{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T08:40:33Z","timestamp":1766738433235,"version":"3.48.0"},"reference-count":34,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22001190"],"award-info":[{"award-number":["22001190"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21702144"],"award-info":[{"award-number":["21702144"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanxi Basic Research Program","award":["202303021221016"],"award-info":[{"award-number":["202303021221016"]}]},{"name":"Shanxi Basic Research Program","award":["20210302123180"],"award-info":[{"award-number":["20210302123180"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>A series of novel triazone derivatives containing acylhydrazone and phenoxypyridine motifs were designed, synthesized, and evaluated for their biological activities. The bioassay results indicated that most of the target compounds exhibited excellent insecticidal activities against bean aphids. In particular, compounds 3i and 3e showed excellent aphicidal activities comparable to pymetrozine, thus emerging as novel insecticidal lead compounds. Additionally, compounds 3c (60%), 3e (60%), and 3f (60%) exhibited good larvicidal activities against C. pipiens pallens at 0.5 mg\/kg. Further fungicidal activity tests revealed that most derivatives exhibited broad-spectrum fungicidal activities. A total of twelve compounds exhibited better fungicidal activities against cercospora arachidicola hori than carbendazim, and eight compounds exhibited better fungicidal activities against fusarium moniliforme than carbendazim. This work suggests that compound 3e could serve as an insecticidal lead compound for further structural optimization.<\/jats:p>","DOI":"10.3390\/ijms27010260","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T08:38:14Z","timestamp":1766738294000},"page":"260","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Discovery of Triazone Derivatives Containing Acylhydrazone and Phenoxypyridine Motifs as Novel Insecticidal and Antiphytopathogenic Fungus Agents"],"prefix":"10.3390","volume":"27","author":[{"given":"Peipei","family":"Cui","sequence":"first","affiliation":[{"name":"College of Architecture and Arts, Taiyuan University of Technology, Jinzhong 030060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Taiyuan 030024, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"105578","DOI":"10.1016\/j.cropro.2021.105578","article-title":"Efficacy of three biopesticides against cotton pests under field conditions in South Africa","volume":"145","author":"Malinga","year":"2021","journal-title":"Crop Prot."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/(SICI)1096-9063(199702)49:2<130::AID-PS509>3.0.CO;2-U","article-title":"Pymetrozine, a fast-acting and selective inhibitor of aphid feeding. 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