{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T07:54:36Z","timestamp":1766994876610,"version":"3.48.0"},"reference-count":34,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>(1) This cross-sectional study aims to elucidate the association between the XPO5 gene polymorphism (rs11544382) and colon cancer (CC). (2) Genotyping of XPO5 (rs11544382) was performed in 120 individuals (60 CC patients and 60 controls) using real-time PCR (qPCR). Logistic regression and Chi-square (\u03c72) tests were used for statistical analysis. (3) Evaluation of the XPO5 gene polymorphism in CC and control groups revealed no statistically significant association between the mutant (GG) genotype and either the wild-type (AA) or heterozygous (AG) genotypes (\u03c72 = 2.07, p = 0.151). The AG genotype was predominant in both patients (86.7%) and controls (91.7%). Smoking and alcohol consumption showed significant associations with CC (p &lt; 0.05). Although the rs11544382 polymorphism was not associated with CC risk, this is a cross-sectional study. In light of these findings, larger and more comprehensive studies with increased sample size are required to clarify the relationship between the XPO5 gene polymorphism (rs11544382) and CC.<\/jats:p>","DOI":"10.3390\/ijms27010345","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T07:52:59Z","timestamp":1766994779000},"page":"345","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["XPO5 Polymorphism in Colon Cancer Patients: A Cross-Sectional Study"],"prefix":"10.3390","volume":"27","author":[{"given":"Tugba","family":"Agbektas","sequence":"first","affiliation":[{"name":"Department of Food Processing Technologies Services, Y\u0131ld\u0131zeli Vocational School, Sivas Cumhuriyet University, Sivas 58140, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Husnu Cagr\u0131","family":"Genc","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Faculty of Medicine, Sivas Cumhuriyet University, Sivas 58140, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cemile","family":"Zontul","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Processing Technologies Services, Y\u0131ld\u0131zeli Vocational School, Sivas Cumhuriyet University, Sivas 58140, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7132-1325","authenticated-orcid":false,"given":"Ayca","family":"Tas","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine, Sivas Cumhuriyet University, Sivas 58140, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e70004","DOI":"10.1002\/mog2.70004","article-title":"WNT2 Blockade Augments Antitumor Immunity by Attenuating Myeloid-Derived Suppressor Cells in Colorectal Cancer","volume":"3","author":"Cui","year":"2024","journal-title":"MedComm\u2013Oncology"},{"key":"ref_2","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. 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