{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:53:26Z","timestamp":1777391606815,"version":"3.51.4"},"reference-count":117,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"UCM-VISUfarma Spain","award":["Article 83: 4158788"],"award-info":[{"award-number":["Article 83: 4158788"]}]},{"name":"UCM-VISUfarma B.V.","award":["Article 60: 4196924"],"award-info":[{"award-number":["Article 60: 4196924"]}]},{"DOI":"10.13039\/501100002911","name":"Complutense University of Madrid","doi-asserted-by":"publisher","award":["CT58\/21-CT59\/21"],"award-info":[{"award-number":["CT58\/21-CT59\/21"]}],"id":[{"id":"10.13039\/501100002911","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002911","name":"Complutense University of Madrid","doi-asserted-by":"publisher","award":["CT15\/23"],"award-info":[{"award-number":["CT15\/23"]}],"id":[{"id":"10.13039\/501100002911","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Basic Vision Sciences Research Group at the IIORC","award":["UCM-920105"],"award-info":[{"award-number":["UCM-920105"]}]},{"name":"Physiopathology of the Mutiorganic Failure: Therapeutical Approaches Research Group","award":["UCM-951579"],"award-info":[{"award-number":["UCM-951579"]}]},{"name":"Motor and Visual Neurophysiology Research Group\u2014IRYCIS"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>This study evaluated the early structural and functional effects of combined citicoline and coenzyme Q10 (CoQ10) (CitiQ10) treatment in a laser-induced ocular hypertension (OHT) model in Swiss albino mice, focusing on retinal inflammation and neuroprotection. Sixty male CD-1 mice were assigned to four groups: vehicle, CitiQ10, OHT, and OHT + CitiQ10. OHT was induced by laser photocoagulation of limbal and episcleral veins, and CitiQ10 was administered orally starting 15 days before induction. Intraocular pressure (IOP) was measured by rebound tonometry, retinal structure was assessed by spectral domain optical coherence tomography (SD-OCT), and function was evaluated using full-field electroretinography (ffERG). At 3 days post-induction, OHT eyes exhibited significant retinal nerve fiber layer (RNFL) thickening, increased vitreous particles, and early functional impairment, particularly reduced scotopic b-wave and oscillatory potentials. CitiQ10 treatment mitigated these changes, reducing vitreous particles, moderating RNFL alterations, and not exhibiting significant changes in ERG amplitudes. At 7 days post-induction, structural and functional deficits persisted but were less pronounced in treated eyes. These findings suggest that CitiQ10 treatment may attenuate early retinal damage in glaucoma, with OCT and ffERG serving as reliable monitoring tools, supporting the therapeutic potential of this approach in early stage disease.<\/jats:p>","DOI":"10.3390\/ijms27021012","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T11:27:58Z","timestamp":1768908478000},"page":"1012","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["In Vivo Functional and Structural Retinal Preservation by Combined Administration of Citicoline and Coenzyme Q10 in a Murine Model of Ocular Hypertension"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0607-5225","authenticated-orcid":false,"given":"Jose","family":"Matamoros","sequence":"first","affiliation":[{"name":"Ramon Castroviejo Institute for Ophthalmic Research, Complutense University of Madrid (ROR 02p0gd045), 28040 Madrid, Spain"},{"name":"Health Research Institute of the Hospital Cl\u00ednico San Carlos (IdISSC) (ROR 014v12a39), 28040 Madrid, Spain"},{"name":"Department of Immunology, Ophthalmology and ENT, Faculty of Optics and Optometry, Complutense University of Madrid, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5939-5551","authenticated-orcid":false,"given":"Elena","family":"Salobrar-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Ramon Castroviejo Institute for Ophthalmic Research, Complutense University of Madrid (ROR 02p0gd045), 28040 Madrid, Spain"},{"name":"Health Research Institute of the Hospital Cl\u00ednico San Carlos (IdISSC) (ROR 014v12a39), 28040 Madrid, Spain"},{"name":"Department of Immunology, Ophthalmology and ENT, Faculty of Optics and Optometry, Complutense University of Madrid, 28040 Madrid, 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Research, Complutense University of Madrid (ROR 02p0gd045), 28040 Madrid, Spain"},{"name":"Department of Immunology, Ophthalmology and ORL, Faculty of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2020-2721","authenticated-orcid":false,"given":"Sara","family":"Rubio-Casado","sequence":"additional","affiliation":[{"name":"Ramon Castroviejo Institute for Ophthalmic Research, Complutense University of Madrid (ROR 02p0gd045), 28040 Madrid, Spain"},{"name":"Department of Immunology, Ophthalmology and ORL, Faculty of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3587-8003","authenticated-orcid":false,"given":"V\u00edctor","family":"Paleo-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Universidad 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Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"ref_1","first-page":"253","article-title":"Glaucoma: Diagnosis and Management","volume":"107","author":"Michels","year":"2023","journal-title":"Am. 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