{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T02:26:19Z","timestamp":1766715979048,"version":"3.48.0"},"reference-count":61,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the National Research Foundation of Korea (NRF) by the Korean Government","award":["2023R1A2C2003446"],"award-info":[{"award-number":["2023R1A2C2003446"]}]},{"name":"the National Research Foundation of Korea (NRF) by the Korean Government","award":["RS-2023-00225239"],"award-info":[{"award-number":["RS-2023-00225239"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>TMBIM6, a transmembrane BAX inhibitor motif containing six proteins, is correlated with tumor progression and metastasis. While its correlation in several malignancies has been shown, its expression in prostate adenocarcinoma (PRAD) is unclear. In this work, we explored, using integrated bioinformatics, a novel ceRNA network of TMBIM6 involved in PRAD prognosis. According to TCGA and GEO datasets, we proposed a new TMBIM6\/hsa-miR-222-3p\/DHRS4-AS1 ceRNA axis associated with PRAD prognosis. The network was estimated by differential expression, correlation, and survival analysis. Co-expression analysis was used to identify pathways involved in tumor progression, and immune infiltration analysis suggested that there is a correlation between the expression of TMBIM6 and the abundance of epithelial cells. Overall, these results indicate that the DHRS4-AS1\/hsa-miR-222-3p\/TMBIM6 axis is involved in the progression of PRAD and may act as a prognostic biomarker. Our results provide a foundation for further experimental validation and potential clinical translation.<\/jats:p>","DOI":"10.3390\/ijms27010213","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T14:27:51Z","timestamp":1766586471000},"page":"213","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of a Prognostic ceRNA Network Regulating TMBIM6 in Prostate Adenocarcinoma via Integrated Bioinformatic Analysis"],"prefix":"10.3390","volume":"27","author":[{"given":"Mst Sahida","family":"Khatun","sequence":"first","affiliation":[{"name":"Department of Pharmacology, College of Dentistry, Jeonbuk National University, Jeonju 54907, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7025-1716","authenticated-orcid":false,"given":"Mohammad Mamun Ur","family":"Rashid","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Institute of New Drug Development, Jeonbuk National University, Jeonju 54896, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2132-2984","authenticated-orcid":false,"given":"Muhammad Kamal","family":"Hossain","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Dentistry, Jeonbuk National University, Jeonju 54907, Republic of Korea"},{"name":"School of Pharmacy and Institute of New Drug Development, Jeonbuk National University, Jeonju 54896, Republic of Korea"},{"name":"Non-Clinical Evaluation Center Biomedical Research Institute, Jeonbuk National University Hospital, Jeonju 54907, Republic of Korea"},{"name":"Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of Science and Technology Chittagong, Chittagong 4202, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6710-6964","authenticated-orcid":false,"given":"Hyung-Ryong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Dentistry, Jeonbuk National University, Jeonju 54907, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1001\/jama.2025.0228","article-title":"Prostate Cancer: A Review","volume":"333","author":"Raychaudhuri","year":"2025","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1142976","DOI":"10.3389\/fonc.2023.1142976","article-title":"Prostate cancer epidemiology and prognostic factors in the United States","volume":"13","author":"Abudoubari","year":"2023","journal-title":"Front. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1170397","DOI":"10.3389\/fonc.2023.1170397","article-title":"CHMP4C as a novel marker regulates prostate cancer progression through cycle pathways and contributes to immunotherapy","volume":"13","author":"Zhang","year":"2023","journal-title":"Front. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.cell.2011.07.014","article-title":"A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?","volume":"146","author":"Salmena","year":"2011","journal-title":"Cell"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1007\/s13258-022-01312-2","article-title":"ceRNA network of lncRNA MIR210HG\/miR-377-3p\/LMX1A in malignant proliferation of glioma cells","volume":"44","author":"Yu","year":"2022","journal-title":"Genes Genom."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Ye, J., Li, J., and Zhao, P. (2021). Roles of ncRNAs as ceRNAs in Gastric Cancer. Genes, 12.","DOI":"10.3390\/genes12071036"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"921194","DOI":"10.3389\/fonc.2022.921194","article-title":"Prognostic Roles of ceRNA Network-Based Signatures in Gastrointestinal Cancers","volume":"12","author":"Qi","year":"2022","journal-title":"Front. Oncol."},{"key":"ref_8","first-page":"1909196","article-title":"Identification of Novel Diagnostic Biomarkers in Prostate Adenocarcinoma Based on the Stromal-Immune Score and Analysis of the WGCNA and ceRNA Network","volume":"2022","author":"Zhang","year":"2022","journal-title":"Dis. Markers"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.biochi.2015.03.001","article-title":"Long noncoding RNA turnover","volume":"117","author":"Yoon","year":"2015","journal-title":"Biochimie"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Szczesniak, M.W., and Makalowska, I. (2016). lncRNA-RNA Interactions across the Human Transcriptome. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0150353"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Luo, L., Zhang, L.L., Tao, W., Xia, T.L., and Li, L.Y. (2021). Prediction of potential prognostic biomarkers in metastatic prostate cancer based on a circular RNA-mediated competing endogenous RNA regulatory network. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0260983"},{"key":"ref_12","first-page":"57","article-title":"An in-silico approach for recognition of long non-coding RNA-associated competing endogenous RNA axes in prostate cancer","volume":"21","author":"Taheri","year":"2024","journal-title":"Cancer. Urol. J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4012","DOI":"10.1038\/s41467-020-17802-4","article-title":"TMBIM6\/BI-1 contributes to cancer progression through assembly with mTORC2 and AKT activation","volume":"11","author":"Kim","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Baetke, S.C., Adriaens, M.E., Seigneuric, R., Evelo, C.T., and Eijssen, L.M. (2012). Molecular pathways involved in prostate carcinogenesis: Insights from public microarray datasets. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0049831"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.ccr.2005.10.001","article-title":"Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression","volume":"8","author":"Varambally","year":"2005","journal-title":"Cancer Cell"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Junjappa, R.P., Kim, H.K., Park, S.Y., Bhattarai, K.R., Kim, K.W., Soh, J.W., Kim, H.R., and Chae, H.J. (2019). Expression of TMBIM6 in Cancers: The Involvement of Sp1 and PKC. Cancers, 11.","DOI":"10.3390\/cancers11070974"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"554","DOI":"10.7150\/jca.81600","article-title":"TMBIM6-mediated miR-181a expression regulates breast cancer cell migration and invasion via the MAPK\/ERK signaling pathway","volume":"14","author":"Shin","year":"2023","journal-title":"J. Cancer"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0002-9440(10)63682-6","article-title":"Bax inhibitor-1 is overexpressed in prostate cancer and its specific down-regulation by RNA interference leads to cell death in human prostate carcinoma cells","volume":"163","author":"Grzmil","year":"2003","journal-title":"Am. J. Pathol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1186\/s12935-022-02779-5","article-title":"Integrated analysis to identify the AC005154.6\/hsa-miR-29c-3p\/CCNL2 axis as a novel prognostic biomarker associated with immune infiltration in prostate cancer","volume":"22","author":"Li","year":"2022","journal-title":"Cancer Cell Int."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3839","DOI":"10.1016\/j.csbj.2022.07.020","article-title":"A comprehensive analysis of ncRNA-mediated interactions reveals potential prognostic biomarkers in prostate adenocarcinoma","volume":"20","author":"Guo","year":"2022","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"13153","DOI":"10.18632\/aging.202997","article-title":"Identification of potential autophagy-associated lncRNA in prostate cancer","volume":"13","author":"Li","year":"2021","journal-title":"Aging"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"155604","DOI":"10.1016\/j.prp.2024.155604","article-title":"Unveiling four axes ADAMTS9-AS2|MEG3\/hsa-miR-150\/PRKCA|MMP14 within prostate cancer through establishment of the ceRNA network","volume":"263","author":"Taheri","year":"2024","journal-title":"Pathol. Res. Pract."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"4252","DOI":"10.1111\/cas.15948","article-title":"Exosomal miR-222-3p contributes to castration-resistant prostate cancer by activating mTOR signaling","volume":"114","author":"Wang","year":"2023","journal-title":"Cancer Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3892\/ol.2023.13926","article-title":"MicroRNA expression profiles associated with the metastatic ability of MDA--MB--231 breast cancer cells","volume":"26","author":"Phannasil","year":"2023","journal-title":"Oncol. Lett."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"843334","DOI":"10.3389\/fendo.2022.843334","article-title":"BRAF(V600E) Mutation-Responsive miRNA-222-3p Promotes Metastasis of Papillary Thyroid Cancer Cells via Snail-Induced EMT","volume":"13","author":"Gao","year":"2022","journal-title":"Front. Endocrinol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"585251","DOI":"10.3389\/fcell.2020.585251","article-title":"LncRNA DHRS4-AS1 Inhibits the Stemness of NSCLC Cells by Sponging miR-224-3p and Upregulating TP53 and TET1","volume":"8","author":"Yan","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"10862","DOI":"10.1080\/21655979.2021.1994719","article-title":"LncRNA DHRS4-AS1 ameliorates hepatocellular carcinoma by suppressing proliferation and promoting apoptosis via miR-522-3p\/SOCS5 axis","volume":"12","author":"Zhou","year":"2021","journal-title":"Bioengineered"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"494","DOI":"10.5603\/ep.99456","article-title":"Feasibility study of lncRNA DHRS4-AS1 sponge miR-222-3p in the diagnosis of thyroid cancer","volume":"75","author":"Xu","year":"2024","journal-title":"Endokrynol. Pol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1186\/s12935-023-03151-x","article-title":"DHRS4-AS1 regulate gastric cancer apoptosis and cell proliferation by destabilizing DHX9 and inhibited the association between DHX9 and ILF3","volume":"23","author":"Xiao","year":"2023","journal-title":"Cancer Cell Int."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"5631","DOI":"10.2147\/OTT.S164984","article-title":"The downregulated long noncoding RNA DHRS4-AS1 is protumoral and associated with the prognosis of clear cell renal cell carcinoma","volume":"11","author":"Wang","year":"2018","journal-title":"OncoTargets Ther."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1158\/1541-7786.MCR-24-0903","article-title":"Exploring STEAP1 Expression in Prostate Cancer Cells in Response to Androgen Deprivation and in Small Extracellular Vesicles","volume":"23","author":"Bizzaro","year":"2025","journal-title":"Mol. Cancer Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"142797","DOI":"10.1016\/j.ijbiomac.2025.142797","article-title":"STEAP Proteins: Roles in disease biology and potential for therapeutic intervention","volume":"309","author":"Cai","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"167974","DOI":"10.1016\/j.bbadis.2025.167974","article-title":"Nop2\/Sun domain family member 5 contributes to tumorigenic properties in prostate cancer by engaging the PI3K-AKT pathway and tumor-associated macrophages","volume":"1871","author":"Huang","year":"2025","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"119010","DOI":"10.1016\/j.ecoenv.2025.119010","article-title":"Integration of network toxicology, machine learning and single-cell sequencing reveals the effects of soil pollutants on prostate cancer","volume":"303","author":"Liu","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.tcb.2025.02.007","article-title":"Cellular homeostatic responses to lysosomal damage","volume":"35","author":"Jia","year":"2025","journal-title":"Trends Cell Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/intimm\/dxab058","article-title":"The immunological significance of tumor necrosis factor receptor-associated factors (TRAFs)","volume":"34","author":"So","year":"2022","journal-title":"Int. Immunol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1002\/pros.24015","article-title":"Androgens modify therapeutic response to cabazitaxel in models of advanced prostate cancer","volume":"80","author":"Begemann","year":"2020","journal-title":"Prostate"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/978-3-319-95693-0_6","article-title":"Epithelial-Mesenchymal Transition (EMT) and Prostate Cancer","volume":"1095","author":"Hawsawi","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e23698","DOI":"10.1096\/fj.202302654RR","article-title":"FOXS1 acts as an oncogene and induces EMT through FAK\/PI3K\/AKT pathway by upregulating HILPDA in prostate cancer","volume":"38","author":"Ren","year":"2024","journal-title":"FASEB J."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/pros.23708","article-title":"TGF-beta receptor I inhibitor enhances response to enzalutamide in a pre-clinical model of advanced prostate cancer","volume":"79","author":"Paller","year":"2019","journal-title":"Prostate"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"D991","DOI":"10.1093\/nar\/gks1193","article-title":"NCBI GEO: Archive for functional genomics data sets\u2014update","volume":"41","author":"Barrett","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Brase, J.C., Johannes, M., Mannsperger, H., Falth, M., Metzger, J., Kacprzyk, L.A., Andrasiuk, T., Gade, S., Meister, M., and Sirma, H. (2011). TMPRSS2-ERG-specific transcriptional modulation is associated with prostate cancer biomarkers and TGF-beta signaling. BMC Cancer, 11.","DOI":"10.1186\/1471-2407-11-507"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1158\/2159-8290.CD-12-0041","article-title":"Genome-wide DNA methylation events in TMPRSS2-ERG fusion-negative prostate cancers implicate an EZH2-dependent mechanism with miR-26a hypermethylation","volume":"2","author":"Borno","year":"2012","journal-title":"Cancer Discov."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"8060389","DOI":"10.1155\/2021\/8060389","article-title":"circITGA7 Acts as a miR-370-3p Sponge to Suppress the Proliferation of Prostate Cancer","volume":"2021","author":"Luo","year":"2021","journal-title":"J. Oncol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"6448","DOI":"10.1158\/0008-5472.CAN-10-0021","article-title":"In silico estimates of tissue components in surgical samples based on expression profiling data","volume":"70","author":"Wang","year":"2010","journal-title":"Cancer Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1158\/0008-5472.CAN-10-2585","article-title":"Diagnosis of prostate cancer using differentially expressed genes in stroma","volume":"71","author":"Jia","year":"2011","journal-title":"Cancer Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00109-012-0949-1","article-title":"The maternal embryonic leucine zipper kinase (MELK) is upregulated in high-grade prostate cancer","volume":"91","author":"Kuner","year":"2013","journal-title":"J. Mol. Med."},{"key":"ref_48","first-page":"A68","article-title":"The Cancer Genome Atlas (TCGA): An immeasurable source of knowledge","volume":"19","author":"Tomczak","year":"2015","journal-title":"Contemp. Oncol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"W556","DOI":"10.1093\/nar\/gkz430","article-title":"GEPIA2: An enhanced web server for large-scale expression profiling and interactive analysis","volume":"47","author":"Tang","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.2147\/JHC.S520917","article-title":"Exploring Autophagy-Related Gene Expression in Hepatocellular Carcinoma via TCGA, GEPIA2, and HPA Databases: Implications for Prognosis","volume":"12","author":"Gu","year":"2025","journal-title":"J. Hepatocell. Carcinoma"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"D956","DOI":"10.1093\/nar\/gkx1090","article-title":"LinkedOmics: Analyzing multi-omics data within and across 32 cancer types","volume":"46","author":"Vasaikar","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"D92","DOI":"10.1093\/nar\/gkt1248","article-title":"starBase v2.0: Decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data","volume":"42","author":"Li","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"D202","DOI":"10.1093\/nar\/gkq1056","article-title":"starBase: A database for exploring microRNA-mRNA interaction maps from Argonaute CLIP-Seq and Degradome-Seq data","volume":"39","author":"Yang","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/ijc.26064","article-title":"MicroRNA profiles of prostate carcinoma detected by multiplatform microRNA screening","volume":"130","author":"Wach","year":"2012","journal-title":"Int. J. Cancer"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ccr.2010.05.026","article-title":"Integrative genomic profiling of human prostate cancer","volume":"18","author":"Taylor","year":"2010","journal-title":"Cancer Cell"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"8847986","DOI":"10.1155\/2020\/8847986","article-title":"eRNAs and Superenhancer lncRNAs Are Functional in Human Prostate Cancer","volume":"2020","author":"Zhang","year":"2020","journal-title":"Dis. Markers"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s12022-014-9345-4","article-title":"The cancer genome atlas research network: A sight to behold","volume":"25","author":"Giordano","year":"2014","journal-title":"Endocr. Pathol."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Guo, L., Kang, Y., Xia, D., Ren, Y., Yang, X., Xiang, Y., Tang, L., Ren, D., Yu, J., and Wang, J.J.G. (2022). Characterization of immune-based molecular subtypes and prognostic model in prostate adenocarcinoma. Genes, 13.","DOI":"10.3390\/genes13061087"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/978-1-0716-0327-7_19","article-title":"Cell-Type Enrichment Analysis of Bulk Transcriptomes Using xCell","volume":"2120","author":"Aran","year":"2020","journal-title":"Methods Mol. Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/s13059-017-1349-1","article-title":"xCell: Digitally portraying the tissue cellular heterogeneity landscape","volume":"18","author":"Aran","year":"2017","journal-title":"Genome Biol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"5048","DOI":"10.18632\/aging.102931","article-title":"Using ESTIMATE algorithm to establish an 8-mRNA signature prognosis prediction system and identify immunocyte infiltration-related genes in Pancreatic adenocarcinoma","volume":"12","author":"Meng","year":"2020","journal-title":"Aging"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/1\/213\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T02:08:47Z","timestamp":1766714927000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/1\/213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,24]]},"references-count":61,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["ijms27010213"],"URL":"https:\/\/doi.org\/10.3390\/ijms27010213","relation":{},"ISSN":["1422-0067"],"issn-type":[{"type":"electronic","value":"1422-0067"}],"subject":[],"published":{"date-parts":[[2025,12,24]]}}}