol. Ther. 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