{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T05:59:19Z","timestamp":1767765559881,"version":"3.48.0"},"reference-count":61,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Previous haplotype Genome Wide Association Studies (GWASs) have suggested several rare loci with a shared increased risk of colorectal, gastric, and prostate cancer. This study aimed to find out more about markers specifically addressing the shared risk of colorectal and gastric cancer, as well as the shared risk of colorectal and prostate cancer. One analysis used 426 colorectal cancer cases with gastric cancer, with no prostate cancer cases in their families, and another analysis used 324 colorectal cancer cases with prostate cancer but no gastric cancer among relatives. The computational program PLINK v1.07 was used for the analysis and for the calculation of corresponding ORs, standard errors, and 95% confidence intervals (CI). The study found support for the loci from previous studies and many new loci with a shared risk of colorectal cancer and gastric cancer. There were no significant loci from the second analysis for a shared risk of colorectal and prostate cancer. Altogether, more than 100 new loci with a shared risk of colorectal cancer and gastric cancer were suggested. A shared risk of colorectal and prostate cancer at some loci could not be ruled out. Haplotype GWAS has again demonstrated its ability to find rare risk loci mostly associated with coding genes.<\/jats:p>","DOI":"10.3390\/ijms27010547","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T15:28:57Z","timestamp":1767626937000},"page":"547","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Haplotype GWAS in Colorectal Cancer Patients with a Family History of Gastric or Prostate Cancer"],"prefix":"10.3390","volume":"27","author":[{"given":"David","family":"Kudr\u00e9n","sequence":"first","affiliation":[{"name":"Department of Oncology, S\u00f6dersjukhuset, 11833 Stockholm, Sweden"},{"name":"Department of Clinical Science and Education, Karolinska Institutet, 11833 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Waage","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Education, Karolinska Institutet, 11833 Stockholm, Sweden"},{"name":"Department of Urology, S\u00f6dersjukhuset, 11833 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3831-4801","authenticated-orcid":false,"given":"Johanna","family":"Samola Winnberg","sequence":"additional","affiliation":[{"name":"Division of Surgery, Department of Clinical Science Intervention and Technology (CLINTEC), Karolinska Institutet, 17177 Stockholm, Sweden"},{"name":"Department of Upper Abdominal Diseases, Karolinska University Hospital, 17166 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mats","family":"Lindblad","sequence":"additional","affiliation":[{"name":"Division of Surgery, Department of Clinical Science Intervention and Technology (CLINTEC), Karolinska Institutet, 17177 Stockholm, Sweden"},{"name":"Department of Upper Abdominal Diseases, Karolinska University Hospital, 17166 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunde","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oncology, S\u00f6dersjukhuset, 11833 Stockholm, Sweden"},{"name":"Department of Clinical Science and Education, Karolinska Institutet, 11833 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7675-7569","authenticated-orcid":false,"given":"Annika","family":"Lindblom","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Karolinska Institutet, 17177 Stockholm, Sweden"},{"name":"Department of Clinical Genetics, Karolinska University Hospital, 17166 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Litika","family":"Vermani","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Karolinska Institutet, 17177 Stockholm, Sweden"},{"name":"Department of Clinical Genetics, Karolinska University Hospital, 17166 Stockholm, Sweden"},{"name":"Dr. S Krishnamurthi Centre for Research and Education in Cancer, Cachar Cancer Hospital and Research Centre, Silchar 788015, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.mam.2019.03.001","article-title":"Update on genetic predisposition to colorectal cancer and polyposis","volume":"69","author":"Valle","year":"2019","journal-title":"Mol. Asp. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"R206","DOI":"10.1093\/hmg\/ddab208","article-title":"From APC to the genetics of hereditary and familial colon cancer syndromes","volume":"30","author":"Olkinuora","year":"2021","journal-title":"Hum. Mol. Genet."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1586\/14737140.4.3.377","article-title":"Colorectal cancer as a complex disease: Defining at-risk subjects in the general population\u2014A preventive strategy","volume":"4","author":"Lindblom","year":"2004","journal-title":"Expert. Rev. Anticancer. Ther."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nature24284","article-title":"Association analysis identifies 65 new breast cancer risk loci","volume":"551","author":"Michailidou","year":"2017","journal-title":"Nature"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1038\/s41467-019-09775-w","article-title":"Association analyses identify 31 new risk loci for colorectal cancer susceptibility","volume":"10","author":"Law","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1038\/s41467-018-04109-8","article-title":"Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants","volume":"9","author":"Dadaev","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/ng.3185","article-title":"Identification of six new susceptibility loci for invasive epithelial ovarian cancer","volume":"47","author":"Kuchenbaecker","year":"2015","journal-title":"Nat. Genet."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nrg2574","article-title":"New insights into the aetiology of colorectal cancer from genome-wide association studies","volume":"10","author":"Tenesa","year":"2009","journal-title":"Nat. Rev. Genet."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3557","DOI":"10.1038\/s41467-024-47399-x","article-title":"Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes","volume":"15","author":"Chen","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"5103","DOI":"10.1158\/0008-5472.CAN-15-2980","article-title":"Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations","volume":"76","author":"Fehringer","year":"2016","journal-title":"Cancer Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.21873\/anticanres.11518","article-title":"Defining New Colorectal Cancer Syndromes in a Population-based Cohort of the Disease","volume":"37","author":"Forsberg","year":"2017","journal-title":"Anticancer. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1002\/gcc.22786","article-title":"Genetic analyses supporting colorectal, gastric, and prostate cancer syndromes","volume":"58","author":"Wallander","year":"2019","journal-title":"Genes. Chromosomes Cancer"},{"key":"ref_13","first-page":"25","article-title":"A genome-wide association study in Swedish colorectal cancer patients with gastric- and prostate cancer in relatives","volume":"22","author":"Vermani","year":"2024","journal-title":"Hered. Cancer Clin. Pr."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Vermani, L., Samola Winnberg, J., Liu, W., Soller, V., Sj\u00f6din, T., Lindblad, M., and Lindblom, A. (2025). A Haplotype GWAS in Syndromic Familial Colorectal Cancer. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26020817"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/mc.23366","article-title":"Colorectal cancer risk susceptibility loci in a Swedish population","volume":"61","author":"Liu","year":"2022","journal-title":"Mol. Carcinog."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1093\/clinchem\/hvab204","article-title":"Genome-Scale Methylation Analysis of Circulating Cell-Free DNA in Gastric Cancer Patients","volume":"68","author":"Ren","year":"2022","journal-title":"Clin. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41418-021-00828-6","article-title":"CDK15 promotes colorectal cancer progression via phosphorylating PAK4 and regulating beta-catenin\/MEK-ERK signaling pathway","volume":"29","author":"Huang","year":"2022","journal-title":"Cell Death Differ."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1093\/jnci\/djp265","article-title":"Analysis of fecal DNA methylation to detect gastrointestinal neoplasia","volume":"101","author":"Nagasaka","year":"2009","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1002\/mc.22527","article-title":"Reelin-Dab1 signaling system in human colorectal cancer","volume":"56","author":"Peral","year":"2017","journal-title":"Mol. Carcinog."},{"key":"ref_20","first-page":"85","article-title":"Epigenetic silencing of RELN in gastric cancer","volume":"36","author":"Dohi","year":"2010","journal-title":"Int. J. Oncol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Kim, S.H., Park, Y.Y., Cho, S.N., Margalit, O., Wang, D., and DuBois, R.N. (2016). Kr\u00fcppel-Like Factor 12 Promotes Colorectal Cancer Growth through Early Growth Response Protein 1. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0159899"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Zhu, L., Yu, Q., Li, Y., Zhang, M., Peng, Z., Wang, S., Quan, Z., and Gao, D. (2023). SKAP1 Is a Novel Biomarker and Therapeutic Target for Gastric Cancer: Evidence from Expression, Functional, and Bioinformatic Analyses. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241411870"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.canlet.2005.06.049","article-title":"Common fragile sites, extremely large genes, neural development and cancer","volume":"232","author":"Smith","year":"2006","journal-title":"Cancer Lett."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Rubina, K., Maier, A., Klimovich, P., Sysoeva, V., Romashin, D., Semina, E., and Tkachuk, V. (2025). T-Cadherin (CDH13) and Non-Coding RNAs: The Crosstalk Between Health and Disease. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26136127"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.cellsig.2009.01.035","article-title":"A guide and guard: The many faces of T-cadherin","volume":"21","author":"Philippova","year":"2009","journal-title":"Cell Signal"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1016\/j.cellsig.2010.04.008","article-title":"T-cadherin attenuates the PERK branch of the unfolded protein response and protects vascular endothelial cells from endoplasmic reticulum stress-induced apoptosis","volume":"22","author":"Kyriakakis","year":"2010","journal-title":"Cell Signal"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1080\/03036758.2025.2511007","article-title":"Hereditary diffuse gastric cancer: The evolution of a cancer syndrome","volume":"55","author":"Godwin","year":"2025","journal-title":"J. R. Soc. N. Z."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"114681","DOI":"10.1016\/j.yexcr.2025.114681","article-title":"Research progress of ASIC family in tumors","volume":"450","author":"Wan","year":"2025","journal-title":"Exp. Cell Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1146\/annurev-physiol-021119-034627","article-title":"The Acidic Tumor Microenvironment as a Driver of Cancer","volume":"82","author":"Pedersen","year":"2020","journal-title":"Annu. Rev. Physiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1093\/carcin\/bgt010","article-title":"Association of polymorphisms and haplotype in the region of TRIT1, MYCL1 and MFSD2A with the risk and clinicopathological features of gastric cancer in a southeast Chinese population","volume":"34","author":"Chen","year":"2013","journal-title":"Carcinogenesis"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/cbf.3395","article-title":"Targeted silencing of MYCL1 by RNA interference inhibits migration and invasion of MGC-803 gastric cancer cells","volume":"37","author":"Qin","year":"2019","journal-title":"Cell Biochem. Funct."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1002\/cac2.12476","article-title":"MFSD2A potentiates gastric cancer response to anti-PD-1 immunotherapy by reprogramming the tumor microenvironment to activate T cell response","volume":"43","author":"Zhang","year":"2023","journal-title":"Cancer Commun."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"14208","DOI":"10.1021\/acsomega.1c00894","article-title":"Proteomic Analysis Reveals That Metformin Suppresses PSMD2, STIP1, and CAP1 for Preventing Gastric Cancer AGS Cell Proliferation and Migration","volume":"6","author":"Wang","year":"2021","journal-title":"ACS Omega"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.biopha.2014.12.037","article-title":"Prognostic significance of combined microRNA-206 and CyclinD2 in gastric cancer patients after curative surgery: A retrospective cohort study","volume":"71","author":"Shi","year":"2015","journal-title":"Biomed. Pharmacother."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"70214","DOI":"10.18632\/oncotarget.19603","article-title":"TGF\u03b2 induced factor homeobox 1 promotes colorectal cancer development through activating Wnt\/\u03b2-catenin signaling","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3233\/CBM-2012-00285","article-title":"Is SCUBE 1 a new biomarker for gastric cancer?","volume":"11","author":"Mentese","year":"2012","journal-title":"Cancer Biomark."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"371","DOI":"10.7555\/JBR.35.20210067","article-title":"PUM1 represses CDKN1B translation and contributes to prostate cancer progression","volume":"35","author":"Li","year":"2021","journal-title":"J. Biomed. Res."},{"key":"ref_38","first-page":"1377","article-title":"Low expression of KCNN3 may affect drug resistance in ovarian cancer","volume":"18","author":"Liu","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s12672-024-01399-x","article-title":"Exploring the interaction between immune cells in the prostate cancer microenvironment combining weighted correlation gene network analysis and single-cell sequencing: An integrated bioinformatics analysis","volume":"15","author":"Bavandi","year":"2024","journal-title":"Discov. Oncol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.freeradbiomed.2021.01.016","article-title":"CCT3 suppression prompts apoptotic machinery through oxidative stress and energy deprivation in breast and prostate cancers","volume":"165","author":"Temiz","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3332","DOI":"10.1158\/0008-5472.CAN-08-3380","article-title":"LEF1 in androgen-independent prostate cancer: Regulation of androgen receptor expression, prostate cancer growth, and invasion","volume":"69","author":"Li","year":"2009","journal-title":"Cancer Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1186\/s13046-023-02774-2","article-title":"LncRNA SNHG4 promotes prostate cancer cell survival and resistance to enzalutamide through a let-7a\/RREB1 positive feedback loop and a ceRNA network","volume":"42","author":"Dong","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e70051","DOI":"10.1002\/gcc.70051","article-title":"Single-Cell Profiling of Mononuclear Cells Identifies Transcriptomics Signatures Differentiating Prostate Cancer From Benign Prostatic Hyperplasia","volume":"64","author":"Enikeeva","year":"2025","journal-title":"Genes. Chromosomes Cancer"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e70044","DOI":"10.1002\/cam4.70044","article-title":"Epigenome-wide association study of prostate cancer in African American men identified differentially methylated genes","volume":"13","author":"Berglund","year":"2024","journal-title":"Cancer Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1006\/geno.2001.6587","article-title":"Transcript map of the 8p23 putative tumor suppressor region","volume":"75","author":"Sun","year":"2001","journal-title":"Genomics"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/onc.2013.7","article-title":"DLC1 induces expression of E-cadherin in prostate cancer cells through Rho pathway and suppresses invasion","volume":"33","author":"Tripathi","year":"2014","journal-title":"Oncogene"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ajur.2021.12.007","article-title":"Deleted in liver cancer 1 suppresses the growth of prostate cancer cells through inhibiting Rho-associated protein kinase pathway","volume":"10","author":"Gong","year":"2023","journal-title":"Asian J. Urol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/pros.20882","article-title":"Genetic and epigenetic inactivation of TNFRSF10C in human prostate cancer","volume":"69","author":"Cheng","year":"2009","journal-title":"Prostate"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Zhang, E., Shiori, F., Zhang, M., Wang, P., He, J., Ge, Y., Song, Y., and Shan, L. (2021). Establishment of Novel Prostate Cancer Risk Subtypes and A Twelve-Gene Prognostic Model. Front. Mol. Biosci., 8.","DOI":"10.3389\/fmolb.2021.676138"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0083-6729(04)67004-X","article-title":"Transcriptional regulation of the TRAIL-R3 gene","volume":"67","author":"Redondo","year":"2004","journal-title":"Vitam. Horm."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.7150\/jca.112954","article-title":"Neuregulin-1 correlates to early castration-resistant prostate cancer after prostate cancer patients receiving androgen deprivation therapy","volume":"16","author":"Li","year":"2025","journal-title":"J. Cancer"},{"key":"ref_52","first-page":"283","article-title":"Transmembrane protein 64 modulates prostate tumor progression by regulating Wnt3a secretion","volume":"18","author":"Moon","year":"2019","journal-title":"Oncol. Lett."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1038\/s41388-019-1085-y","article-title":"DEPTOR is an in vivo tumor suppressor that inhibits prostate tumorigenesis via the inactivation of mTORC1\/2 signals","volume":"39","author":"Chen","year":"2020","journal-title":"Oncogene"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1002\/pros.70037","article-title":"Confirmation of BIK and SAMHD1 as Prostate Cancer Susceptibility Genes","volume":"85","author":"Pavlovich","year":"2025","journal-title":"Prostate"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1038\/s41467-025-56944-1","article-title":"Assessing the contribution of rare protein-coding germline variants to prostate cancer risk and severity in 37,184 cases","volume":"16","author":"Mitchell","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_56","unstructured":"(2025, November 06). Infinium OncoArray-500K BeadChip. Available online: https:\/\/emea.illumina.com\/content\/dam\/illumina-marketing\/documents\/products\/datasheets\/datasheet_oncoarray500k.pdf."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1093\/jnci\/djy099","article-title":"Novel Common Genetic Susceptibility Loci for Colorectal Cancer","volume":"111","author":"Schmit","year":"2019","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: A tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"ref_59","first-page":"921","article-title":"Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population","volume":"12","author":"Excoffier","year":"1995","journal-title":"Mol. Biol. Evol."},{"key":"ref_60","unstructured":"Purcell, S. (2010). PLINK (1.07) Documentation, Harvard University."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/gepi.20297","article-title":"Estimation of significance thresholds for genomewide association scans","volume":"32","author":"Dudbridge","year":"2008","journal-title":"Genet. Epidemiol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/1\/547\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T05:26:44Z","timestamp":1767763604000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/1\/547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,5]]},"references-count":61,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["ijms27010547"],"URL":"https:\/\/doi.org\/10.3390\/ijms27010547","relation":{},"ISSN":["1422-0067"],"issn-type":[{"type":"electronic","value":"1422-0067"}],"subject":[],"published":{"date-parts":[[2026,1,5]]}}}