{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:16:26Z","timestamp":1776384986284,"version":"3.51.2"},"reference-count":82,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Latvian Council of Sciences, Project &quot;Innovative anti-inflammatory and antipathogenic systems based on proanthocyanidins isolated from fruit shrubs agricultural lignocellulosic waste","award":["lzp-2022\/1-0599"],"award-info":[{"award-number":["lzp-2022\/1-0599"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Fruit shrubs\u2019 lignocellulosic biomass remaining as waste after harvesting and\/or after pruning is an underutilized, little-explored bioresource. Sea buckthorn (Hippophae rhamnoides L.), aronia (Aronia melanocarpa) and blackcurrant (Ribes nigrum) berries are rich in biologically active compounds, so these shrubs\u2019 woody biomass derivatives are prospective investigation objects. The influence of pre-treated biomass, extracts, and purified proanthocyanidins on the oxidative stability of lipid-based systems was studied by accelerated oxidation method. Emulsion stability, antimicrobial activity against bacteria that causes acne\u2014Cutibacterium acnes; contaminating wounds; skin care products\u2014Streptococcus pyogenes, Pseudomonas aeruginosa, Staphylococcus aureus, and Bacillus cereus; cytotoxicity and phototoxicity of extracts and proanthocyanidins on HaCaT human keratinocytes were tested. The study established that biomass, lipophilic extracts obtained using liquefied hydrofluorocarbon, and hydrophilic extracts obtained by aqueous ethanol increased oxidative stability of lipid-based formulations. Compounds with skin-protecting properties were detected. Sea buckthorn and aronia hydrophilic extracts and proanthocyanidins had the highest antimicrobial activity. Low phototoxicity was revealed, emphasizing safety and applicability in topical formulations; human HaCaT keratinocyte viability was the best with aronia extracts, but none of the other samples decreased cell viability by more than 50%. It was proven that agro-waste biomass is a prospective source of multifunctional ingredients for cosmetic and pharmaceutical topical formulations.<\/jats:p>","DOI":"10.3390\/ijms27020701","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T16:03:16Z","timestamp":1767974596000},"page":"701","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sea Buckthorn, Aronia, and Black Currant Pruning Waste Biomass as a Source of Multifunctional Skin-Protecting Cosmetic and Pharmaceutical Cream Ingredients"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7177-7752","authenticated-orcid":false,"given":"Anna","family":"Andersone","sequence":"first","affiliation":[{"name":"Lignin Chemistry Laboratory, Latvian State Institute of Wood Chemistry, Dzerbenes Street 27, LV-1006 Riga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0097-0931","authenticated-orcid":false,"given":"Anna","family":"Ramata-Stunda","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Life Sciences, University of Latvia, Jelgavas Street 1, LV-1004 Riga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalija","family":"Zaharova","sequence":"additional","affiliation":[{"name":"Lignin Chemistry Laboratory, Latvian State Institute of Wood Chemistry, Dzerbenes Street 27, LV-1006 Riga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0169-3027","authenticated-orcid":false,"given":"Liga","family":"Petersone","sequence":"additional","affiliation":[{"name":"Laboratory of Finished Dosage Forms, Riga Stradin\u0161 University, Dzirciema 16, LV-1007 Riga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gints","family":"Rieksts","sequence":"additional","affiliation":[{"name":"Lignin Chemistry Laboratory, Latvian State Institute of Wood Chemistry, Dzerbenes Street 27, LV-1006 Riga, Latvia"},{"name":"The Institute of Physics, Faculty of Science and Technology, University of Latvia, Miera Street 32, LV-2169 Salaspils, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5559-3737","authenticated-orcid":false,"given":"Uldis","family":"Spulle","sequence":"additional","affiliation":[{"name":"Lignin Chemistry Laboratory, Latvian State Institute of Wood Chemistry, Dzerbenes Street 27, LV-1006 Riga, Latvia"},{"name":"Institute of Civil Engineering and Woodworking, Latvia University of Life Sciences and Technologies, Dobeles Street 41, LV-3001 Jelgava, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9831-1525","authenticated-orcid":false,"given":"Galina","family":"Telysheva","sequence":"additional","affiliation":[{"name":"Lignin Chemistry Laboratory, Latvian State Institute of Wood Chemistry, Dzerbenes Street 27, LV-1006 Riga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3567-4377","authenticated-orcid":false,"given":"Sarmite","family":"Janceva","sequence":"additional","affiliation":[{"name":"Lignin Chemistry Laboratory, Latvian State Institute of Wood Chemistry, Dzerbenes Street 27, LV-1006 Riga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Alia\u00f1o-Gonz\u00e1lez, M.J., Gabaston, J., Ortiz-Somovilla, V., and Cantos-Villar, E. 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