{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T03:43:00Z","timestamp":1785469380237,"version":"3.56.0"},"reference-count":58,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260802"],"award-info":[{"award-number":["82260802"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012547","name":"Natural Science Foundation of Guangxi","doi-asserted-by":"publisher","award":["2025JJA141021"],"award-info":[{"award-number":["2025JJA141021"]}],"id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Curcumin is the main active ingredient in Curcuma longa turmeric, with a wide range of biological effects. It shows significant therapeutic potential in the field of stem cell therapy. This article aims to explore the modulatory effects and underlying mechanisms of curcumin on mesenchymal stem cells (MSCs), providing a theoretical basis based on experimental evidence for its clinical application in regenerative medicine. First, the physicochemical properties, main pharmacological activities, and metabolic pathways of curcumin are described. Subsequently, the key molecular mechanisms by which curcumin regulates MSCs are analyzed in depth, demonstrating that curcumin can significantly promote MSC proliferation and inhibit apoptosis by modulating signaling pathways and gene expression. Additionally, curcumin directs the differentiation of MSCs into osteoblasts and chondrocytes. It also inhibits their differentiation into adipocytes, thereby regulating the physiological functions of MSCs such as proliferation, differentiation, and apoptosis. Finally, several main challenges in current research are highlighted. These include the low oral bioavailability of curcumin; the regulatory effects that vary depending on doses and microenvironmental conditions; the underlying mechanisms not being fully elucidated; the research being mostly limited to in vitro cell models and animal experiments; and the lack of quality standards and production process control systems for curcumin preparations.<\/jats:p>","DOI":"10.3390\/ijms27021015","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T11:27:58Z","timestamp":1768908478000},"page":"1015","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Research Progress on the Regulatory Effect of Curcumin on Mesenchymal Stem Cells"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7643-4609","authenticated-orcid":false,"given":"Lei","family":"Sun","sequence":"first","affiliation":[{"name":"School of Public Health, Guilin Medical University, Guilin 541199, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Die","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Public Health, Guilin Medical University, Guilin 541199, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Dong","sequence":"additional","affiliation":[{"name":"School of Public Health, Guilin Medical University, Guilin 541199, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4809-7262","authenticated-orcid":false,"given":"Ruihua","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Public Health, Guilin Medical University, Guilin 541199, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"He","sequence":"additional","affiliation":[{"name":"School of Public Health, Guilin Medical University, Guilin 541199, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1140-5685","authenticated-orcid":false,"given":"Yunjian","family":"Pan","sequence":"additional","affiliation":[{"name":"School of Public Health, Guilin Medical University, Guilin 541199, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingjie","family":"Li","sequence":"additional","affiliation":[{"name":"School of Public Health, Guilin Medical University, Guilin 541199, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuekun","family":"Xing","sequence":"additional","affiliation":[{"name":"School of Public Health, Guilin Medical University, Guilin 541199, China"},{"name":"Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Heath, School of Public Health, Guilin Medical University, Guilin 541199, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.2174\/1381612826666200420144805","article-title":"Progress of Mesenchymal Stem Cell-Derived Exosomes in Tissue Repair","volume":"26","author":"Zhao","year":"2020","journal-title":"Curr. Pharm. Des."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"108537","DOI":"10.1016\/j.intimp.2022.108537","article-title":"Mesenchymal stromal\/stem cells and their exosomes application in the treatment of intervertebral disc disease: A promising frontier","volume":"105","author":"Widjaja","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e13219","DOI":"10.1590\/1414-431x2024e13219","article-title":"Multipotent mesenchymal stromal\/stem cell-based therapies for acute respiratory distress syndrome: Current progress, challenges, and future frontiers","volume":"57","author":"Sababathy","year":"2024","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Kaur, K., Al-Khazaleh, A.K., Bhuyan, D.J., Li, F., and Li, C.G. (2024). A Review of Recent Curcumin Analogues and Their Antioxidant, Anti-Inflammatory, and Anticancer Activities. 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Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"155234","DOI":"10.1016\/j.phymed.2023.155234","article-title":"Curcumin and analogues in mitigating liver injury and disease consequences: From molecular mechanisms to clinical perspectives","volume":"123","author":"Jiang","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1080\/10937404.2020.1860842","article-title":"Potential protective roles of curcumin against cadmium-induced toxicity and oxidative stress","volume":"24","author":"Park","year":"2021","journal-title":"J. Toxicol. Environ. Health Part B Crit. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"117372","DOI":"10.1016\/j.ecoenv.2024.117372","article-title":"Curcumin mitigates sodium fluoride toxicity in Caenorhabditis elegans","volume":"288","author":"Xu","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"7249","DOI":"10.2147\/IJN.S213942","article-title":"Analysis of toxicity and anticancer activity of micelles of sodium alginate-curcumin","volume":"14","author":"Karabasz","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"118237","DOI":"10.1016\/j.carbpol.2021.118237","article-title":"Chitosan-based nanoparticle co-delivery of docetaxel and curcumin ameliorates anti-tumor chemoimmunotherapy in lung cancer","volume":"268","author":"Zhu","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1002\/ptr.6054","article-title":"Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances: Review","volume":"32","author":"Soleimani","year":"2018","journal-title":"Phytother. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"943","DOI":"10.2147\/IJN.S237536","article-title":"The Safety and Exploration of the Pharmacokinetics of Intrapleural Liposomal Curcumin","volume":"15","author":"Hocking","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.phrs.2016.12.037","article-title":"Curcumin: A potentially powerful tool to reverse cisplatin-induced toxicity","volume":"117","author":"Rezaee","year":"2017","journal-title":"Pharmacol. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0304-3835(95)03903-A","article-title":"Effects of curcumin on the formation of benzo[a]pyrene derived DNA adducts In Vitro","volume":"96","author":"Deshpande","year":"1995","journal-title":"Cancer Lett."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1002\/ptr.8165","article-title":"The ameliorative effect of turmeric (Curcuma longa Linn) extract and its major constituent, curcumin, and its analogs on ethanol toxicity","volume":"38","author":"Hosseinzadeh","year":"2024","journal-title":"Phytother. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"5006","DOI":"10.1002\/ptr.70086","article-title":"Efficacy and Safety of Curcumin as an Adjuvant to Standard Chemotherapy in Advanced and Metastatic Breast Cancer Patients: A Randomized Controlled Study","volume":"39","author":"Goyal","year":"2025","journal-title":"Phytother. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1007\/s11655-025-3939-1","article-title":"Effect and Safety of Phytosomal Curcumin Supplementation on Migraine Patients: A Randomized, Double-Blind and Placebo-Controlled Trial","volume":"31","author":"Shojaei","year":"2025","journal-title":"Chin. J. Integr. Med."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Tuntiyatorn, P., Lerspongpaibool, C., Kanchanathepsak, T., Watcharananan, I., and Tawonsawatruk, T. (2025). Efficacy and safety of curcumin in patients with hand osteoarthritis: A pilot double-blinded randomised controlled trial. BMC Complement. Med. Ther., 25.","DOI":"10.1186\/s12906-025-05096-2"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.ijpharm.2006.12.043","article-title":"Formulation and characterization of curcuminoids loaded solid lipid nanoparticles","volume":"337","author":"Tiyaboonchai","year":"2007","journal-title":"Int. J. Pharm."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"144699","DOI":"10.1016\/j.ijbiomac.2025.144699","article-title":"In Vitro and In Vivo efficacy evaluation of new self-assembling curcumin loaded nanohyaluronan-glycerosomes on wound restoring in health and diabetic rats","volume":"315","author":"Garcia","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.ejps.2009.03.009","article-title":"Development of curcuminoids loaded poly(butyl) cyanoacrylate nanoparticles: Physicochemical characterization and stability study","volume":"37","author":"Mulik","year":"2009","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Karaosmanoglu, S., Zhang, Y., Zhou, W., Ouyang, D., and Chen, X. (2022). Synthesis of Carrier-Free Paclitaxel-Curcumin Nanoparticles: The Role of Curcuminoids. Bioengineering, 9.","DOI":"10.3390\/bioengineering9120815"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1002\/jps.22785","article-title":"Liposomal delivery system enhances anti-inflammatory properties of curcumin","volume":"101","author":"Basnet","year":"2012","journal-title":"J. Pharm. Sci."},{"key":"ref_26","first-page":"2285","article-title":"Evaluation of the protective effects of curcuminoid (curcumin and bisdemethoxycurcumin)-loaded liposomes against bone turnover in a cell-based model of osteoarthritis","volume":"9","author":"Yeh","year":"2015","journal-title":"Drug Des. Devel Ther."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"6409","DOI":"10.7150\/thno.99033","article-title":"Genetically engineered cellular nanoparticles loaded with curcuminoids for cancer immunotherapy","volume":"14","author":"Liao","year":"2024","journal-title":"Theranostics"},{"key":"ref_28","first-page":"1187","article-title":"Stimulating effect of nanocurcumin and crocin on proliferation and pluripotency of bone marrow-derived mesenchymal stem cells","volume":"27","author":"Sabouni","year":"2024","journal-title":"Iran. J. Basic Med. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"110751","DOI":"10.1016\/j.msec.2020.110751","article-title":"A human epidermal growth factor-curcumin bandage bioconjugate loaded with mesenchymal stem cell for In Vivo diabetic wound healing","volume":"111","author":"Mohanty","year":"2020","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/bcpt.13477","article-title":"Complex effect of continuous curcumin exposure on human bone marrow-derived mesenchymal stem cell regenerative properties through matrix metalloproteinase regulation","volume":"128","author":"Yang","year":"2021","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"102742","DOI":"10.1016\/j.tice.2025.102742","article-title":"The effect of curcumin, catechin and resveratrol on viability, proliferation and cytotoxicity of human umbilical cord Wharton\u2019s jelly derived mesenchymal stem cells","volume":"93","author":"Lakshminarayanan","year":"2025","journal-title":"Tissue Cell"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"111919","DOI":"10.1016\/j.biopha.2021.111919","article-title":"Design and optimization of curcumin loaded nano lipid carrier system using Box-Behnken design","volume":"141","author":"Agrawal","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1186\/s13287-025-04672-0","article-title":"A comprehensive review of curcumin-based scaffolds in cartilage tissue engineering","volume":"16","author":"Talouki","year":"2025","journal-title":"Stem Cell Res. Ther."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1002\/jcb.24459","article-title":"Polyphenols suppress hydrogen peroxide-induced oxidative stress in human bone-marrow derived mesenchymal stem cells","volume":"114","author":"Yagi","year":"2013","journal-title":"J. Cell Biochem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"17974","DOI":"10.3390\/ijms151017974","article-title":"Curcumin-induced heme oxygenase-1 expression prevents H2O2-induced cell death in wild type and heme oxygenase-2 knockout adipose-derived mesenchymal stem cells","volume":"15","author":"Cremers","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_36","first-page":"405","article-title":"Immunoregulatory, proliferative and anti-oxidant effects of nanocurcuminoids on adipose-derived mesenchymal stem cells","volume":"18","author":"Yousefi","year":"2019","journal-title":"EXCLI J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1007\/s10571-020-01018-7","article-title":"Curcumin Improves Human Umbilical Cord-Derived Mesenchymal Stem Cell Survival via ERK1\/2 Signaling and Promotes Motor Outcomes After Spinal Cord Injury","volume":"42","author":"Wu","year":"2022","journal-title":"Cell Mol. Neurobiol."},{"key":"ref_38","first-page":"9140541","article-title":"Therapeutic Effects of CUR-Activated Human Umbilical Cord Mesenchymal Stem Cells on 1-Methyl-4-phenylpyridine-Induced Parkinson\u2019s Disease Cell Model","volume":"2016","author":"Li","year":"2016","journal-title":"Biomed. Res. Int."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"R127","DOI":"10.1186\/ar3065","article-title":"Curcumin mediated suppression of nuclear factor-kappaB promotes chondrogenic differentiation of mesenchymal stem cells in a high-density co-culture microenvironment","volume":"12","author":"Buhrmann","year":"2010","journal-title":"Arthritis Res. Ther."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s12010-022-04090-5","article-title":"Curcumin-Loaded Mesenchymal Stem Cell-Derived Exosomes Efficiently Attenuate Proliferation and Inflammatory Response in Rheumatoid Arthritis Fibroblast-Like Synoviocytes","volume":"195","author":"He","year":"2023","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e202401106","DOI":"10.1002\/cbdv.202401106","article-title":"Biocompatible PAMAM-PLGA-PCL Nanocarrier for Efficient Curcumin Delivery to Lung Cancer Cells: In Vitro Studies","volume":"21","author":"Jawad","year":"2024","journal-title":"Chem. Biodivers."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"10855","DOI":"10.1111\/jcmm.15714","article-title":"Curcumin reinforces MSC-derived exosomes in attenuating osteoarthritis via modulating the miR-124\/NF-kB and miR-143\/ROCK1\/TLR9 signalling pathways","volume":"24","author":"Qiu","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"202","DOI":"10.4103\/0973-1296.99285","article-title":"Curcumin increases rat mesenchymal stem cell osteoblast differentiation but inhibits adipocyte differentiation","volume":"8","author":"Gu","year":"2012","journal-title":"Pharmacogn. Mag."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"194903","DOI":"10.1016\/j.bbagrm.2022.194903","article-title":"Effective role of Curcumin on expression regulation of EZH2 histone methyltransferase as a dynamic epigenetic factor in osteogenic differentiation of human mesenchymal stem cells","volume":"1866","author":"Ghorbaninejad","year":"2023","journal-title":"Biochim. Biophys. Acta Gene Regul. Mech."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"9980137","DOI":"10.1155\/2021\/9980137","article-title":"Early Osteogenic Differentiation Stimulation of Dental Pulp Stem Cells by Calcitriol and Curcumin","volume":"2021","author":"Samiei","year":"2021","journal-title":"Stem Cells Int."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jphs.2016.10.005","article-title":"Curcumin protects human adipose-derived mesenchymal stem cells against oxidative stress-induced inhibition of osteogenesis","volume":"132","author":"Wang","year":"2016","journal-title":"J. Pharmacol. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Chen, S., Liang, H., Ji, Y., Kou, H., Zhang, C., Shang, G., Shang, C., Song, Z., Yang, L., and Liu, L. (2021). Curcumin Modulates the Crosstalk Between Macrophages and Bone Mesenchymal Stem Cells to Ameliorate Osteogenesis. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.634650"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1520052","DOI":"10.1155\/2021\/1520052","article-title":"Osteogenic Differentiation of Mesenchymal Stem Cells via Curcumin-Containing Nanoscaffolds","volume":"2021","author":"Khezri","year":"2021","journal-title":"Stem Cells Int."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"31291","DOI":"10.1038\/s41598-024-82614-1","article-title":"Curcumin liposomes alleviate senescence of bone marrow mesenchymal stem cells by activating mitophagy","volume":"14","author":"Li","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"101874","DOI":"10.1016\/j.mtbio.2025.101874","article-title":"Curcumin-encapsulated exosomes in bisphosphonate-modified hydrogel microspheres promote bone repair through macrophage polarization and DNA damage mitigation","volume":"32","author":"Si","year":"2025","journal-title":"Mater. Today Bio"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1248\/cpb.c17-00225","article-title":"Curcumin Inhibits Chondrocyte Hypertrophy of Mesenchymal Stem Cells through IHH and Notch Signaling Pathways","volume":"65","author":"Cao","year":"2017","journal-title":"Chem. Pharm. Bull."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13287-025-04836-y","article-title":"Curcumin controls the senescence of adipose-derived mesenchymal stem cells via the FoxO3\/autophagy signaling pathway to enhance joint homeostasis for osteoarthritis therapy","volume":"17","author":"Zhang","year":"2025","journal-title":"Stem Cell Res. Ther."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"tkab021","DOI":"10.1093\/burnst\/tkab021","article-title":"Curcumin preconditioning enhances the efficacy of adipose-derived mesenchymal stem cells to accelerate healing of burn wounds","volume":"9","author":"Azam","year":"2021","journal-title":"Burns Trauma"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12974-023-02738-5","article-title":"Human umbilical cord-derived mesenchymal stem cell transplantation supplemented with curcumin improves the outcomes of ischemic stroke via AKT\/GSK-3beta\/beta-TrCP\/Nrf2 axis","volume":"20","author":"Li","year":"2023","journal-title":"J. Neuroinflamm."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"155635","DOI":"10.1016\/j.phymed.2024.155635","article-title":"Curcumin-primed olfactory mucosa-derived mesenchymal stem cells mitigate cerebral ischemia\/reperfusion injury-induced neuronal PANoptosis by modulating microglial polarization","volume":"129","author":"Lan","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s12951-022-01339-3","article-title":"Curcumin primed ADMSCs derived small extracellular vesicle exert enhanced protective effects on osteoarthritis by inhibiting oxidative stress and chondrocyte apoptosis","volume":"20","author":"Xu","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41413-024-00319-7","article-title":"A DNA tetrahedron-based ferroptosis-suppressing nanoparticle: Superior delivery of curcumin and alleviation of diabetic osteoporosis","volume":"12","author":"Li","year":"2024","journal-title":"Bone Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"100630","DOI":"10.1016\/j.mtbio.2023.100630","article-title":"Incorporation of synthetic water-soluble curcumin polymeric drug within calcium phosphate cements for bone defect repairing","volume":"20","author":"Zhang","year":"2023","journal-title":"Mater. 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