{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T10:55:39Z","timestamp":1767869739655,"version":"3.49.0"},"reference-count":86,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["23-15-00188"],"award-info":[{"award-number":["23-15-00188"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The growth and development of breast cancer are accompanied by an increase in oxidative stress. A close relationship is known to exist between the biological activity of several antioxidant enzymes and the regulation of estrogen-mediated signaling in breast cancer. The aim of this study was to study the activity of salivary antioxidant enzymes and the level of lipid peroxidation products in breast cancer before and after surgical treatment. The study included 115 patients with breast cancer (58.7 \u00b1 10.9 years) and 60 healthy volunteers (51.8 \u00b1 12.1 years). Saliva samples were obtained again from 53 patients 4 weeks after surgery. The content of lipid peroxidation products, catalase activity, total antioxidant activity (AOA) and total peroxidase activity (TPA) in saliva were analyzed before and after breast cancer surgery. An increase in lipid peroxidation products in saliva was observed with positive estrogen receptor expression. For the first time, it was shown that in patients with breast cancer, the levels of salivary TPA and AOA increased, which is likely due to the important role of the salivary glands in antioxidant protection. It can be speculated that the effectiveness of antioxidant defense was associated with estrogen and progesterone receptor expression and was reduced in prognostically unfavorable breast cancer phenotypes (non-luminal and triple-negative breast cancer).<\/jats:p>","DOI":"10.3390\/ijms27020587","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T15:09:36Z","timestamp":1767712176000},"page":"587","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Salivary Antioxidant and Peroxidase Activity as a Marker of Steroid Hormone Receptor Expression in Breast Cancer"],"prefix":"10.3390","volume":"27","author":[{"given":"Elena A.","family":"Sarf","sequence":"first","affiliation":[{"name":"Biochemistry Research Laboratory, Omsk State Pedagogical University, 644099 Omsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6147-4854","authenticated-orcid":false,"given":"Lyudmila V.","family":"Bel\u2019skaya","sequence":"additional","affiliation":[{"name":"Biochemistry Research Laboratory, Omsk State Pedagogical University, 644099 Omsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.exger.2014.07.006","article-title":"Circulating oxidative stress parameters in pre- and post-menopausal healthy women and in women suffering from breast cancer treated or not with neoadjuvant chemotherapy","volume":"58","author":"Mayas","year":"2014","journal-title":"Exp. 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