{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:21:36Z","timestamp":1788963696132,"version":"build-2803163510"},"reference-count":38,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2022R1A2C2006607"],"award-info":[{"award-number":["2022R1A2C2006607"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"GRRC program of Gyeonggi Province","award":["GRRCA-jou2023-B02"],"award-info":[{"award-number":["GRRCA-jou2023-B02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Nonsteroidal anti-inflammatory drugs (NSAIDs) can exacerbate urticaria and\/or angioedema in up to 30% of patients with chronic urticaria (CU), representing a distinct subtype characterized by heightened inflammation and leukotriene-driven pathophysiology. MicroRNAs (miRNAs) are post-transcriptional regulators that modulate immune and inflammatory responses. This study aimed to identify differentially expressed miRNAs (DEMs) according to NSAID hypersensitivity status and to elucidate their molecular networks in CU. Serum miRNA profiles were analyzed in 14 NSAID-exacerbated CU (NECU) and 16 NSAID-tolerant CU (NTCU) patients using an Affymetrix GeneChip\u00ae miRNA 4.0 Array. DEMs were identified (fold difference &gt; 1.5, p &lt; 0.05), and validated targets were retrieved from the multiMiR database for network construction and Gene Ontology enrichment analyses. NECU patients exhibited a higher frequency of angioedema and systemic corticosteroid use than NTCU patients. Eight DEMs were identified, including upregulated miR-5001-5p, miR-4270, and miR-6869-5p, and downregulated miR-6511b-5p, miR-2277-5p, and miR-378h in NECU. Network integration revealed AGO2-BTG2-LMNB2, NFIC-ZZZ3, and NUFIP2-GLG1 as central clusters, implicating dysregulation of mRNA decay and inflammatory signaling pathways. Reduced miR-6511b-5p expression may derepress BRG1, enhancing chromatin accessibility for inflammatory and leukotriene-synthetic genes. Distinct miRNA signatures differentiate NECU from NTCU, implying a miR-5001-5p\/miR-6511b-5p\u2013mRNA decay axis that links impaired post-transcriptional regulation with leukotriene-driven inflammation in CU. These findings highlight candidate miRNAs as potential biomarkers for disease endotyping and therapeutic stratification.<\/jats:p>","DOI":"10.3390\/ijms27020904","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T09:28:12Z","timestamp":1768555692000},"page":"904","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Distinct Serum MicroRNA Signatures and mRNA Decay Pathway Dysregulation in NSAID-Exacerbated Chronic Urticaria"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7517-1715","authenticated-orcid":false,"given":"Young-Min","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7335-5025","authenticated-orcid":false,"given":"Jin Young","family":"Noh","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Graduate School of Ajou University, Suwon 16499, Republic of Korea"},{"name":"Department of Physiology, Ajou University School of Medicine, Suwon 16499, Republic of Korea"},{"name":"Ajou Translational Omics Center (ATOC), Research Institute for Innovative Medicine, Ajou University Medical Center, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1334-0154","authenticated-orcid":false,"given":"Seung Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Physiology, Ajou University School of Medicine, Suwon 16499, Republic of Korea"},{"name":"Ajou Translational Omics Center (ATOC), Research Institute for Innovative Medicine, Ajou University Medical Center, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8537-2601","authenticated-orcid":false,"given":"Jiwon","family":"Yoon","sequence":"additional","affiliation":[{"name":"Clinical Trial Center, Ajou University Medical Center, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8224-8137","authenticated-orcid":false,"given":"Da-Hye","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon 16499, Republic of Korea"},{"name":"Department of Biomedical Sciences, Graduate School of Ajou University, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6827-8752","authenticated-orcid":false,"given":"Boyoun","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se-Min","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0653-5742","authenticated-orcid":false,"given":"Kun-Woo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon 16499, Republic of Korea"},{"name":"Department of Biomedical Sciences, Graduate School of Ajou University, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jungmo","family":"Kim","sequence":"additional","affiliation":[{"name":"Ajou Translational Omics Center (ATOC), Research Institute for Innovative Medicine, Ajou University Medical Center, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Goo","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Graduate School of Ajou University, Suwon 16499, Republic of Korea"},{"name":"Department of Physiology, Ajou University School of Medicine, Suwon 16499, Republic of Korea"},{"name":"Ajou Translational Omics Center (ATOC), Research Institute for Innovative Medicine, Ajou University Medical Center, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1111\/all.12260","article-title":"Classification and practical approach to the diagnosis and management of hypersensitivity to nonsteroidal anti-inflammatory 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