{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T10:06:44Z","timestamp":1788170804278,"version":"build-2803163510"},"reference-count":149,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"SECIHTI grants","doi-asserted-by":"publisher","award":["Ciencia de Frontera CF-2023-I-2402"],"award-info":[{"award-number":["Ciencia de Frontera CF-2023-I-2402"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"SECIHTI grants","doi-asserted-by":"publisher","award":["PRONAII-7-Virus y C\u00e1ncer 303044"],"award-info":[{"award-number":["PRONAII-7-Virus y C\u00e1ncer 303044"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Instituto Nacional de Cancerolog\u00eda grants","award":["(024\/019\/IBI) (CEI\/025\/24)"],"award-info":[{"award-number":["(024\/019\/IBI) (CEI\/025\/24)"]}]},{"name":"Instituto Nacional de Cancerolog\u00eda grants","award":["(015\/039\/IBI) (CEI\/998\/15)"],"award-info":[{"award-number":["(015\/039\/IBI) (CEI\/998\/15)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Despite screening programs and vaccination campaigns, cervical cancer (CC) remains a health problem worldwide. The involvement of the E6 and E7 oncoproteins of Human Papillomavirus (HPV) is crucial for the development and progression of this type of cancer. Metabolic reprogramming by cancer cells has gained relevance in the last decade due to its ability to promote cell growth, survival, invasion, metastasis, and resistance to therapy. In this review, we focus on alterations in cholesterol metabolism that significantly influence the development and progression of CC, as well as the clinical outcome of patients. Furthermore, evidence from comprehensive omics studies suggesting that E6 and E7 are involved in the exacerbation of elements related to cholesterol metabolism is analyzed. Preclinical and clinical studies are also discussed that demonstrate that cholesterol metabolism is a potential therapeutic target, highlighting its impact on reducing tumor growth, altering the tumor microenvironment, and improving antitumor immunity.<\/jats:p>","DOI":"10.3390\/ijms27020591","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T15:09:36Z","timestamp":1767712176000},"page":"591","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cholesterol Metabolism: An Ally in the Development and Progression of Cervical Cancer"],"prefix":"10.3390","volume":"27","author":[{"given":"Imelda","family":"Mart\u00ednez-Ram\u00edrez","sequence":"first","affiliation":[{"name":"Subdirecci\u00f3n de Investigaci\u00f3n B\u00e1sica, Unidad de Investigaci\u00f3n Biom\u00e9dica en C\u00e1ncer, Instituto Nacional de Cancerolog\u00eda, Mexico City 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6809-0212","authenticated-orcid":false,"given":"J. Omar","family":"Mu\u00f1oz-Bello","sequence":"additional","affiliation":[{"name":"Subdirecci\u00f3n de Investigaci\u00f3n B\u00e1sica, Unidad de Investigaci\u00f3n Biom\u00e9dica en C\u00e1ncer, Instituto Nacional de Cancerolog\u00eda, Mexico City 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Contreras-Paredes","sequence":"additional","affiliation":[{"name":"Subdirecci\u00f3n de Investigaci\u00f3n B\u00e1sica, Unidad de Investigaci\u00f3n Biom\u00e9dica en C\u00e1ncer, Instituto Nacional de Cancerolog\u00eda, Mexico City 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u00edas","family":"Parra-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Gerencia de An\u00e1lisis y Desarrollo de Pruebas Biol\u00f3gicas, Comisi\u00f3n de Control Anal\u00edtico y Ampliaci\u00f3n de Cobertura (CCAYAC)-Comisi\u00f3n Federal para la Protecci\u00f3n Contra Riesgos Sanitarios (COFEPRIS), Mexico City 14050, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adela","family":"Carrillo-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Subdirecci\u00f3n de Investigaci\u00f3n B\u00e1sica, Unidad de Investigaci\u00f3n Biom\u00e9dica en C\u00e1ncer, Instituto Nacional de Cancerolog\u00eda, Mexico City 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7553-2541","authenticated-orcid":false,"given":"Marcela","family":"Lizano","sequence":"additional","affiliation":[{"name":"Subdirecci\u00f3n de Investigaci\u00f3n B\u00e1sica, Unidad de Investigaci\u00f3n Biom\u00e9dica en C\u00e1ncer, Instituto Nacional de Cancerolog\u00eda, Mexico City 14080, Mexico"},{"name":"Departamento de Medicina Gen\u00f3mica y Toxicolog\u00eda Ambiental, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad Universitaria, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1111\/cas.14682","article-title":"Human Papillomavirus Vaccine to Prevent Cervical Intraepithelial Neoplasia in Japan: A Nationwide Case-Control Study","volume":"112","author":"Ikeda","year":"2021","journal-title":"Cancer Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"30","DOI":"10.2807\/1560-7917.ES.2018.23.41.1700737","article-title":"The Impact of 10 Years of Human Papillomavirus (HPV) Vaccination in Australia: What Additional Disease Burden Will a Nonavalent Vaccine Prevent?","volume":"23","author":"Patel","year":"2018","journal-title":"Eurosurveillance"},{"key":"ref_3","unstructured":"(2025, November 18). 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