{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T09:43:09Z","timestamp":1768383789977,"version":"3.49.0"},"reference-count":68,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Alice Charitable Foundation","award":["19-\u041823"],"award-info":[{"award-number":["19-\u041823"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Fetal growth restriction (FGR) remains a significant problem in obstetrics and is a key risk factor for perinatal brain injury. The fetal neuronal vesicles (FNVs) isolated from maternal blood represent an innovative approach\u2014a \u201cfetal brain liquid biopsy\u201d\u2014enabling early diagnostics of neuronal dysfunction in FGR. Western blotting was used to evaluate the protein pattern expression of FNVs isolated from the blood of pregnant women with FGR and uncomplicated pregnancy. Significant changes in the neurotrophic proteins levels (pro-BDNF, pro-NGF) and presynaptic neurotransmission proteins (SYN1, SYP, SYNPO) were identified. New data were obtained on changes in the expression of proteins of sumoylation (SUMO2\/3\/4) and neddylation (NAE1, UBC12), which differs in early-onset and late-onset FGR. Moreover, increased SUMO2\/3\/4 levels can be considered as an endogenous neuroprotective response to cerebral hemodynamic reaction in fetuses with late-onset growth restriction. An association has been established between changes in the expression of the studied proteins and intraventricular hemorrhage (IVH) in newborns with late-onset growth restriction.<\/jats:p>","DOI":"10.3390\/ijms27020679","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T11:45:33Z","timestamp":1767959133000},"page":"679","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fetal Neuronal Vesicles in the Assessment of Perinatal Brain Dysfunction and Late-Onset Growth Restriction: A Pilot Study"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3990-6224","authenticated-orcid":false,"given":"Vladislava","family":"Gusar","sequence":"first","affiliation":[{"name":"Laboratory of Applied Transcriptomics, Federal State Budget Institution \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d of the Ministry of Health of the Russian Federation, 4, Oparina Street, Moscow 117997, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5087-5946","authenticated-orcid":false,"given":"Natalia","family":"Kan","sequence":"additional","affiliation":[{"name":"Federal State Budget Institution \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d of the Ministry of Health of the Russian Federation, 4, Oparina Street, Moscow 117997, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6707-3464","authenticated-orcid":false,"given":"Anastasia","family":"Leonova","sequence":"additional","affiliation":[{"name":"Department of Molecular Diagnostic Methods and Personalized Medicine, Federal State Budget Institution \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d of the Ministry of Health of the Russian Federation, 4, Oparina Street, Moscow 117997, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5120-376X","authenticated-orcid":false,"given":"Vitaliy","family":"Chagovets","sequence":"additional","affiliation":[{"name":"Laboratory of Metabolomics and Bioinformatics, Federal State Budget Institution \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d of the Ministry of Health of the Russian Federation, 4, Oparina Street, Moscow 117997, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5830-5099","authenticated-orcid":false,"given":"Victor","family":"Tyutyunnik","sequence":"additional","affiliation":[{"name":"Center for Scientific and Clinical Research, Federal State Budget Institution \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d of the Ministry of Health of the Russian Federation, 4, Oparina Street, Moscow 117997, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7014-2627","authenticated-orcid":false,"given":"Anna","family":"Zolotareva","sequence":"additional","affiliation":[{"name":"Federal State Budget Institution \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d of the Ministry of Health of the Russian Federation, 4, Oparina Street, Moscow 117997, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4907-8325","authenticated-orcid":false,"given":"Nataliya","family":"Tyutyunnik","sequence":"additional","affiliation":[{"name":"Department of Molecular Diagnostic Methods and Personalized Medicine, Federal State Budget Institution \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d of the Ministry of Health of the Russian Federation, 4, Oparina Street, Moscow 117997, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4337-7644","authenticated-orcid":false,"given":"Ekaterina","family":"Yarotskaya","sequence":"additional","affiliation":[{"name":"Federal State Budget Institution \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d of the Ministry of Health of the Russian Federation, 4, Oparina Street, Moscow 117997, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7712-1260","authenticated-orcid":false,"given":"Gennadiy","family":"Sukhikh","sequence":"additional","affiliation":[{"name":"Federal State Budget Institution \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d of the Ministry of Health of the Russian Federation, 4, Oparina Street, Moscow 117997, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"key":"ref_1","first-page":"31","article-title":"A Model for Diagnosing Fetal Growth Restriction Using Functional Diagnostic Methods","volume":"2","author":"Volochaeva","year":"2025","journal-title":"Obstet. Gynecol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"102154","DOI":"10.1016\/j.jogc.2023.05.022","article-title":"Guideline No. 442: Fetal Growth Restriction: Screening, Diagnosis, and Management in Singleton Pregnancies","volume":"45","author":"Kingdom","year":"2023","journal-title":"J. Obstet. Gynaecol. 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