{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:40:47Z","timestamp":1780447247097,"version":"3.54.1"},"reference-count":39,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T00:00:00Z","timestamp":1766793600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST106-2320-B040-010"],"award-info":[{"award-number":["MOST106-2320-B040-010"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Artemisia indica Willd., a traditional medicinal and dietary herb, has been widely recognized for its diverse bioactivities. This study aimed to evaluate the effects of Artemisia indica Willd. aqueous extract (AAE) on dysglycemia and dyslipidemia. HPLC\u2013ESI\u2013MS\/MS analysis identified 4,5-dicaffeoylquinic acid as the major active constituent of AAE. BALB\/cByJNarl mice subjected to a high-fat diet (HFD) and streptozotocin (STZ) injection were supplemented with AAE for 6 weeks. To elucidate the underlying mechanisms, we examined multiple metabolic pathways, including oxidative stress, lipid metabolism, and the polyol pathway. AAE administration attenuated fasting blood glucose and reduced fructosamine levels and also ameliorated protein kinase C \u03b1 (PKC-\u03b1) and nuclear factor kappa B (NF-\u03baB) expression. Histopathological evaluation showed that AAE reduced lipid accumulation by modulating sterol regulatory element-binding protein 1 (SREBP-1) and fatty acid synthase (FAS) expression. Additionally, AAE inhibited polyol pathway activation and restored antioxidant enzyme activities. Collectively, these findings indicate that AAE modulates glucose and cholesterol metabolism, attenuates oxidative stress, and improves metabolic homeostasis, supporting its potential as a natural herbal therapeutic agent.<\/jats:p>","DOI":"10.3390\/ijms27010297","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T05:28:19Z","timestamp":1766986099000},"page":"297","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Metabolic and Antioxidant Modulation by Artemisia indica Willd. Aqueous Extract in Glucose and Cholesterol Dysregulation"],"prefix":"10.3390","volume":"27","author":[{"given":"Chiao-Yun","family":"Tseng","sequence":"first","affiliation":[{"name":"Department of Nutrition, Chung Shan Medical University, Taichung City 40201, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueching","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Chung Shan Medical University, Taichung City 40201, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6801-5573","authenticated-orcid":false,"given":"Charng-Cherng","family":"Chyau","sequence":"additional","affiliation":[{"name":"Research Institute of Biotechnology, Hungkuang University, No. 1018, Sec. 6, Taiwan Boulevard, Shalu District, Taichung City 43302, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hsuan","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Chung Shan Medical University, Taichung City 40201, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0021-5709","authenticated-orcid":false,"given":"Hui-Hsuan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung City 40201, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5756-5959","authenticated-orcid":false,"given":"Jing-Hsien","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Chung Shan Medical University, Taichung City 40201, Taiwan"},{"name":"Department of Medical Research, Chung Shan Medical University Hospital, Taichung City 40201, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/s11910-022-01236-0","article-title":"Pre-diabetes, Diabetes, Hyperglycemia, and Stroke: Bittersweet Therapeutic Opportunities","volume":"22","author":"Bruno","year":"2022","journal-title":"Curr. 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