{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T14:58:45Z","timestamp":1784127525147,"version":"3.55.0"},"reference-count":47,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Health & Welfare","award":["RS-2023-00267453"],"award-info":[{"award-number":["RS-2023-00267453"]}]},{"name":"Ministry of Health & Welfare","award":["RS-2021-KH113822"],"award-info":[{"award-number":["RS-2021-KH113822"]}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT","doi-asserted-by":"crossref","award":["RS-2023-00223559"],"award-info":[{"award-number":["RS-2023-00223559"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT","doi-asserted-by":"crossref","award":["RS-2021-NR062031"],"award-info":[{"award-number":["RS-2021-NR062031"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Obesity treatments increasingly target multiple pathways beyond appetite suppression. We evaluated KBN2202, a salicylate-derived small molecule, in a high-fat diet (60% kcal from fat) mouse model using female and male C57BL\/6J mice treated for 8 weeks with oral KBN2202 (20 mg\/kg\/day) or a matched-volume vehicle (1% DMSO\/PBS). Body weight was recorded weekly, and food intake was measured daily; serum hormones and cytokines, adipose tissue histology, and open-field behavior were assessed at the end of the study. Under our experimental conditions, HFD increased body weight and gonadal white adipose tissue (gWAT)\/brown adipose tissue (BAT) mass in females, whereas males showed only modest HFD-associated weight gain and did not develop a clear obesity phenotype. KBN2202 significantly reduced peri-ovarian gWAT mass and adipocyte size without altering overall body weight. In females, circulating glucagon-like peptide-1 (GLP-1) increased, uncoupling protein 1 (UCP1) in gWAT showed a non-significant upward trend, and serum TNF-\u03b1 was selectively decreased, while MCP-1 and IL-1\u03b2 were unchanged. Locomotor activity was unaltered, and anxiety-like behavior was reduced. Male mice did not show comparable adipose effects. These findings indicate depot-specific, peripheral modulation of adipose remodeling, hormonal balance, and inflammatory tone by KBN2202, supporting its further investigation as an adipose-targeted metabolic modulator complementary to incretin-based therapies.<\/jats:p>","DOI":"10.3390\/ijms27020627","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T09:01:29Z","timestamp":1767862889000},"page":"627","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["KBN2202 Suppresses Gonadal White Adipose Tissue Expansion in Female Mice Fed a High-Fat Diet"],"prefix":"10.3390","volume":"27","author":[{"given":"Moonhang","family":"Kim","sequence":"first","affiliation":[{"name":"Efficacy Test Center for Mental & Behavioral Disorders, Ajou University Hospital, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2483-4376","authenticated-orcid":false,"given":"Jeong-Hyeon","family":"Heo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Ajou University School of Medicine, Suwon 16499, Republic of Korea"},{"name":"BK21 R&E Initiative for Advanced Precision Medicine, Suwon 16499, Republic of Korea"},{"name":"Department of Biomedical Sciences, Graduate School of Ajou University, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok Hwan","family":"Chang","sequence":"additional","affiliation":[{"name":"Efficacy Test Center for Mental & Behavioral Disorders, Ajou University Hospital, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun-Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Efficacy Test Center for Mental & Behavioral Disorders, Ajou University Hospital, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Ajou University School of Medicine, Suwon 16499, Republic of Korea"},{"name":"BK21 R&E Initiative for Advanced Precision Medicine, Suwon 16499, Republic of Korea"},{"name":"Department of Biomedical Sciences, Graduate School of Ajou University, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon-Geun","family":"Shin","sequence":"additional","affiliation":[{"name":"Efficacy Test Center for Mental & Behavioral Disorders, Ajou University Hospital, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Sung","family":"Kim","sequence":"additional","affiliation":[{"name":"Efficacy Test Center for Mental & Behavioral Disorders, Ajou University Hospital, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Ran","family":"Choi","sequence":"additional","affiliation":[{"name":"Efficacy Test Center for Mental & Behavioral Disorders, Ajou University Hospital, Suwon 16499, Republic of Korea"},{"name":"Laboratory Animal Research Center, Ajou University School of Medicine, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Rae","family":"Lee","sequence":"additional","affiliation":[{"name":"Efficacy Test Center for Mental & Behavioral Disorders, Ajou University Hospital, Suwon 16499, Republic of Korea"},{"name":"Department of Pharmacology, Ajou University School of Medicine, Suwon 16499, Republic of Korea"},{"name":"BK21 R&E Initiative for Advanced Precision Medicine, Suwon 16499, Republic of Korea"},{"name":"Department of Biomedical Sciences, Graduate School of Ajou University, Suwon 16499, Republic of Korea"},{"name":"Laboratory Animal Research Center, Ajou University School of Medicine, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Lin, X., and Li, H. 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