{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T07:51:00Z","timestamp":1768722660670,"version":"3.49.0"},"reference-count":33,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004352","name":"Suranaree University of Technology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004352","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100017170","name":"Thailand Science Research and Innovation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100017170","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Science, Research and Innovation Fund","award":["195614"],"award-info":[{"award-number":["195614"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Gestational diabetes mellitus (GDM) causes adverse effects on both mothers and offspring. This study investigated the effects of a polyherbal formulation combining Pandanus amaryllifolius root and Tectona grandis leaf extracts on maternal and fetal outcomes in streptozotocin (STZ)-induced GDM rats, compared with metformin. Pregnant rats were assigned to a non-diabetic reference group and diabetic groups, including an untreated diabetic group (negative control), a metformin-treated group (positive control), and diabetic groups treated with low, medium, or high doses of the pandan\u2013teak formulation from gestation day 7 to 21. Medium and high doses significantly increased maternal body weight and pancreatic mass index (p &lt; 0.05) without altering maternal glycemia or insulin levels. Fetal weight increased at medium and high doses, whereas crown\u2013rump length increased only at the high dose. Placental index and fetal glucose levels decreased in a dose-dependent manner (p &lt; 0.05), with no significant change in implantation loss. These findings suggest that the pandan\u2013teak formulation may exert complementary actions that support placental\u2013fetal glucose regulation and fetal growth while maintaining maternal glycemic stability, indicating its potential as a plant-based adjunct approach for gestational diabetes focused on fetal protection.<\/jats:p>","DOI":"10.3390\/ijms27020857","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T08:26:36Z","timestamp":1768465596000},"page":"857","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pandanus amaryllifolius and Tectona grandis Extracts Improve Fetal Outcomes in Streptozotocin-Induced Gestational Diabetes in Rats"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7742-8169","authenticated-orcid":false,"given":"Sasitorn","family":"Kerdsuknirund","sequence":"first","affiliation":[{"name":"School of Preclinical Sciences, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pakanit","family":"Kupittayanant","sequence":"additional","affiliation":[{"name":"School of Animal Technology and Innovation, Institute of Agricultural Technology, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pattama","family":"Tongdee","sequence":"additional","affiliation":[{"name":"School of Obstetrics and Gynecology, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand"},{"name":"Suranaree University of Technology Hospital, Nakhon Ratchasima 30000, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Porntip","family":"Nimkuntod","sequence":"additional","affiliation":[{"name":"Suranaree University of Technology Hospital, Nakhon Ratchasima 30000, Thailand"},{"name":"School of Internal Medicine, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sajeera","family":"Kupittayanant","sequence":"additional","affiliation":[{"name":"School of Preclinical Sciences, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s13300-019-0589-3","article-title":"The Association Between Trimester-Specific Weight Gain and Severe Preeclampsia\/Adverse Perinatal Outcome in Gestational Diabetes Mellitus Complicated by Preeclampsia: A Retrospective Case Study","volume":"10","author":"Zhang","year":"2019","journal-title":"Diabetes Ther."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Lende, M., and Rijhsinghani, A. 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