{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:19:22Z","timestamp":1792012762629,"version":"4.4.0"},"reference-count":67,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Ocular allergy (OA) is a subtype of seasonal allergy that causes symptoms of itchiness, redness, swelling and irritation of the ocular surface and eyelids, often triggering allergy-induced eye rubbing and sustained inflammation for up to six months of the year during peak allergy season. These symptoms, coupled with reduced sleep quality, impaired daily productivity and decreased mood, highlight a significant yet underrepresented disease burden. Recent advances in tear-based multi-omics have enabled detailed characterisation of OA-associated biochemical changes on the ocular surface, highlighting human tears as a promising biospecimen for diagnostic biomarker and therapeutic target research. This review discusses emerging proteomic, lipidomic, metabolomic and miRNA findings comparing OA sufferers with healthy controls, and, where relevant, with comorbid conditions such as dry eye disease and keratoconus. Differential expression patterns across these analytes implicate key pathways involved in immune response, wound healing, angiogenesis, inflammation, oxidative stress and return to homeostasis on the ocular surface. By integrating these data into a stepwise model of OA biopathway activation, this review outlines candidate biomarkers and highlights methodological advances that may support translation of tear multi-omics into clinical tools for OA management.<\/jats:p>","DOI":"10.3390\/ijms27020671","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T10:35:52Z","timestamp":1767954952000},"page":"671","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["From Proteome to miRNome: A Review of Multi-Omics Ocular Allergy Research Using Human Tears"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7537-3624","authenticated-orcid":false,"given":"Esrin","family":"Aydin","sequence":"first","affiliation":[{"name":"Neuro Allergy Research Laboratory (NARL), School of Life and Environmental Sciences, Deakin University, Geelong, VIC 3216, Australia"},{"name":"School of Medicine (Optometry), Deakin University, Geelong, VIC 3216, Australia"},{"name":"Institute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, VIC 3216, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3420-4098","authenticated-orcid":false,"given":"Serap","family":"Azizoglu","sequence":"additional","affiliation":[{"name":"Neuro Allergy Research Laboratory (NARL), School of Life and Environmental Sciences, Deakin University, Geelong, VIC 3216, Australia"},{"name":"School of Medicine (Optometry), Deakin University, Geelong, VIC 3216, Australia"},{"name":"Institute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, VIC 3216, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5694-4500","authenticated-orcid":false,"given":"Luke","family":"Chong","sequence":"additional","affiliation":[{"name":"Neuro Allergy Research Laboratory (NARL), School of Life and Environmental Sciences, Deakin University, Geelong, VIC 3216, Australia"},{"name":"School of Medicine (Optometry), Deakin University, Geelong, VIC 3216, Australia"},{"name":"Institute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, VIC 3216, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5702-6736","authenticated-orcid":false,"given":"Moneisha","family":"Gokhale","sequence":"additional","affiliation":[{"name":"Neuro Allergy Research Laboratory (NARL), School of Life and Environmental Sciences, Deakin University, Geelong, VIC 3216, Australia"},{"name":"School of Medicine (Optometry), Deakin University, Geelong, VIC 3216, Australia"},{"name":"Institute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, VIC 3216, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0101-0668","authenticated-orcid":false,"given":"Cenk","family":"Suphioglu","sequence":"additional","affiliation":[{"name":"Neuro Allergy Research Laboratory (NARL), School of Life and Environmental Sciences, Deakin University, Geelong, VIC 3216, Australia"},{"name":"Institute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, VIC 3216, Australia"},{"name":"Centre for Sustainable Bioproducts (CSB), Deakin University, Geelong, VIC 3216, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1185\/03007990903021968","article-title":"Relative strength of relationships of nasal congestion and ocular symptoms with sleep, mood and productivity","volume":"25","author":"Stull","year":"2009","journal-title":"Curr. 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