{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T09:03:36Z","timestamp":1792746216805,"version":"4.5.0"},"reference-count":221,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The functional deterioration of granulosa cells (GCs), essential for follicular growth, steroidogenesis, and oocyte competence, indicates ovarian aging and reduced fertility. An expanding corpus of research indicates that oxidative stress is a primary molecular contributor to granulosa cell dysfunction, culminating in mitochondrial impairment, reduced metabolic support for oocytes, and the activation of regulated apoptotic pathways that end in follicular atresia. Ferroptosis, an emergent type of iron-dependent lipid peroxidation, has been identified as a crucial mechanism contributing to chemotherapy-induced ovarian insufficiency, polycystic ovary syndrome (PCOS), and granulosa cell death in aging ovaries, in addition to conventional apoptosis. The SIRT1-Nrf2 axis acts as a crucial anti-oxidative and anti-ferroptotic system that protects GC viability, maintains mitochondrial homeostasis, and upholds redox equilibrium. SIRT1 promotes mitochondrial biogenesis and metabolic resilience by deacetylating downstream proteins, including FOXO3 and PGC-1\u03b1. Nrf2 simultaneously controls the transcriptional activation of detoxifying and antioxidant enzymes, including HO-1, SOD2, NQO1, and GPX4, which are critical inhibitors of ferroptosis. Disruption of SIRT1-Nrf2 signalling accelerates GC senescence, follicular depletion, and reproductive aging. In contrast, pharmaceutical and nutraceutical therapies, including metformin, melatonin, resveratrol, and agents that increase NAD+ levels, may reverse ovarian deterioration and reactivate SIRT1-Nrf2 activity. This narrative review highlights innovative treatment prospects for ovarian aging, fertility preservation, and assisted reproduction by synthesising current evidence on ferroptotic pathways, SIRT1-Nrf2 interactions, and oxidative stress in granulosa cells. An understanding of these interrelated biological networks enables the development of tailored therapies that postpone ovarian ageing and enhance reproductive outcomes for women receiving fertility therapy.<\/jats:p>","DOI":"10.3390\/ijms27020950","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T09:24:34Z","timestamp":1768901074000},"page":"950","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Oxidative Stress and SIRT1-Nrf2 Anti-Ferroptotic Pathways in Granulosa Cells: A Molecular Key to Follicular Atresia and Ovarian Aging"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9477-7619","authenticated-orcid":false,"given":"Charalampos","family":"Voros","sequence":"first","affiliation":[{"name":"1st Department of Obstetrics and Gynecology, \u2018Alexandra\u2019 General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fotios","family":"Chatzinikolaou","sequence":"additional","affiliation":[{"name":"Laboratory of Forensic Medicine and Toxicology, School of Medicine, Aristotle University of Thessaloniki, 54124 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Papadimas","sequence":"additional","affiliation":[{"name":"Athens Medical School, National and Kapodistrian University of Athens, 15772 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spyridon","family":"Polykalas","sequence":"additional","affiliation":[{"name":"Athens Medical School, National and Kapodistrian University of Athens, 15772 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1220-6594","authenticated-orcid":false,"given":"Despoina","family":"Mavrogianni","sequence":"additional","affiliation":[{"name":"1st Department of Obstetrics and Gynecology, \u2018Alexandra\u2019 General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristotelis-Marios","family":"Koulakmanidis","sequence":"additional","affiliation":[{"name":"1st Department of Obstetrics and Gynecology, \u2018Alexandra\u2019 General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diamantis","family":"Athanasiou","sequence":"additional","affiliation":[{"name":"King\u2019s College Hospitals NHS Foundation Trust, London SE5 9RS, 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opportunities","volume":"171","author":"Wang","year":"2025","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Santiquet, N., Robert, C., and Richard, F.J. (2013). The Dynamics of Connexin Expression, Degradation and Localisation Are Regulated by Gonadotropins during the Early Stages of In Vitro Maturation of Swine Oocytes. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0068456"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Ga\u0142\u0119ska, E., Kowalczyk, A., Wrzeci\u0144ska, M., Garc\u00eda, M.C., Czerniawska-Pi\u0105tkowska, E., Gwo\u017adziewicz, S., Witkiewicz, W., and Dobrza\u0144ski, Z. (2025). The Importance of Mitochondrial Processes in the Maturation and Acquisition of Competences of Oocytes and Embryo Culture. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26094098"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.cellsig.2006.02.011","article-title":"FSH signaling pathways in immature granulosa cells that regulate target gene expression: Branching out from protein kinase A","volume":"18","author":"Hunzickerdunn","year":"2006","journal-title":"Cell. Signal."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"111927","DOI":"10.1016\/j.cbpa.2025.111927","article-title":"Up-regulation of cell apoptosis, autophagy and mitochondrial dynamics in ovarian granulosa cells of Daurian ground squirrels during the pre-hibernation period","volume":"310","author":"Wang","year":"2025","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/s13048-024-01484-3","article-title":"Granulosa cell insight: Unraveling the potential of menstrual blood-derived stem cells and their exosomes on mitochondrial mechanisms in polycystic ovary syndrome (PCOS)","volume":"17","author":"Mansoori","year":"2024","journal-title":"J. Ovarian Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e70259","DOI":"10.1002\/mco2.70259","article-title":"Mitochondria-Associated Endoplasmic Reticulum Membranes in Human Health and Diseases","volume":"6","author":"Liu","year":"2025","journal-title":"MedComm"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"547","DOI":"10.3390\/endocrines5040040","article-title":"Granulosa Cells: Central Regulators of Female Fertility","volume":"5","author":"Batalha","year":"2024","journal-title":"Endocrines"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e20230175","DOI":"10.1590\/1806-9282.20230175","article-title":"Granulosa cells and follicular development: A brief review","volume":"69","author":"Cavalcanti","year":"2023","journal-title":"Rev. Assoc. M\u00e9d. Bras."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1007\/s43032-025-01854-2","article-title":"The Role of Ovarian Granulosa Cells Related-ncRNAs in Ovarian Dysfunctions: Mechanism Research and Clinical Exploration","volume":"32","author":"Liu","year":"2025","journal-title":"Reprod. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s13048-022-01032-x","article-title":"The role of oxidative stress in ovarian aging: A review","volume":"15","author":"Yan","year":"2022","journal-title":"J. Ovarian Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"102659","DOI":"10.1016\/j.redox.2023.102659","article-title":"Reactive oxygen species and ovarian diseases: Antioxidant strategies","volume":"62","author":"Liang","year":"2023","journal-title":"Redox Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1210\/js.2018-00021","article-title":"Multimodal Regulation of Circadian Glucocorticoid Rhythm by Central and Adrenal Clocks","volume":"2","author":"Son","year":"2018","journal-title":"J. Endocr. Soc."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.tcb.2014.04.002","article-title":"NAD+ and sirtuins in aging and disease","volume":"24","author":"Imai","year":"2014","journal-title":"Trends Cell Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1139\/h11-070","article-title":"Deacetylation of PGC-1\u03b1 by SIRT1: Importance for skeletal muscle function and exercise-induced mitochondrial biogenesis","volume":"36","author":"Gurd","year":"2011","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s10495-021-01667-z","article-title":"The role of P53 up-regulated modulator of apoptosis (PUMA) in ovarian development, cardiovascular and neurodegenerative diseases","volume":"26","author":"Li","year":"2021","journal-title":"Apoptosis"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1038\/s41423-021-00740-6","article-title":"NLRP3 inflammasome activation and cell death","volume":"18","author":"Huang","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Coluzzi, E., Leone, S., and Sgura, A. (2019). Oxidative Stress Induces Telomere Dysfunction and Senescence by Replication Fork Arrest. Cells, 8.","DOI":"10.3390\/cells8010019"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2014.01.004","article-title":"Oxidative stress induces mitochondrial dysfunction and a protective unfolded protein response in RPE cells","volume":"69","author":"Cano","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Yao, J., Zhang, M., Wang, Y., and Shi, X. (2023). Mitochondria-associated endoplasmic reticulum membranes (MAMs): Possible therapeutic targets in heart failure. Front. Cardiovasc. Med., 10.","DOI":"10.3389\/fcvm.2023.1083935"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Maldonado, E., Morales-Pison, S., Urbina, F., and Solari, A. (2023). Aging Hallmarks and the Role of Oxidative Stress. Antioxidants, 12.","DOI":"10.3390\/antiox12030651"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1477-7827-10-49","article-title":"The effects of oxidative stress on female reproduction: A review","volume":"10","author":"Agarwal","year":"2012","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Kausar, S., Wang, F., and Cui, H. (2018). The Role of Mitochondria in Reactive Oxygen Species Generation and Its Implications for Neurodegenerative Diseases. Cells, 7.","DOI":"10.3390\/cells7120274"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Li, Y., Kang, K., Bao, H., Liu, S., Zhao, B., Hu, G., and Wu, J. (2025). Research Progress on the Interaction Between SIRT1 and Mitochondrial Biochemistry in the Aging of the Reproductive System. Biology, 14.","DOI":"10.3390\/biology14060643"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1750-1326-4-24","article-title":"Oxidative modifications, mitochondrial dysfunction, and impaired protein degradation in Parkinson\u2019s disease: How neurons are lost in the Bermuda triangle","volume":"4","author":"Malkus","year":"2009","journal-title":"Mol. Neurodegener."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Ran, Q., Gao, C., Xiang, C., He, X., Zhang, Y., Zhang, Y., and Chen, H. (2025). Mitochondrial fission process 1 protein: A comprehensive review of its core roles in mitochondrial dynamics, disease, and therapeutic targets. Front. Cell Dev. Biol., 13.","DOI":"10.3389\/fcell.2025.1646072"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Kowalczyk, P., Sulejczak, D., Kleczkowska, P., Bukowska-O\u015bko, I., Kucia, M., Popiel, M., Wietrak, E., Kramkowski, K., Wrzosek, K., and Kaczy\u0144ska, K. (2021). Mitochondrial Oxidative Stress\u2014A Causative Factor and Therapeutic Target in Many Diseases. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222413384"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Szanto, I. (2022). NADPH Oxidase 4 (NOX4) in Cancer: Linking Redox Signals to Oncogenic Metabolic Adaptation. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23052702"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.redox.2015.08.010","article-title":"Calcium and ROS: A mutual interplay","volume":"6","author":"Bertram","year":"2015","journal-title":"Redox Biol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Manoharan, R.R., Prasad, A., Posp\u00ed\u0161il, P., and Kzhyshkowska, J. (2024). ROS signaling in innate immunity via oxidative protein modifications. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1359600"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Liu, S., Jia, Y., Meng, S., Luo, Y., Yang, Q., and Pan, Z. (2023). Mechanisms of and Potential Medications for Oxidative Stress in Ovarian Granulosa Cells: A Review. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24119205"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s43556-025-00338-8","article-title":"ROS homeostasis in cell fate, pathophysiology, and therapeutic interventions","volume":"6","author":"Chen","year":"2025","journal-title":"Mol. Biomed."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1089\/ars.2017.7115","article-title":"GPx4, Lipid Peroxidation, and Cell Death: Discoveries, Rediscoveries, and Open Issues","volume":"29","author":"Maiorino","year":"2018","journal-title":"Antioxid. Redox Signal."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Georgiou-Siafis, S.K., and Tsiftsoglou, A.S. (2023). The Key Role of GSH in Keeping the Redox Balance in Mammalian Cells: Mechanisms and Significance of GSH in Detoxification via Formation of Conjugates. Antioxidants, 12.","DOI":"10.3390\/antiox12111953"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.redox.2012.10.001","article-title":"The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer","volume":"1","author":"Kansanen","year":"2013","journal-title":"Redox Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.chembiol.2020.03.011","article-title":"Breakdown of an Ironclad Defense System: The Critical Role of NRF2 in Mediating Ferroptosis","volume":"27","author":"Anandhan","year":"2020","journal-title":"Cell Chem. Biol."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Narendra, D.P., Jin, S.M., Tanaka, A., Suen, D.-F., Gautier, C.A., Shen, J., Cookson, M.R., and Youle, R.J. (2010). PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin. PLoS Biol., 8.","DOI":"10.1371\/journal.pbio.1000298"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1111\/bph.12516","article-title":"Mitochondrial fusion and fission proteins: Novel therapeutic targets for combating cardiovascular disease","volume":"171","author":"Hall","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Mani, S., Srivastava, V., Shandilya, C., Kaushik, A., and Singh, K.K. (2024). Mitochondria: The epigenetic regulators of ovarian aging and longevity. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1424826"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1128\/MCB.00389-16","article-title":"Absolute Amounts and Status of the Nrf2-Keap1-Cul3 Complex within Cells","volume":"36","author":"Iso","year":"2016","journal-title":"Mol. Cell. Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.bcp.2017.06.112","article-title":"Lipoxygenase inhibitors protect acute lymphoblastic leukemia cells from ferroptotic cell death","volume":"140","author":"Probst","year":"2017","journal-title":"Biochem. Pharmacol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/s41392-025-02253-4","article-title":"Mitochondria in oxidative stress, inflammation and aging: From mechanisms to therapeutic advances","volume":"10","author":"Xu","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Cuollo, L., Antonangeli, F., Santoni, A., and Soriani, A. (2020). The Senescence-Associated Secretory Phenotype (SASP) in the Challenging Future of Cancer Therapy and Age-Related Diseases. Biology, 9.","DOI":"10.3390\/biology9120485"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Voros, C., Athanasiou, D., Papapanagiotou, I., Mavrogianni, D., Varthaliti, A., Bananis, K., Athanasiou, A., Athanasiou, A., Papadimas, G., and Gkirgkinoudis, A. (2025). Cracking the Code of Oocyte Quality: The Oxidative Stress Link to IVF Success. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26136377"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Liu, X., Zeng, T., Zhang, E., Bin, C., Liu, Q., Wu, K., Luo, Y., and Wei, S. (2025). Plant-based bioactives and oxidative stress in reproduction: Anti-inflammatory and metabolic protection mechanisms. Front. Nutr., 12.","DOI":"10.3389\/fnut.2025.1650347"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/978-3-031-55163-5_5","article-title":"Molecular Mechanisms Determining Mammalian Oocyte Quality with the Treatment of Cancer Therapy","volume":"Volume 238","author":"Balboula","year":"2024","journal-title":"Molecular Mechanisms Determining Mammalian Oocyte Quality"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"276","DOI":"10.5114\/pm.2022.124019","article-title":"Oxidative homeostasis in follicular fluid and reproductive outcomes\u2014From bench to bedside","volume":"21","author":"Zec","year":"2022","journal-title":"Menopausal Rev."},{"key":"ref_48","first-page":"6571413","article-title":"Elevated Plasma Level of 8-Hydroxy-2\u2032-deoxyguanosine Is Associated with Primary Open-Angle Glaucoma","volume":"2020","author":"Kondkar","year":"2020","journal-title":"J. Ophthalmol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/s13048-025-01764-6","article-title":"Mitochondrial dysfunction in oocytes: Implications for fertility and ageing","volume":"18","author":"Wang","year":"2025","journal-title":"J. Ovarian Res."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Gao, Y., Zou, Y., Wu, G., and Zheng, L. (2023). Oxidative stress and mitochondrial dysfunction of granulosa cells in polycystic ovarian syndrome. Front. Med., 10.","DOI":"10.3389\/fmed.2023.1193749"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev-pharmtox-011112-140320","article-title":"Role of Nrf2 in Oxidative Stress and Toxicity","volume":"53","author":"Ma","year":"2013","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Gonnella, F., Konstantinidou, F., Di Berardino, C., Capacchietti, G., Peserico, A., Russo, V., Barboni, B., Stuppia, L., and Gatta, V. (2022). A Systematic Review of the Effects of High-Fat Diet Exposure on Oocyte and Follicular Quality: A Molecular Point of View. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23168890"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/jat.4664","article-title":"Impact of oxidative stress induced by heavy metals on ovarian function","volume":"45","author":"Xiao","year":"2025","journal-title":"J. Appl. Toxicol."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez-Varela, C., and Labarta, E. (2020). Clinical Application of Antioxidants to Improve Human Oocyte Mitochondrial Function: A Review. Antioxidants, 9.","DOI":"10.3390\/antiox9121197"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"H18","DOI":"10.1152\/ajpheart.00260.2010","article-title":"Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2","volume":"299","author":"Ungvari","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e70846","DOI":"10.1096\/fj.202500921R","article-title":"Reverse Effects of Nicotinamide Mononucleotide Supplementation on Declining Quality of Oocytes with Polycystic Ovary Syndrome","volume":"39","author":"Fan","year":"2025","journal-title":"FASEB J."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Rakha, S.I., Elmetwally, M.A., El-Sheikh Ali, H., Balboula, A., Mahmoud, A.M., and Zaabel, S.M. (2022). Importance of Antioxidant Supplementation during In Vitro Maturation of Mammalian Oocytes. Vet. Sci., 9.","DOI":"10.3390\/vetsci9080439"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Zhang, Y., Zang, J., Li, Y., and Wu, X. (2023). Pharmaceutical Therapies for Necroptosis in Myocardial Ischemia\u2013Reperfusion Injury. J. Cardiovasc. Dev. Dis., 10.","DOI":"10.3390\/jcdd10070303"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s12672-025-01911-x","article-title":"Advances in understanding ferroptosis mechanisms and their impact on immune cell regulation and tumour immunotherapy","volume":"16","author":"Zhu","year":"2025","journal-title":"Discov. Oncol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Voros, C., Chatzinikolaou, F., Papadimas, G., Polykalas, S., Mavrogianni, D., Koulakmanidis, A.-M., Athanasiou, D., Kanaka, V., Kanaka, M., and Bananis, K. (2025). Ferroptosis in the Ovarian Follicular Microenvironment: A Redox-Dependent Cell Death Pathway with Emerging Roles in PCOS, Oocyte Quality, and IVF Outcomes. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms262110381"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Kotla, N.K., Dutta, P., Parimi, S., and Das, N.K. (2022). The Role of Ferritin in Health and Disease: Recent Advances and Understandings. Metabolites, 12.","DOI":"10.3390\/metabo12070609"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1091\/mbc.E20-02-0129","article-title":"Unconventional endocytosis and trafficking of transferrin receptor induced by iron","volume":"32","author":"Gammella","year":"2021","journal-title":"Mol. Biol. Cell"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13045-024-01564-3","article-title":"Ferroptosis: Principles and significance in health and disease","volume":"17","author":"Chen","year":"2024","journal-title":"J. Hematol. Oncol."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Santana-Codina, N., and Mancias, J.D. (2018). The Role of NCOA4-Mediated Ferritinophagy in Health and Disease. Pharmaceuticals, 11.","DOI":"10.20944\/preprints201809.0148.v1"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Liu, M.-Z., Kong, N., Zhang, G.-Y., Xu, Q., Xu, Y., Ke, P., and Liu, C. (2022). The critical role of ferritinophagy in human disease. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.933732"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Tian, Y., Tian, Y., Yuan, Z., Zeng, Y., Wang, S., Fan, X., Yang, D., and Yang, M. (2022). Iron Metabolism in Aging and Age-Related Diseases. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23073612"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2529196","DOI":"10.1080\/27694127.2025.2529196","article-title":"The role of autophagy in the pathogenesis and treatment of multiple sclerosis","volume":"4","author":"Righes","year":"2025","journal-title":"Autophagy Rep."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Liu, Y., Zhan, J., Wang, J., Zeng, X., Liu, S., Huang, L., Niu, L., Sun, C., Ding, Z., and Xing, Y. (2025). Ferroptosis: A double-edged sword that enhances radiation sensitivity and facilitates radiation-induced injury in tumors. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1591172"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Jabir, M.S., Ahmed, A.T., Hussen, A., Alkhathami, A.G., Rekha, M.M., Sharma, Y., Rani, P., Prasad, G.V.S., and Ahmed, J.K. (2025). The ferroptosis-ncRNA-exosome triad: Key orchestrators in cancer immunopathogenesis. Naunyn. Schmiedebergs Arch. Pharmacol., 85\u201387.","DOI":"10.1007\/s00210-025-04584-z"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Kielan, B., Pa\u0142asz, A., Krysta, K., and Krzystanek, M. (2025). Ferroptosis as a Form of Cell Death-Medical Importance and Pharmacological Implications. Pharmaceuticals, 18.","DOI":"10.3390\/ph18081183"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Sun, D., Wang, L., Wu, Y., Yu, Y., Yao, Y., Yang, H., and Hao, C. (2025). Lipid metabolism in ferroptosis: Mechanistic insights and therapeutic potential. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1545339"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Jiang, Y., Zhang, M., and Sun, M. (2025). ACSL4 at the helm of the lipid peroxidation ship: A deep-sea exploration towards ferroptosis. Front. Pharmacol., 16.","DOI":"10.3389\/fphar.2025.1594419"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"16267","DOI":"10.3390\/ijms131216267","article-title":"Lysophosphatidylcholine Acyltransferase 3 Is the Key Enzyme for Incorporating Arachidonic Acid into Glycerophospholipids during Adipocyte Differentiation","volume":"13","author":"Eto","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1007\/s12672-025-02283-y","article-title":"LPCAT3 regulates the immune infiltration and prognosis of ccRCC patients by mediating ferroptosis and endoplasmic reticulum stress","volume":"16","author":"Feng","year":"2025","journal-title":"Discov. Oncol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/s41392-022-01090-z","article-title":"ALOX15-launched PUFA-phospholipids peroxidation increases the susceptibility of ferroptosis in ischemia-induced myocardial damage","volume":"7","author":"Ma","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.cotox.2017.10.003","article-title":"Role of cytochrome P450s in the generation and metabolism of reactive oxygen species","volume":"7","author":"Veith","year":"2018","journal-title":"Curr. Opin. Toxicol."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Lee, J., Yeo, S.G., Lee, J.M., Kim, S.S., Lee, J.-W., Chung, N., and Park, D.C. (2025). Expression of Free Radicals and Reactive Oxygen Species in Endometriosis: Current Knowledge and Its Implications. Antioxidants, 14.","DOI":"10.3390\/antiox14070877"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"100285","DOI":"10.1016\/j.cellin.2025.100285","article-title":"Mitochondrial cristae remodeling: Mechanisms, functions, and pathology","volume":"4","author":"Yu","year":"2025","journal-title":"Cell Insight"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1165\/rcmb.2023-0467OC","article-title":"FSP1 Acts in Parallel with GPX4 to Inhibit Ferroptosis in Chronic Obstructive Pulmonary Disease","volume":"72","author":"Yang","year":"2025","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12958-024-01208-8","article-title":"Endometrial stem cells alleviate cisplatin-induced ferroptosis of granulosa cells by regulating Nrf2 expression","volume":"22","author":"Pan","year":"2024","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Li, F.-J., Long, H.-Z., Zhou, Z.-W., Luo, H.-Y., Xu, S.-G., and Gao, L.-C. (2022). System Xc\u2212\/GSH\/GPX4 axis: An important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.910292"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"115780","DOI":"10.1016\/j.ecoenv.2023.115780","article-title":"The ROS\/SIRT1\/STAR axis as a target for melatonin ameliorating atrazine-induced mitochondrial dysfunction and steroid disorders in granulosa cells","volume":"269","author":"Li","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Jyotsana, N., Ta, K.T., and DelGiorno, K.E. (2022). The Role of Cystine\/Glutamate Antiporter SLC7A11\/xCT in the Pathophysiology of Cancer. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.858462"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s40104-025-01231-8","article-title":"SIRT3 mediates CPT2 delactylation to enhance mitochondrial function and proliferation in goat granulosa cells","volume":"16","author":"Song","year":"2025","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"25310","DOI":"10.18632\/oncotarget.15813","article-title":"Oxidative stress-induced apoptosis in granulosa cells involves JNK, p53 and Puma","volume":"8","author":"Yang","year":"2017","journal-title":"Oncotarget"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Fujii, J., Osaki, T., Soma, Y., and Matsuda, Y. (2023). Critical Roles of the Cysteine\u2013Glutathione Axis in the Production of \u03b3-Glutamyl Peptides in the Nervous System. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24098044"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Passlick, S., Rose, C.R., Petzold, G.C., and Henneberger, C. (2021). Disruption of Glutamate Transport and Homeostasis by Acute Metabolic Stress. Front. Cell. Neurosci., 15.","DOI":"10.3389\/fncel.2021.637784"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Pan, L., Gong, C., Sun, Y., Jiang, Y., Duan, X., Han, Y., and Wang, Y. (2022). Induction mechanism of ferroptosis: A novel therapeutic target in lung disease. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.1093244"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"863","DOI":"10.32604\/or.2024.054201","article-title":"The role of glutathione peroxidase 4 in the progression, drug resistance, and targeted therapy of non-small cell lung cancer","volume":"33","author":"Wei","year":"2025","journal-title":"Oncol. Res."},{"key":"ref_91","first-page":"99","article-title":"Ferroptosis: Regulated cell death","volume":"71","author":"Dodig","year":"2020","journal-title":"Arch. Ind. Hyg. Toxicol."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Zhang, L.-L., Tang, R.-J., and Yang, Y.-J. (2022). The underlying pathological mechanism of ferroptosis in the development of cardiovascular disease. Front. Cardiovasc. Med., 9.","DOI":"10.3389\/fcvm.2022.964034"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Lyamzaev, K.G., Panteleeva, A.A., Simonyan, R.A., Avetisyan, A.V., and Chernyak, B.V. (2023). Mitochondrial Lipid Peroxidation Is Responsible for Ferroptosis. Cells, 12.","DOI":"10.3390\/cells12040611"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"e250186","DOI":"10.1530\/EC-25-0186","article-title":"The role of mitochondrial dysfunction in ovarian granulosa cells in polycystic ovary syndrome","volume":"14","author":"Yan","year":"2025","journal-title":"Endocr. Connect."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.freeradbiomed.2025.03.029","article-title":"Reductive stress and mitochondrial dysfunction: The hidden link in chronic disease","volume":"233","author":"Mercola","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Ashok, A., Andrabi, S.S., Mansoor, S., Kuang, Y., Kwon, B.K., and Labhasetwar, V. (2022). Antioxidant Therapy in Oxidative Stress-Induced Neurodegenerative Diseases: Role of Nanoparticle-Based Drug Delivery Systems in Clinical Translation. Antioxidants, 11.","DOI":"10.3390\/antiox11020408"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Zhang, Y., An, Y., Sun, L.-J., Qu, H.-L., Li, X., He, X.-T., Wu, R.-X., Chen, F.-M., Tian, B.-M., and Yin, Y. (2023). NADPH-dependent ROS accumulation contributes to the impaired osteogenic differentiation of periodontal ligament stem cells under high glucose conditions. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1152845"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s12551-023-01126-w","article-title":"The critical role of mitochondrial lipid peroxidation in ferroptosis: Insights from recent studies","volume":"15","author":"Lyamzaev","year":"2023","journal-title":"Biophys. Rev."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"5537330","DOI":"10.1155\/2021\/5537330","article-title":"Ferroptosis in Different Pathological Contexts Seen through the Eyes of Mitochondria","volume":"2021","author":"Otasevic","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"115415","DOI":"10.1016\/j.biopha.2023.115415","article-title":"The emerging role of ferroptosis in female reproductive disorders","volume":"166","author":"Liu","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/s12967-025-06223-w","article-title":"The impact of mitochondrial dysfunction on ovarian aging","volume":"23","author":"Zhang","year":"2025","journal-title":"J. Transl. Med."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1007\/s43032-024-01634-4","article-title":"Mitochondrial Quality Control in Ovarian Function: From Mechanisms to Therapeutic Strategies","volume":"32","author":"Wang","year":"2025","journal-title":"Reprod. Sci."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Wang, X., Wei, Y., Wei, F., and Kuang, H. (2023). Regulatory mechanism and research progress of ferroptosis in obstetrical and gynecological diseases. Front. Cell Dev. Biol., 11.","DOI":"10.3389\/fcell.2023.1146971"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Lin, P.-H., Su, W.-P., Li, C.-J., Lin, L.-T., Sheu, J., Wen, Z.-H., Cheng, J.-T., and Tsui, K.-H. (2023). Investigating the Role of Ferroptosis-Related Genes in Ovarian Aging and the Potential for Nutritional Intervention. Nutrients, 15.","DOI":"10.3390\/nu15112461"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Yao, Y., Wang, B., Jiang, Y., Guo, H., and Li, Y. (2023). The mechanisms crosstalk and therapeutic opportunities between ferroptosis and ovary diseases. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1194089"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"101947","DOI":"10.1016\/j.redox.2021.101947","article-title":"NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer\u2019s diseases","volume":"41","author":"Park","year":"2021","journal-title":"Redox Biol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/s41419-023-05859-0","article-title":"Chemotherapy impairs ovarian function through excessive ROS-induced ferroptosis","volume":"14","author":"Zhang","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41392-020-00428-9","article-title":"Ferroptosis: Mechanisms and links with diseases","volume":"6","author":"Yan","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Sinha, B.K. (2025). Ferroptosis in Toxicology: Present and Future. Int. J. Mol. Sci., 26.","DOI":"10.20944\/preprints202505.0586.v1"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Grzeczka, A., and Kordowitzki, P. (2022). Resveratrol and SIRT1: Antiaging Cornerstones for Oocytes?. Nutrients, 14.","DOI":"10.3390\/nu14235101"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Bagnjuk, K., and Mayerhofer, A. (2019). Human Luteinized Granulosa Cells\u2014A Cellular Model for the Human Corpus Luteum. Front. Endocrinol., 10.","DOI":"10.3389\/fendo.2019.00452"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.stem.2014.12.004","article-title":"The NAD+-Dependent SIRT1 Deacetylase Translates a Metabolic Switch into Regulatory Epigenetics in Skeletal Muscle Stem Cells","volume":"16","author":"Ryall","year":"2015","journal-title":"Cell Stem Cell"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s10238-025-01759-z","article-title":"SIRT1 as a masterful reciprocal regulator of molecular mechanisms and signaling pathways involved in tumor growth and expansion","volume":"25","author":"Hashemi","year":"2025","journal-title":"Clin. Exp. Med."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1089\/ars.2012.4713","article-title":"SirT1 regulation of antioxidant genes is dependent on the formation of a FoxO3a\/PGC-1\u03b1 complex","volume":"19","author":"Olmos","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Sun, H., Li, D., Wei, C., Liu, L., Xin, Z., Gao, H., and Gao, R. (2024). The relationship between SIRT1 and inflammation: A systematic review and meta-analysis. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1465849"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1126\/science.1094637","article-title":"Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase","volume":"303","author":"Brunet","year":"2004","journal-title":"Science"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Kong, F., Li, N., Tao, L., Zhai, J., Ma, J., and Zhang, S. (2025). Potential role of SIRT1 in cell ferroptosis. Front. Cell Dev. Biol., 13.","DOI":"10.3389\/fcell.2025.1525294"},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Paw\u0142owska, M., Nuszkiewicz, J., Jarek, D.J., and Wo\u017aniak, A. (2025). Ferroptosis and Metabolic Dysregulation: Emerging Chemical Targets in Cancer and Infection. Molecules, 30.","DOI":"10.3390\/molecules30143020"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1515\/hsz-2012-0119","article-title":"Mitophagy: Mechanisms, pathophysiological roles, and analysis","volume":"393","author":"Ding","year":"2012","journal-title":"Biol. Chem."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"e13204","DOI":"10.1111\/acel.13204","article-title":"Sirt1 sustains female fertility by slowing age-related decline in oocyte quality required for post-fertilization embryo development","volume":"19","author":"Iljas","year":"2020","journal-title":"Aging Cell"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s13048-024-01457-6","article-title":"Folliculogenesis and steroidogenesis alterations after chronic exposure to a human-relevant mixture of environmental toxicants spare the ovarian reserve in the rabbit model","volume":"17","author":"Frenois","year":"2024","journal-title":"J. Ovarian Res."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.crphys.2021.03.002","article-title":"Interplay between oxidative stress, SIRT1, reproductive and metabolic functions","volume":"4","author":"Alam","year":"2021","journal-title":"Curr. Res. Physiol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s13048-024-01427-y","article-title":"Ovarian aging: Energy metabolism of oocytes","volume":"17","author":"Bao","year":"2024","journal-title":"J. Ovarian Res."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.biochi.2019.12.001","article-title":"SIRT1\/PGC-1 pathway activation triggers autophagy\/mitophagy and attenuates oxidative damage in intestinal epithelial cells","volume":"170","author":"Liang","year":"2020","journal-title":"Biochimie"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"3834","DOI":"10.3390\/ijms14023834","article-title":"Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process","volume":"14","author":"Salminen","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1007\/s00405-022-07696-x","article-title":"Identification and validation of ferroptosis-related genes for chronic rhinosinusitis with nasal polyps","volume":"280","author":"Huang","year":"2023","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s43556-023-00142-2","article-title":"The mechanism of ferroptosis and its related diseases","volume":"4","author":"Feng","year":"2023","journal-title":"Mol. Biomed."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.7150\/ijbs.83348","article-title":"The crosstalk between ferroptosis and mitochondrial dynamic regulatory networks","volume":"19","author":"Li","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Karolczak, K., and Watala, C. (2023). Estradiol as the Trigger of Sirtuin-1-Dependent Cell Signaling with a Potential Utility in Anti-Aging Therapies. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241813753"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.tips.2013.12.004","article-title":"Small molecule SIRT1 activators for the treatment of aging and age-related diseases","volume":"35","author":"Hubbard","year":"2014","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/s40001-022-00746-4","article-title":"The role of Sirtuin 1 in the pathophysiology of polycystic ovary syndrome","volume":"27","author":"Wu","year":"2022","journal-title":"Eur. J. Med. Res."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"e37421","DOI":"10.1097\/MD.0000000000037421","article-title":"Ferroptosis and oxidative stress in endometriosis: A systematic review of the literature","volume":"103","author":"Ni","year":"2024","journal-title":"Medicine"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1158\/1535-7163.MCT-24-0957","article-title":"Pharmacologic Inhibition of SIRT1 Limits the Growth of Tumoral and Metastatic Granulosa Cells by Affecting mTOR, Myc, and E2F Pathways","volume":"24","author":"Cluzet","year":"2025","journal-title":"Mol. Cancer Ther."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3892\/mmr.2020.11658","article-title":"Role of the SIRT1\/p53 regulatory axis in oxidative stress-mediated granulosa cell apoptosis","volume":"23","author":"Park","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1038\/s44321-024-00119-w","article-title":"Fertility protection during chemotherapy treatment by boosting the NAD(P)+ metabolome","volume":"16","author":"Ho","year":"2024","journal-title":"EMBO Mol. Med."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1124\/pr.110.003905","article-title":"Targeting Sirtuin 1 to Improve Metabolism: All You Need Is NAD(+)?","volume":"64","author":"Auwerx","year":"2012","journal-title":"Pharmacol. Rev."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"9912436","DOI":"10.1155\/2021\/9912436","article-title":"Reactive Oxygen Species (ROS) Regulates Different Types of Cell Death by Acting as a Rheostat","volume":"2021","author":"Gibson","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Wan, W., Hua, F., Fang, P., Li, C., Deng, F., Chen, S., Ying, J., and Wang, X. (2022). Regulation of Mitophagy by Sirtuin Family Proteins: A Vital Role in Aging and Age-Related Diseases. Front. Aging Neurosci., 14.","DOI":"10.3389\/fnagi.2022.845330"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1111\/cns.13973","article-title":"Ferroptosis contributes to hypoxic\u2013ischemic brain injury in neonatal rats: Role of the SIRT1\/Nrf2\/GPx4 signaling pathway","volume":"28","author":"Li","year":"2022","journal-title":"CNS Neurosci. Ther."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1111\/jcmm.17874","article-title":"Resveratrol inhibits ferroptosis and decelerates heart failure progression via Sirt1\/p53 pathway activation","volume":"27","author":"Zhang","year":"2023","journal-title":"J. Cell. Mol. Med."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Alqrad, M.A.I., El-Agamy, D.S., Ibrahim, S.R.M., Sirwi, A., Abdallah, H.M., Abdel-Sattar, E., El-Halawany, A.M., Elsaed, W.M., and Mohamed, G.A. (2023). SIRT1\/Nrf2\/NF-\u03baB Signaling Mediates Anti-Inflammatory and Anti-Apoptotic Activities of Oleanolic Acid in a Mouse Model of Acute Hepatorenal Damage. Medicina, 59.","DOI":"10.3390\/medicina59071351"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.gene.2015.09.043","article-title":"Are sirtuins markers of ovarian aging?","volume":"575","author":"Zhang","year":"2016","journal-title":"Gene"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/rmb2.12323","article-title":"Resveratrol protects mitochondrial quantity by activating SIRT1\/PGC-1\u03b1 expression during ovarian hypoxia","volume":"19","author":"Nishigaki","year":"2020","journal-title":"Reprod. Med. Biol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/s13048-021-00912-y","article-title":"Melatonin enhances SIRT1 to ameliorate mitochondrial membrane damage by activating PDK1\/Akt in granulosa cells of PCOS","volume":"14","author":"Zheng","year":"2021","journal-title":"J. Ovarian Res."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Yang, Y., He, Y., Gan, M., Zhao, X., Liao, T., Lei, Y., Chen, L., Niu, L., Zhao, Y., and Wang, Y. (2025). The Mechanism of Ferroptosis Regulating Granulosa Cell Apoptosis and Oxidative Stress Through the NF-\u03baB\/PTGS2 Axis in Porcine Atretic Follicles. Antioxidants, 14.","DOI":"10.3390\/antiox14091071"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"17930","DOI":"10.18632\/aging.203231","article-title":"Research progress of melatonin (MT) in improving ovarian function: A review of the current status","volume":"13","author":"Guo","year":"2021","journal-title":"Aging"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"e00099-20","DOI":"10.1128\/MCB.00099-20","article-title":"The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway","volume":"40","author":"Baird","year":"2020","journal-title":"Mol. Cell. Biol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1007\/s12032-025-02916-w","article-title":"Wedelolactone induces pyroptosis to suppress retinoblastoma by inhibiting the Nrf2\/Keap1 signaling pathway","volume":"42","author":"Jiang","year":"2025","journal-title":"Med. Oncol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"4501","DOI":"10.1128\/MCB.25.11.4501-4513.2005","article-title":"Keap1 Regulates the Oxidation-Sensitive Shuttling of Nrf2 into and out of the Nucleus via a Crm1-Dependent Nuclear Export Mechanism","volume":"25","author":"Velichkova","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"101149","DOI":"10.1016\/j.bonr.2021.101149","article-title":"The role of the Nrf2\/Keap1 signaling cascade in mechanobiology and bone health","volume":"15","author":"Priddy","year":"2021","journal-title":"Bone Rep."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s13048-025-01639-w","article-title":"Overview of Nrf2 as a target in ovary and ovarian dysfunctions focusing on its antioxidant properties","volume":"18","author":"Ghantabpour","year":"2025","journal-title":"J. Ovarian Res."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s12035-025-05517-w","article-title":"Nrf2\/Keap1 Signaling Axis in the Brain: Master Regulator of Oxidative Stress in Neurodegenerative and Psychiatric Disorders","volume":"63","author":"Goel","year":"2026","journal-title":"Mol. Neurobiol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1089\/ars.2017.7176","article-title":"The Roles of NRF2 in Modulating Cellular Iron Homeostasis","volume":"29","author":"Kerins","year":"2018","journal-title":"Antioxid. Redox Signal."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/hep.28251","article-title":"Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells","volume":"63","author":"Sun","year":"2016","journal-title":"Hepatology"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"10228","DOI":"10.1093\/nar\/gks827","article-title":"Nrf2\u2013MafG heterodimers contribute globally to antioxidant and metabolic networks","volume":"40","author":"Hirotsu","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1007\/s00018-016-2223-0","article-title":"Role of Nrf2\/HO-1 system in development, oxidative stress response and diseases: An evolutionarily conserved mechanism","volume":"73","author":"Loboda","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Lee, W.-S., Ham, W., and Kim, J. (2021). Roles of NAD(P)H:quinone Oxidoreductase 1 in Diverse Diseases. Life, 11.","DOI":"10.3390\/life11121301"},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"L\u00f6ser, A., Schwarz, M., and Kipp, A.P. (2024). NRF2 and Thioredoxin Reductase 1 as Modulators of Interactions between Zinc and Selenium. Antioxidants, 13.","DOI":"10.3390\/antiox13101211"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.freeradbiomed.2015.04.036","article-title":"The emerging role of Nrf2 in mitochondrial function","volume":"88","author":"Abramov","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Gao, X., Wang, B., Huang, Y., Wu, M., Li, Y., Li, Y., Zhu, X., and Wu, M. (2023). Role of the Nrf2 Signaling Pathway in Ovarian Aging: Potential Mechanism and Protective Strategies. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241713327"},{"key":"ref_161","first-page":"3546","article-title":"Expression and localization of nuclear factor erythroid 2-related factor 2 in the ovarian tissues of mice at different ages","volume":"16","author":"Sindan","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Song, Y., Qu, Y., Mao, C., Zhang, R., Jiang, D., and Sun, X. (2024). Post-translational modifications of Keap1: The state of the art. Front. Cell Dev. Biol., 11.","DOI":"10.3389\/fcell.2023.1332049"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"e13998","DOI":"10.14814\/phy2.13998","article-title":"Effects of Nrf2 deficiency on mitochondrial oxidative stress in aged skeletal muscle","volume":"7","author":"Kitaoka","year":"2019","journal-title":"Physiol. Rep."},{"key":"ref_164","first-page":"e5229","article-title":"Pyroglutamic Acidemia: An Underrecognized and Underdiagnosed Cause of High Anion Gap Metabolic Acidosis\u2014A Case Report and Review of Literature","volume":"11","author":"Venkataraman","year":"2019","journal-title":"Cureus"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"eade9585","DOI":"10.1126\/sciadv.ade9585","article-title":"NRF2 controls iron homeostasis and ferroptosis through HERC2 and VAMP8","volume":"9","author":"Anandhan","year":"2023","journal-title":"Sci. Adv."},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Voros, C., Chatzinikolaou, F., Sapantzoglou, I., Papadimas, G., Polykalas, S., Mavrogianni, D., Koulakmanidis, A.-M., Athanasiou, D., Kanaka, V., and Kanaka, M. (2025). Non-Invasive Extracellular Vesicle Biomarkers in Endometriosis, Molecular Signatures Linking Pelvic Inflammation, Oocyte Quality, and IVF Outcomes. Curr. Issues Mol. Biol., 47.","DOI":"10.3390\/cimb47110956"},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Gautam, R., Maan, P., Jyoti, A., Kumar, A., Malhotra, N., and Arora, T. (2025). The Role of Lifestyle Interventions in PCOS Management: A Systematic Review. Nutrients, 17.","DOI":"10.3390\/nu17020310"},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Yao, X., Liu, W., Xie, Y., Xi, M., and Xiao, L. (2023). Fertility loss: Negative effects of environmental toxicants on oogenesis. Front. Physiol., 14.","DOI":"10.3389\/fphys.2023.1219045"},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Zhao, N., Li, S., Wu, H., Wei, D., Pu, N., Wang, K., Liu, Y., Tao, Y., and Song, Z. (2025). Ferroptosis: An Energetic Villain of Age-Related Macular Degeneration. Biomedicines, 13.","DOI":"10.3390\/biomedicines13040986"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.redox.2013.08.006","article-title":"Effect of Nrf2 activators on release of glutathione, cysteinylglycine and homocysteine by human U373 astroglial cells","volume":"1","author":"Steele","year":"2013","journal-title":"Redox Biol."},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Kasai, S., Mimura, J., Ozaki, T., and Itoh, K. (2018). Emerging Regulatory Role of Nrf2 in Iron, Heme, and Hemoglobin Metabolism in Physiology and Disease. Front. Vet. Sci., 5.","DOI":"10.3389\/fvets.2018.00242"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"111256","DOI":"10.1016\/j.cellsig.2024.111256","article-title":"The main molecular mechanisms of ferroptosis and its role in chronic kidney disease","volume":"121","author":"Wang","year":"2024","journal-title":"Cell. Signal."},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Baiskhanova, D., and Sch\u00e4fer, H. (2024). The Role of Nrf2 in the Regulation of Mitochondrial Function and Ferroptosis in Pancreatic Cancer. Antioxidants, 13.","DOI":"10.3390\/antiox13060696"},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Yan, R., Lin, B., Jin, W., Tang, L., Hu, S., and Cai, R. (2023). NRF2, a Superstar of Ferroptosis. Antioxidants, 12.","DOI":"10.20944\/preprints202308.1554.v1"},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Yu, D., Hu, Y., Ma, M., Li, W., and Zhao, X. (2025). The landscape of research on ferroptosis under hypoxic conditions: A bibliometric analysis. Front. Pharmacol., 16.","DOI":"10.3389\/fphar.2025.1519000"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"e70268","DOI":"10.1002\/mco2.70268","article-title":"Oxidative Stress: Signaling Pathways, Biological Functions, and Disease","volume":"6","author":"Liu","year":"2025","journal-title":"MedComm"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1093\/biolre\/ioab150","article-title":"Sirt1 and Nrf2: Regulation of Leydig cell oxidant\/antioxidant intracellular environment and steroid formation\u2020","volume":"105","author":"Chung","year":"2021","journal-title":"Biol. Reprod."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.18632\/aging.101609","article-title":"Sirt1\/Nrf2 pathway is involved in oocyte aging by regulating Cyclin B1","volume":"10","author":"Ma","year":"2018","journal-title":"Aging"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1172\/JCI88574","article-title":"Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2","volume":"127","author":"Yang","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"120111","DOI":"10.1016\/j.lfs.2021.120111","article-title":"Nrf2\/Keap1\/ARE signaling: Towards specific regulation","volume":"291","author":"Ulasov","year":"2022","journal-title":"Life Sci."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1007\/s10753-020-01242-9","article-title":"Role of Silent Information Regulator 1 (SIRT1) in Regulating Oxidative Stress and Inflammation","volume":"43","author":"Singh","year":"2020","journal-title":"Inflammation"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1089\/ars.2017.7290","article-title":"The Role of Sirtuins in Antioxidant and Redox Signaling","volume":"28","author":"Singh","year":"2018","journal-title":"Antioxid. Redox Signal."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1002\/ijc.33871","article-title":"SIRT1-mediated deacetylation of FOXO3a transcription factor supports pro-angiogenic activity of interferon-deficient tumor-associated neutrophils","volume":"150","author":"Bordbari","year":"2022","journal-title":"Int. J. Cancer"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1172\/JCI31807","article-title":"Foxo3 is required for the regulation of oxidative stress in erythropoiesis","volume":"117","author":"Marinkovic","year":"2007","journal-title":"J. Clin. Investig."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/2041-9414-4-6","article-title":"SIRT1\/PARP1 crosstalk: Connecting DNA damage and metabolism","volume":"4","author":"Luna","year":"2013","journal-title":"Genome Integr."},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"Chen, M., Shi, Z., Sun, Y., Ning, H., Gu, X., and Zhang, L. (2023). Prospects for Anti-Tumor Mechanism and Potential Clinical Application Based on Glutathione Peroxidase 4 Mediated Ferroptosis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24021607"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2020.02.027","article-title":"Lipid peroxidation and ferroptosis: The role of GSH and GPx4","volume":"152","author":"Ursini","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"ref_188","doi-asserted-by":"crossref","unstructured":"Song, X., and Long, D. (2020). Nrf2 and Ferroptosis: A New Research Direction for Neurodegenerative Diseases. Front. Neurosci., 14.","DOI":"10.3389\/fnins.2020.00267"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/s41420-022-01212-0","article-title":"GPX4-independent ferroptosis\u2014A new strategy in disease\u2019s therapy","volume":"8","author":"Ma","year":"2022","journal-title":"Cell Death Discov."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"521","DOI":"10.3892\/mmr.2014.2724","article-title":"Sirtuin 1 activation enhances the PGC-1\u03b1\/mitochondrial antioxidant system pathway in status epilepticus","volume":"11","author":"Wang","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"ref_191","doi-asserted-by":"crossref","unstructured":"Liu, J., Zhang, C., Wang, J., Hu, W., and Feng, Z. (2020). The Regulation of Ferroptosis by Tumor Suppressor p53 and its Pathway. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21218387"},{"key":"ref_192","doi-asserted-by":"crossref","unstructured":"Weaver, K., and Skouta, R. (2022). The Selenoprotein Glutathione Peroxidase 4: From Molecular Mechanisms to Novel Therapeutic Opportunities. Biomedicines, 10.","DOI":"10.20944\/preprints202202.0316.v1"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"103821","DOI":"10.1016\/j.redox.2025.103821","article-title":"NRF2-dependent suppression of selenoprotein P expression promotes intracellular selenium metabolic remodeling and upregulation of antioxidant selenoproteins in hepatocellular carcinoma","volume":"86","author":"Arisawa","year":"2025","journal-title":"Redox Biol."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"111763","DOI":"10.1016\/j.cbi.2025.111763","article-title":"Rotenone induces ferroptosis and neurotoxicity through inhibition of SIRT1-Nrf2-ferroportin 1\/GPX4 pathways in SH-SY5Y cells and mice","volume":"421","author":"Liu","year":"2025","journal-title":"Chem. Biol. Interact."},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"Sreerangaraja Urs, D.B., Wu, W.-H., Komrskova, K., Postlerova, P., Lin, Y.-F., Tzeng, C.-R., and Kao, S.-H. (2020). Mitochondrial Function in Modulating Human Granulosa Cell Steroidogenesis and Female Fertility. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21103592"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.redox.2015.09.003","article-title":"Complex I and complex III inhibition specifically increase cytosolic hydrogen peroxide levels without inducing oxidative stress in HEK293 cells","volume":"6","author":"Forkink","year":"2015","journal-title":"Redox Biol."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.mad.2016.02.003","article-title":"Regulation of SIRT1 in aging: Roles in mitochondrial function and biogenesis","volume":"155","author":"Yuan","year":"2016","journal-title":"Mech. Ageing Dev."},{"key":"ref_198","doi-asserted-by":"crossref","unstructured":"McCarty, M.F., Lewis Lujan, L., and Iloki Assanga, S. (2022). Targeting Sirt1, AMPK, Nrf2, CK2, and Soluble Guanylate Cyclase with Nutraceuticals: A Practical Strategy for Preserving Bone Mass. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23094776"},{"key":"ref_199","doi-asserted-by":"crossref","unstructured":"Fujii, J., and Imai, H. (2024). Oxidative Metabolism as a Cause of Lipid Peroxidation in the Execution of Ferroptosis. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25147544"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1038\/s41556-025-01668-z","article-title":"Endoplasmic reticulum\u2013mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis","volume":"27","author":"Sassano","year":"2025","journal-title":"Nat. Cell Biol."},{"key":"ref_201","doi-asserted-by":"crossref","unstructured":"Wei, Y., Lin, Y., Li, Y., Liu, J., Yang, Y., Chen, H., Han, Z., Wang, K., Qian, T., and Ju, Y. (2025). Redefining cell death: Ferroptosis as a game-changer in ophthalmology. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1709354"},{"key":"ref_202","doi-asserted-by":"crossref","unstructured":"Chen, X., Yu, C., Kang, R., and Tang, D. (2020). Iron Metabolism in Ferroptosis. Front. Cell Dev. Biol., 8.","DOI":"10.3389\/fcell.2020.590226"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s00204-023-03660-8","article-title":"Ferroptosis regulation through Nrf2 and implications for neurodegenerative diseases","volume":"98","author":"Xiang","year":"2024","journal-title":"Arch. Toxicol."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"8819627","DOI":"10.1155\/2020\/8819627","article-title":"Healthy Lifestyle Recommendations: Do the Beneficial Effects Originate from NAD+ Amount at the Cellular Level?","volume":"2020","author":"Poljsak","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_205","doi-asserted-by":"crossref","unstructured":"Zhang, T., Wang, L., Duan, X., Niu, Y., Li, M., Yun, L., Sun, H., Ma, Y., and Guo, Y. (2024). Sirtuins mediate mitochondrial quality control mechanisms: A novel therapeutic target for osteoporosis. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1281213"},{"key":"ref_206","first-page":"1452696","article-title":"PGC-1 \u03b1, Inflammation, and Oxidative Stress: An Integrative View in Metabolism","volume":"2020","author":"Ortega","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"105609","DOI":"10.1016\/j.bspc.2023.105609","article-title":"PulseID: Multi-scale photoplethysmographic identification using a deep convolutional neural network","volume":"88","author":"Wei","year":"2024","journal-title":"Biomed. Signal Process. Control"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"156084","DOI":"10.1016\/j.prp.2025.156084","article-title":"The role of the Nrf2 pathway in inhibiting ferroptosis in kidney disease and its future prospects","volume":"272","author":"Huang","year":"2025","journal-title":"Pathol.-Res. Pract."},{"key":"ref_209","doi-asserted-by":"crossref","unstructured":"Battaglia, A.M., Chirillo, R., Aversa, I., Sacco, A., Costanzo, F., and Biamonte, F. (2020). Ferroptosis and Cancer: Mitochondria Meet the \u201cIron Maiden\u201d Cell Death. Cells, 9.","DOI":"10.3390\/cells9061505"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"57459","DOI":"10.1007\/s11356-021-14699-4","article-title":"A novel identified circ-ANKHD1 targets the miR-27a-3p\/SFRP1 signaling pathway and modulates the apoptosis of granulosa cells","volume":"28","author":"Li","year":"2021","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.mce.2017.10.002","article-title":"Activation of Nrf2 might reduce oxidative stress in human granulosa cells","volume":"470","author":"Akino","year":"2018","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_212","doi-asserted-by":"crossref","unstructured":"Zhang, M., Yu, X., Li, D., Ma, N., Wei, Z., Ci, X., and Zhang, S. (2022). Nrf2 Signaling Pathway Mediates the Protective Effects of Daphnetin Against D-Galactose Induced-Premature Ovarian Failure. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.810524"},{"key":"ref_213","doi-asserted-by":"crossref","unstructured":"Sharata, E.E., Bakry, T., Atta, H.G., Mohammed, H.A., Diab, N.S., Atef, R.A., Hosney, R.S., Omar, M.M., and Hemeida, R.A.M. (2025). Molecular mechanisms underlying cyclophosphamide-induced ovarian injury and protective strategies. Naunyn. Schmiedebergs Arch. Pharmacol., 123.","DOI":"10.1007\/s00210-025-04550-9"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"e70469","DOI":"10.1096\/fj.202401580RR","article-title":"Ovarian aging-associated downregulation of GPX4 expression regulates ovarian follicular development by affecting granulosa cell functions and oocyte quality","volume":"39","author":"Hu","year":"2025","journal-title":"FASEB J."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s13048-024-01434-z","article-title":"Cyclophosphamide induces ovarian granulosa cell ferroptosis via a mechanism associated with HO-1 and ROS-mediated mitochondrial dysfunction","volume":"17","author":"Chen","year":"2024","journal-title":"J. Ovarian Res."},{"key":"ref_216","doi-asserted-by":"crossref","unstructured":"Yu, Y., Shan, Y., Lu, J., Xian, Y., Tang, Z., Guo, X., Huang, Y., and Ni, X. (2025). Ferroptosis and Sterol Biosynthesis Dysregulation in Granulosa Cells of Patients with Diminished Ovarian Reserve. Antioxidants, 14.","DOI":"10.3390\/antiox14060749"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"108556","DOI":"10.1016\/j.reprotox.2024.108556","article-title":"Excessive fluoride induces ovarian function impairment by regulating levels of ferroptosis in fluorosis women and ovarian granulosa cells","volume":"125","author":"Geng","year":"2024","journal-title":"Reprod. Toxicol."},{"key":"ref_218","doi-asserted-by":"crossref","unstructured":"Zhang, T., He, M., Zhang, J., Tong, Y., Chen, T., Wang, C., Pan, W., and Xiao, Z. (2023). Mechanisms of primordial follicle activation and new pregnancy opportunity for premature ovarian failure patients. Front. Physiol., 14.","DOI":"10.3389\/fphys.2023.1113684"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.3390\/cimb45030133","article-title":"Regulation of SIRT1 in Ovarian Function: PCOS Treatment","volume":"45","author":"Li","year":"2023","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"148931","DOI":"10.1016\/j.ijbiomac.2025.148931","article-title":"SIRT1 inhibits ferroptosis of granulosa cells in polycystic ovarian syndrome","volume":"334","author":"An","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s10815-024-03301-8","article-title":"Role of epigenetic regulation in diminished ovarian reserve","volume":"42","author":"Chen","year":"2024","journal-title":"J. Assist. Reprod. Genet."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/2\/950\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T15:34:11Z","timestamp":1769009651000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/2\/950"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,18]]},"references-count":221,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["ijms27020950"],"URL":"https:\/\/doi.org\/10.3390\/ijms27020950","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,18]]}}}