{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:24:14Z","timestamp":1792517054251,"version":"4.5.0"},"reference-count":57,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Gastric cancer (GC) is the fifth most common type of cancer and a leading cause of cancer-related deaths worldwide. Surgery remains the most effective treatment, but new therapeutic strategies are urgently needed. The use of natural polyphenolic compounds such as curcumin (CUR) and resveratrol (RSV) has played a significant role in this effort. This review provides a comprehensive overview of the current applications and molecular mechanisms of curcumin and resveratrol in gastric cancer, highlighting their therapeutic potential and translational relevance. Analytically, CUR induces apoptosis, endoplasmic stress and cell cycle arrest. On the other hand, resveratrol enhances apoptosis and reduces inflammation. Both compounds increase cancer cell sensitivity to chemotherapy and help prevent chemoresistance, highlighting their potential as molecular enhancers in anticancer therapy. Combined with standard therapeutic drugs, they represent an innovative strategy for GC treatment. By presenting these innovative approaches, this review offers a global perspective on how their administration could shape future treatment strategies.<\/jats:p>","DOI":"10.3390\/ijms27020753","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T10:25:23Z","timestamp":1768213523000},"page":"753","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Natural Compounds in Gastric Cancer Therapy: Molecular Mechanisms and Potential Treatment Options"],"prefix":"10.3390","volume":"27","author":[{"given":"Alexandra","family":"Dimaki","sequence":"first","affiliation":[{"name":"Department of General Surgery, University Hospital of Larissa, 41110 Larissa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Lazaridou","sequence":"additional","affiliation":[{"name":"Department of General Surgery, University Hospital of Larissa, 41110 Larissa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalliopi","family":"Vakalou","sequence":"additional","affiliation":[{"name":"Department of General Surgery, University Hospital of Larissa, 41110 Larissa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasilios","family":"Zervas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, General Hospital of Athens \u201cEvaggelismos\u201d, Ypsilantou 45-47, 10076 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitra","family":"Bartzi","sequence":"additional","affiliation":[{"name":"Department of Oncology, The 251 Airforce General Hospital, 11525 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyriaki","family":"Tsagkidou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University Hospital of Larisa, 41100 Larisa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis Dimitrios","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"Department of General Surgey, Spitalverbund Appenzel Ausserrhoden, Spital Herisau, Spitalstrasse 6, 9100 Herisau, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos Eleftherios","family":"Koumarelas","sequence":"additional","affiliation":[{"name":"Department of General Surgey, Spitalverbund Appenzel Ausserrhoden, Spital Herisau, Spitalstrasse 6, 9100 Herisau, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grigorios","family":"Christodoulidis","sequence":"additional","affiliation":[{"name":"Department of General Surgery, University Hospital of Larissa, 41110 Larissa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.sjbs.2018.02.016","article-title":"Gastric cancer & prospects of cancer in Saudi Arabia peninsula","volume":"26","author":"Abuderman","year":"2019","journal-title":"Saudi J. 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