{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:22:15Z","timestamp":1791912135153,"version":"4.3.4"},"reference-count":72,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Recovery and Resilience Facility of the European Union","award":["RRF-2.3.1-21-2022-00012"],"award-info":[{"award-number":["RRF-2.3.1-21-2022-00012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Microplastics and nanoplastics (&lt;5 mm and &lt;1 \u03bcm, respectively) are emerging contaminants now ubiquitous across environmental matrices and increasingly recognized for their impacts on human health. These particles commonly adsorb or contain endocrine-disrupting chemicals\u2014such as bisphenol-A and phthalate additives\u2014that together trigger complex biological responses. This review examines the central role of oxidative stress in mediating the toxicity of microplastics and associated endocrine disruptors across multiple organ systems. We discuss mechanisms including cellular uptake, reactive oxygen species generation, mitochondrial dysfunction, impairment of antioxidant defenses, and activation of key signaling pathways. Organ-specific effects on reproductive health, cardiovascular function, hepatic metabolism, gut barrier integrity, and neurological systems are highlighted. Current evidence strongly supports oxidative stress as a pivotal mechanism linking microplastic exposure to systemic toxicity, underscoring important implications for public health policy and clinical intervention strategies.<\/jats:p>","DOI":"10.3390\/ijms27010399","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T15:30:32Z","timestamp":1767195032000},"page":"399","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Microplastics, Endocrine Disruptors, and Oxidative Stress: Mechanisms and Health Implications"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4014-3300","authenticated-orcid":false,"given":"Kalman","family":"Kovacs","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Medical School, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"MTA-PTE Human Reproduction Scientific Research Group, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"National Laboratory on Human Reproduction, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jozsef","family":"Bodis","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Medical School, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"MTA-PTE Human Reproduction Scientific Research Group, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"National Laboratory on Human Reproduction, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reka A.","family":"Vass","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Medical School, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"MTA-PTE Human Reproduction Scientific Research Group, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"National Laboratory on Human Reproduction, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"106274","DOI":"10.1016\/j.envint.2020.106274","article-title":"Plasticenta: First evidence of microplastics in human placenta","volume":"146","author":"Ragusa","year":"2021","journal-title":"Environ. Int."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"107199","DOI":"10.1016\/j.envint.2022.107199","article-title":"Discovery and quantification of plastic particle pollution in human blood","volume":"163","author":"Leslie","year":"2022","journal-title":"Environ. Int."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Kadac-Czapska, K., and Jankowska-Steifer, E. (2024). Microplastics and oxidative stress\u2014Current problems and prospects. Antioxidants, 13.","DOI":"10.3390\/antiox13050579"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Wang, W., Guan, J., Feng, Y., Liu, S., Zhao, Y., Xu, Y., Xu, H., and Fu, F. (2023). Polystyrene microplastics induced ovarian toxicity in juvenile rats via oxidative stress and activation of the PERK\u2013eIF2\u03b1\u2013CHOP pathway. Toxics, 11.","DOI":"10.3390\/toxics11030225"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/em.22072","article-title":"Induction of oxidative stress by bisphenol A and its pleiotropic effects","volume":"58","author":"Gassman","year":"2017","journal-title":"Environ. Mol. Mutagen."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"112636","DOI":"10.1016\/j.envres.2021.112636","article-title":"Oxidative stress induced by phthalates in mammals: State of the art and potential biomarkers","volume":"206","year":"2022","journal-title":"Environ. Res."},{"key":"ref_7","unstructured":"Yang, Y., Chen, R., Li, X., Chen, X., and Chen, S. (2023). Microplastics exposure and endocrine disruption in mammals. Front. Endocrinol., 13."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1021\/acs.est.0c07587","article-title":"Oxidative stress, endocrine disturbance, and immune interference in humans in relation to serum bisphenol levels in a heavily industrialized area","volume":"55","author":"Gao","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"103688","DOI":"10.1016\/j.redox.2025.103688","article-title":"Mitigating microplastic-induced organ damage: Mechanistic insights from the microplastic\u2013macrophage axis","volume":"84","author":"Cui","year":"2025","journal-title":"Redox Biol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"de Sousa, A.K.A., Pires, K.S.N., Cavalcante, I.H., Cavalcante, I.C.L., Santos, J.D., Queiroz, M.I.C., Leite, A.C.R., Crispim, A.C., da Rocha Junior, E.R., and Aquino, T.M. (2024). Polystyrene microplastics exposure on human placental explants induces time-dependent cytotoxicity and oxidative stress. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1481014"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"139673","DOI":"10.1016\/j.jhazmat.2025.139673","article-title":"Exposure and toxicokinetics of microplastics in arthropods: Mechanisms and consequences","volume":"497","author":"Das","year":"2025","journal-title":"J. Hazard. Mater."},{"key":"ref_12","unstructured":"Sobhani, Z., Taylor, M., and Naderi, M. (2021). Protective effect of N-acetylcysteine against microplastic-induced toxicity in rats. Antioxidants, 10."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"124028","DOI":"10.1016\/j.jhazmat.2020.124028","article-title":"Reproductive toxicity of polystyrene microplastics: An in vivo experimental study in mice","volume":"404","author":"Hou","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"ref_14","unstructured":"Cai, L., Wang, J., Peng, J., Tan, Z., Zhan, Z., and Tan, X. (2023). Microplastics exposure induces oxidative stress, inflammation, and endocrine disruption in mammals. Int. J. Mol. Sci., 24."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.redox.2015.08.010","article-title":"Calcium and ROS: A mutual interplay","volume":"6","author":"Bertram","year":"2015","journal-title":"Redox Biol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1210\/er.2015-1010","article-title":"EDC-2: The Endocrine Society\u2019s second scientific statement on endocrine-disrupting chemicals","volume":"36","author":"Gore","year":"2015","journal-title":"Endocr. Rev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"6634","DOI":"10.1021\/acs.est.7b00423","article-title":"Plastic and human health: A micro issue?","volume":"51","author":"Wright","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.reprotox.2013.08.008","article-title":"Bisphenol A and human health: A review of the literature","volume":"42","author":"Rochester","year":"2013","journal-title":"Reprod. Toxicol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Campanale, C., Massarelli, C., Savino, I., Locaputo, V., and Uricchio, V.F. (2020). A Detailed Review Study on Potential Effects of Microplastics and Additives of Concern on Human Health. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17041212"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"14507","DOI":"10.1021\/acs.est.2c05108","article-title":"Polyvinyl Chloride Microplastics Leach Phthalates into the Aquatic Environment over Decades","volume":"56","author":"Henkel","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"115392","DOI":"10.1016\/j.marpolbul.2023.115392","article-title":"Plasticiser Leaching from Polyvinyl Chloride Microplastics and the Implications for Environmental Risk Assessment","volume":"195","author":"Gulizia","year":"2023","journal-title":"Mar. Pollut. Bull."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/s42004-024-01310-3","article-title":"Photoaging Enhances the Leaching of di(2-ethylhexyl) Phthalate and Transformation Products from Polyvinyl Chloride Microplastics into Aquatic Environments","volume":"7","author":"Henkel","year":"2024","journal-title":"Commun. Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"126899","DOI":"10.1016\/j.envpol.2025.126899","article-title":"Research advances of micro\/nanoplastics in groundwater: Occurrence, environmental impacts and control strategies","volume":"383","author":"Jin","year":"2025","journal-title":"Environ Pollut."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"134238","DOI":"10.1016\/j.chemosphere.2022.134238","article-title":"Aging of Microplastics Increases Their Adsorption Affinity towards Organic Contaminants","volume":"298","author":"Bhagat","year":"2022","journal-title":"Chemosphere"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"47277","DOI":"10.1021\/acsami.2c13987","article-title":"Tailor-Made Protein Corona Formation on Polystyrene Microparticles and Its Effect on Epithelial Cell Uptake","volume":"14","author":"Jasinski","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"157948","DOI":"10.1016\/j.scitotenv.2022.157948","article-title":"Protein-Coated Microplastics Corona Complex: An Underestimated Risk of Microplastics","volume":"851","author":"Luo","year":"2022","journal-title":"Sci. Total Environ."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Lujic, T., Mutic, T., Simovic, A., Vasovic, T., Ivanovic, S., Krstic Ristivojevic, M., Jovanovic, V., and Cirkovic Velickovic, T. (2025). Protein Corona Stability and Removal from PET Microplastics: Analytical and Spectroscopic Evaluation in Simulated Intestinal Conditions. Foods, 14.","DOI":"10.20944\/preprints202508.1571.v1"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"154907","DOI":"10.1016\/j.scitotenv.2022.154907","article-title":"Detection of microplastics in human lung tissue","volume":"831","author":"Jenner","year":"2022","journal-title":"Sci. Total Environ."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Ragusa, A., Notarstefano, V., Svelato, A., Belloni, A., Gioacchini, G., Blondeel, C., Zucchelli, E., De Luca, C., D\u2019avino, S., and Gulotta, A. (2022). Microplastics in human breast milk. Polymers, 14.","DOI":"10.3390\/polym14132700"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.1007\/s00204-025-04092-2","article-title":"Post-mortem evidence of microplastic bioaccumulation in human organs: Insights from advanced imaging and spectroscopic analysis","volume":"99","author":"Komaniecka","year":"2025","journal-title":"Arch. Toxicol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/s41591-024-03453-1","article-title":"Nanoplastic bioaccumulation in human brain and other organs","volume":"31","author":"Nihart","year":"2025","journal-title":"Nat. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1056\/NEJMoa2309822","article-title":"Microplastics and nanoplastics in atherosclerotic plaques and cardiovascular events","volume":"390","author":"Marfella","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"158699","DOI":"10.1016\/j.scitotenv.2022.158699","article-title":"Detection of various microplastics in placentas, meconium, infant feces, breastmilk and infant formula: A pilot prospective study","volume":"854","author":"Liu","year":"2023","journal-title":"Sci Total Environ."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Braun, T., Ehrlich, L., Henrich, W., Koeppel, S., Lomako, I., Schwabl, P., and Liebmann, B. (2021). Detection of microplastic in human placenta and meconium in a clinical setting. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13070921"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"126124","DOI":"10.1016\/j.jhazmat.2021.126124","article-title":"Presence of airborne microplastics in human lung tissue","volume":"416","author":"Ando","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"104147","DOI":"10.1016\/j.ebiom.2022.104147","article-title":"Microplastics detected in cirrhotic liver tissue","volume":"82","author":"Horvatits","year":"2022","journal-title":"EBioMedicine"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"135266","DOI":"10.1016\/j.jhazmat.2024.135266","article-title":"Discovery and analysis of microplastics in human bone marrow","volume":"15","author":"Guo","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/toxsci\/kfae060","article-title":"Microplastic presence in dog and human testis and its potential association with sperm count and weights of testis and epididymis","volume":"200","author":"Hu","year":"2024","journal-title":"Toxicol. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/jgh3.12457","article-title":"Detection of microplastics in human colectomy specimens","volume":"5","author":"Ibrahim","year":"2020","journal-title":"JGH Open"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Rotchell, J.M., Jenner, L.C., Chapman, E., Bennett, R.T., Bolanle, I.O., Loubani, M., Sadofsky, L., and Palmer, T.M. (2023). Detection of microplastics in human saphenous vein tissue using \u03bcFTIR: A pilot study. PLoS ONE, 18.","DOI":"10.1371\/journal.pone.0280594"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"117796","DOI":"10.1016\/j.ecoenv.2025.117796","article-title":"Characterization of microplastics in human follicular fluid and assessment of their potential impact on mouse oocyte maturation in vitro","volume":"291","author":"Ni","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"117868","DOI":"10.1016\/j.ecoenv.2025.117868","article-title":"First evidence of microplastics in human ovarian follicular fluid: An emerging threat to female fertility","volume":"291","author":"Montano","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"138748","DOI":"10.1016\/j.jhazmat.2025.138748","article-title":"Association of microplastics in human cerebrospinal fluid with Alzheimer\u2019s disease-related changes","volume":"494","author":"He","year":"2025","journal-title":"J. Hazard. Mater."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"11452","DOI":"10.1038\/s41598-017-10813-0","article-title":"Brain damage and behavioural disorders in fish induced by plastic nanoparticles delivered through the food chain","volume":"7","author":"Mattsson","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Yong, C.Q.Y., Valiyaveettil, S., and Tang, B.L. (2020). Toxicity of microplastics and nanoplastics in mammalian systems. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17051509"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"103118","DOI":"10.1016\/j.earscirev.2020.103118","article-title":"Atmospheric microplastics: A review on current status and perspectives","volume":"203","author":"Zhang","year":"2020","journal-title":"Earth-Sci. Rev."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Shi, X., Wang, Y., and Xu, L. (2025). An overview of research on the association between microplastics and central nervous system disorders. Front. Public Health, 13.","DOI":"10.3389\/fpubh.2025.1629181"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxlet.2025.06.021","article-title":"Toxicological effects of micro\/nano-plastics on human reproductive health: A review","volume":"412","author":"Talaie","year":"2025","journal-title":"Toxicol. Lett."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"113122","DOI":"10.1016\/j.envpol.2019.113122","article-title":"Maternal exposure to different sizes of polystyrene microplastics during gestation causes metabolic disorders in their offspring","volume":"255","author":"Luo","year":"2019","journal-title":"Environ. Pollut."},{"key":"ref_50","first-page":"127560","article-title":"Microplastics in human tissues: Accumulation, biological effects, and health implications","volume":"424","author":"Sun","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"ref_51","first-page":"112377","article-title":"Polystyrene microplastics induce dose- and time-dependent ROS-mediated apoptotic responses in zebrafish","volume":"220","author":"Umamaheswari","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"122550","DOI":"10.1016\/j.envpol.2023.122550","article-title":"Cellular and bioenergetic effects of polystyrene microplastics in intestinal cells","volume":"337","author":"Peng","year":"2023","journal-title":"Environ. Pollut."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12989-021-00414-1","article-title":"Polystyrene micro- and nanoplastics jointly induce intestinal damage via ROS-mediated apoptosis","volume":"18","author":"Liang","year":"2021","journal-title":"Part. Fibre Toxicol."},{"key":"ref_54","first-page":"e85696","article-title":"Evidence, mechanisms, and clinical implications of microplastics and nanoplastics as cardiovascular risk factors","volume":"17","author":"Moorthy","year":"2025","journal-title":"Cureus"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Wang, Z., Wang, Y., Zhang, J., Feng, G., Miao, S., Lu, R., Tian, X., and Ye, Y. (2025). Antioxidant intervention against microplastic hazards: The role of NADPH oxidase activation. Antioxidants, 14.","DOI":"10.3390\/antiox14070797"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"156502","DOI":"10.1016\/j.scitotenv.2022.155825","article-title":"Oxidative stress mediated by TLR4\/NOX2 signalling in uterine fibrosis induced by polystyrene microplastics","volume":"838","author":"Wu","year":"2022","journal-title":"Sci. Total Environ."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Ngo, V., and Duennwald, M.L. (2022). Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease. Antioxidants, 11.","DOI":"10.3390\/antiox11122345"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1080\/15376516.2025.2527154","article-title":"Evaluation of polyethylene microplastics toxicity using Nrf2\/ARE and MAPK\/Nrf2 signaling pathways","volume":"35","author":"Mohamed","year":"2025","journal-title":"Toxicol. Mech. Methods"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"102652","DOI":"10.1016\/j.jksus.2024.103343","article-title":"Sakuranetin counteracts polyethylene microplastics-induced toxicity by modulating the Nrf2\/Keap1 pathway","volume":"36","author":"Akbar","year":"2024","journal-title":"J. King Saud Univ. Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"144","DOI":"10.3892\/ijmm.2025.5584","article-title":"Emerging threat of environmental microplastics: A comprehensive analysis of hepatic metabolic dysregulation and hepatocellular damage (Review)","volume":"56","author":"Yue","year":"2025","journal-title":"Int. J. Mol. Med."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Mahmud, F., Sarker, D.B., Jocelyn, J.A., and Sang, Q.-X.A. (2024). Molecular and Cellular Effects of Microplastics and Nanoplastics: Focus on Inflammation and Senescence. Cells, 13.","DOI":"10.3390\/cells13211788"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"133794","DOI":"10.1016\/j.scitotenv.2019.133794","article-title":"Internalization and toxicity: A preliminary study of effects of nanoplastic particles on human lung epithelial cell","volume":"694","author":"Xu","year":"2022","journal-title":"Sci. Total Environ."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"C817","DOI":"10.1152\/ajpcell.00139.2004","article-title":"Calcium, ATP, and ROS: A mitochondrial love\u2013hate triangle","volume":"287","author":"Brookes","year":"2004","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"153545","DOI":"10.1016\/j.tox.2023.153545","article-title":"Hematological consequences of polyethylene microplastics toxicity in male rats: Oxidative stress, genetic, and epigenetic links","volume":"492","author":"Farag","year":"2023","journal-title":"Toxicology"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1080\/10408444.2019.1621263","article-title":"Bisphenol A co-exposure effects: A key factor in understanding BPA\u2019s complex mechanism and health outcomes","volume":"49","author":"Sonavane","year":"2019","journal-title":"Crit Rev Toxicol."},{"key":"ref_66","first-page":"10","article-title":"Impact of bisphenol A on structure and function of mitochondria: A systematic review","volume":"260","author":"Nayak","year":"2022","journal-title":"Rev. Environ. Contam. Toxicol."},{"key":"ref_67","first-page":"576","article-title":"Bisphenol-A analogue (bisphenol-S) exposure alters female reproductive tract and apoptosis\/oxidative gene expression in blastocyst-derived cells","volume":"23","author":"Nourian","year":"2020","journal-title":"Iran. J. Basic Med. Sci."},{"key":"ref_68","first-page":"635","article-title":"Bisphenol A effects on granulosa cell function via GPER-mediated pathways","volume":"101","author":"Brehm","year":"2019","journal-title":"Biol. Reprod."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1289\/ehp.1307728","article-title":"Bisphenol A and reproductive toxicity: A systematic review","volume":"122","author":"Peretz","year":"2014","journal-title":"Environ. Health Perspect."},{"key":"ref_70","first-page":"44","article-title":"Effects of environmental BPA on male fertility","volume":"401","author":"Rahman","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Wei, Y., Zhang, M., Song, J., Wang, T., Ma, Y., Qin, L., Li, J., Qian, X., and Chen, J. (2025). Nephrotoxicity of Phthalates: A Review Based on Epidemiological and Toxicological Evidence. Toxics, 13.","DOI":"10.3390\/toxics13110947"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Xu, Y., Xu, Y., Gu, W., Zhou, X., Wu, H., and Yang, X. (2025). Exploring the association b\u00e9t\u00e1\u00e9in exposure to pesticides, polycyclic aromatic hydrocarbons, and phthalates and metabolic syndrome in National Health and Nutrition Examination Survey in the USA, 2007\u20132012: Utilizing a multi-step statistical strategy. BMC Public Health, 25.","DOI":"10.1186\/s12889-025-21864-8"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/1\/399\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T12:39:28Z","timestamp":1767616768000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/1\/399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,30]]},"references-count":72,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["ijms27010399"],"URL":"https:\/\/doi.org\/10.3390\/ijms27010399","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,30]]}}}