{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:54:21Z","timestamp":1790351661867,"version":"4.1.0"},"reference-count":169,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Acute lung injury (ALI) is in part precipitated by hyperbaric oxygen or other mechanical insults. It constitutes the fundamental pathological process underlying acute respiratory distress syndrome (ARDS). The manifestation of the condition is characterized by an uncontrolled inflammatory response and alveolar edema, consequent to the disruption of the alveolar\u2013capillary barrier. This phenomenon is associated with elevated morbidity and mortality rates. The current therapeutic interventions for ALI are not well researched or articulated. However, recent studies have indicated that stem cells may possess therapeutic potential in the context of ALI. The present study demonstrates that these exosome preparations have the capacity to significantly ameliorate radiographic findings, histological parameters, and vascular permeability in murine models of ALI. Concurrently, they attenuate the inflammatory response to a certain extent. The present review commences with an examination of the pathogenic mechanisms and manifestations of pulmonary injury induced by hyperbaric oxygen or other external factors. The subsequent sections of the text provide detailed accounts of the latest advances in exosome-based therapies for mitigating such injury, including their mechanisms of action and future translational prospects. While exosome-based treatments have demonstrated considerable advancement in preclinical research, numerous challenges must be surmounted before their widespread implementation in clinical settings can be realized, underscoring the necessity for sustained research in this domain.<\/jats:p>","DOI":"10.3390\/ijms27020836","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T15:12:04Z","timestamp":1768403524000},"page":"836","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Acute Lung Injury Induced by Hyperbaric Oxygen or Other External Factors, with a Focus on Exosomes"],"prefix":"10.3390","volume":"27","author":[{"given":"Jing","family":"Shi","sequence":"first","affiliation":[{"name":"Naval Medical Center, Naval Medical University, Shanghai 200433, China"},{"name":"National Key Laboratory of Immunity and Inflammation, Shanghai 200433, China"},{"name":"Translational Medical Research Center, Naval Medical University, Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Naval Medical Center, Naval Medical University, Shanghai 200433, China"},{"name":"National Key Laboratory of Immunity and Inflammation, Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyang","family":"Yan","sequence":"additional","affiliation":[{"name":"Translational Medical Research Center, Naval Medical University, Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Technology, Tongji University, Shanghai 200092, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1855-5568","authenticated-orcid":false,"given":"Qi","family":"Zhu","sequence":"additional","affiliation":[{"name":"Naval Medical Center, Naval Medical University, Shanghai 200433, China"},{"name":"National Key Laboratory of Immunity and Inflammation, Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Ding","sequence":"additional","affiliation":[{"name":"Naval Medical Center, Naval Medical University, Shanghai 200433, China"},{"name":"National Key Laboratory of Immunity and Inflammation, Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longfei","family":"Wang","sequence":"additional","affiliation":[{"name":"Naval Medical Center, Naval Medical University, Shanghai 200433, China"},{"name":"National Key Laboratory of Immunity and Inflammation, Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunpeng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Translational Medical Research Center, Naval Medical University, Shanghai 200433, China"},{"name":"Shanghai Institute of Stem Cell Research and Clinical Translation, Shanghai 200092, China"},{"name":"Shanghai Key Laboratory of Cell Engineering, Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[{"name":"Translational Medical Research Center, Naval Medical University, Shanghai 200433, China"},{"name":"Shanghai Institute of Stem Cell Research and Clinical Translation, Shanghai 200092, China"},{"name":"Shanghai Key Laboratory of Cell Engineering, Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqun","family":"Fang","sequence":"additional","affiliation":[{"name":"Naval Medical Center, Naval Medical University, Shanghai 200433, China"},{"name":"National Key Laboratory of Immunity and Inflammation, Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Wang, S., Chen, H., Li, Z., Xu, G., and Bao, X. 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