{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T18:06:16Z","timestamp":1768759576643,"version":"3.49.0"},"reference-count":44,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011011","name":"FEDER\/Junta de Andaluc\u00eda-Consejer\u00eda de Econom\u00eda y Conocimiento","doi-asserted-by":"publisher","award":["B-AGR-652-UGR20"],"award-info":[{"award-number":["B-AGR-652-UGR20"]}],"id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011011","name":"FEDER\/Junta de Andaluc\u00eda-Consejer\u00eda de Econom\u00eda y Conocimiento","doi-asserted-by":"publisher","award":["P20_00336"],"award-info":[{"award-number":["P20_00336"]}],"id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011011","name":"FEDER\/Junta de Andaluc\u00eda-Consejer\u00eda de Econom\u00eda y Conocimiento","doi-asserted-by":"publisher","award":["C-CTS-303-UGR23"],"award-info":[{"award-number":["C-CTS-303-UGR23"]}],"id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Junta de Andalucia","award":["POSTDOC_21_028"],"award-info":[{"award-number":["POSTDOC_21_028"]}]},{"DOI":"10.13039\/501100007480","name":"Universidad de Castilla-La Mancha","doi-asserted-by":"crossref","award":["01105JD21.541A"],"award-info":[{"award-number":["01105JD21.541A"]}],"id":[{"id":"10.13039\/501100007480","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Edible flowers have garnered increasing attention due to their high content of bioactive compounds, making them promising candidates for biomedical and functional food applications. This work evaluated the metabolomic data of fresh Rosa x hybrida petals, revealing seven types of metabolites, including amino acids, organic acids, vitamins, sugars, phenolic acids, and flavonoids. Notably, quercetin, kaempferol and their derivatives were the main flavonoids determined. Furthermore, in vitro studies were conducted to evaluate the potential antiproliferative effects against triple-negative breast cancer (TNBC). Thus, the methanolic extract derived from Rosa x hybrida petals demonstrated significant antitumoral activity against both sensitive and resistant TNBC cells, as evidenced by reduced MTT metabolization, colony formation, and wound healing activity. Furthermore, the cell death mechanism associated with the petal extract was studied. The antiproliferative activity was mediated by reactive oxygen species generation, triggering cell death mechanisms such as apoptosis and autophagy. In conclusion, these results propose Rosa x hybrida could be a new tool for nutraceuticals and functional food production.<\/jats:p>","DOI":"10.3390\/ijms27020907","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T11:39:37Z","timestamp":1768563577000},"page":"907","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rosa x hybrida: A New Tool for Functional Food Development with Triple-Negative Breast Antitumoral Implications"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0413-8432","authenticated-orcid":false,"given":"Lorenzo","family":"Rivas-Garcia","sequence":"first","affiliation":[{"name":"Department of Physiology, Institute of Nutrition and Food Technology \u201cJos\u00e9 Mataix Verd\u00fa\u201d, Biomedical Research Centre, University of Granada, 18016 Armilla, Spain"},{"name":"Instituto de Biomedicina (IB_UCLM), Universidad de 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Cristina","family":"Abreu","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Physics, Research Centre CIAIMBITAL, University of Almer\u00eda, 04120 Almer\u00eda, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8355-580X","authenticated-orcid":false,"given":"Ignacio","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Physics, Research Centre CIAIMBITAL, University of Almer\u00eda, 04120 Almer\u00eda, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7982-1359","authenticated-orcid":false,"given":"Pilar","family":"Aranda","sequence":"additional","affiliation":[{"name":"Department of Physiology, Institute of Nutrition and Food Technology \u201cJos\u00e9 Mataix Verd\u00fa\u201d, Biomedical Research Centre, University of Granada, 18016 Armilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6803-2584","authenticated-orcid":false,"given":"Juan","family":"Llopis","sequence":"additional","affiliation":[{"name":"Department of Physiology, Institute of Nutrition and Food Technology \u201cJos\u00e9 Mataix Verd\u00fa\u201d, Biomedical Research Centre, University of Granada, 18016 Armilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9689-6945","authenticated-orcid":false,"given":"Elena","family":"Nebot-Valenzuela","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5758-7592","authenticated-orcid":false,"given":"Eva M.","family":"Galan-Moya","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina (IB_UCLM), Universidad 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