{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:20:34Z","timestamp":1777652434291,"version":"3.51.4"},"reference-count":160,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the MBIE program","award":["PROP-1574-ENDRP-UOA"],"award-info":[{"award-number":["PROP-1574-ENDRP-UOA"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Cochlear homeostasis is critical for the preservation of hearing sensitivity by maintaining optimal cochlear fluid composition, sustaining electrochemical gradients, and supporting the function of sensory and supporting cells in the cochlea. Sensorineural hearing loss, resulting from the damage or loss of sensory hair cells, auditory neurons and other cochlear cells and structures, is intimately linked to disruptions in the homeostatic environment. In this narrative review, we explore the cellular and molecular pathways underpinning cochlear homeostasis in health and disease and examine the mechanisms by which failed homeostasis leads to sensorineural hearing loss. We further discuss current research avenues and emerging therapeutic strategies to restore or compensate for the loss of homeostatic balance. These interventions suggest a future where regenerative healing is possible, ultimately leading to permanent repair and functional recovery.<\/jats:p>","DOI":"10.3390\/ijms27010102","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T11:43:31Z","timestamp":1766403811000},"page":"102","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cochlear Homeostasis in Sensorineural Hearing Loss: Mechanisms, Implications, and Therapeutic Prospects"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8548-6844","authenticated-orcid":false,"given":"Srdjan M.","family":"Vlajkovic","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland 1023, New Zealand"},{"name":"Eisdell Moore Centre, Faculty of Medical and Health Sciences, The University of Auckland, Auckland 1023, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4860-3527","authenticated-orcid":false,"given":"Haruna","family":"Suzuki-Kerr","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland 1023, New Zealand"},{"name":"Eisdell Moore Centre, Faculty of Medical and Health Sciences, The University of Auckland, Auckland 1023, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1069-6059","authenticated-orcid":false,"given":"Bryony A.","family":"Nayagam","sequence":"additional","affiliation":[{"name":"Department of Audiology and Speech Pathology, The University of Melbourne, Parkville, VIC 3010, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0361-9230(03)00047-9","article-title":"Structure and Innervation of the Cochlea","volume":"60","author":"Raphael","year":"2003","journal-title":"Brain Res. Bull."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.pharmthera.2019.05.003","article-title":"New Molecular Therapies for the Treatment of Hearing Loss","volume":"200","author":"Ma","year":"2019","journal-title":"Pharmacol. Ther."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-5955(02)00279-4","article-title":"K+ Cycling and the Endocochlear Potential","volume":"165","author":"Wangemann","year":"2002","journal-title":"Hear. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.heares.2016.11.013","article-title":"Cellular Mechanisms of Noise-Induced Hearing Loss","volume":"349","author":"Kurabi","year":"2017","journal-title":"Hear. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.cophys.2020.09.012","article-title":"Cochlear Homeostasis: A Molecular Physiological Perspective on Maintenance of Sound Transduction and Auditory Neurotransmission with Noise and Ageing","volume":"18","author":"Housley","year":"2020","journal-title":"Curr. Opin. Physiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/169241a0","article-title":"Resting Potentials Inside the Cochlear Partition of the Guinea Pig","volume":"169","year":"1952","journal-title":"Nature"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/nature01059","article-title":"Prestin is Required for Electromotility of the Outer Hair Cell and for the Cochlear Amplifier","volume":"419","author":"Liberman","year":"2002","journal-title":"Nature"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1121\/1.382104","article-title":"Stimulated Acoustic Emissions from within the Human Auditory System","volume":"64","author":"Kemp","year":"1978","journal-title":"J. Acoust. Soc. Am."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1152\/physiol.00018.2009","article-title":"Potassium Ion Movement in the Inner Ear: Insights from Genetic Disease and Mouse Models","volume":"24","author":"Zdebik","year":"2009","journal-title":"Physiology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0378-5955(03)00338-1","article-title":"Expression Patterns of Claudins, Tight Junction Adhesion Molecules, in the Inner Ear","volume":"187","author":"Kitajiri","year":"2004","journal-title":"Hear. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"5057","DOI":"10.1523\/JNEUROSCI.2234-22.2023","article-title":"The Stria Vascularis in Mice and Humans is an Early Site of Age-Related Cochlear Degeneration, Macrophage Dysfunction, and Inflammation","volume":"43","author":"Lang","year":"2023","journal-title":"J. Neurosci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.joto.2016.01.003","article-title":"Cell Junction Proteins within the Cochlea: A Review of Recent Research","volume":"10","author":"Wang","year":"2015","journal-title":"J. Otol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1113\/jphysiol.2006.112888","article-title":"Supporting Sensory Transduction: Cochlear Fluid Homeostasis and the Endocochlear Potential","volume":"576","author":"Wangemann","year":"2006","journal-title":"J. Physiol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Magistretti, J., Spaiardi, P., Johnson, S.L., and Masetto, S. (2015). Elementary Properties of Ca2+ Channels and their Influence on Multivesicular Release and Phase-Locking at Auditory Hair Cell Ribbon Synapses. Front. Cell. Neurosci., 9.","DOI":"10.3389\/fncel.2015.00123"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Thulasiram, M.R., Ogier, J.M., and Dabdoub, A. (2022). Hearing Function, Degeneration, and Disease: Spotlight on the Stria Vascularis. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.841708"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Kociszewska, D., and Vlajkovic, S. (2022). Age-Related Hearing Loss: The Link between Inflammaging, Immunosenescence, and Gut Dysbiosis. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23137348"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s00441-014-2029-z","article-title":"Connexins and Gap Junctions in the Inner Ear\u2014It\u2019s Not just about K+ Recycling","volume":"360","author":"Jagger","year":"2015","journal-title":"Cell Tissue Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.neuroscience.2014.01.036","article-title":"The Role of an Inwardly Rectifying K+ Channel (Kir4.1) in the Inner Ear and Hearing Loss","volume":"265","author":"Chen","year":"2014","journal-title":"Neuroscience"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Fracaro, S., Hellies, F., Marioni, G., Brotto, D., Franchella, S., Zanoletti, E., Albertin, G., and Astolfi, L. (2024). Role of Kir4.1 Channel in Auditory Function: Impact on Endocochlear Potential and Hearing Loss. Appl. Sci., 14.","DOI":"10.3390\/app14124985"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s00424-009-0754-z","article-title":"How is the Highly Positive Endocochlear Potential Formed? the Specific Architecture of the Stria Vascularis and the Roles of the Ion-Transport Apparatus","volume":"459","author":"Hibino","year":"2010","journal-title":"Pflug. Arch.-Eur. J. Physiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1056\/NEJM199705293362204","article-title":"Molecular Basis of the Long-QT Syndrome Associated with Deafness","volume":"336","author":"Splawski","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"5522717","DOI":"10.1155\/2021\/5522717","article-title":"Key Signaling Pathways Regulate the Development and Survival of Auditory Hair Cells","volume":"2021","author":"Liu","year":"2021","journal-title":"Neural Plast."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Yeo, X.Y., Kwon, S., Rinai, K.R., Lee, S., Jung, S., and Park, R. (2024). A Consolidated Understanding of the Contribution of Redox Dysregulation in the Development of Hearing Impairment. Antioxidants, 13.","DOI":"10.3390\/antiox13050598"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s10162-012-0329-0","article-title":"Effects of Repeated \u201cBenign\u201d Noise Exposures in Young CBA Mice: Shedding Light on Age-Related Hearing Loss","volume":"13","author":"Wang","year":"2012","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.aud.0000191942.36672.f3","article-title":"The Role of Oxidative Stress in Noise-Induced Hearing Loss","volume":"27","author":"Henderson","year":"2006","journal-title":"Ear Hear."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"108783","DOI":"10.1016\/j.heares.2023.108783","article-title":"Role of Mitochondrial Dysfunction and Oxidative Stress in Sensorineural Hearing Loss","volume":"434","author":"Tan","year":"2023","journal-title":"Hear. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"6913","DOI":"10.1007\/s12035-024-04470-4","article-title":"The Role and Research Progress of Mitochondria in Sensorineural Hearing Loss","volume":"62","author":"Xu","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0197-4580(02)00069-6","article-title":"Modulation of Ion Channels by Reactive Oxygen and Nitrogen Species: A Pathophysiological Role in Brain Aging?","volume":"23","author":"Annunziato","year":"2002","journal-title":"Neurobiol. Aging"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3170801","DOI":"10.1155\/2018\/3170801","article-title":"Inner Ear Hair Cell Protection in Mammals Against the Noise-Induced Cochlear Damage","volume":"2018","author":"Waqas","year":"2018","journal-title":"Neural Plast."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Pak, J.H., Kim, Y., Yi, J., and Chung, J.W. (2020). Antioxidant Therapy Against Oxidative Damage of the Inner Ear: Protection and Preconditioning. Antioxidants, 9.","DOI":"10.3390\/antiox9111076"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Wong, A.C.Y., and Ryan, A.F. (2015). Mechanisms of Sensorineural Cell Damage, Death and Survival in the Cochlea. Front. Aging Neurosci., 7.","DOI":"10.3389\/fnagi.2015.00058"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Vlajkovic, S.M., and Thorne, P.R. (2022). Purinergic Signalling in the Cochlea. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232314874"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"7494","DOI":"10.1073\/pnas.1222295110","article-title":"ATP-Gated Ion Channels Mediate Adaptation to Elevated Sound Levels","volume":"110","author":"Housley","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1080\/03036758.2024.2359945","article-title":"Auckland Hearing Science Discovery and Translation in Purinergic Signaling and Inner Ear Therapeutics","volume":"55","author":"Vlajkovic","year":"2025","journal-title":"J. R. Soc. N. Z."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Han, B.R., Lin, S.C., Espinosa, K., Thorne, P.R., and Vlajkovic, S.M. (2019). Inhibition of the Adenosine A2A Receptor Mitigates Excitotoxic Injury in Organotypic Tissue Cultures of the Rat Cochlea. Cells, 8.","DOI":"10.3390\/cells8080877"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Shin, M., Pandya, M., Espinosa, K., Telang, R., Boix, J., Thorne, P.R., and Vlajkovic, S.M. (2021). Istradefylline Mitigates Age-Related Hearing Loss in C57BL\/6J Mice. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22158000"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"24907","DOI":"10.1038\/srep24907","article-title":"Round-Window Delivery of Neurotrophin 3 Regenerates Cochlear Synapses After Acoustic Overexposure","volume":"6","author":"Suzuki","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1097\/MAO.0000000000001191","article-title":"Applying Neurotrophins to the Round Window Rescues Auditory Function and Reduces Inner Hair Cell Synaptopathy After Noise-Induced Hearing Loss","volume":"37","author":"Sly","year":"2016","journal-title":"Otol. Neurotol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Xiao, Y., and Li, D. (2023). The Role of Epigenetic Modifications in Sensory Hair Cell Development, Survival, and Regulation. Front. Cell Neurosci., 17.","DOI":"10.3389\/fncel.2023.1210279"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1097\/MOO.0000000000000741","article-title":"Understanding the Differentiation and Epigenetics of Cochlear Sensory Progenitors in Pursuit of Regeneration","volume":"29","author":"Kwan","year":"2021","journal-title":"Curr. Opin. Otolaryngol. Head Neck Surg."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"144996","DOI":"10.1016\/j.gene.2020.144996","article-title":"Recent Advancements in Understanding the Role of Epigenetics in the Auditory System","volume":"761","author":"Mittal","year":"2020","journal-title":"Gene"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Zhang, Q., Liu, H., Soukup, G.A., and He, D.Z.Z. (2014). Identifying MicroRNAs Involved in Aging of the Lateral Wall of the Cochlear Duct. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0112857"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.gene.2018.10.075","article-title":"Role of microRNAs in Inner Ear Development and Hearing Loss","volume":"686","author":"Mittal","year":"2019","journal-title":"Gene"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Ushakov, K., Rudnicki, A., and Avraham, K.B. (2013). MicroRNAs in Sensorineural Diseases of the Ear. Front. Mol. Neurosci., 6.","DOI":"10.3389\/fnmol.2013.00052"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"112355","DOI":"10.1016\/j.isci.2025.112355","article-title":"Therapeutic Restoration of miR-96 Prevents Hearing Loss in Mice through Modulation of Noise-Induced and Genetic Pathways","volume":"28","author":"Xia","year":"2025","journal-title":"iScience"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Lee, J., Jung, J., Kang, H., Park, K., Lee, J.B., and Choi, S. (2025). Differential Expression and Regulation of FASLG by miR-5195\/miR-3941 in Age-Related Hearing Loss. PLoS ONE, 20.","DOI":"10.1371\/journal.pone.0331661"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.heares.2016.01.010","article-title":"Pathophysiology of the Cochlear Intrastrial Fluid-Blood Barrier (Review)","volume":"338","author":"Shi","year":"2016","journal-title":"Hear. Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"109405","DOI":"10.1016\/j.heares.2025.109405","article-title":"Ethacrynic Acid Regulates Gentamicin Ototoxicity Via the Blood-Labyrinth Barrier","volume":"466","author":"Li","year":"2025","journal-title":"Hear. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"109432","DOI":"10.1016\/j.heares.2025.109432","article-title":"OSBPL2 Deficiency Impaired Cochlear Blood-Labyrinth Barrier Via Activation of NF-\u03baB Signaling Pathway","volume":"467","author":"Yang","year":"2025","journal-title":"Hear. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e2322124121","DOI":"10.1073\/pnas.2322124121","article-title":"Rescue of Cochlear Vascular Pathology Prevents Sensory Hair Cell Loss in Norrie Disease","volume":"121","author":"Patel","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"101423","DOI":"10.1016\/j.arr.2021.101423","article-title":"Diabetes Mellitus and Hearing Loss: A Review","volume":"71","author":"Wu","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Kociszewska, D., and Vlajkovic, S.M. (2022). The Association of Inflammatory Gut Diseases with Neuroinflammatory and Auditory Disorders. Front. Biosci., 14.","DOI":"10.31083\/j.fbe1402008"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1002\/ohn.1346","article-title":"Type 2 Diabetes Mellitus and Hearing Loss: A Prisma Systematic Review and Meta-Analysis","volume":"173","year":"2025","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1172\/JCI87316","article-title":"Extracellular Vesicles: Masters of Intercellular Communication and Potential Clinical Interventions","volume":"126","author":"Pitt","year":"2016","journal-title":"J. Clin. Investig."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1172\/JCI135710","article-title":"Exosome-Mediated Protection of Auditory Hair Cells from Ototoxic Insults","volume":"130","year":"2020","journal-title":"J. Clin. Investig."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1172\/JCI128867","article-title":"Exosomes Mediate Sensory Hair Cell Protection in the Inner Ear","volume":"130","author":"Breglio","year":"2020","journal-title":"J. Clin. Investig."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1021\/acschemneuro.2c00234","article-title":"Exosomes Derived from microRNA-21 Overexpressing Neural Progenitor Cells Prevent Hearing Loss from Ischemia-Reperfusion Injury in Mice Via Inhibiting the Inflammatory Process in the Cochlea","volume":"13","author":"Hao","year":"2022","journal-title":"ACS Chem. Neurosci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.heares.2017.01.003","article-title":"Cochlear Synaptopathy in Acquired Sensorineural Hearing Loss: Manifestations and Mechanisms","volume":"349","author":"Liberman","year":"2017","journal-title":"Hear. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/coa.13756","article-title":"The Inaugural World Report on Hearing: From Barriers to a Platform for Change","volume":"46","author":"McMahon","year":"2021","journal-title":"Clin. Otolaryngol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Zhang, W., Kim, S.M., Wang, W., Cai, C., Feng, Y., Kong, W., and Lin, X. (2018). Cochlear Gene Therapy for Sensorineural Hearing Loss: Current Status and Major Remaining Hurdles for Translational Success. Front. Mol. Neurosci., 11.","DOI":"10.3389\/fnmol.2018.00221"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Fu, X., Wan, P., Li, P., Wang, J., Guo, S., Zhang, Y., An, Y., Ye, C., Liu, Z., and Gao, J. (2021). Mechanism and Prevention of Ototoxicity Induced by Aminoglycosides. Front. Cell Neurosci., 15.","DOI":"10.3389\/fncel.2021.692762"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Tan, W.J.T., and Vlajkovic, S.M. (2023). Molecular Characteristics of Cisplatin-Induced Ototoxicity and Therapeutic Interventions. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242216545"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"eadk9878","DOI":"10.1126\/sciadv.adk9878","article-title":"Macrophage Depletion Protects Against Cisplatin-Induced Ototoxicity and Nephrotoxicity","volume":"10","author":"Sung","year":"2024","journal-title":"Sci. Adv."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3389\/fnagi.2022.930105","article-title":"The Influence of Metabolic Syndrome on Age-Related Hearing Loss from the Perspective of Mitochondrial Dysfunction","volume":"14","author":"Guo","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S1672-2930(13)50017-1","article-title":"Effects of Diabetes on Hearing and Cochlear Structures","volume":"8","author":"Xipeng","year":"2013","journal-title":"J. Otol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Liu, H., Li, Y., Chen, L., Zhang, Q., Pan, N., Nichols, D.H., Zhang, W.J., Fritzsch, B., and He, D.Z.Z. (2016). Organ of Corti and Stria Vascularis: Is there an Interdependence for Survival?. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0168953"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1002\/j.2040-4603.2017.tb00783.x","article-title":"Hair Cell Transduction, Tuning and Synaptic Transmission in the Mammalian Cochlea","volume":"7","author":"Fettiplace","year":"2017","journal-title":"Compr. Physiol."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Chen, P., Wu, W., Zhang, J., Chen, J., Li, Y., Sun, L., Hou, S., and Yang, J. (2022). Pathological Mechanisms of connexin26-Related Hearing Loss: Potassium Recycling, ATP-Calcium Signaling, Or Energy Supply?. Front. Mol. Neurosci., 15.","DOI":"10.3389\/fnmol.2022.976388"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.freeradbiomed.2019.02.022","article-title":"Targeting Dysregulation of Redox Homeostasis in Noise-Induced Hearing Loss: Oxidative Stress and ROS Signaling","volume":"135","author":"Fetoni","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.anl.2024.05.009","article-title":"Idiopathic Sudden Sensorineural Hearing Loss: A Review Focused on the Contribution of Vascular Pathologies","volume":"51","author":"Tsuzuki","year":"2024","journal-title":"Auris Nasus Larynx"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Wang, J., and Puel, J. (2020). Presbycusis: An Update on Cochlear Mechanisms and Therapies. J. Clin. Med., 9.","DOI":"10.3390\/jcm9010218"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Maniaci, A., La Via, L., Lechien, J.R., Sangiorgio, G., Iannella, G., Magliulo, G., Pace, A., Mat, Q., Lavalle, S., and Lentini, M. (2024). Hearing Loss and Oxidative Stress: A Comprehensive Review. Antioxidants, 13.","DOI":"10.3390\/antiox13070842"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.heares.2013.01.008","article-title":"Lead Roles for Supporting Actors: Critical Functions of Inner Ear Supporting Cells","volume":"303","author":"Monzack","year":"2013","journal-title":"Hear. Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"4020","DOI":"10.1121\/1.5132545","article-title":"Inflammation Associated with Noise-Induced Hearing Loss","volume":"146","author":"Frye","year":"2019","journal-title":"J. Acoust. Soc. Am."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Liu, Y., and Xu, K. (2024). Macrophage-Related Immune Responses in Inner Ear: A Potential Therapeutic Target for Sensorineural Hearing Loss. Front. Neurosci., 17.","DOI":"10.3389\/fnins.2023.1339134"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Wood, M.B., and Zuo, J. (2017). The Contribution of Immune Infiltrates to Ototoxicity and Cochlear Hair Cell Loss. Front. Cell Neurosci., 11.","DOI":"10.3389\/fncel.2017.00106"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Li, Y., Fu, X., Wang, P., Wang, Q., Meng, W., Wang, T., Yang, J., and Chai, R. (2021). The Detrimental and Beneficial Functions of Macrophages After Cochlear Injury. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.631904"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Steinacher, C., Chacko, L.J., Liu, W., Rask-Andersen, H., Bader, W., Dudas, J., Sergi, C.M., Dhanaseelan, T., Moreno, N., and Glueckert, R. (2022). Visualization of Macrophage Subsets in the Development of the Fetal Human Inner Ear. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.965196"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Deng, Y., Ehiogu, B., Luca, E., Dabdoub, A., Cao, K.L., Wells, C.A., and Nayagam, B.A. (2025). Trophic and Temporal Dynamics of Macrophage Biology in Human Inner Ear Organogenesis. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1690583"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/cne.20619","article-title":"Mononuclear Phagocytes Migrate into the Murine Cochlea After Acoustic Trauma","volume":"489","author":"Hirose","year":"2005","journal-title":"J. Comp. Neurol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00441-010-1040-2","article-title":"Resident Macrophages in the Cochlear Blood-Labyrinth Barrier and their Renewal Via Migration of Bone-Marrow-Derived Cells","volume":"342","author":"Shi","year":"2010","journal-title":"Cell Tissue Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s00418-016-1436-5","article-title":"Characterisation of Cochlear Inflammation in Mice Following Acute and Chronic Noise Exposure","volume":"146","author":"Tan","year":"2016","journal-title":"Histochem. Cell Biol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/jnr.20764","article-title":"Proinflammatory Cytokines Expression in Noise-Induced Damaged Cochlea","volume":"83","author":"Fujioka","year":"2006","journal-title":"J. Neurosci. Res."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Kalinec, G.M., Lomberk, G., Urrutia, R.A., and Kalinec, F. (2017). Resolution of Cochlear Inflammation: Novel Target for Preventing Or Ameliorating Drug-, Noise- and Age-Related Hearing Loss. Front. Cell. Neurosci., 11.","DOI":"10.3389\/fncel.2017.00192"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Fujioka, M., Okano, H., and Ogawa, K. (2014). Inflammatory and Immune Responses in the Cochlea: Potential Therapeutic Targets for Sensorineural Hearing Loss. Front. Pharmacol., 5.","DOI":"10.3389\/fphar.2014.00287"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Homma, K. (2022). The Pathological Mechanisms of Hearing Loss Caused by KCNQ1 and KCNQ4 Variants. Biomedicines, 10.","DOI":"10.3390\/biomedicines10092254"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s10048-016-0477-1","article-title":"Recessive Mutations of TMC1 Associated with Moderate to Severe Hearing Loss","volume":"17","author":"Imtiaz","year":"2016","journal-title":"Neurogenetics"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"e1195043","DOI":"10.1080\/21675511.2016.1195043","article-title":"EAST Syndrome: Clinical, Pathophysiological, and Genetic Aspects of Mutations in KCNJ10","volume":"4","author":"Abdelhadi","year":"2016","journal-title":"Rare Dis."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1073\/pnas.1222285110","article-title":"Mutation of the ATP-Gated P2X2 Receptor Leads to Progressive Hearing Loss and Increased Susceptibility to Noise","volume":"110","author":"Yan","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1089\/ars.2008.2138","article-title":"Gap-Junction Channels Dysfunction in Deafness and Hearing Loss","volume":"11","author":"Figueroa","year":"2009","journal-title":"Antioxid. Redox Signal"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Wingard, J.C., and Zhao, H. (2015). Cellular and Deafness Mechanisms Underlying Connexin Mutation-Induced Hearing Loss\u2014A Common Hereditary Deafness. Front. Cell. Neurosci., 9.","DOI":"10.3389\/fncel.2015.00202"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Vona, B., Rad, A., and Reisinger, E. (2020). The Many Faces of DFNB9: Relating OTOF Variants to Hearing Impairment. Genes, 11.","DOI":"10.3390\/genes11121411"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.neuron.2010.10.011","article-title":"Hearing Impairment: A Panoply of Genes and Functions","volume":"68","author":"Dror","year":"2010","journal-title":"Neuron"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Pisani, A., Paciello, F., Montuoro, R., Rolesi, R., Galli, J., and Fetoni, A.R. (2023). Antioxidant Therapy as an Effective Strategy Against Noise-Induced Hearing Loss: From Experimental Models to Clinic. Life, 13.","DOI":"10.3390\/life13041035"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Kishimoto-Urata, M., Urata, S., Fujimoto, C., and Yamasoba, T. (2022). Role of Oxidative Stress and Antioxidants in Acquired Inner Ear Disorders. Antioxidants, 11.","DOI":"10.3390\/antiox11081469"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Fujimoto, C., and Yamasoba, T. (2019). Mitochondria-Targeted Antioxidants for Treatment of Hearing Loss: A Systematic Review. Antioxidants, 8.","DOI":"10.3390\/antiox8040109"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s12964-025-02152-9","article-title":"SIRT1 Prevents Noise-Induced Hearing Loss by Enhancing Cochlear Mitochondrial Function","volume":"23","author":"Luo","year":"2025","journal-title":"Cell Commun. Signal."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1097\/CM9.0000000000003506","article-title":"Targeting Inflammation to Prevent and Treat Sensorineural Hearing Loss","volume":"138","author":"Li","year":"2025","journal-title":"Chin. Med. J."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1055\/s-0039-1684045","article-title":"Otoprotectants: From Research to Clinical Application","volume":"40","year":"2019","journal-title":"Semin. Hear."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1056\/NEJMoa1801109","article-title":"Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss","volume":"378","author":"Brock","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1200\/JCO.23.02353","article-title":"Use of Sodium Thiosulfate as an Otoprotectant in Patients with Cancer Treated with Platinum Compounds: A Review of the Literature","volume":"42","author":"Meijer","year":"2024","journal-title":"J. Clin. Oncol."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Duhon, B.H., Bielefeld, E.C., Ren, Y., and Naidoo, J. (2024). Gene Therapy Advancements for the Treatment of Acquired and Hereditary Hearing Loss. Front. Audiol. Otol., 2.","DOI":"10.3389\/fauot.2024.1423853"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"107947","DOI":"10.1016\/j.heares.2020.107947","article-title":"Adeno-Associated Virus Gene Replacement for Recessive Inner Ear Dysfunction: Progress and Challenges","volume":"394","author":"Askew","year":"2020","journal-title":"Hear. Res."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s10544-025-00751-4","article-title":"Novel Dual-Lumen Microneedle Delivers Adeno-Associated Viral Vectors in the Guinea Pig Inner Ear Via the Round Window Membrane","volume":"27","author":"Hammer","year":"2025","journal-title":"Biomed. Microdevices"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/s41576-023-00597-7","article-title":"Deafness: From Genetic Architecture to Gene Therapy","volume":"24","author":"Petit","year":"2023","journal-title":"Nat. Rev. Genet."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1016\/S0140-6736(23)02874-X","article-title":"AAV1-hOTOF Gene Therapy for Autosomal Recessive Deafness 9: A Single-Arm Trial","volume":"403","author":"Lv","year":"2024","journal-title":"Lancet"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.heares.2008.02.007","article-title":"Response of the Flat Cochlear Epithelium to Forced Expression of Atoh1","volume":"240","author":"Izumikawa","year":"2008","journal-title":"Hear. Res."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Atkinson, P.J., Wise, A.K., Flynn, B.O., Nayagam, B.A., and Richardson, R.T. (2014). Hair Cell Regeneration After ATOH1 Gene Therapy in the Cochlea of Profoundly Deaf Adult Guinea Pigs. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0102077"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1038\/s41591-024-03023-5","article-title":"Bilateral Gene Therapy in Children with Autosomal Recessive Deafness 9: Single-Arm Trial Results","volume":"30","author":"Wang","year":"2024","journal-title":"Nat. Med."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s00424-014-1582-3","article-title":"Transmembrane Channel-Like (TMC) Genes are Required for Auditory and Vestibular Mechanosensation","volume":"467","author":"Kawashima","year":"2015","journal-title":"Pflug. Arch.-Eur. J. Physiol."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Cho, S.H., Yun, Y., Lee, D.H., Cha, J.H., Lee, S.M., Lee, J., Suh, M.H., Lee, J.H., Oh, S., and Park, M.K. (2023). Novel Autosomal Dominant TMC1 Variants Linked to Hearing Loss: Insight into Protein-Lipid Interactions. BMC Med. Genom., 16.","DOI":"10.1186\/s12920-023-01766-7"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s00335-025-10126-y","article-title":"Advancing Precision Ear Medicine: Leveraging Animal Models for Disease Insights and Therapeutic Innovations","volume":"36","author":"Vitry","year":"2025","journal-title":"Mamm. Genome"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"952","DOI":"10.3390\/audiolres13060083","article-title":"Gene Therapy for Inherited Hearing Loss: Updates and Remaining Challenges","volume":"13","author":"Hahn","year":"2023","journal-title":"Audiol. Res."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"109151","DOI":"10.1016\/j.heares.2024.109151","article-title":"Gene Therapy for Hereditary Hearing Loss","volume":"455","author":"Fu","year":"2025","journal-title":"Hear. Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ymthe.2003.11.020","article-title":"Antioxidant Gene Therapy can Protect Hearing and Hair Cells from Ototoxicity","volume":"9","author":"Kawamoto","year":"2004","journal-title":"Mol. Ther."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"102157","DOI":"10.1016\/j.omtn.2024.102157","article-title":"Protection from Cisplatin-Induced Hearing Loss with Lentiviral Vector-Mediated Ectopic Expression of the Anti-Apoptotic Protein BCL-XL","volume":"35","author":"Nassauer","year":"2024","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"2392755","DOI":"10.1080\/10717544.2024.2392755","article-title":"Development of a Drug Delivering Round Window Niche Implant for Cochlear Pharmacotherapy","volume":"31","author":"Wei","year":"2024","journal-title":"Drug Deliv."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1080\/1061186X.2023.2216900","article-title":"The Applications of Targeted Delivery for Gene Therapies in Hearing Loss","volume":"31","author":"Jones","year":"2023","journal-title":"J. Drug Target."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s10162-005-0012-9","article-title":"Survival of Partially Differentiated Mouse Embryonic Stem Cells in the Scala Media of the Guinea Pig Cochlea","volume":"6","author":"Hildebrand","year":"2005","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3727\/000000006783981819","article-title":"Fate of Embryonic Stem Cells Transplanted into the Deafened Mammalian Cochlea","volume":"15","author":"Coleman","year":"2006","journal-title":"Cell Transpl."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1002\/neu.20310","article-title":"Engraftment and Differentiation of Embryonic Stem Cell-Derived Neural Progenitor Cells in the Cochlear Nerve Trunk: Growth of Processes into the Organ of Corti","volume":"66","author":"Corrales","year":"2006","journal-title":"J. Neurobiol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1186\/s13287-018-0967-1","article-title":"Differentiation and Transplantation of Human Induced Pluripotent Stem Cell-Derived Otic Epithelial Progenitors in Mouse Cochlea","volume":"9","author":"Chen","year":"2018","journal-title":"Stem Cell Res. Ther."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1038\/s41598-018-20277-5","article-title":"Engraftment of Human Pluripotent Stem Cell-Derived Progenitors in the Inner Ear of Prenatal Mice","volume":"8","author":"Takeda","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nature11415","article-title":"Restoration of Auditory Evoked Responses by Human ES-Cell-Derived Otic Progenitors","volume":"490","author":"Chen","year":"2012","journal-title":"Nature"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.ymthe.2019.03.018","article-title":"Engraftment of Human Stem Cell-Derived Otic Progenitors in the Damaged Cochlea","volume":"27","author":"Lahlou","year":"2019","journal-title":"Mol. Ther."},{"key":"ref_126","unstructured":"(2025, November 02). First-in-Human Trial for Regenerative Cell Therapy for Sensorineural Hearing Loss Approved. Available online: https:\/\/sheffield.ac.uk\/news\/first-human-trial-regenerative-cell-therapy-sensorineural-hearing-loss-approved#:~:text=The%20UK\u2019s%20Medicine%20and%20Healthcare%20products%20Regulatory%20Agency%20(MHRA)%20approved,implantation%20or%20cochlear%20implantation%20alone%20."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"112623","DOI":"10.1016\/j.celrep.2023.112623","article-title":"A Single-Cell Level Comparison of Human Inner Ear Organoids with the Human Cochlea and Vestibular Organs","volume":"42","author":"Steinhart","year":"2023","journal-title":"Cell Rep."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Mattei, C., Lim, R., Drury, H., Nasr, B., Li, Z., Tadros, M.A., D\u2019Abaco, G.M., Stok, K.S., Nayagam, B.A., and Dottori, M. (2019). Generation of Vestibular Tissue-Like Organoids from Human Pluripotent Stem Cells using the Rotary Cell Culture System. Front. Cell Dev. Biol., 7.","DOI":"10.3389\/fcell.2019.00025"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nbt.3840","article-title":"Generation of Inner Ear Organoids Containing Functional Hair Cells from Human Pluripotent Stem Cells","volume":"35","author":"Koehler","year":"2017","journal-title":"Nat. Biotechnol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"109256","DOI":"10.1016\/j.heares.2025.109256","article-title":"Hearing Restoration through Hair Cell Regeneration: A Review of Recent Advancements and Current Limitations","volume":"461","author":"McGovern","year":"2025","journal-title":"Hear. Res."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"e2304680121","DOI":"10.1073\/pnas.2304680121","article-title":"Expression of Atoh1, Gfi1, and Pou4f3 in the Mature Cochlea Reprograms Nonsensory Cells into Hair Cells","volume":"121","author":"McGovern","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"pgae445","DOI":"10.1093\/pnasnexus\/pgae445","article-title":"Reprogramming with Atoh1, Gfi1, and Pou4f3 Promotes Hair Cell Regeneration in the Adult Organ of Corti","volume":"3","author":"McGovern","year":"2024","journal-title":"PNAS Nexus"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0378-5955(87)90135-3","article-title":"Regeneration of Hair Cell Stereociliary Bundles in the Chick Cochlea Following Severe Acoustic Trauma","volume":"30","author":"Cotanche","year":"1987","journal-title":"Hear. Res."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1126\/science.3381100","article-title":"Regeneration of Sensory Hair Cells After Acoustic Trauma","volume":"240","author":"Corwin","year":"1988","journal-title":"Science"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.ymthe.2019.03.017","article-title":"Therapeutic Potential of Wnt and Notch Signaling and Epigenetic Regulation in Mammalian Sensory Hair Cell Regeneration","volume":"27","author":"Samarajeewa","year":"2019","journal-title":"Mol. Ther."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Noda, T., Meas, S.J., Nogami, J., Amemiya, Y., Uchi, R., Ohkawa, Y., Nishimura, K., and Dabdoub, A. (2018). Direct Reprogramming of Spiral Ganglion Non-Neuronal Cells into Neurons: Toward Ameliorating Sensorineural Hearing Loss by Gene Therapy. Front. Cell Dev. Biol., 6.","DOI":"10.3389\/fcell.2018.00016"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1038\/s41467-025-57016-0","article-title":"Bio-Inspired Electronics: Soft, Biohybrid, and \u201cLiving\u201d Neural Interfaces","volume":"16","author":"Boufidis","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.stem.2022.04.002","article-title":"Biomaterials to Enhance Stem Cell Transplantation","volume":"29","author":"Kharbikar","year":"2022","journal-title":"Cell Stem Cell"},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Xu, X., Zheng, J., He, Y., Lin, K., Li, S., Zhang, Y., Song, P., Zhou, Y., and Chen, X. (2021). Nanocarriers for Inner Ear Disease Therapy. Front. Cell Neurosci., 15.","DOI":"10.3389\/fncel.2021.791573"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"036005","DOI":"10.1088\/1741-2552\/add091","article-title":"Spatially Precise Activation of the Mouse Cochlea with a Multi-Channel Hybrid Cochlear Implant","volume":"22","author":"Azees","year":"2025","journal-title":"J. Neural Eng."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"eadl2741","DOI":"10.1126\/sciadv.adl2741","article-title":"Piezoelectric Nanofiber\u2013based Intelligent Hearing System","volume":"11","author":"Chang","year":"2025","journal-title":"Sci. Adv."},{"key":"ref_142","unstructured":"(2025). BaDGE\u00ae Bionic Array Directed Gene Electrotransfer DNA\/RNA Therapeutics Delivery Platform, School of Biomedical Sciences, UNSW."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"e2401392","DOI":"10.1002\/advs.202401392","article-title":"Gene Electrotransfer Via Conductivity-Clamped Electric Field Focusing Pivots Sensori-Motor DNA Therapeutics: \u201cA Spoonful of Sugar Helps the Medicine Go Down\u201d","volume":"11","author":"Pinyon","year":"2024","journal-title":"Adv. Sci."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"2104033","DOI":"10.1002\/advs.202104033","article-title":"Extracellular Biomarkers of Inner Ear Disease and their Potential for Point-of-Care Diagnostics","volume":"9","author":"Mahshid","year":"2021","journal-title":"Adv. Sci."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1093\/ageing\/afr140","article-title":"Markers of Inflammatory Status are Associated with Hearing Threshold in Older People: Findings from the Hertfordshire Ageing Study","volume":"41","author":"Verschuur","year":"2012","journal-title":"Age Ageing"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1097\/MAO.0000000000001164","article-title":"Outer Hair Cell Molecular Protein, Prestin, as a Serum Biomarker for Hearing Loss: Proof of Concept","volume":"37","author":"Parham","year":"2016","journal-title":"Otol. Neurotol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s00335-009-9230-5","article-title":"MicroRNAs and Epigenetic Regulation in the Mammalian Inner Ear: Implications for Deafness","volume":"20","author":"Friedman","year":"2009","journal-title":"Mamm. Genome"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"102206","DOI":"10.1016\/j.xcrm.2025.102206","article-title":"Comprehensive Genetic Profiling of Sensorineural Hearing Loss using an Integrative Diagnostic Approach","volume":"6","author":"Lee","year":"2025","journal-title":"Cell Rep. Med."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Peter, M.S., Warnecke, A., and Staecker, H. (2022). A Window of Opportunity: Perilymph Sampling from the Round Window Membrane can Advance Inner Ear Diagnostics and Therapeutics. J. Clin. Med., 11.","DOI":"10.3390\/jcm11020316"},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Tavazzani, E., Spaiardi, P., Contini, D., Sancini, G., Russo, G., and Masetto, S. (2024). Precision Medicine: A New Era for Inner Ear Diseases. Front. Pharmacol., 15, Correction in Front. Pharmacol. 2024, 15, 1385698.","DOI":"10.3389\/fphar.2024.1328460"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"26795","DOI":"10.1038\/s41598-024-74661-5","article-title":"A Novel Therapeutic Pathway to the Human Cochlear Nerve","volume":"14","author":"Li","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1634\/stemcells.2007-0393","article-title":"Concise Review: The Potential of Stem Cells for Auditory Neuron Generation and Replacement","volume":"25","author":"Coleman","year":"2007","journal-title":"Stem Cells"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.stem.2025.03.008","article-title":"A Cloaked Human Stem-Cell-Derived Neural Graft Capable of Functional Integration and Immune Evasion in Rodent Models","volume":"32","author":"Pavan","year":"2025","journal-title":"Cell Stem Cell"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.stem.2017.09.014","article-title":"Human Trials of Stem Cell-Derived Dopamine Neurons for Parkinson\u2019s Disease: Dawn of a New Era","volume":"21","author":"Barker","year":"2017","journal-title":"Cell Stem Cell"},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Bovee, S., Klump, G.M., K\u00f6ppl, C., and Pyott, S.J. (2024). The Stria Vascularis: Renewed Attention on a Key Player in Age-Related Hearing Loss. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25105391"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"116972","DOI":"10.1016\/j.envres.2023.116972","article-title":"Meniere\u2019s Disease: Pathogenesis, Treatments, and Emerging Approaches for an Idiopathic Bioenvironmental Disorder","volume":"238","author":"Falahati","year":"2023","journal-title":"Environ. Res."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Chari, D.A., Bose, A., Ramirez, K., Robles-Bolivar, P., Lin, K., Juliano, A.F., Rauch, S.D., and Eckhard, A.H. (2025). A Modern Conceptual Framework for Study and Treatment of Meniere\u2019s Disease. Front. Neurol., 16.","DOI":"10.3389\/fneur.2025.1607435"},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Yuan, V.G., Xia, A., and Santa Maria, P.L. (2025). Immunological Mechanisms in Meniere\u2019s Disease. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1639916"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1097\/AUD.0000000000000890","article-title":"Fiber-Specific Changes in White Matter Microstructure in Individuals with X-Linked Auditory Neuropathy","volume":"41","author":"Zanin","year":"2020","journal-title":"Ear Hear."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.heares.2019.02.014","article-title":"Review: Using Diffusion-Weighted Magnetic Resonance Imaging Techniques to Explore the Microstructure and Connectivity of Subcortical White Matter Tracts in the Human Auditory System","volume":"377","author":"Zanin","year":"2019","journal-title":"Hear. 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