{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:14:08Z","timestamp":1792455248521,"version":"4.5.0"},"reference-count":35,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Cervical cancer, primarily caused by high-risk Human Papilloma Virus (HPV), remains a global health concern. Prognostic biomarkers reflecting systemic inflammation and immune response\u2014the Systemic Immune-Inflammation Index (SII) and the Systemic Inflammation Response Index (SIRI)\u2014have recently attracted interest for their potential predictive value in cervical cancer. We conducted a retrospective observational study including 344 patients who underwent loop electrosurgical excision of cervical intraepithelial neoplasia at Semmelweis University, Budapest, Hungary, between 2021 and 2024. Demographic, cytologic, histologic, and laboratory data were collected, and SII and SIRI were calculated. Statistical analyses, including Receiver Operating Characteristic (ROC) analyses, were performed. Higher SII and SIRI values were significantly associated with higher-grade lesions and invasive carcinoma. ROC analyses indicated good discriminatory performance, with negative predictive values of 96\u2013100%, suggesting potential utility in ruling out malignant transformation. SII and SIRI are simple, cost-effective, and minimally invasive biomarkers that correlate with lesion severity in cervical disease. Their high negative predictive value supports a potential role as complementary rule-out tools in diagnostic evaluation. Further prospective studies are needed to validate these findings and to define clinically meaningful cut-off values for routine use.<\/jats:p>","DOI":"10.3390\/ijms27010435","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T16:08:00Z","timestamp":1767197280000},"page":"435","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Systemic Inflammatory Indices\u2014Systemic Immune-Inflammation Index (SII) and the Systemic Inflammation Response Index (SIRI)\u2014As Potential Rule-Out Biomarkers for Invasive Cervical Carcinoma"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4886-3481","authenticated-orcid":false,"given":"M\u00e1rton","family":"Keszthelyi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Semmelweis University, \u00dcll\u0151i Road 78\/A, 1082 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9ka Eszter","family":"Sziva","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Semmelweis University, \u00dcll\u0151i Road 78\/A, 1082 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zs\u00f3fia","family":"Havr\u00e1n","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Semmelweis University, \u00dcll\u0151i Road 26, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verita","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Semmelweis University, \u00dcll\u0151i Road 26, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"No\u00e9mi","family":"Kalas","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Semmelweis University, \u00dcll\u0151i Road 26, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotti","family":"L\u0151czi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Semmelweis University, \u00dcll\u0151i Road 78\/A, 1082 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2358-307X","authenticated-orcid":false,"given":"Barbara","family":"Seb\u0151k","sequence":"additional","affiliation":[{"name":"Workgroup of Research Management, Doctoral School, Semmelweis University, \u00dcll\u0151i Road 26, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Merkely","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Semmelweis University, \u00dcll\u0151i Road 78\/A, 1082 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00e1ndor","family":"\u00c1cs","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Semmelweis University, \u00dcll\u0151i Road 78\/A, 1082 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szabolcs","family":"V\u00e1rb\u00edr\u00f3","sequence":"additional","affiliation":[{"name":"Workgroup of Research Management, Doctoral School, Semmelweis University, \u00dcll\u0151i Road 26, 1085 Budapest, Hungary"},{"name":"Department of Obstetrics and Gynecology, University of Szeged, Semmelweis Street 1, 6725 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bal\u00e1zs","family":"Lintner","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Semmelweis University, \u00dcll\u0151i Road 78\/A, 1082 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9535-5821","authenticated-orcid":false,"given":"Rich\u00e1rd","family":"T\u00f3th","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Semmelweis University, \u00dcll\u0151i Road 78\/A, 1082 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.currproblcancer.2018.06.003","article-title":"Cervical cancer worldwide","volume":"42","author":"Vu","year":"2018","journal-title":"Curr. 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