{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:04:45Z","timestamp":1789193085450,"version":"build-2803163510"},"reference-count":83,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The circulating renin\u2013angiotensin\u2013aldosterone system (RAAS) plays a key role in regulating blood volume and electrolyte levels. While important for the maintenance of intravascular volume systemically, the local activation of tissue RAAS and the generation of angiotensin II contribute to inflammation and fibrosis. In the kidney, angiotensin II plays a key role in the development and progression of glomerular injury. Angiotensin-converting enzyme 2 (ACE2), an enzyme that degrades angiotensin II, is expressed in the glomerulus, focusing attention not only on the complexity of the RAAS but also identifying a potential new determinant of glomerular injury. Accordingly, we performed a narrative review using the search terms ACE2 and glomerulus in PubMed and Google Scholar to summarize the current understanding of the role of ACE2 in glomerular injury. We also discuss the role of ACE2 as a cellular receptor for SARS-CoV-2 and the potential impact of this function on glomerular injury in the setting of COVID-19.<\/jats:p>","DOI":"10.3390\/ijms27021033","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T17:20:42Z","timestamp":1768929642000},"page":"1033","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Renin Angiotensin System: Insights into the Role of ACE2 in Glomerular Injury Including SARS-CoV-2 Infection"],"prefix":"10.3390","volume":"27","author":[{"given":"Everton","family":"Smith","sequence":"first","affiliation":[{"name":"Department of Physiology, University of Toronto, Toronto, ON M5S 3K3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Scholey","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Toronto, Toronto, ON M5S 3H2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"ref_1","unstructured":"(2024, January 21). About Kidney Health, World Kidney Day 2024. Available online: https:\/\/www.worldkidneyday.org\/about-kidney-health\/."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1001\/jama.2019.14745","article-title":"Chronic Kidney Disease Diagnosis and Management","volume":"322","author":"Chen","year":"2019","journal-title":"JAMA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.tem.2004.03.001","article-title":"ACE2, a new regulator of the renin\u2013angiotensin system","volume":"15","author":"Burrell","year":"2004","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1172\/JCI112013","article-title":"Control of glomerular hypertension limits glomerular injury in rats with reduced renal mass","volume":"76","author":"Anderson","year":"1985","journal-title":"J. Clin. Investig."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1161\/HYPERTENSIONAHA.110.164244","article-title":"Prevention of Angiotensin II\u2013Mediated Renal Oxidative Stress, Inflammation, and Fibrosis by Angiotensin-Converting Enzyme 2","volume":"57","author":"Zhong","year":"2011","journal-title":"Hypertension"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3904\/kjim.2020.355","article-title":"Angiotensin-converting enzyme 2 and kidney diseases in the era of coronavirus disease 2019","volume":"36","author":"Suh","year":"2021","journal-title":"Korean J. Intern. Med."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"El-Arif, G., Khazaal, S., Farhat, A., Harb, J., Annweiler, C., Wu, Y., Cao, Z., Kovacic, H., Khattar, Z.A., and Fajloun, Z. (2022). Angiotensin II Type I Receptor (AT1R): The Gate towards COVID-19-Associated Diseases. Molecules, 27.","DOI":"10.3390\/molecules27072048"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"srep44911","DOI":"10.1038\/srep44911","article-title":"Angiotensin II induces kidney inflammatory injury and fibrosis through binding to myeloid differentiation protein-2 (MD2)","volume":"7","author":"Xu","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s11906-020-1028-6","article-title":"Recent Research Advances in Renin-Angiotensin-Aldosterone System Receptors","volume":"22","author":"Azushima","year":"2020","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"R1461","DOI":"10.1152\/ajpregu.00014.2007","article-title":"NO and cGMP mediate angiotensin AT2 receptor-induced renal renin inhibition in young rats","volume":"293","author":"Siragy","year":"2007","journal-title":"Am. J. Physiol. Integr. Comp. Physiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1177\/1470320309347786","article-title":"The angiotensin II type 2 receptor and the kidney","volume":"11","author":"Siragy","year":"2009","journal-title":"J. Renin-Angiotensin-Aldosterone Syst."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"4277","DOI":"10.1038\/s41598-023-31454-6","article-title":"Angiotensin II type 2 receptor activation preserves megalin in the kidney and prevents proteinuria in high salt diet fed rats","volume":"13","author":"Kulkarni","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"S95","DOI":"10.1046\/j.1523-1755.1998.06719.x","article-title":"Physiological and pharmacological implications of AT1 versus AT2 receptors","volume":"54","author":"Chung","year":"1998","journal-title":"Kidney Int."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/j.kint.2020.09.015","article-title":"SARS-CoV-2 receptor networks in diabetic and COVID-19\u2013associated kidney disease","volume":"98","author":"Menon","year":"2020","journal-title":"Kidney Int."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1161\/HYPERTENSIONAHA.120.15276","article-title":"Sex-Specific Modulation of Blood Pressure and the Renin-Angiotensin System by ACE (Angiotensin-Converting Enzyme) 2","volume":"76","author":"Ji","year":"2020","journal-title":"Hypertension"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Maksimowski, N., Williams, V.R., and Scholey, J.W. (2020). Kidney ACE2 expression: Implications for chronic kidney disease. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0241534"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Maksimowski, N.A., Scholey, J.W., Williams, V.R., and Nephrotic Syndrome Study Network (NEPTUNE) (2021). Sex and kidney ACE2 expression in primary focal segmental glomerulosclerosis: A NEPTUNE study. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0252758"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.cjco.2021.05.020","article-title":"Cardiovascular and Renal Risk Factors and Complications Associated with COVID-19","volume":"3","author":"Touyz","year":"2021","journal-title":"CJC Open"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Zheng, Y., Tang, L., Huang, W., Yan, R., Ren, F., Luo, L., and Zhang, L. (2015). Anti-Inflammatory Effects of Ang-(1-7) in Ameliorating HFD-Induced Renal Injury through LDLr-SREBP2-SCAP Pathway. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0136187"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/bph.12159","article-title":"ACE2, angiotensin-(1-7) and Mas receptor axis in inflammation and fibrosis","volume":"169","author":"Silveira","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1161\/ATVBAHA.116.307787","article-title":"Mechanisms of Mas1 Receptor-Mediated Signaling in the Vascular Endothelium","volume":"37","author":"Hoffmann","year":"2017","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Yalcin, H.C., Sukumaran, V., Al-Ruweidi, M.K.A.A., and Shurbaji, S. (2021). Do Changes in ACE-2 Expression Affect SARS-CoV-2 Virulence and Related Complications: A Closer Look into Membrane-Bound and Soluble Forms. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22136703"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Wang, J., Zhao, H., and An, Y. (2022). ACE2 Shedding and the Role in COVID-19. Front. Cell. Infect. Microbiol., 11.","DOI":"10.3389\/fcimb.2021.789180"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Xiao, F., Zimpelmann, J., Burger, D., Kennedy, C., H\u00e9bert, R.L., and Burns, K.D. (2016). Protein Kinase C-\u03b4 Mediates Shedding of Angiotensin-Converting Enzyme 2 from Proximal Tubular Cells. Front. Pharmacol., 7.","DOI":"10.3389\/fphar.2016.00146"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.yjmcc.2013.11.017","article-title":"Angiotensin II induced proteolytic cleavage of myocardial ACE2 is mediated by TACE\/ADAM-17: A positive feedback mechanism in the RAS","volume":"66","author":"Patel","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1139\/cjpp-2014-0065","article-title":"Urinary ACE2 in healthy adults and patients with uncomplicated type 1 diabetes","volume":"92","author":"Cherney","year":"2014","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"438","DOI":"10.2353\/ajpath.2007.060977","article-title":"Loss of Angiotensin-Converting Enzyme-2 (Ace2) Accelerates Diabetic Kidney Injury","volume":"171","author":"Wong","year":"2007","journal-title":"Am. J. Pathol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1681\/ASN.2006050423","article-title":"Glomerular Localization and Expression of Angiotensin-Converting Enzyme 2 and Angiotensin-Converting Enzyme","volume":"17","author":"Ye","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nrneph.2013.169","article-title":"The podocyte slit diaphragm\u2014From a thin grey line to a complex signalling hub","volume":"9","author":"Grahammer","year":"2013","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1038\/ki.2008.497","article-title":"Decreased glomerular and tubular expression of ACE2 in patients with type 2 diabetes and kidney disease","volume":"74","author":"Reich","year":"2008","journal-title":"Kidney Int."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.2353\/ajpath.2006.051091","article-title":"Loss of Angiotensin-Converting Enzyme-2 Leads to the Late Development of Angiotensin II-Dependent Glomerulosclerosis","volume":"168","author":"Oudit","year":"2006","journal-title":"Am. J. Pathol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"529","DOI":"10.2337\/db09-1218","article-title":"Human Recombinant ACE2 Reduces the Progression of Diabetic Nephropathy","volume":"59","author":"Oudit","year":"2009","journal-title":"Diabetes"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/ki.2012.83","article-title":"Podocyte-specific overexpression of human angiotensin-converting enzyme 2 attenuates diabetic nephropathy in mice","volume":"82","author":"Nadarajah","year":"2012","journal-title":"Kidney Int."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.kint.2023.04.007","article-title":"Transgenic angiotensin-converting enzyme 2 overexpression in the rat vasculature protects kidneys from ageing-induced injury","volume":"104","author":"Sanad","year":"2023","journal-title":"Kidney Int."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Silveira, K.D., Barroso, L.C., Vieira, A.T., Cisalpino, D., Lima, C.X., Bader, M., Arantes, R.M.E., Dos Santos, R.A.S., Sim\u00f5es-E-Silva, A.C., and Teixeira, M.M. (2013). Beneficial Effects of the Activation of the Angiotensin-(1\u20137) Mas Receptor in a Murine Model of Adriamycin-Induced Nephropathy. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0066082"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1038\/ki.2009.61","article-title":"Genetic deletion of the angiotensin-(1\u20137) receptor Mas leads to glomerular hyperfiltration and microalbuminuria","volume":"75","author":"Pinheiro","year":"2009","journal-title":"Kidney Int."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"F532","DOI":"10.1152\/ajprenal.00316.2023","article-title":"Renin-angiotensin system-mediated nitric oxide signaling in podocytes","volume":"327","author":"Semenikhina","year":"2024","journal-title":"Am. J. Physiol. Physiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e000643","DOI":"10.20945\/2359-3997000000643","article-title":"Ang-(1-7) attenuates podocyte injury induced by high glucose in vitro","volume":"67","author":"Lu","year":"2023","journal-title":"Arq. Bras. Endocrinol. Metabol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1161\/HYPERTENSIONAHA.116.07572","article-title":"G-Protein\u2013Coupled Receptor MrgD Is a Receptor for Angiotensin-(1\u20137) Involving Adenylyl Cyclase, cAMP, and Phosphokinase A","volume":"68","author":"Tetzner","year":"2016","journal-title":"Hypertension"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1161\/HYPERTENSIONAHA.123.21364","article-title":"Alternative Renin-Angiotensin System","volume":"81","author":"Bader","year":"2024","journal-title":"Hypertension"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.kint.2019.04.024","article-title":"Addition of cyclic angiotensin-(1-7) to angiotensin-converting enzyme inhibitor therapy has a positive add-on effect in experimental diabetic nephropathy","volume":"96","author":"Cassis","year":"2019","journal-title":"Kidney Int."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"F579","DOI":"10.1152\/ajprenal.00548.2009","article-title":"Infusion of angiotensin-(1\u20137) reduces glomerulosclerosis through counteracting angiotensin II in experimental glomerulonephritis","volume":"298","author":"Zhang","year":"2010","journal-title":"Am. J. Physiol. Physiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"117990","DOI":"10.1016\/j.biopha.2025.117990","article-title":"The anti-atherosclerotic effect of chronic AT1 receptor blocker treatment also depends on the ACE2\/Ang(1\u22127)\/Mas axis","volume":"186","author":"Klersy","year":"2025","journal-title":"Biomed. Pharmacother."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1161\/HYPERTENSIONAHA.124.22064","article-title":"ACE2, from the Kidney to SARS-CoV-2: Donald Seldin Award Lecture 2023","volume":"82","author":"Batlle","year":"2025","journal-title":"Hypertension"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1161\/CIRCRESAHA.120.317015","article-title":"Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System: Celebrating the 20th Anniversary of the Discovery of ACE2","volume":"126","author":"Gheblawi","year":"2020","journal-title":"Circ. Res."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Wang, M.-Y., Zhao, R., Gao, L.-J., Gao, X.-F., Wang, D.-P., and Cao, J.-M. (2020). SARS-CoV-2: Structure, Biology, and Structure-Based Therapeutics Development. Front. Cell. Infect. Microbiol., 10.","DOI":"10.3389\/fcimb.2020.587269"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41580-021-00418-x","article-title":"Mechanisms of SARS-CoV-2 entry into cells","volume":"23","author":"Jackson","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.cell.2023.01.039","article-title":"Angiotensin-converting enzyme 2\u2014At the heart of the COVID-19 pandemic","volume":"186","author":"Oudit","year":"2023","journal-title":"Cell"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"ar147","DOI":"10.1091\/mbc.E22-02-0045","article-title":"SARS-CoV-2 down-regulates ACE2 through lysosomal degradation","volume":"33","author":"Lu","year":"2022","journal-title":"Mol. Biol. Cell"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Sultan, R.H., Abdallah, M., Ali, T.M., Ahmed, A.E., Assal, H.H., Elesawy, B.H., and Ahmed, O.M. (2022). The Associations between Cytokine Levels, Kidney and Heart Function Biomarkers, and Expression Levels of Angiotensin-Converting Enzyme-2 and Neuropilin-1 in COVID-19 Patients. Vaccines, 10.","DOI":"10.3390\/vaccines10071045"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1093\/ckj\/sfac215","article-title":"Urinary angiotensin-converting enzyme 2 and metabolomics in COVID-19-mediated kidney injury","volume":"16","author":"Vergara","year":"2022","journal-title":"Clin. Kidney J."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Isnard, P., Vergnaud, P., Garbay, S., Jamme, M., Eloudzeri, M., Karras, A., Anglicheau, D., Galantine, V., Eddine, A.J., and Gosset, C. (2023). A specific molecular signature in SARS-CoV-2\u2013infected kidney biopsies. J. Clin. Investig., 8.","DOI":"10.1172\/jci.insight.165192"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1053\/j.ajkd.2020.10.001","article-title":"Multicenter Clinicopathologic Correlation of Kidney Biopsies Performed in COVID-19 Patients Presenting with Acute Kidney Injury or Proteinuria","volume":"77","author":"Akilesh","year":"2021","journal-title":"Am. J. Kidney Dis."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1681\/ASN.2020060802","article-title":"Kidney Biopsy Findings in Patients with COVID-19","volume":"31","author":"Kudose","year":"2020","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1056\/NEJMra1106556","article-title":"Focal Segmental Glomerulosclerosis","volume":"365","author":"Kaskel","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.semnephrol.2017.07.007","article-title":"The Cell Biology of APOL1","volume":"37","author":"Bruggeman","year":"2017","journal-title":"Semin. Nephrol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1053\/j.ackd.2014.06.005","article-title":"APOL1 Kidney Risk Alleles: Population Genetics and Disease Associations","volume":"21","author":"Limou","year":"2014","journal-title":"Adv. Chronic Kidney Dis."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev-physiol-021119-034345","article-title":"APOL1 and Kidney Disease: From Genetics to Biology","volume":"82","author":"Friedman","year":"2020","journal-title":"Annu. Rev. Physiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1681\/ASN.2020050558","article-title":"AKI and Collapsing Glomerulopathy Associated with COVID-19 and APOL 1 High-Risk Genotype","volume":"31","author":"Wu","year":"2020","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1056\/NEJMoa2202396","article-title":"Inaxaplin for Proteinuric Kidney Disease in Persons with Two APOL1 Variants","volume":"388","author":"Egbuna","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s13613-021-00914-5","article-title":"Acute kidney injury prevalence, progression and long-term outcomes in critically ill patients with COVID-19: A cohort study","volume":"11","author":"Lumlertgul","year":"2021","journal-title":"Ann. Intensiv. Care"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1681\/ASN.2021060734","article-title":"Kidney Outcomes in Long COVID","volume":"32","author":"Bowe","year":"2021","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1001\/jamainternmed.2023.8225","article-title":"COVID-19\u2212Associated Acute Kidney Injury and Longitudinal Kidney Outcomes","volume":"184","author":"Aklilu","year":"2024","journal-title":"JAMA Intern. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.nefro.2024.08.003","article-title":"Long-term outcomes after AKI in hospitalized patients with COVID-19","volume":"45","author":"Gameiro","year":"2025","journal-title":"Nefrolog\u00eda"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.1016\/j.ekir.2022.09.027","article-title":"Renal Prognosis of COVID-19 Associated Nephropathy","volume":"7","author":"Giannini","year":"2022","journal-title":"Kidney Int. Rep."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000520235","article-title":"Similarities and Differences between COVID-19-Associated Nephropathy and HIV-Associated Nephropathy","volume":"8","author":"Chen","year":"2021","journal-title":"Kidney Dis."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1046\/j.1523-1755.2003.00230.x","article-title":"Long-term renal survival in HIV-associated nephropathy with angiotensin-converting enzyme inhibition","volume":"64","author":"Wei","year":"2003","journal-title":"Kidney Int."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1093\/ndt\/gfv207","article-title":"Trends in the outcomes of end-stage renal disease secondary to human immunodeficiency virus-associated nephropathy","volume":"30","author":"Chaudhary","year":"2015","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Andre, M., Lau, L.-S., Pokharel, M.D., Ramelow, J., Owens, F., Souchak, J., Akkaoui, J., Ales, E., Brown, H., and Shil, R. (2023). From Alpha to Omicron: How Different Variants of Concern of the SARS-Coronavirus-2 Impacted the World. Biology, 12.","DOI":"10.3390\/biology12091267"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/FPC.0000000000000436","article-title":"ACE2 polymorphism and susceptibility for SARS-CoV-2 infection and severity of COVID-19","volume":"31","author":"Breuckmann","year":"2021","journal-title":"Pharmacogenetics Genom."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s12985-022-01782-6","article-title":"SNPs of ACE1 (rs4343) and ACE2 (rs2285666) genes are linked to SARS-CoV-2 infection but not with the severity of disease","volume":"19","author":"Alimoradi","year":"2022","journal-title":"Virol. J."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"e2323","DOI":"10.1002\/rmv.2323","article-title":"Genetic polymorphisms of ACE1, ACE2, and TMPRSS2 associated with COVID-19 severity: A systematic review with meta-analysis","volume":"32","author":"Saengsiwaritt","year":"2022","journal-title":"Rev. Med. Virol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"e369","DOI":"10.1016\/S2666-5247(23)00011-3","article-title":"Advances in developing ACE2 derivatives against SARS-CoV-2","volume":"4","author":"Zhang","year":"2023","journal-title":"Lancet Microbe"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.cell.2020.04.004","article-title":"Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2","volume":"181","author":"Monteil","year":"2020","journal-title":"Cell"},{"key":"ref_75","unstructured":"Apeiron Biologics (2023, December 31). Recombinant Human Angiotensin-Converting Enzyme 2 (rhACE2) as a Treatment for Patients with COVID-19. clinicaltrials.gov, Clinical Trial Registration NCT04335136, Available online: https:\/\/clinicaltrials.gov\/study\/NCT04335136."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/S2213-2600(20)30418-5","article-title":"Human recombinant soluble ACE2 in severe COVID-19","volume":"8","author":"Zoufaly","year":"2020","journal-title":"Lancet Respir. Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1007\/s40262-013-0072-7","article-title":"Pharmacokinetics and Pharmacodynamics of Recombinant Human Angiotensin-Converting Enzyme 2 in Healthy Human Subjects","volume":"52","author":"Haschke","year":"2013","journal-title":"Clin. Pharmacokinet."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-med-042420-113838","article-title":"SARS-CoV-2 Neutralizing Antibodies for COVID-19 Prevention and Treatment","volume":"73","author":"Li","year":"2022","journal-title":"Annu. Rev. Med."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"5143","DOI":"10.1021\/acsnano.0c02857","article-title":"Computational Design of ACE2-Based Peptide Inhibitors of SARS-CoV-2","volume":"14","author":"Han","year":"2020","journal-title":"ACS Nano"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"C279","DOI":"10.1152\/ajpcell.00478.2020","article-title":"Soluble ACE2 as a potential therapy for COVID-19","volume":"320","author":"Krishnamurthy","year":"2021","journal-title":"Am. J. Physiol. Physiol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.semnephrol.2009.07.012","article-title":"Podocytes and Glomerular Function with Aging","volume":"29","author":"Wiggins","year":"2009","journal-title":"Semin. Nephrol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1056\/NEJMoa2025845","article-title":"Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes","volume":"383","author":"Bakris","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1056\/NEJMoa2403347","article-title":"Effects of Semaglutide on Chronic Kidney Disease in Patients with Type 2 Diabetes","volume":"391","author":"Perkovic","year":"2024","journal-title":"N. Engl. J. Med."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/2\/1033\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T17:21:30Z","timestamp":1768929690000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/2\/1033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,20]]},"references-count":83,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["ijms27021033"],"URL":"https:\/\/doi.org\/10.3390\/ijms27021033","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,20]]}}}